Month: November 2022

Wei, Wei; Liu, Chao; Wang, Meng; Jiang, Wei; Wang, Caihong; Zhang, Shuqun published an article in 2022, the title of the article was Prognostic signature and tumor immune landscape of N7-methylguanosine-related lncRNAs in hepatocellular carcinoma.COA of Formula: C6H7N5 And the article contains the following content:

Despite great advances in the treatment of liver hepatocellular carcinoma (LIHC), such as immunotherapy, the prognosis remains extremely poor, and there is an urgent need to develop novel diagnostic and prognostic markers. Recently, RNA methylation-related long non-coding RNAs (lncRNAs) have been demonstrated to be novel potential biomarkers for tumor diagnosis and prognosis as well as immunotherapy response, such as N6- methyladenine (m6A) and 5-methylcytosine (m5C). N7-Methylguanosine (m7G) is a widespread RNA modification in eukaryotes, but the relationship between m7G-related lncRNAs and prognosis of LIHC patients as well as tumor immunotherapy response is still unknown. In this study, based on the LIHC patients’ clin. and transcriptomic data from TCGA database, a total of 992 m7G-related lncRNAs that co-expressed with 22 m7G regulatory genes were identified using Pearson correlation anal. Univariate regression anal. was used to screen prognostic m7G-related lncRNAs, and the least absolute shrinkage and selection operator (LASSO) and multivariate Cox regression were applied to construct a 9-m7G-related-lncRNA risk model. The m7G-related lncRNA risk model was validated to exhibit good prognostic performance through Kaplan-Meier anal. and ROC anal. Together with the clinicopathol. features, the m7G-related lncRNA risk score was found to be an independent prognostic factor for LIHC. Furthermore, the high-risk group of LIHC patients was unveiled to have a higher tumor mutation burden (TMB), and their tumor microenvironment was more prone to the immunosuppressive state and exhibited a lower response rate to immunotherapy. In addition, 47 anti-cancer drugs were identified to exhibit a difference in drug sensitivity between the high-risk and low-risk groups. Taken together, the m7G-related lncRNA risk model might display potential value in predicting prognosis, immunotherapy response, and drug sensitivity in LIHC patients. The experimental process involved the reaction of N-Methyl-7H-purin-6-amine(cas: 443-72-1).COA of Formula: C6H7N5

The Article related to n methylguanosine lncrna hepatocellular carcinoma prognosis tumor immunity, lihc, immune response, lncrna, m7g methylation, prognostic model, Immunochemistry: Other (Immunity, Immune Suppression, Tolerance, etc.) and other aspects.COA of Formula: C6H7N5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zhou, Guobin; Guan, Yueqing published an article in 2016, the title of the article was An efficient asymmetric approach to the R-enantiomer impurity of esomeprazole.Recommanded Product: 73590-85-9 And the article contains the following content:

The R-enantiomer of esomeprazole (5-methoxy-2-[(4-methoxy-3, 5-dimethyl-2-pyridinylmethyl)sulfinyl]-1H-benzimidazole) was synthesized with high enantioselectivity by asym. oxidation of prochiral sulfide using the oxaziridinium salt. This (R)-enantiomer, useful as a reference for the quality control of esomeprazole was characterized by 1H and 13CNMR, IR and HRMS. The enantiomeric excess was determined by HPLC. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Recommanded Product: 73590-85-9

The Article related to esomeprazole preparation enantioselective, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Recommanded Product: 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 5, 2022, Das, Mithun; Baran Bhattacharya, Asit; Rahman Parathodika, Arshad; Naskar, Kinsuk published an article.Synthetic Route of 5036-48-6 The title of the article was Room temperature Self-healable and extremely stretchable elastomer with improved mechanical Properties: Exploring a simplistic Metal-Ligand interaction. And the article contained the following:

The dynamic supramol. crosslinking reactions like imine bond formation, disulfide metathesis reactions, Diels Alder reactions, metal-ligand interactions, H-bonding, and ionic interactions are broadly used for the self-healing application of elastomers. Herein, we have developed a new self-healable and extremely stretchable elastomer based on robustness and dynamic metal-ligand coordination bonds between the API ligand and the Zn2+ metal ion moieties incorporated onto the XNBR rubber backbone. The FT-IR anal. confirmed the formation of amide linkage and metal-ligand coordination bonds into the XNBR rubber backbone. The healing performance and mech. properties of various rubber compounds depend on the dosages of metal ions and the type of crosslinking systems. The metal-ligand crosslink compounds exhibit excellent healing performance over the sulfur crosslinking system. Differential scanning calorimetry, rubber process analyzer, crosslinking d., and morphol. studies are indicated to characterize the metal-ligand interactions in the XNBR rubber matrix. The metal-ligand crosslinked XNBR rubber with 3 parts of Zn2+ metal ion demonstrates an excellent healing performance of 91.2%, with the tensile strength of 5.7±0.8 MPa at room temperature for 24 h is much higher than the covalently crosslinked elastomers. The metal-ligand coordination bonds are entirely dynamic and thermoreversible during the rebuilding process and obtain an excellent self-healing property than the sulfur curing system. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Synthetic Route of 5036-48-6

The Article related to carboxylated nitrile rubber metal ligand interaction self healing, Synthetic Elastomers and Natural Rubber: Physical Properties and Testing and other aspects.Synthetic Route of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 15, 2022, Xu, Qingzhu; Xiao, Xinrui; Zhou, Rui; Zhang, Xu; Yu, Lei published an article.Related Products of 73590-85-9 The title of the article was Concise selenization of polystyrene via the FeCl3-catalyzed reaction with (PhSe)2. And the article contained the following:

Selenization of polystyrene is a key process for preparing the selenium-containing functional materials with industrial application potential. However, traditional methods suffer from tedious reaction steps and the use of inflammable or hazardous reagents. Herein, we report a novel method for polystyrene selenization just by immersing the material in (PhSe)2/FeCl3 solution under mild conditions. This is the first report on the selenization of materials using PhSe+ cation via the electrophilic substitution strategy. The selenized styrene was catalytically active for the oxidation of Ufiprazole to Omeprazole, an important reaction in pharmaceutical industry. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Related Products of 73590-85-9

The Article related to selenization polystyrene iron trichloride catalyst, Chemistry of Synthetic High Polymers: Chemical Transformation Of Polymers and other aspects.Related Products of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 19, 2022, Santa Chalarca, Cristiam F.; Dalal, Rishad J.; Chapa, Alejandra; Hanson, Mckenna G.; Reineke, Therefsa M. published an article.Electric Literature of 5036-48-6 The title of the article was Cation Bulk and pKa Modulate Diblock Polymer Micelle Binding to pDNA. And the article contained the following:

Polymer-based gene delivery relies on the binding, protection, and final release of nucleic acid cargo using polycations. Engineering polymeric vectors, by exploring novel topologies and cationic moieties, is a promising avenue to improve their performance, which hinges on the development of simple synthetic methods that allow facile preparation In this work, we focus on cationic micelles formed from block polymers, which are examined as promising gene compaction agents and carriers. In this study, we report the synthesis and assembly of six amphiphilic poly(Bu acrylate)-b-poly(cationic acrylamide) diblock polymers with different types of cationic groups ((dialkyl)amine, morpholine, or imidazole) in their hydrophilic corona. The polycations were obtained through the parallel postpolymn. modification of a poly(Bu acrylate)-b-poly(pentafluorophenyl acrylate) reactive scaffold, which granted diblock polymers with equivalent ds.p. and subsequent quant. functionalization with cations of different pKa. Ultrasound-assisted direct dissolution of the polycations in different aqueous buffers (pH = 1-7) afforded micellar structures with low size dispersities and hydrodynamic radii below 100 nm. The formation and properties of micelle-DNA complexes (“micelleplexes”) were explored via DLS, zeta potential, and dye-exclusion assays revealing that binding is influenced by the cation type present in the micelle corona where bulkiness and pKa are the drivers of micelleplex formation. Combining parallel synthesis strategies with simple direct dissolution formulation opens opportunities to optimize and expand the range of micelle delivery vehicles available by facile tuning of the composition of the cationic micelle corona. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Electric Literature of 5036-48-6

The Article related to diblock fluoropolymer raft polymerization cationic micelle pdna complex polyplex, Chemistry of Synthetic High Polymers: Chemical Transformation Of Polymers and other aspects.Electric Literature of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 14, 2021, Yang, Rui; Dai, Pei; Zhang, Shu; Xu, Ri-Wei; Hong, Song; Lin, Wen-Feng; Wu, Yi-Xian published an article.Product Details of 5036-48-6 The title of the article was In-situ synthesis of cross-linked imidazolium functionalized Poly(styrene-b-isobutylene-b-styrene) for anion exchange membranes. And the article contained the following:

The crosslinked imidazolium functionalized anion-exchange membranes is in-situ prepared via reaction of chloromethylated poly(styrene-b-isobutylene-b-styrene) with 1,1′-(1,6-hexanediyl)bisimidazole and N-methylimidazole. The composite membranes of cross-linked imidazolium poly(styrene-b-isobutylene-b-styrene) with a small amount of modified graphene oxide grafted with octadecyl and Pr Ph imidazolium could be further prepared These membranes exhibit significantly high chem. stability and ionic conductivity (σ), marked by low methanol permeability, together with improved dynamic mech. properties. The ionic conductivity of crosslinked imidazolium poly(styrene-b-isobutylene-b-styrene) reaches 2.09 x 10-2 S cm-1 at 80°C by introduction of 0.5 wt% loading of modified graphene oxide. This membrane also behaves an excellent chem. stability and σ can remain ca. 82% of the original value after immerged in strong alk. medium (2 M NaOH) at 60°C for 500 h, which is almost the same as that (ca. 82%) of com. Nafion 115 in acid medium (2 M H2SO4) at 60°C for 500 h. The cross-linked imidazolium poly(styrene-b-isobutylene-b-styrene) is characterized as a promising anion exchange membrane materials in fuel cell for its high ionic conductivity, chem. stability and low methanol permeability. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6

The Article related to crosslinked imidazolium functionalized polystyrene isobutylene triblock copolymer, anion exchange membrane, Chemistry of Synthetic High Polymers: Chemical Transformation Of Polymers and other aspects.Product Details of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Muljana, Henky; Remerie, Klaas; Boven, Gert; Picchioni, Francesco; Bose, Ranjita K. published an article in 2022, the title of the article was Crosslinking of Polypropylene with Thiophene and Imidazole.Safety of N-(3-Aminopropyl)-imidazole And the article contains the following content:

In this work, two novel routes to synthesis crosslinked polypropylene (PP) are introduced by using two different precursors (2-thiophenemethyl amine (TMA) and 1-(3 aminopropyl) imidazole (API)), both crosslinked with 1,1′-(methylenedi-4,1-phenylene) bismaleimide (BM) at two different annealing temperature values (T = 50°C and T = 150°C). Both Diels-Alder (DA) and Michael addition reactions were successfully performed with TMA and API, resp., albeit with different reactivity. Imidazole clearly shows a higher reactivity compared to thiophene. In addition, an increase in annealing temperature leads to a higher degree of crosslinking. The highest degree of crosslinking was obtained by the imidazole product after annealing at 150°C (IMG1A150) as evident from the highest complex viscosity (η*) value of IMG1A150. A difference in rheol. and thermal properties between the imidazole and thiophene crosslinked products was also observed However, both products have superior melt properties and thermal stability compared with the starting material. They show processability at high temperatures The melt flow behavior and de-crosslinking at higher temperatures can be tuned depending on the choice of imidazole or thiophene. This study shows an advance on the crosslinked PP processing and its product performances for further application on the com. scale. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to polypropylene thiophene imidazole crosslinking, diels–alder, cross-linked, imidazole-bismaleimide, polypropylene, thermo-reversible, thiophene-bismaleimide, Chemistry of Synthetic High Polymers: Chemical Transformation Of Polymers and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Brzeczek-Szafran, Alina; Wieclawik, Justyna; Barteczko, Natalia; Szelwicka, Anna; Byrne, Emily; Kolanowska, Anna; Swadzba Kwasny, Malgorzata; Chrobok, Anna published an article in 2021, the title of the article was Protic ionic liquids from di- or triamines: even cheaper Bronsted acidic catalysts.Synthetic Route of 5036-48-6 And the article contains the following content:

Dicationic and tricationic ionic liquids, synthesized by proton transfer from sulfuric acid and corresponding di- and triamines, were characterised and used as Bronsted acidic catalysts in biodiesel production It has been demonstrated that the new ionic liquids are less expensive than those based on monoamines (even on triethylamine) and are highly acidic. Their performance in a model catalytic esterification reaction surpassed that of sulfuric acid and other literature reports, due to the capability of the ionic liquids to absorb water while phase-separating the ester, thereby shifting the reaction equilibrium towards products. The overall catalytic performance was an interplay between acidity (quantified by Gutmann AN) and phys. properties: d. and viscosity, which enabled easy phase separation, thereby separating water from the ester. The substrate scope and recycling studies have demonstrated that the new ionic liquids are robust and recyclable catalysts. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Synthetic Route of 5036-48-6

The Article related to protic ionic liquid esterification reaction phys thermal catalytic property, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Catalysts and other aspects.Synthetic Route of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 17, 2021, Le, My Linh; Rawlings, Dakota; Danielsen, Scott P. O.; Kennard, Rhiannon M.; Chabinyc, Michael L.; Segalman, Rachel A. published an article.Product Details of 5036-48-6 The title of the article was Aqueous Formulation of Concentrated Semiconductive Fluid Using Polyelectrolyte Coacervation. And the article contained the following:

Conjugated polyelectrolytes (CPEs), which combine π-conjugated backbones with ionic side chains, are intrinsically soluble in polar solvents and have demonstrated tunability with respect to solution processability and optoelectronic performance. However, this class of polymers often suffers from limited solubility in water. Here, polyelectrolyte coacervation was utilized for aqueous processing of conjugated polymers at extremely high polymer loading. Sampling various mixing conditions, compositions that enable the formation of complex coacervates of an alkoxysulfonate-substituted PEDOT (PEDOT-S) with poly(3-methyl-1-propylimidazolylacrylamide) (PA-MPI) were identified. The resulting coacervate is a viscous fluid containing 50% weight/volume polymer and can be readily blade-coated into films of 4 ± 0.5μm thickness. Subsequent acid doping of the film increased the elec. conductivity of the coacervate to twice that of a doped film of neat PEDOT-S. This higher conductivity of the doped coacervate film suggests an enhancement in charge carrier transport along PEDOT-S backbone, in agreement with spectroscopic data, which shows an enhancement in the conjugation length of PEDOT-S upon coacervation. This study illustrates the utilization of electrostatic interactions in aqueous processing of conjugated polymers, which will be useful in large-scale industrial processing of semiconductive materials using limited solvent and with added enhancements to optoelectronic properties. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Product Details of 5036-48-6

The Article related to polythiophene conjugated polymer polyelectrolyte coacervation semiconductive fluid, Physical Properties of Synthetic High Polymers: Polymer Solutions and Gels and other aspects.Product Details of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On November 15, 2018, Kettle, Jason Grant; Bagal, Sharanjeet Kaur; Boyd, Scott; Eatherton, Andrew John; Fillery, Shaun Michael; Robb, Graeme Richard; Raubo, Piotr Antoni published a patent.Category: imidazoles-derivatives The title of the patent was Preparation of heteroaryl compounds as inhibitors as G12C mutant RAS proteins. And the patent contained the following:

The invention relates to compounds of formula I and pharmaceutically acceptable salts thereof; their preparation, pharmaceutical compositions containing them and their use in the treatment of cell proliferative disorders. Compounds of formula I wherein ring A is aryl, monocyclic heteroaryl and bicyclic heteroaryl; R1 is C1-4 alkyl, halo, OH, etc.; n is 0 – 3; W is N and CR13; X is O and NR14; Y is CR15R16, CO, COCR21R22; R2 is H, CN, halo, etc.; R3 is H, C1-3 fluoroalkyl, OH and derivatives, etc.; R4 is H and Me, R5 is H and Me; R6 is H and CH2NMe2; R13 is H, C1-4 alkyl, halo, etc.; R15, R16 are independently H and C1-3 alkyl; R21 and R22 are independently H, C1-3 alkyl, and F; and pharmaceutically acceptable salt thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their KRas protein inhibitory activity (some data given). The experimental process involved the reaction of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one(cas: 40644-16-4).Category: imidazoles-derivatives

The Article related to pyrazinooxazepinoquinazoline preparation g12c mutant ras protein inhibitor anticancer, Heterocyclic Compounds (More Than One Hetero Atom): Other 7-Membered Rings and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem