Carini, David J. published the artcileNonpeptide angiotensin II receptor antagonists: the discovery of a series of N-(biphenylylmethyl)imidazoles as potent, orally active antihypertensives, Formula: C8H13ClN2O, the publication is Journal of Medicinal Chemistry (1991), 34(8), 2525-47, database is CAplus and MEDLINE.
Nonpeptide angiotensin II receptor antagonists I (R = CH2OH, CH2OMe, CHO; R1 = tetrazolyl, (un)substituted triazolyl, CO2H, CONHR2, R2 = OH, OMe, OCH2Ph, SO2Ph, NHSO2CF3, COCF3, SO2CF3) were prepared and produced a potent antihypertensive effect upon oral administration. The acidic group at the 2′-position of the biphenyl is essential. Only ortho-substituted acids possess both high affinity for the AII receptor and good oral antihypertensive potency. The carboxylic acid group has been replaced with a variety of acidic isosteres, and the tetrazole ring was the most effective.
Journal of Medicinal Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, Formula: C8H13ClN2O.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem