Month: November 2022

Xu, Yan-Hong published the artcileSelf-assembly of zinc polymers based on a flexible linear ligand at different pH values: Syntheses, structures and fluorescent properties, Application of 4-((1H-Imidazol-1-yl)methyl)benzoic acid, the main research area is zinc imidazolylmethylbenzonitrile imidazolylmethylbenzoate terephthalate complex polymer preparation structure fluorescence; crystal structure zinc imidazolylmethylbenzonitrile imidazolylmethylbenzoate terephthalate complex polymer.

Five novel coordination polymers, [Zn(imbz)2]n (1), {[Zn(imbz)2]·H2O}n (2), [Zn(imbz)(μ2-OH)]n (3), [Zn3(imbt)2(p-bdc)3]n (4), [Zn4(μ3-OH)2(imbt)2(p-bdc)3]n (5), (imbt = 4′-(imidazol-1-ylmethyl)benzonitrile, imbz- = 4′-(imidazol-1-ylmethyl)benzoate and p-bdc = terephthalate) were hydrothermally prepared through systematically changing the pH values of reaction mixture, and structurally characterized by elemental anal., IR spectroscopy and single-crystal x-ray crystallog. Compounds 1 and 2 exhibit similar 2-dimensional (4,4) grid structures, whereas compound 2 contains a right-handed helix along b-axis. Compound 3 has a distorted diamond framework which was constructed via imbz- ligands and μ2-OH groups linking metal atoms. Compound 4 shows a 2-dimensional 6-connected network with trinuclear zinc clusters as secondary building units (SBUs), whereas 5 shows a distorted α-Po with tetranuclear zinc clusters as SBUs, in which p-bdc ligands act as bridges. Also, compounds 1-5 all exhibit strong blue photoluminescence in the solid state at room temperature

Solid State Sciences published new progress about Crystal structure. 94084-75-0 belongs to class imidazoles-derivatives, name is 4-((1H-Imidazol-1-yl)methyl)benzoic acid, and the molecular formula is C11H10N2O2, Application of 4-((1H-Imidazol-1-yl)methyl)benzoic acid.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Panzica, Raymond P. published the artcileAnalogs of AICA- and iso-AICA ribosides and their methylated base counterparts, Application In Synthesis of 21343-04-4, the main research area is imidazole thiocarboxamide selenocarboxamide riboside preparation kinetics; AICA riboside analog preparation reaction kinetics.

A mild, convenient and efficient synthesis has been developed for imidazole-4-thiocarboxamide and imidazole-5-thiocarboxamide ribosides and the analogous selenocarboxamides. This methodol., i.e., DMF saturated with H2S or H2Se, also converts the corresponding N-methylated bases to the corresponding amides. The imidazole-4(5)-selenocarboxamides were shown to be sensitive to base (pH 11) and were easily converted back to their cyano precursors. The kinetics of these reactions were determined and they indicate that the C5 amides were more reactive than their C4 analogs.

Nucleosides & Nucleotides published new progress about Reaction kinetics. 21343-04-4 belongs to class imidazoles-derivatives, name is 5-Amino-1-methyl-1H-imidazole-4-carboxamide, and the molecular formula is C5H8N4O, Application In Synthesis of 21343-04-4.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wang, Meng published the artcileCopper-catalyzed N-arylation and aerobic oxidative C-H/C-H coupling: one-pot synthesis of indoloimidazoquinoline derivatives, Recommanded Product: 5,6-Dimethoxy-1H-benzo[d]imidazole, the main research area is copper arylation aerobic oxidation coupling indoloimidazoquinoline preparation; benzimidazoindoloquinoline preparation.

A novel and efficient copper-catalyzed one-pot synthesis of indoloimidazoquinoline derivatives has been developed. The synthesis of the target compounds was achieved by a protocol using readily available substituted 2-(2-bromophenyl)-1H-indole derivatives, imidazole and benzimidazole derivatives as starting materials, inexpensive copper bromide (CuBr) as a catalyst, air as a terminal oxidant. The procedure underwent a sequential copper-catalyzed intermol. N-arylation and an aerobic oxidative intramol. C-H/C-H coupling. The title compounds thus formed included a heterocyclic compound (I) [i.e., 5H-benzimidazo[1,2-a]indolo[3,2-c]quinoline] and related substances, such as 9H-imidazo[1,2-a]indolo[3,2-c]quinoline.

RSC Advances published new progress about Arylation. 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, Recommanded Product: 5,6-Dimethoxy-1H-benzo[d]imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Boncel, Slawomir published the artcileMichael-type addition of azoles of broad-scale acidity to methyl acrylate, Application of 5-Bromo-2-methyl-4-nitroimidazole, the main research area is Michael addition azole methyl acrylate; 1,2,4-triazole derivatives; Michael-type addition; imidazole derivatives; methyl acrylate; pyrazole derivatives.

An optimization of Michael-type addition of azole derivatives of broad-scale acidity – ranging from 5.20 to 15.00 pKa units – namely 4-nitropyrazole, 3,5-dimethyl-4-nitropyrazole, 4(5)-nitroimidazole, 4,5-diphenylimidazole, 4,5-dicyanoimidazole, 2-methyl-4(5)-nitroimidazole, 5(4)-bromo-2-methyl-4(5)-nitroimidazole and 3-nitro-1,2,4-triazole to Me acrylate as an acceptor was carried out. The optimization process involved the use of an appropriate basic catalyst (DBU, DIPEA, NaOH, NaH, TEDA), a donor/base/acceptor ratio and the reaction temperature The reactions were performed in DMF as solvent. Target Michael adducts I (R1 = R2 = R4 = H, Me, R3 = NO2, X = N, Y = Z = C; R1 = H, R2 = none, R 3 = R 4 = Ph, X = Z = C, Y = N; R1 = none, R2 = NO2, R3 = none, R4 = Z, Y = C) were obtained in medium to excellent yields. Importantly, for imidazole and 1,2,4-triazole derivatives, no corresponding regioisomers were obtained.

Beilstein Journal of Organic Chemistry published new progress about Michael reaction. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Application of 5-Bromo-2-methyl-4-nitroimidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bamborough, Paul published the artcile5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase, Safety of 5,6-Dimethoxy-1H-benzo[d]imidazole, the main research area is IKK kinase inhibitor benzimidazolyl thiophenecarbonitrile preparation SAR.

The identification and hit-to-lead exploration of a novel, potent and selective series of substituted benzimidazole-thiophene carbonitrile inhibitors of IKK-ε kinase is described. Compound 12e (I) was identified with an IKK-ε enzyme potency of pIC50 7.4, and has a highly encouraging wider selectivity profile, including selectivity within the IKK kinase family.

Bioorganic & Medicinal Chemistry Letters published new progress about Epidermal growth factor receptors Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, Safety of 5,6-Dimethoxy-1H-benzo[d]imidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Llona-Minguez, Sabin published the artcileVinylic MIDA Boronates: New Building Blocks for the Synthesis of Aza-Heterocycles, Related Products of imidazoles-derivatives, the main research area is haloarene MIDA boronate palladium catalyst Suzuki Miyaura coupling reaction; nitro vinylarene preparation Cadogan Sundberg reductive cyclization; aza heterocycle preparation; MIDA; aminophosphonate; boronate; cyclization; heterocycles; nitrene.

A two-step synthesis of structurally diverse pyrrole-containing bicyclic systems was reported. ortho-Nitro-haloarenes coupled with vinylic N-methyliminodiacetic acid (MIDA) boronates generated ortho-vinyl-nitroarenes, which underwent a ‘metal-free’ nitrene insertion, resulted in a new pyrrole ring. The Synthetic approach has a wide substrate tolerance and it was applicable in the preparation of more complex ‘drug-like’ mols. An ortho-nitro-allylarenes furnished a cyclic β-aminophosphonate motif.

Chemistry – A European Journal published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kharaneko, A. O. published the artcileSynthesis of 3-Phenyl-1H-[1,4]oxazino[4,3-a]benzimidazol-1-one and Its Transformation into 4-Phenyl-2,5-dihydro-1H-[1,2,5]triazepino[5,4-a]benzimidazol-1-one, Recommanded Product: Methyl 1H-benzo[d]imidazole-2-carboxylate, the main research area is phenyl oxazinobenzimidazolone preparation; dihydrotriazepinobenzimidazolone preparation; phenylpyrazino benzimidazolone preparation; benzimidazole preparation.

A synthetic route was proposed to 3-phenyl-1H-[1,4]oxazino[4,3-a]benzimidazol-1-one I, which was the first representative of a new heterocyclic system. The transformation of the title compound I to 4-phenyl-2,5-dihydro-1H-[1,2,5]triazepino[5,4-a]benzimidazol-1-one II via reaction with hydrazine hydrate was studied.

Russian Journal of Organic Chemistry published new progress about Fused heterocyclic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 5805-53-8 belongs to class imidazoles-derivatives, name is Methyl 1H-benzo[d]imidazole-2-carboxylate, and the molecular formula is C9H8N2O2, Recommanded Product: Methyl 1H-benzo[d]imidazole-2-carboxylate.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Stock, Nicholas S. published the artcile5-Lipoxygenase-Activating Protein (FLAP) Inhibitors. Part 4: Development of 3-[3-tert-Butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic Acid (AM803), a Potent, Oral, Once Daily FLAP Inhibitor, Name: Imidazo[1,2-a]pyridin-2-ylmethanol, the main research area is lipoxygenase activating protein inhibitor AM803 GSK2190915 antiasthmatic; FLAP inhibitor SAR.

The potent 5-lipoxygenase-activating protein (FLAP) inhibitor 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxypyridin-3-yl)benzyl]-5-(5-methylpyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethylpropionic acid 11cc (I) is described (AM803, now GSK2190915). Building upon AM103, SAR studies centering around the pyridine moiety led to the discovery of compounds that exhibit significantly increased potency in a human whole blood assay measuring LTB4 inhibition with longer drug preincubation times (15 min vs 5 h). Further studies identified 11cc with a potency of 2.9 nM in FLAP binding, an IC50 of 76 nM for inhibition of LTB4 in human blood (5 h incubation) and excellent preclin. toxicol. and pharmacokinetics in rat and dog. 11Cc also demonstrated an extended pharmacodynamic effect in a rodent bronchoalveolar lavage (BAL) model. This compound has successfully completed phase 1 clin. studies in healthy volunteers and is currently undergoing phase 2 trials in asthmatic patients.

Journal of Medicinal Chemistry published new progress about Blood serum albumins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (human serum albumin – FLAP binding equilibrium). 82090-52-6 belongs to class imidazoles-derivatives, name is Imidazo[1,2-a]pyridin-2-ylmethanol, and the molecular formula is C8H8N2O, Name: Imidazo[1,2-a]pyridin-2-ylmethanol.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wettasinghe, Mahinda published the artcileVolatiles from Roasted Byproducts of the Poultry-Processing Industry, HPLC of Formula: 30086-17-0, the main research area is chicken byproduct volatile composition.

Volatiles of roasted chicken breast muscle and byproducts, such as backbones, breastbones, spent bones, and skin, were investigated. Total volatile concentrations ranged from 2030 ppb in the roasted backbones to 4049 ppb in the roasted skin. The major classes of volatile compounds detected in roasted samples were aldehydes (648-1532 ppb) and alcs. (336-1006 ppb). Nitrogen- and/or sulfur-containing compounds were also detected in appreciable quantities (161-706 ppb) in all samples. For all samples, hexanal and 2-methyl-2-buten-1-ol were dominant among the aldehydes and alcs., resp. Among the nitrogen- and sulfur-containing compounds, Maillard reaction products, such as tetrahydropyridazines, piperidines, and thiazoles, were the major contributors to the total volatile content in all samples. The composition of volatiles observed in roasted byproducts was markedly different from that of the roasted breast muscle. Therefore, the blending of the byproducts in appropriate proportions or blending of volatile flavor extracts from different byproducts may be necessary to obtain an aroma that mimics roasted chicken aroma.

Journal of Agricultural and Food Chemistry published new progress about Aldehydes Role: BAC (Biological Activity or Effector, Except Adverse), BSU (Biological Study, Unclassified), BIOL (Biological Study). 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, HPLC of Formula: 30086-17-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem