Synthesis of dimethyl succinate catalyzed by ionic liquids was written by Zhao, Dishun;Liu, Mengshuai;Xu, Zhice;Zhang, Juan;Zhang, Di;Fu, Jiangtao;Ren, Peibing. And the article was included in Huagong Xuebao (Chinese Edition) in 2012.Electric Literature of C10H20N2O4S The following contents are mentioned in the article:
Seven kinds of ionic liquids, 1-hexyl-3-methylimidazolium hydrogensulfate ([Hmim]HSO4), 1-butyl-3-methylimidazolium dihydrogen phosphate ([Bmim]H2PO4), 1-butyl-3-methylimidazolium hydrogen sulfate ([Bmim]HSO4), 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF4), 1-butylpyridinium hydrogen sulfate ([Bpy]HSO4), 1-butylpyridinium dihydrogen phosphate ([Bpy]H2PO4), 1-ethylpyridinium hydrogen sulfate ([Epy]HSO4), were designed and synthesized. The synthesis of di-Me succinate catalyzed by ionic liquids was studied for the first time. It was shown that [Epy]HSO4 had the best catalytic performance, and optimal conditions for the synthesis of di-Me succinate were obtained, succinic acid and methanol molar ratio 1 : 3.0, amount of catalyst 5% (g/g) of succinic acid, reaction temperature 70掳C and reaction time 2 h. Under the optimal conditions, the yield of di-Me succinate was up to 91.83%, esterification rate was 96.32%. The catalyst was recycled 7 times without substantial decrease in activity. Moreover, compared to conventional industrial catalysts, ionic liquid catalyst had the superiority of smaller catalyst dosage, less byproduct, mild reaction conditions, high yield, and recycled catalyst usage. Finally, the mechanism of esterification catalyzed by ionic liquids was discussed. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Electric Literature of C10H20N2O4S).
1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C10H20N2O4S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem