Pharma Chemica published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Safety of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.
Kumar, N. D. Mahesh published the artcile“D-Glucose” phase transfer catalyzed synthesis of benzimidazolyl oxadiazole derivatives, Safety of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, the publication is Pharma Chemica (2010), 2(4), 224-230, database is CAplus.
Condensation of 2-(chloromethyl)benzimidazole with 2-mercapto-1,3,4-oxadiazoles gave 2-[(5-phenyl-1,3,4-oxadiazol-2-yl)thiomethyl]-1H-benzimidazole (I). Alternatively, I was also prepared by treatment of 1,2-C6H4(NH2)2 with 1,3,4-oxadiazole-2-thioacetate under Philips conditions. Subsequent treatment with dialkyl sulfate in MeCN using D-glucose as phase-transfer catalyst (PTC) gave the corresponding N-alkylated 2-[(benzimidazol-2-ylmethyl)thio]-1,3,4-oxadiazoles. The latter were also prepared by the reaction of 2-(chloromethyl)-N-methylbenzimidazole with 2-mercapto-1,3,4-oxadiazoles. Even though, there are several other PTCs reported in literature, the authors employed D-glucose because it has got characteristics similar to that of crown ethers and polyethylene glycol. Furthermore, it is readily available, reasonably cheap, non-toxic, and eco-friendly.
Pharma Chemica published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Safety of 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem