Month: November 2022

Peng, Xiao-Chong published the artcileActivated carbon supported hafnium(IV) chloride as an efficient, recyclable, and facile removable catalyst for expeditious parallel synthesis of benzimidazoles, Application of 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Catalysts (2020), 10(4), 436, database is CAplus.

A highly efficient method for parallel synthesis of a diversity of 1,2-disubstituted benzimidazoles from N-substituted phenylenediamines and aldehydes has been developed by using 10 mol% HfCl₄ on activated carbon (HfCl₄/C) as the catalyst. The newly reported HfCl₄/C catalyst not only mediated fast and clean formation of benzimidazoles but also could be easily removed from the reaction solution and reused up to eight times. Scanning electron microscope (SEM) and thermal desorption studies showed that activated carbon could reversibly adsorb and release Hf(IV) in ethanol upon cooling and heating, thereby serving as a thermal-controlled solid support.

Catalysts published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Application of 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Miralles, Nuria published the artcileCopper-Mediated S_N2′ Allyl-Alkyl and Allyl-Boryl Couplings of Vinyl Cyclic Carbonates, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Organic Letters (2017), 19(22), 6096-6099, database is CAplus and MEDLINE.

A method for the Cu-catalyzed borylmethylation and borylation of vinyl cyclic carbonates through an S_N2′ mechanism is reported. These singular reactions involve selective S_N2′ allylic substitutions with concomitant ring opening of the cyclic carbonate and with extrusion of CO₂ and formation of a useful hydroxyl functionality in a single step. The stereoselectivity of the homoallylic borylation and allylic borylation processes can be controlled, and synthetically useful unsaturated (E)-pent-2-ene-1,5-diols and (E)-but-2-ene-1,4-diols are accessed.

Organic Letters published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Molderings, G. J. published the artcileInhibitory presynaptic imidazoline receptors on sympathetic nerves in the rabbit aorta differ from I₁– and I₂-imidazoline binding sites, Quality Control of 2508-72-7, the publication is Naunyn-Schmiedeberg’s Archives of Pharmacology (1995), 351(5), 507-16, database is CAplus and MEDLINE.

The involvement of imidazoline receptors in modulation of noradrenaline release was investigated in the rabbit aorta preincubated with [³H]noradrenaline and superfused with physiol. salt solution containing cocaine, corticosterone and propranolol. After blockade of α₂-autoreceptors by rauwolscine, the elec. evoked tritium overflow was inhibited by various imidazolines and guanidines. The rank order of potency was BDF 7579 (4-chloro-2-isoindolinylguanidine) ≥ BDF 6143 (4-chloro-2-(2-imidazolin-2-ylamino)-isoindoline) > BDF 6100 [2-(2-imidazolin-2-ylamino)-isoindoline] > clonidine > ST587 (2-(2-chloro-5-trifluoromethylphenylimino)imidazolidine nitrate) ≥ cirazoline > tolazoline > idazoxan > phentolamine. Comparison of the potencies of these drugs with those previously found for the presynaptic imidazoline receptors in the rabbit pulmonary artery revealed a very good correlation. In contrast, no pos. correlation was found with their affinities for the I₁– and I₂-imidazoline binding sites in bovine adrenal medullary membranes and with their lipophilicity (log P values). The elec. evoked tritium overflow was also inhibited by the recently identified endogenous imidazoline receptor ligand agmatine, but was not affected by amiloride. In further series of experiments, the ability of putative antagonist at presynaptic imidazoline receptors to counteract the inhibitory effect of imidazoline derivatives was determined Amiloride, imidazole-4-acetic acid and 1-benzylimidazole did not attenuate the inhibitory effect of BDF 6143 on the elec. evoked tritium overflow. In contrast, rauwolscine antagonized the inhibitory effect of various imidazolines; rauwolscine was clearly less potent in antagonizing the effect of clonidine, BDF 6143 and cirazoline (apparent pA₂ 6.48-7.32) than in antagonizing that of oxymetazoline and moxonidine (apparent pA₂ 8.33 and 8.12, resp.). In a final series of experiments, BDF 6143 (under the conditions applied a selective agonist at presynaptic imidazoline receptors) proved to be considerably less potent in inhibiting tritium overflow evoked by high K⁺ than by elec. stimulation, whereas moxonidine (in rabbit aorta a selective agonist at presynaptic α₂-adrenoceptors) exhibited similar potency in inhibiting the overflow evoked by both methods of stimulation. It is concluded that noradrenaline release in the rabbit aorta is inhibited via both α₂-autoreceptors and presynaptic imidazoline receptors which can be activated by the endogenous imidazoline receptor ligand agmatine. The occurrence of such an α₂-adrenoceptor-independent mechanism is compatible with the ability of K⁺ ions to attenuate the inhibitory effect of an imidazoline receptor agonist but not of an α₂-adrenoceptor agonist, since susceptibility to K⁺ ions has been suggested to be a typical feature of imidazoline recognition sites. The presynaptic imidazoline receptor in rabbit aorta appears to be identical with the previously characterized presynaptic imidazoline receptor in rabbit pulmonary artery, but differs clearly from the I₁ and I₂ binding sites in the bovine adrenal medulla.

Naunyn-Schmiedeberg’s Archives of Pharmacology published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Quality Control of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Borcard, Francoise published the artcileCovalent Cell Surface Functionalization of Human Fetal Osteoblasts for Tissue Engineering, Safety of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Bioconjugate Chemistry (2011), 22(7), 1422-1432, database is CAplus and MEDLINE.

The chem. functionalization of cell-surface proteins of human primary fetal bone cells with hydrophilic bioorthogonal intermediates was investigated. Toward this goal, chem. pathways were developed for click reaction-mediated coupling of alkyne derivatives with cellular azido-expressing proteins. The incorporation via a tetraethylene glycol linker of a dipeptide and a reporter biotin allowed the proof of concept for the introduction of cell-specific peptide ligands and allowed us to follow the reaction in living cells. Tuning the conditions of the click reaction resulted in chem. functionalization of living human fetal osteoblasts with excellent cell survival.

Bioconjugate Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Safety of N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kurdziel, K. published the artcileCoordination properties of 4(5)-hydroxymethylimidazole and 4(5)-hydroxymethyl-5(4)-methylimidazole towards cobalt(II) ions, Safety of (2-Methyl-1H-imidazol-4-yl)methanol, the publication is Journal of Coordination Chemistry (2007), 60(8), 877-889, database is CAplus.

Two new complexes of imidazole alcs., 4-hydroxymethylimidazole (4-CH₂OHim) and 4-hydroxymethyl-5-methylimidazole (4-CH₂OH-5-CH₃i.m.), with Co(II), [CoL₂(H₂O)₂](NO₃)₂ were obtained. These compounds were characterized through single x-ray diffraction studies, spectroscopic (IR, far-IR, UV-visible-NIR) and magnetic measurements. The hydroxymethylimidazole ligands are bidentate, coordinating the heterocyclic ring through pyridine-like N atoms and the O atom of the hydroxymethyl group (chromophore CoN₂O₄). The Co(II) coordination polyhedra are distorted octahedrons, with the equatorial plane defined by the 4-CH₂OHim (or 4-CH2OH-5-CH₃i.m.) bidentate ligands and two H₂O mols. occupying axial (trans) positions. Formation of successive Co(II) complexes with 4-CH₂OH-5-CH₃i.m. in aqueous solution was followed quant. by potentiometry.

Journal of Coordination Chemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Safety of (2-Methyl-1H-imidazol-4-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Jares-Erijman, E. published the artcileImaging quantum dots switched on and off by photochromic fluorescence resonance energy transfer (pcFRET), Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Molecular Crystals and Liquid Crystals (2005), 257-265, database is CAplus.

The reversible modulation of the emission of CdSe/ZnS semiconductor nanocrystals (quantum dots) was achieved by binding photochromic diheteroarylethenes and switchable acceptors for fluorescence resonance energy transfer. A biotinylated diheteroarylethene derivative was bound to quantum dots bearing conjugated streptavidin, leading to an intensity decrease as a consequence of energy transfer to the closed form of the acceptor. Interconversion between the open and closed forms by irradiation with 365 and 546 nm light enabled deactivation and activation, resp., of the FRET process with a corresponding modulation of quantum dot emission, observed both in solution and by sequential wide-field imaging.

Molecular Crystals and Liquid Crystals published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kankate, Rani S. published the artcileMicrowave assisted synthesis, antifungal evaluation and molecular docking of benzimidazole derivatives, Application In Synthesis of 7467-35-8, the publication is Pharma Chemica (2014), 6(6), 396-405/1-396-405/10, 10 pp., database is CAplus.

A novel series of benzimidazole derivatives, carrying biphenyl carbonyl piperazine moiety based on an initial design by mol. docking study of this scaffold at the active site of the fungal enzyme of cytochrome P 450 family, lanosterol 14 α-demethylase (CYP51) was synthesized by microwave irradiation The screening of the synthesized compounds for in vitro antifungal activity against Candida albicans revealed activity for many compounds as comparable to that of ketoconazole.

Pharma Chemica published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Application In Synthesis of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kankate, Rani S. published the artcileSynthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives, HPLC of Formula: 7467-35-8, the publication is Oriental Journal of Chemistry (2014), 30(4), 1855-1863, database is CAplus.

A series of [(benzimidazolylalkyl)piperazinyl]phenylmethanone derivatives I [R¹ = H, Cl, R² = H, Me, Et, R³ = H, Me, Ph] was synthesized by microwave irradiation and evaluated for in vitro antifungal activity using ketoconazole as the standard Among the tested compounds, benzimidazole derivatives with an N-1 Me, a C2 asym. center and C5 chlorine substitution showed good antifungal activity against the C. albicans strain using the turbidimetric method.

Oriental Journal of Chemistry published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, HPLC of Formula: 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kankate, Rani S. published the artcileMicrowave assisted synthesis, antifungal evaluation and molecular docking of benzimidazole derivatives, Related Products of imidazoles-derivatives, the publication is Pharma Chemica (2014), 6(6), 396-405/1-396-405/10, 10 pp., database is CAplus.

A novel series of benzimidazole derivatives, carrying biphenyl carbonyl piperazine moiety based on an initial design by mol. docking study of this scaffold at the active site of the fungal enzyme of cytochrome P 450 family, lanosterol 14 α-demethylase (CYP51) was synthesized by microwave irradiation The screening of the synthesized compounds for in vitro antifungal activity against Candida albicans revealed activity for many compounds as comparable to that of ketoconazole.

Pharma Chemica published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kankate, Rani S. published the artcileSynthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives, Computed Properties of 4760-35-4, the publication is Oriental Journal of Chemistry (2014), 30(4), 1855-1863, database is CAplus.

A series of [(benzimidazolylalkyl)piperazinyl]phenylmethanone derivatives I [R¹ = H, Cl, R² = H, Me, Et, R³ = H, Me, Ph] was synthesized by microwave irradiation and evaluated for in vitro antifungal activity using ketoconazole as the standard Among the tested compounds, benzimidazole derivatives with an N-1 Me, a C2 asym. center and C5 chlorine substitution showed good antifungal activity against the C. albicans strain using the turbidimetric method.

Oriental Journal of Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Computed Properties of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem