Month: November 2022

On December 31, 2022, Wang, Yongjie; Chen, Junfei; Gao, Wei-Qiang; Yang, Ru published an article.Safety of N-Methyl-7H-purin-6-amine The title of the article was METTL14 promotes prostate tumorigenesis by inhibiting THBS1 via an m6A-YTHDF2-dependent mechanism. And the article contained the following:

N6-methyladenine (m6A) is the most predominant RNA modification, which has been shown to be related to many types of cancers. However, understanding of its role in prostate cancer (PCa) is largely unknown. Here, we report an upregulation of METTL14 that was correlated with poor prognosis in PCa patients. Functionally, knocking down METTL14 inhibited tumor proliferation both in vitro and in vivo. Mech., RNA-seq and MeRIP-seq analyses identified THBS1 as the downstream target of METTL14 in PCa. METTL14 downregulated THBS1 expression in an m6A-dependent manner, which resulted in the recruitment of YTHDF2 to recognize and degrade Thrombospondin 1 (THBS1) mRNA. Thus, our findings revealed that METTL14 acted as an oncogene by inhibiting THBS1 expression via an m6A-YTHDF2-dependent manner. METTL14 could be a potential prognosis marker and a therapeutic target. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Safety of N-Methyl-7H-purin-6-amine

The Article related to pancreatic cancer mettl14 tumorigenesis thbs1 m6a ythdf2, Placeholder for records without volume info and other aspects.Safety of N-Methyl-7H-purin-6-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 9, 2021, Nosratabad, Neda Arabzadeh; Jin, Zhicheng; Du, Liang; Thakur, Mannat; Mattoussi, Hedi published an article.Synthetic Route of 5036-48-6 The title of the article was N-Heterocyclic Carbene-Stabilized Gold Nanoparticles: Mono- Versus Multidentate Ligands. And the article contained the following:

Over the past decade, N-heterocyclic carbenes (NHCs) have attracted remarkable attention as metal-coordinating ligands because of their ability to strongly interact with transition metal complexes and surfaces. We investigate the coordination interaction between colloidal gold nanoparticles (AuNPs) and three sets of hydrophilic NHC-based ligands: an amine-modified small mol., a monomeric NHC appended with a poly(ethylene glycol) (PEG) block, and a modified poly(isobutylene-alt-maleic anhydride), PIMA, that simultaneously presents multiple NHC groups and several short PEG chains. In this report, we find that all three ligands can rapidly coordinate onto AuNPs, as characterized using a combination of NMR spectroscopy, high-resolution transmission electron microscopy, and dynamic light scattering. These measurements have been supplemented with colloidal stability tests as well as competition from dithiothreitol mols. Overall, we find that multidentate NHC polymer coating exhibits the highest affinity to AuNPs, which manifests in long-term colloidal stability in buffer media, absence of any aggregation, and better resistance to competition from reducing mols. We further exploit these data to infer addnl. insights into the interaction and coordination of NHC mols. with Au surfaces. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Synthetic Route of 5036-48-6

The Article related to heterocyclic carbene stabilized gold nanoparticle ligand, Placeholder for records without volume info and other aspects.Synthetic Route of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Gutierrez-Pena, Cristian L.; Poyatos, Macarena; Peris, Eduardo published an article in 2022, the title of the article was A redox-switchable catalyst with an unplugged redox tag.Application In Synthesis of N-(3-Aminopropyl)-imidazole And the article contains the following content:

Two bis-(propyl-imidazolium)-naphthalenediimide (NDI) salts were prepared and used as N-heterocyclic carbene (NHC) precursors for the preparation of dimetallic complexes of rhodium and iridium. IR spectroelectrochem. studies indicate that the metals are sensitive to changes in the electronic state of the NDI moiety. The catalytic behavior of the rhodium and iridium complexes was tested in the cycloisomerization of alkynoic acids, where the complexes showed effective redox-switching properties. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Application In Synthesis of N-(3-Aminopropyl)-imidazole

The Article related to ndi salt nhc redox switchable cycloisomerization catalyst, Placeholder for records without volume info and other aspects.Application In Synthesis of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 14, 2020, Chatterjee, Kajari; Pathak, Anil D.; Sahu, Kisor Kumar; Singh, Akhilesh Kumar published an article.Quality Control of N-(3-Aminopropyl)-imidazole The title of the article was New Thiourea-Based Ionic Liquid as an Electrolyte Additive to Improve Cell Safety and Enhance Electrochemical Performance in Lithium-Ion Batteries. And the article contained the following:

Our society is critically dependent on lithium-ion batteries (LIBs) as a power source for portable electronic gadgets. One of the major problems with these batteries is the degradation of the materials inside them. In addition to the reduced cell life, building-up of these degraded products inside the cells is very detrimental to the safe operation. Herein, we report the synthesis and characterization of a novel thiourea-based room temperature ionic liquid (IL), 3-heptyl-1-(3-(3-heptyl-3-phenylthioureido)propyl)-1H-imidazole-3-ium hexafluorophosphate. Its electrochem. and thermal properties including transport phenomena have been studied. It is proposed to be used as a nominal additive to com. used electrolytes, ethylene carbonate and di-Me carbonate mixtures The comparative performance characteristics of the LIBs in the presence and the absence of this IL additive have been demonstrated with a traditional lithium nickel cobalt manganese oxide cathode (NMC111), a graphite anode, and an ethylene carbonate and di-Me carbonate (1:1, volume/volume) electrolyte. It is further demonstrated that use of this electrolyte additive in batteries helps to address some of the major concerns of the conventional electrolytes such as safety issues and cycling performance as well as coulombic efficiency with enhanced discharge capacities. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Quality Control of N-(3-Aminopropyl)-imidazole

The Article related to lithium ion battery electrolyte ionic liquid additive safety, Placeholder for records without volume info and other aspects.Quality Control of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 23, 2021, Fallica, Antonino N.; Sorrenti, Valeria; D鈥睞mico, Agata G.; Salerno, Loredana; Romeo, Giuseppe; Intagliata, Sebastiano; Consoli, Valeria; Floresta, Giuseppe; Rescifina, Antonio; D鈥睞gata, Velia; Vanella, Luca; Pittala, Valeria published an article.Product Details of 5036-48-6 The title of the article was Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent In Vitro Antiproliferative Activity. And the article contained the following:

Heme oxygenase-1 (HO-1) promotes heme catabolism exercising cytoprotective roles in normal and cancer cells. Herein, we report the design, synthesis, mol. modeling, and biol. evaluation of novel HO-1 inhibitors. Specifically, an amide linker in the central spacer and an imidazole were fixed, and the hydrophobic moiety required by the pharmacophore was largely modified. In many tumors, overexpression of HO-1 correlates with poor prognosis and chemoresistance, suggesting the inhibition of HO-1 as a possible antitumor strategy. Accordingly, compounds 7i and 7l-p emerged for their potency against HO-1 and were investigated for their anticancer activity against prostate (DU145), lung (A549), and glioblastoma (U87MG, A172) cancer cells. The selected compounds showed the best activity toward U87MG cells. Compound 7l was further investigated for its in-cell enzymic HO-1 activity, expression levels, and effects on cell invasion and vascular endothelial growth factor (VEGF) extracellular release. The obtained data suggest that 7l can reduce cell invasivity acting through modulation of HO-1 expression. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6

The Article related to acetamide derivative heme oxygenase inhibitor preparation cancer, Placeholder for records without volume info and other aspects.Product Details of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hardy, Alexis; Matelot, Melody; Touzeau, Amandine; Klopp, Christophe; Lopez-Roques, Celine; Duharcourt, Sandra; Defrance, Matthieu published an article in 2021, the title of the article was DNAModAnnot: a R toolbox for DNA modification filtering and annotation.Safety of N-Methyl-7H-purin-6-amine And the article contains the following content:

Long-read sequencing technologies can be employed to detect and map DNA modifications at the nucleotide resolution on a genome-wide scale. However, published software packages neglect the integration of genomic annotation and comprehensive filtering when analyzing patterns of modified bases detected using Pacific Biosciences (PacBio) or Oxford Nanopore Technologies (ONT) data. Here, we present DNA Modification Annotation (DNAModAnnot), a R package designed for the global anal. of DNA modification patterns using adapted filtering and visualization tools. We tested our package using PacBio sequencing data to analyze patterns of the 6-methyladenine (6mA) in the ciliate Paramecium tetraurelia, in which high 6mA amounts were previously reported. We found P. tetraurelia 6mA genome-wide distribution to be similar to other ciliates. We also performed 5-methylcytosine (5mC) anal. in human lymphoblastoid cells using ONT data and confirmed previously known patterns of 5mC. DNAModAnnot provides a tool-box for the genome-wide anal. of different DNA modifications using PacBio and ONT long-read sequencing data. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Safety of N-Methyl-7H-purin-6-amine

The Article related to deoxyribonucleic acid modification annotation r toolbox filtering, Placeholder for records without volume info and other aspects.Safety of N-Methyl-7H-purin-6-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Izevbekhai, Oisaemi Uduagele; Gitari, Wilson Mugera; Tavengwa, Nikita Tawanda; Ayinde, Wasiu Babatunde; Mudzielwana, Rabelani published an article in 2021, the title of the article was Synthesis and evaluation of the oil removal potential of 3-bromo-benzimidazolone polymer grafted silica gel.Name: 4-Bromo-1H-benzo[d]imidazol-2(3H)-one And the article contains the following content:

This work reports the synthesis of 3-bromo-benzimidazolone using melt condensation, its polymerization and functionalization on silica which was extracted from diatomaceous earth in our previous work. The synthesized compounds were characterized using FTIR, NMR, SEM-EDS and TEM. The FTIR and NMR spectra of the synthesized benzimidazolones showed the compounds to have several functional groups: A band due to Si-O-C at 1085.41 cm-1, a broad band at 3380 cm-1 and chem. shifts: pos. distortionless enhancement by polarization transfer (DEPT) 13C peaks (indicating lack of CH2 and CH3 groups), 1H NMR – 11.053 ppm (N-H), 7.086 ppm (Ar-H); 13C NMR – 155.34 ppm (CO), 101.04 ppm (C-Br) characteristic of benzimidazolones. SEM-EDS of the functionalized silica showed a rough irregular morphol. with Si and O as the major elements. Carbon was also present indicating that silica was successfully functionalized with 3-bromo-benzimidazolone and TEM showed interconnected smear-like particles arranged irregularly. The functionalized silica was then applied in the treatment of oily wastewater and factors like initial oil concentration, adsorption dosage and time were optimized using the central composite design of response surface methodol. in the design expert software. The amount of oil adsorbed was obtained by quantifying the total organic carbon using TOC test kits. Results showed that the optimum conditions for oil removal were 6650 mg L-1 oil concentration, with adsorbent dosage of 0.004 g and a contact time of 16 h. Under these conditions, the percentage adsorption was 97.9% with a desirability of 0.99. The materials were therefore seen to be applicable to field wastewaters. The experimental process involved the reaction of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one(cas: 40644-16-4).Name: 4-Bromo-1H-benzo[d]imidazol-2(3H)-one

The Article related to oil removal 3 bromo benzimidazolone polymer silica gel adsorption, Placeholder for records without volume info and other aspects.Name: 4-Bromo-1H-benzo[d]imidazol-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Qu, Shanqiang; Chen, Zhixin; Liu, Bin; Liu, Jin; Wang, Huafu published an article in 2021, the title of the article was N6-methyladenine-related genes affect biological behavior and the prognosis of glioma.Application In Synthesis of N-Methyl-7H-purin-6-amine And the article contains the following content:

Although aberrant expression of N6-methyladenine (m6A) methylation-related genes contribute to tumorigenesis in many solid tumors, the prognostic value of the m6A-related genes and their correlation with clinicopathol. features in gliomas need advanced study. Nine m6A-related genes were identified as independent prognostic factors, which were mostly enriched in RNA splicing, regulation of immune response and vesicle-mediated transport. We constructed risk score of each patient, which was highly associated with clinicopathol. features. Kaplan-Meier curve showed that the prognosis of patients with high-risk scores was significantly worse than that with low-risk scores (HR = 4.30, 95% CI = 3.16-5.85, p < 0.0001). A nomogram was constructed based on the nine m6A-related genes signature and clinicopathol. features with well-fitted calibration curves (c-index = 0.82), showing high specificity and sensitivity (area under the curve for 1-, 3-, and 5-years survival probability = 0.874, 0.918, and 0.934). A nine m6A-related genes signature was identified in gliomas. The m6A-related risk score is a novel prognostic factor for patients with glioma, and is associated with clinicopathol. features. Moreover, the nomogram based on the nine m6A-related genes signature and clinicopathol. features had good efficacy in predicting the survival probability. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).Application In Synthesis of N-Methyl-7H-purin-6-amine

The Article related to glioma n6 methyladenine prognosis, neoplasms, nomograms, prognosis, Placeholder for records without volume info and other aspects.Application In Synthesis of N-Methyl-7H-purin-6-amine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Sisi; Du, Liang; Donmez, Selin; Xin, Yan; Mattoussi, Hedi published an article in 2021, the title of the article was Polysalt ligands achieve higher quantum yield and improved colloidal stability for CsPbBr3 quantum dots.Reference of N-(3-Aminopropyl)-imidazole And the article contains the following content:

Colloidal lead halide perovskite quantum dots (PQDs) are relatively new semiconductor nanocrystals with great potential for use in optoelectronic applications. They also present a set of new scientifically challenging fundamental problems to investigate and understand. One of them is to address the rather poor colloidal and structural stability of these materials under solution phase processing and/or transfer between solvents. In this contribution, we detail the synthesis of a new family of multi-coordinating, bromide-based polysalt ligands and test their ability to stabilize CsPbBr3 nanocrystals in polar solutions The ligands present multiple salt groups involving quaternary cations, namely ammonium and imidazolium as anchors for coordination onto PQD surfaces, along with several alkyl chains with varying chain length to promote solubilization in various conditions. The ligands provide a few key benefits including the ability to repair damaged surface sites, allow rapid ligand exchange and phase transfer, and preserve the crystalline structure and morphol. of the nanocrystals. The polysalt-coated PQDs exhibit near unity PLQY and significantly enhanced colloidal stability in ethanol and methanol. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Reference of N-(3-Aminopropyl)-imidazole

The Article related to cesium lead bromide quantum dot polysalt ligand colloidal stability, Placeholder for records without volume info and other aspects.Reference of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 31, 2009, Shainsky, Janna; Derry, Netta-Lee; Leichtmann-Bardoogo, Yael; Wood, Thomas K.; Fishman, Ayelet published an article.Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole The title of the article was Rapid methods for high-throughput detection of sulfoxides. And the article contained the following:

Enantiopure sulfoxides are prevalent in drugs and are useful chiral auxiliaries in organic synthesis. The biocatalytic enantioselective oxidation of prochiral sulfides is a direct and economical approach for the synthesis of optically pure sulfoxides. The selection of suitable biocatalysts requires rapid and reliable high-throughput screening methods. Here we present four different methods for detecting sulfoxides produced via whole-cell biocatalysis, three of which were exploited for high-throughput screening. Fluorescence detection based on the acid activation of omeprazole was utilized for high-throughput screening of mutant libraries of toluene monooxygenases, but no active variants have been discovered yet. The second method is based on the reduction of sulfoxides to sulfides, with the coupled release and measurement of iodine. The availability of solvent-resistant microtiter plates enabled us to modify the method to a high-throughput format. The third method, selective inhibition of horse liver alc. dehydrogenase, was used to rapidly screen highly active and/or enantioselective variants at position V106 of toluene ortho-monooxygenase in a saturation mutagenesis library, using methyl-p-tolyl sulfide as the substrate. A success rate of 89% (i.e., 11% false positives) was obtained, and two new mutants were selected. The fourth method is based on the colorimetric detection of adrenochrome, a back-titration procedure which measures the concentration of the periodate-sensitive sulfide. Due to low sensitivity during whole-cell screening, this method was found to be useful only for determining the presence or absence of sulfoxide in the reaction. The methods described in the present work are simple and inexpensive and do not require special equipment. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to high throughput toluene monooxygenase detection enantiopure sulfoxide, Enzymes: Analysis (Determination-Detection) and other aspects.Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem