Bovy, P. R. published the artcileConformationally restricted polysubstituted biphenyl derivatives with angiotensin II receptors antagonist properties, Computed Properties of 79047-41-9, the publication is Journal of Medicinal Chemistry (1991), 34(8), 2410-14, database is CAplus and MEDLINE.
The synthesis and in vitro activity of new nonpeptide angiotensin II antagonists is presented. Compared to previously reported biphenyl compounds, the new analogs I and II have reduced conformational freedom derived from steric hindrance. Me 4′-methyl-2′,6′-dimethoxy[1,1′-biphenyl]-2-carboxylate was prepared by Von Pechmann condensation of orcinol with oxocyclohexane-2-carboxylate followed by dehydrogenation. This scheme provided the carbon skeleton of the biphenyl potentially substituted on the 2-, 2′-, 4′-, and 6′-positions. Elaboration of the substituents led to a biphenyl derivative used to alkylate a 2-butyl-4-chloro-5-(hydroxymethyl)imidazole. After coupling with the imidazole, 2 regioisomers were separated and identified by NMR. NOESY experiments were useful to establish regiochem. of the final products that have angiotensin II blocking activity. Their affinity for angiotensin II receptors was established in a binding assay experiment and in an isolated organ test. The presence of 2′,6′-dimethoxy substituent on the biphenyl moiety of the antagonist significantly decreased the affinity for the receptor.
Journal of Medicinal Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, Computed Properties of 79047-41-9.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem