Study of 5(6)-hydroxybenzimidazole aminomethylation was written by Smirnov, L. D.;Kuznetsov, Yu. V.;Stolyarova, L. G.;Lezina, V. P.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1985.Reference of 101018-70-6 The following contents are mentioned in the article:
Treating benzimidazole I (R = Me, R1 = R2 = H) with N-(methoxymethyl)piperidine, -morpholine, and N,N,N‘,N‘-tetramethylmethylenediamine in alc. gave 92.7, 88.7, and 65.4% aminomethylated derivatives I (R = Me, R1 = piperidinomethyl, morpholinomethyl, Me2NCH2; R2 = H). Treating I (R-R2 = H) with piperidine and paraformaldehyde under Mannich reaction conditions gave I (R = H, R1 = piperidinomethyl, R2 = H, piperidinomethyl). Analogously obtained was I (R = H, R1 = R2 = Me2NCH2). This study involved multiple reactions and reactants, such as 4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6Reference of 101018-70-6).
4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 101018-70-6
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem