Nitrolysis of hexamethylenetetramine in presence of ionic liquids was written by Wang, Nai;Shi, Yu;Yang, Hong-wei;Chen, Guang-bin;Lu, Chun-xu. And the article was included in Hanneng Cailiao in 2011.Safety of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:
Direct nitrolysis of hexamethylenetetramine catalyzed by ionic liquids was studied. The effects of dosage of ionic liquid and different ionic liquids on the nitrolysis were investigated in the systems of 95% nitric acid and nitrogen pentoxide/nitric acid. In the system of 95% nitric acid, [Hmim]NO3 shows the best catalytic activity in all of ionic liquids screened. The optimal reaction condition is 1.5mol% ionic liquid loading, 12 : 1 of quality ratio of 95% nitric acid to hexamethylenetetramine and 90 min of reaction time at -5-0 °C. 1,3,5-Tri-nitroperhydro-1,3,5-triazine can be obtained in yield of 75.9% using ionic liquid as catalyst under optimized condition, while 1,3,5-tri-nitroperhydro-1,3,5-triazine can be generated in lower yield of 68.3% without adding ionic liquid In the system of nitrogen pentoxide/nitric acid, [Bmim]BF4 shows the best catalytic activity. The optimal reaction conditions are 5mol% ionic liquid loading, 9 : 1 of mass ratio of 100% nitric acid to hexamethylenetetramine, 2 : 1 of quality ratio of 100% hexamethylenetetramine to nitrogen pentoxide and 60 min of reaction time at -5-0 °C. Under optimized conditions, 77.6% yield of 1,3,5-tri-nitroperhydro-1,3,5-triazine can be obtained without adding ionic liquid, while yield of 1,3,5-tri-nitroperhydro-1,3,5-triazine can be improved to 85.4% using ionic liquid as catalyst. It indicates that ionic liquids have observably catalytic activity on the direct nitrolysis of hexamethylenetetramine. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Safety of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).
1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Safety of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem