Tang, Shengzhuang; Chen, Jesse; Cannon, Jayme; Cao, Zhengyi; Baker, James R. Jr; Wang, Su He published an article in 2021, the title of the article was Dendrimer-based posaconazole nanoplatform for antifungal therapy.Safety of N-(3-Aminopropyl)-imidazole And the article contains the following content:
We examined formulating a new antifungal agent, posaconazole (POS) and its derivatives, with different mol. vehicles. Several combinations of drug and carrier mols. were synthesized, and their antifungal activities were evaluated against Aspergillus fumigatus. Posaconazole and four of its derivatives were conjugated to either generation 5 (G5) dendrimers or partially modified G5 dendrimers. The in vitro antifungal activities of these compounds suggest that conjugates with specific chem. linkages showed better fungistatic activity than direct conjugates to POS. In particular, a polyethylene glycol (PEG)-imidazole modified G5 dendrimer demonstrated improved antifungal efficacy relative to the parent G5 mol. Further studies were then conducted with POS derived mols. coupled to PEG-imidazole modified G5 dendrimers to achieve a highly soluble and active conjugate of POS. This conjugated macromol. averaged 23 POS mols. per G5 and had a high solubility with 50 mg/mL, which improved the molar solubility of POS from less than 0.03 mg/mL to as high as 16 mg/mL in water. The primary release profile of the drug in human plasma was extended to over 72 h, which is reflected in the in vitro inhibition of A. fumigatus growth of over 96 h. These POS-polymer conjugates appear to be novel and efficient antifungal agents. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole
The Article related to posaconazole nanoplatform dendrimer antifungal therapy, demethylase inhibitor, antifungal drug, biocompatible, polymer, Placeholder for records without volume info and other aspects.Safety of N-(3-Aminopropyl)-imidazole
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem