Synthesis of propylparaben catalyzed by acidic ionic liquid was written by Huang, Yanxian;Shen, Jinlan. And the article was included in Guangdong Huagong in 2013.Application In Synthesis of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:
With p-hydroxybenzoic acid and n-propanol as raw materials, synthesis of propylparaben catalyzed by acidic ionic liquid [Hmim]HSO4 was researched. The structure of propylparaben was characterized by IR and LC-MS. The effects of the molar ratio of p-hydroxybenzoic acid to n-propanol, reaction time, reaction temperature and catalyst amount on the yield of propylparaben were investigated. The optimal conditions were obtained as follows: the molar ratio of p-hydroxybenzoic acid to n-propanol 1:3, the catalyst amount of reactant total mass 4%, reaction time 3 h, and reaction temperature 90°C. Under above conditions, the yield of the propylparaben reached 91.8%. The catalytic activity of [Hmim]HSO4, was remained mostly after it was reused for 5 times. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Application In Synthesis of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).
1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem