Carini, David J. published the artcilePart VI. Nonpeptide angiotensin II receptor antagonists: N-[(benzyloxy)benzyl]imidazoles and related compounds as potent antihypertensives, Application of (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, the publication is Journal of Medicinal Chemistry (1990), 33(5), 1330-6, database is CAplus and MEDLINE.
A series of title compounds (I, R1 = Bu, SEt, SPr; R2 = H, Cl, CH2OH, CH2OAc; R3 = CH2OH, Cl, CH2OAc, CH2NHCO2Me; R4 = CO2H, NHSO2CF3; X = NHCO, CO, O, S, OCH2 etc.; n = 0-1) was synthesized and demonstrated to be antagonists of the angiotensin II (AII) receptor. I are structurally related to the N-(benzamidobenzyl)imidazoles and extend the scope of this new class of nonpeptide AII antagonists. The amide linkage (X = NHCO) in the N-(benzamidobenzyl)imidazoles can be replaced successfully by a variety of groups (X = O, S, CO, OCH2, CH:CH, NHCONH; n = 0-1); linkers of 0-1 atoms in length are most effective. When administered i.v. to awake renal hypertensive rats, these compounds exhibited potent antihypertensive activity.
Journal of Medicinal Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, Application of (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem