Management of Waldenstrom’s macroglobulinemia on the basis of cytogenetic abnormality was written by Sekiguchi, Naohiro. And the article was included in Ketsueki Naika in 2022.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:
Indeed, in the last decade, the mol. pathogenesis of WM, such as chromosomal abnormalities, gene mutations, and signal transduction, has progressed rapidly, and new drugs, including BTK inhibitors, have been vigorously developed. While there are reports indicating that searching for chromosomal/genetic abnormalities at the time of diagnosis is highly significant in predicting the response rate and long-term prognosis in the therapeutic intervention of WM, in Japan, it is difficult to say that such searches are sufficiently performed in routine clin. practice. At present, there are no high-evidence-level clin. practice guidelines or prognostic models based on chromosomal/genetic abnormalities. It is hoped that in the next 10 years established a stratification of clin. practice based on chromosomal/genetic abnormalities in WM. In this article, the author like to explain the chromosomal/genetic abnormalities that can be detected by WM, and also discuss the prognostic significance of chromosomal/genetic abnormalities, proposed treatment algorithms based on chromosomal/genetic abnormalities, and issues, including my personal views. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).
4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application In Synthesis of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem