Venkata Mallavadhani, Uppuluri et al. published their research in Journal of Asian Natural Products Research in 2020 |CAS: 5036-48-6

The Article related to cervical lung breast pancreatic cancer antiproliferative usnic acid, (+)- usnic acid, antiproliferative activity, apoptosis, cell cycle arrest, enamine, pyrazole, Placeholder for records without volume info and other aspects.Name: N-(3-Aminopropyl)-imidazole

Venkata Mallavadhani, Uppuluri; Vanga, Nagi Reddy; Balabhaskara Rao, Kancharana; Jain, Nishanth published an article in 2020, the title of the article was Synthesis and antiproliferative activity of novel (+)- usnic acid analogues.Name: N-(3-Aminopropyl)-imidazole And the article contains the following content:

Twenty one novel (+)- usnic acid-based analogs belonging to three classes such as enamines, imines, and pyrazoles were synthesized. All the synthesized compounds were characterized by their spectral data (1H NMR, 13C NMR, IR, and HRMS). The synthesized compounds were evaluated for their antiproliferative activity against a panel of four human cancer cell lines including HeLa (cervix), MDA-MB-231 (breast), A549 (lung), and MiaPaca (pancreas) by employing SRB cell proliferation assay. Screening results indicated that all synthesized compounds showed enhanced activity than the parent compound Most significantly, compounds and showed potent antiproliferative activity against all the cancer cell lines tested. Compounds and arrested the cell cycle in G2/M phase and induced apoptosis in HeLa cells. In view of significant antiproevaliferative activity, compounds and can be considered as lead mols. for further development. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Name: N-(3-Aminopropyl)-imidazole

The Article related to cervical lung breast pancreatic cancer antiproliferative usnic acid, (+)- usnic acid, antiproliferative activity, apoptosis, cell cycle arrest, enamine, pyrazole, Placeholder for records without volume info and other aspects.Name: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem