Month: November 2022

On July 20, 2018, Bong, Yong Koy; Song, Shiwei; Nazor, Jovana; Vogel, Michael; Widegren, Magnus; Smith, Derek; Collier, Steven J.; Wilson, Rob; Palanivel, S. M.; Narayanaswamy, Karthik; Mijts, Ben; Clay, Michael D.; Fong, Ryan; Colbeck, Jeff; Appaswami, Amritha; Muley, Sheela; Zhu, Jun; Zhang, Xiyun; Liang, Jack; Entwistle, David published an article.Electric Literature of 73590-85-9 The title of the article was Baeyer-Villiger Monooxygenase-Mediated Synthesis of Esomeprazole As an Alternative for Kagan Sulfoxidation. And the article contained the following:

A wild-type Baeyer-Villiger monooxygenase was engineered to overcome numerous liabilities to mediate a com. oxidation of pyrmetazole to esomeprazole, using air as the terminal oxidant in an almost exclusively aqueous reaction matrix. The developed enzyme and process compares favorably to the incumbent Kagan inspired chemocatalytic oxidation, as esomeprazole was isolated in 87% yield, in >99% purity, with an enantiomeric excess of >99%. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Electric Literature of 73590-85-9

The Article related to baeyer villiger monooxygenase esomeprazole preparation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Electric Literature of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 2, 2009, Li, Xie; Du, Youguo; Zong, Zaiwei; Chen, Xiangfeng published an article.Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole The title of the article was Research on synthesis of S-(-)-omeprazole sodium. And the article contained the following:

A method for the synthesis of the title compound [i.e., 6-methoxy-2-[(S)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole sodium salt (1:1)] is reported here. (-)-Omeprazole was prepared from 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methylthio]benzimidazole (i.e., a sulfide derivative) and cumene hydroperoxide by an asym. oxidation method. The product was treated with sodium hydroxide to give S-(-)-omeprazole sodium. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to proton pump inhibitor s omeprazole sodium asym oxidation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Name: 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 30, 2009, Yang, Chuanbo; Jin, Qingping; Zhang, Hua; Liao, Jian; Zhu, Jin; Yu, Bin; Deng, Jingen published an article.Product Details of 73590-85-9 The title of the article was Tetra(tetraalkylammonium)octamolybdate catalysts for selective oxidation of sulfides to sulfoxides with hydrogen peroxide. And the article contained the following:

A method for the synthesis of the title compounds [i.e., tetrabutylammonium octamolybdate and tetrakis(1-butylpyridinium) octamolybdate] is reported here. Tetra(tetraalkylammonium)octamolybdate catalysts are successfully applied in the selective oxidation of various sulfides to sulfoxides with 30% aqueous hydrogen peroxide as oxidant under mild reaction conditions in 94-100% yield and 95-100% selectivity. The octamolybdate catalysts show high catalytic activity in a high ratio of substrate to catalyst (up to 10000:1) and are recyclable, with actively functional groups, including hydroxyl group and C:C bonds, tolerated in the oxidation The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Product Details of 73590-85-9

The Article related to octamolybdate ammonium preparation oxidation sulfoxidation catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Product Details of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On October 29, 2014, Duan, Hongdong; Xu, Ting; Bu, Juan published a patent.Application In Synthesis of 2-Nitro-1H-benzo[d]imidazole The title of the patent was Benzimidazolylbenzaldehyde p-phenylenediamine Schiff base, its preparation method and application in fluorescence material and sensor. And the patent contained the following:

The invention disclosed a kind of benzimidazolylbenzaldehyde p-phenylenediamine Schiff base, its preparation method and application in fluorescence material and sensor. The claimed benzimidazolylbenzaldehyde p-phenylenediamine Schiff base is shown in structure I (R = H, F, Cl, NO2, OH, CN). The claimed compound is prepared with benzimidazole or benzimidazole derivative and p-fluorobenzaldehyde via N-C coupling to obtain 4-benzimidazolylbenzaldehyd or its derivative, then condensation with p-phenylenediamine to generate the Schiff base product. The obtained compound has the advantages of conjugated and rigid plane structure with good fluorescence performance and metal ion selectivity. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Application In Synthesis of 2-Nitro-1H-benzo[d]imidazole

The Article related to benzimidazolylbenzaldehyde phenylenediamine schiff base preparation, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application In Synthesis of 2-Nitro-1H-benzo[d]imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 19, 2020, Akahoshi, Issei; Sumikawa, Yoshitake; Furuta, Sadayoshi; Fukushima, Keiichiro; Imazu, Takuya; Kotaka, Ryota published a patent.Quality Control of 6-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid The title of the patent was Preparation of novel heteroaromatic amide derivatives and medicines containing them. And the patent contained the following:

The present invention provides novel heteroaromatic amide derivatives I [X1-X2 = N-C or C-N; Y1, Y2, Y3 and Y4 = independently single bond, -CH2-, -CR4aH-, CR4bH-, NR4c-, -O-, etc.; Z1 = single bond, -O-, -S-, etc.; ring A = a 3-7-membered monocyclic aromatic ring or an 8-12-membered bicyclic aromatic ring; R1a and R1b = H, halogen, alkyl, etc.; R2 = H, halogen, OH, etc.; R3a, R3b and R3c = independently H, halogen, CN, (un)substituted C1-6 alkyl, (un)substituted C1-6 haloalkyl, etc.; R4a, R4b, and R4c = independently (un)substituted C1-6 haloalkyl or C1-6 haloalkoxy, etc.; R5a = H, alkyl, etc.; R5b = H, alkyl, etc.; R5c = H, alkyl, etc.; R5a and R5b can join together to form -CH2O- or the like; R6a and R6b = independently H, halogen, alkyl, etc.; n = 1 or 2] and medicines containing them. For example, compound II (preparation given) was coupled with compound III to provide compound IV. The invention compounds selectively inhibit Nav1.7 rather than Nav1.5, and they are highly effective for various diseases associated with Nav1.7 such as pain. The experimental process involved the reaction of 6-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid(cas: 1774893-22-9).Quality Control of 6-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid

The Article related to heteroaromatic amide derivative preparation nav inhibitor pain treatment, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Quality Control of 6-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 23, 2021, Kim, Young Kwan; Jo, Min Mi; Park, Jun published a patent.Safety of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride The title of the patent was Preparation of GLP-1 receptor agonist for treatment or prophylaxis of various metabolic diseases. And the patent contained the following:

The present invention relates to a novel compound I [A = (CH2)m, O, N(Ra) where m = 1-3; Ra = hydrogen, alkyl; R1 = (cycloalkyl)alkyl, (heterocycloalkyl)alkyl, arylalkyl, heteroarylalkyl; R2-R4 = hydrogen, deuterium, halogen, etc.; n = 1-4; Z1-Z7 = CH, CF, CCl, CBr, CI, N; isomer or pharmaceutically acceptable salt thereof] useful as an agent for treatment or prophylaxis of various metabolic diseases such as obesity or diabetes and hyperlipidemia, by means of excellent GLP-1 agonist activity and an excellent DMPK profile. For example II was prepared and exhibited EC50 of 0.007 nM against GLP-1R. The experimental process involved the reaction of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride(cas: 1255717-13-5).Safety of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride

The Article related to preparation glp 1 receptor agonist treatment prophylaxis metabolic disease, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Safety of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On June 30, 2006, Yutilov, Yu. M.; Smolyar, N. N.; Lomov, D. A. published an article.Reference of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the article was Synthesis of 1- and 3-substituted imidazo[4,5-b]pyridin-2-ones. And the article contained the following:

1- And 3-Substituted imidazo[4,5-b]pyridin-2-ones were synthesized by heating equimolar amounts of 3-amino-2-chloropyridine or 2-chloro-3-methylaminopyridine, urea, and the corresponding arylamine at 150-210°. The reaction of 3-amino-2-chloropyridine with urea and p-phenylenediamine or p,p’-diaminobiphenyl at a ratio of 2:2:1 under analogous conditions gave 1,4-bis-(2-oxoimidazo[4,5-b]pyridin-3-yl)benzene or 1,4-bis(2-oxoimidazo[4,5-b]pyridin-3-yl)biphenyl, resp. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Reference of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to cyclization aminochloropyridine urea arylamine preparation imidazopyridinone, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Reference of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 13, 2019, Aspnes, Gary Erik; Bagley, Scott W.; Curto, John M.; Edmonds, David James; Flanagan, Mark E.; Futatsugi, Kentaro; Griffith, David A.; Huard, Kim; Lian, Yajing; Limberakis, Chris; Londregan, Allyn T.; Mathiowetz, Alan M.; Piotrowski, David W.; Riggeri, Roger B. published a patent.Category: imidazoles-derivatives The title of the patent was Preparation of 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists for the treatment of diseases. And the patent contained the following:

Provided herein are 6-carboxylic acids of benzimidazoles and 4-aza-, 5-aza-, and 7-aza-benzimidazoles as GLP-1R agonists, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof. The example compound (I) was prepared by multistep synthesis (procedure given). The compounds of the invention were evaluated for their biol. activity (data given). The compounds of the invention can be used in treatment of diseases, such as NASH, diabetes, obesity and like. The experimental process involved the reaction of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride(cas: 1255717-13-5).Category: imidazoles-derivatives

The Article related to benzimidazole carboxylic acid salt preparation glp1r agonist disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 28, 1992, Li, M. J.; Li, S. Z.; Zhuang, X. L.; Chen, A.; Zhang, H. Q.; Pang, X. C.; Hu, B. published an article.Application of 5709-67-1 The title of the article was Synthesis and radiosensitizing activity of benzimidazoles. And the article contained the following:

Reaction of 2-nitrobenzimidazole with Et chloroformate yielded Et (2-nitrobenzimidazol-1-yl)formate or Et (2-hydroxybenzimidazol-1-yl)formate, depending upon the solvents used. Reaction of 2-nitrobenzimidazole with 1,2-epoxy-3-chloropropane gave a cyclized compound I. In an attempt to increase hydrophilicity, 1-substituted 2-(3′-pyridyl)-5-nitrobenzimidazoles were prepared by reaction of 2-(3′-pyridyl)-5(6)-nitrobenzimidazole with alkyl epoxides or Et chloroacetate. Some of the compounds synthesized were tested for radiosensitizing activity in Ehrlich ascites carcinoma-bearing mice. Preliminary results showed that some compounds have radiosensitizing activity. The radiosensitizing enhancement ratio (SER) of compounds I and II (R = H, Me) were 1.50, 1.52 and 1.65 resp. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Application of 5709-67-1

The Article related to benzimidazole preparation radiosensitizer, nitrobenzimidazole preparation radiosensitizer, Heterocyclic Compounds (More Than One Hetero Atom): Imidazoles and other aspects.Application of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On October 31, 1983, Kovac, T.; Oklobdzija, M.; Comisso, G.; Decorte, E.; Fajdiga, T.; Moimas, F.; Angeli, C.; Zonno, F.; Toso, R.; Sunjic, V. published an article.Safety of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one The title of the article was New synthesis of 11-acyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ones and related studies. And the article contained the following:

11-Acyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-ones I (R = 4-methylpiperazino, imidazolo, 2-methylimidazolo) were prepared via N-α-chloroacetylation and aminolysis. Other attempts at cyclization to form I are also reported. The experimental process involved the reaction of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one(cas: 41010-50-8).Safety of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

The Article related to aminoacetylpyridobenzodiazepinone, pyridobenzodiazepinone aminoacetyl, benzodiazepinone pyrido, Heterocyclic Compounds (More Than One Hetero Atom): Diazepines and other aspects.Safety of 3-Phenyl-1H-imidazo[4,5-b]pyridin-2(3H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem