Study on synthesis of methyl oleate catalyzed by 1-alkyl-3-methylimidazolium hydrosulfate was written by Sun, Hua;Li, Shengqing;Chen, Hao;Liu, Junchao;Xue, Aifang;Liu, Hanlan. And the article was included in Wuhan Gongcheng Daxue Xuebao in 2009.Safety of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:
Five acidic ionic liquids with an hydrogen sulfate group were synthesized ([CnMIm]HSO4, n = 0, 2, 4, 6 and 8). Their acidity was studied. Their application in esterification utilizing oleic acid and methanol was explored. The exptl. results showed 1-hexyl-3-methyl-imidazolium hydrogen sulfate ([C6MIm]HSO4) was the best catalyst of acidic ionic liquid in esterification. Under optimal esterification conditions: n(methanol):n(oleic acid) = 2.5:1, m(oleic acid):m([C6MIm]HSO4) = 1:0.08, temperature 90°C and time 14 h, mass fraction of fatty acid Me ester could reach more than 91%. The ionic liquids were stable and could be reused. Me oleate was separated from raw material easily, and even if ionic liquid was reused beyond 6 times, the conversion of esterification did not decrease. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Safety of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).
1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Safety of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem