Acidic-functionalized ionic liquid as an efficient, green, and metal-free catalyst for benzylation of sulfur, nitrogen, and carbon nucleophiles to benzylic alcohols was written by Chu, Xue-Qiang;Jiang, Ran;Fang, Yi;Gu, Zheng-Yang;Meng, Hua;Wang, Shun-Yi;Ji, Shun-Jun. And the article was included in Tetrahedron in 2013.COA of Formula: C10H20N2O4S The following contents are mentioned in the article:
A series of HSO4– functionalized ILs was synthesized and used as efficient, green, and metal-free catalysts for benzylation. Notably, the catalytic system has wide substrate scopes and the ionic liquid catalysts were applied to investigate three different types of nucleophiles to give the desired benzylation products with moderate to excellent yields. Thus, benzylation of thiols, anilines, and indoles by benzylic alcs. was catalyzed by an acid-functionalized ionic liquid E.g., in presence of 1-methyl-3-pentylimidazolium hydrogen sulfate, benzylation of benzothiazole-2-thiol by 4-MeOC6H4CH2OH gave 91% benzylic thioether (I). This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4COA of Formula: C10H20N2O4S).
1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C10H20N2O4S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem