On September 23, 2021, Fallica, Antonino N.; Sorrenti, Valeria; D鈥睞mico, Agata G.; Salerno, Loredana; Romeo, Giuseppe; Intagliata, Sebastiano; Consoli, Valeria; Floresta, Giuseppe; Rescifina, Antonio; D鈥睞gata, Velia; Vanella, Luca; Pittala, Valeria published an article.Product Details of 5036-48-6 The title of the article was Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent In Vitro Antiproliferative Activity. And the article contained the following:
Heme oxygenase-1 (HO-1) promotes heme catabolism exercising cytoprotective roles in normal and cancer cells. Herein, we report the design, synthesis, mol. modeling, and biol. evaluation of novel HO-1 inhibitors. Specifically, an amide linker in the central spacer and an imidazole were fixed, and the hydrophobic moiety required by the pharmacophore was largely modified. In many tumors, overexpression of HO-1 correlates with poor prognosis and chemoresistance, suggesting the inhibition of HO-1 as a possible antitumor strategy. Accordingly, compounds 7i and 7l-p emerged for their potency against HO-1 and were investigated for their anticancer activity against prostate (DU145), lung (A549), and glioblastoma (U87MG, A172) cancer cells. The selected compounds showed the best activity toward U87MG cells. Compound 7l was further investigated for its in-cell enzymic HO-1 activity, expression levels, and effects on cell invasion and vascular endothelial growth factor (VEGF) extracellular release. The obtained data suggest that 7l can reduce cell invasivity acting through modulation of HO-1 expression. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6
The Article related to acetamide derivative heme oxygenase inhibitor preparation cancer, Placeholder for records without volume info and other aspects.Product Details of 5036-48-6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem