Synthesis of ethyl 2-chloropropionate catalyzed by acidic imidazolium ionic liquids was written by Zhou, Xiansi;Liu, Jiabin;Luo, Wenfeng;Zhang, Yiwen;Song, Hang. And the article was included in Huaxue Yanjiu Yu Yingyong in 2011.Formula: C10H20N2O4S The following contents are mentioned in the article:
The synthesis of Et 2-chloropropanoate in acidic imidazolium ionic liquids was studied. Four imidazolium ionic liquids were prepared and employed as catalysts in the esterification. Their acidities were measured by Hammett method and the acidity-catalytic activity relationship was investigated. [Hmim]HSO4 was found to be the most efficient catalyst. The effects of reaction time, reaction temperature, the molar ratio of alc. to acid, the amount of ILs on the yield of Et 2-chloropropanoate were investigated. The optimum esterification conditions were obtained: reaction time was 2h, n(2-chloropropanoic acid):n(IL):n(ethanol)=1:1:2 and reaction temperature was 90°C. The yield of Et 2-chloropropanoate was 85.5% and the purity of product detected by GC was 99% under the optimum conditions. Even if the catalyst was repeatedly used for 5 times, the catalytic activity maintains stable. The reusability of the IL was excellent and it could be reused for 5 times without obviously catalytic activity decrease. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Formula: C10H20N2O4S).
1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Formula: C10H20N2O4S
Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem