Synthesis of N-cyanoethyl-N-hydroxyethylaniline catalyzed by acidic ionic liquid was written by Guo, Hui;Yin, Yuanyuan;Zhang, Xueying;Zhuang, Yuwei;Cao, Jian;Zhang, Guobao. And the article was included in Yingyong Huaxue in 2020.Application of 478935-29-4 The following contents are mentioned in the article:
N-Cyanoethyl-N-hydroxyethylaniline is an important dye intermediate with a wide range of applications. A green and efficient protocol for the synthesis of N-cyanoethyl-N-hydroxyethylaniline by reaction of acrylonitrile and N-hydroxyethyl aniline with 1-butyl-3-methylimidazolium hydrogen sulfate ionic liquid ([Bmim]HSO4) as a catalyst has been developed, eliminating inert-gas welding and complex operation of traditional methods. The effect of ionic liquid, the amount of ionic liquid, the ratio of substrates, temperature and time were investigated. The optimum reaction conditions were obtained as follow: [BMIM]HSO4 0.8 mmol, n (N-hydroxyethyl aniline):n (acrylonitrile) = 1:1.2, reaction time of 12 h, reaction temperature of 90°C. The acidic ionic liquid could be easily separated and reused for at least 5 times without significantly decrease in catalytic activity. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Application of 478935-29-4).
1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application of 478935-29-4
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem