Liu, Dan; Xue, Aiqi; Wang, Haifeng; Luan, Tian; Li, Xue published an article in 2022, the title of the article was Design, synthesis and biological evaluation of 4-amino-quinolines as antitumor agents.Recommanded Product: N-(3-Aminopropyl)-imidazole And the article contains the following content:
Fifteen novel 4-amino-quinolines (I1-III3) as antitumor agent were synthesized by p-nitroaniline and ethoxymethylene malonic ester (EMME) via condensation, cyclization, hydrolysis, decarboxylation, chlorination, nucleophilic substitution, reduction and amidation. The antitumor activity of compounds I1-III3 was evaluated on SGC-7901, BEL-7402 and A549 cancer cell lines. In vitro bioassay indicated that some compounds showed different degree activity against all tested cancer cell lines. Compound I1, I4 and II2 exhibited high effects against A549 cell lines (IC50 = 1.34渭M, 1.36渭M and 3.00渭M, resp.). In addition, the result of mol. docking showed that compound I1, I4 and II2 could dock into the pocket of EGFR. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Recommanded Product: N-(3-Aminopropyl)-imidazole
The Article related to amino quinoline antitumor agent egfr receptor, Placeholder for records without volume info and other aspects.Recommanded Product: N-(3-Aminopropyl)-imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem