A novel chemoenzymatic synthesis of propyl caffeate using lipase-catalyzed transesterification in ionic liquid was written by Pang, Na;Gu, Shuang-Shuang;Wang, Jun;Cui, Hong-Sheng;Wang, Fang-Qin;Liu, Xi;Zhao, Xing-Yu;Wu, Fu-An. And the article was included in Bioresource Technology in 2013.Computed Properties of C10H20N2O4S The following contents are mentioned in the article:
Pr caffeate has the highest antioxidant capacity in the caffeate alkyl esters family, but industrial production of Pr caffeate is hindered by low yields using either the chem. or enzymic catalysis method. To set up a high-yield process for obtaining Pr caffeate, a novel chemoenzymic synthesis method using lipase-catalyzed transesterification of an intermediate Me caffeate or Et caffeate and 1-propanol in ionic liquid was established. The maximum Pr caffeate yield of 98.5% was obtained using lipase-catalyzed transesterification under the following optimal conditions: Novozym 435 as a biocatalyst, [Bmim][CF3SO3] as a medium, a molar ratio of Me caffeate to 1-propanol of 1:5, a mass ratio of Me caffeate to lipase of 1:20, and a reaction temperature of 60 °C. The two-step conversion of caffeic acid to Pr caffeate via Me caffeate is an efficient way to prepare Pr caffeate with an overall yield of 82.7%. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Computed Properties of C10H20N2O4S).
1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Computed Properties of C10H20N2O4S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem