Month: November 2022

Babiak, Peter; Kyslikova, Eva; Stepanek, Vaclav; Valesova, Renata; Palyzova, Andrea; Maresova, Helena; Hajicek, Josef; Kyslik, Pavel published an article in 2011, the title of the article was Whole-cell oxidation of omeprazole sulfide to enantiopure esomeprazole with Lysinibacillus sp. B71.SDS of cas: 73590-85-9 And the article contains the following content:

Production of enantiopure esomeprazole by biocatalysis is of great demand by pharmaceutical industry. A Gram-pos. bacterium oxidizing omeprazole sulfide (5-methoxy-2-[((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)thio]-1H-benzoimidazole) to (S)-sulfoxide esomeprazole (S)-5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl]-3H-benzoimidazole was isolated from soil polluted with elemental sulfur. The strain exhibited the highest identity with the genus Lysinibacillus and catalyzed oxidation of 1a into enantiopure esomeprazole with conversion of 77% in a stirred bioreactor, fed-batch culture. No consecutive oxidation of (S)-sulfoxide to sulfone was observed during whole-cell catalysis. The unique characteristics of the catalyst provide a solid basis for further improvement and development of sustainable green bioprocess. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).SDS of cas: 73590-85-9

The Article related to lysinibacillus omeprazole sulfide oxidation enantiomer, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.SDS of cas: 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On October 31, 2021, Zhang, Yuanyuan; Lv, Kuiying; Deng, Yashan; Li, Huiling; Wang, Zhiyong; Li, Depeng; Gao, Xin; Wang, Fanye published an article.Formula: C17H19N3O2S The title of the article was Asymmetric Bio-oxidation Using Resting Cells of Rhodococcus rhodochrous ATCC 4276 Mutant QZ-3 for Preparation of (S)-Omeprazole in a Chloroform-Water Biphasic System Using Response Surface Methodology. And the article contained the following:

Abstract: (S)-Omeprazole is a very effective anti-ulcer medicine that is difficult to be prepared using whole cells at elevated substrate concentrations In the chloroform-water biphasic system, resting cells of the mutant QZ-3 of Rhodococcus rhodochrous (R. rhodochrous) ATCC 4276 were used to catalyze the bio-oxidation of omeprazole sulfide for preparation of (S)-omeprazole. Using response surface methodol. (RSM), the reaction was optimized to work at a substrate concentration of 180 mM and a cell concentration of 100 g/L. The optimal yield of (S)-omeprazole obtained was 92.9% with enantiomeric excess (ee) (> 99%), and no sulfone byproduct was detected under the optimal working conditions; reaction temperature 37°C, pH 7.3 and reaction time, 43 h. A quadratic polynomial model was established, which predicts the exptl. data with very high accuracy (R2 = 0.9990). The chloroform-water biphasic system may contribute to the significant improvement in substrate tolerance because almost all substrates are partitioned in the organic phase (water solubility of omeprazole sulfide is only about 0.5 mg/mL), resulting in little damage and inhibition to cells by substrates. The mutant QZ-3 of R. rhodochrous ATCC 4276 exhibited high enantioselectivity, activity and substrate and product tolerance. The aerated flask provides enough oxygen for a high concentration of cells. Accordingly, bio-oxidation is thus more promising for efficient preparation of chiral sulfoxides. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Formula: C17H19N3O2S

The Article related to rhodococcus s omeprazole chloroform water biphasic system, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.Formula: C17H19N3O2S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 18, 2022, Ueda, Yuki; Eguchi, Ayano; Tokunaga, Kohei; Kikuchi, Kei; Sugita, Tsuyoshi; Okamura, Hiroyuki; Naganawa, Hirochika published an article.Synthetic Route of 5036-48-6 The title of the article was Urea-Introduced Ionic Liquid for the Effective Extraction of Pt(IV) and Pd(II) Ions. And the article contained the following:

A urea-introduced imidazolium-based ionic liquid (IL), 1-butyl-3-{3-(3-methyl-2H-imidazol-1-yl)propyl}urea bis(trifluoromethylsulfonyl)imide (L1), whose selectivity to Pt(IV) and Pd(II) was changed only by a pH region, was synthesized, and its Pt(IV) and Pd(II) extraction behaviors were investigated. In the conventional organic extraction system, an organic extractant with a urea group, 1-butyl-3-(2-ethylhexyl)urea, in isooctane extracted Pt(IV) and Pd(II) in a similar pH range, the extraction equilibrium half-time (t1/2) of Pd(II) was 8.95 h. In contrast, in the IL extraction system, Pt(IV) and Pd(II) were extracted in the lower and higher pH regions, resp., indicating the mutual separation of Pt(IV) and Pd(II) by pH-change. Furthermore, the extraction equilibrium t1/2 of Pd(II) with the IL extraction system was 0.18 h. UV-visible and extended X-ray absorption fine structure spectroscopies of Pt(IV) and Pd(II) after extraction using the IL were conducted to determine the extraction mechanism. As a result, Pt(IV) was extracted as [PtCl6]2- via anion-exchange (outer-sphere complex). On the other hand, Pd(II) was extracted via a mixed reaction of ligand-exchange (inner-sphere complex) and anion-exchange. Finally, the IL extraction system did not produce a third phase even when loaded with a high concentration of Pt(IV). The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Synthetic Route of 5036-48-6

The Article related to urea introduced ionic liquid extraction platinum palladium ion, Phase Equilibriums, Chemical Equilibriums, and Solutions: Partition, Extraction and other aspects.Synthetic Route of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 31, 2022, Tang, Hui; Zhang, Yuanyuan; Deng, Yashan; Du, Shanshan; Li, Depeng; Wang, Zhiyong; Li, Huiling; Gao, Xin; Wang, Fanye published an article.Recommanded Product: 73590-85-9 The title of the article was Optimization of Synthesis of (S)-Omeprazole Catalyzed by Soybean Pod Peroxidase in Water-in-Oil Microemulsions Using RSM. And the article contained the following:

Response surface methodol. (RSM) was used to optimize the oxidizing the omeprazole sulfide to (S)-omeprazole catalyzed by environmentally friendly catalyst soybean pod peroxidase (SPP) in cetyltrimethylammonium bromide (CTAB)/isooctane/n-Bu alc./water water-in-oil microemulsions. With the initial concentration of SPP of 3200 U ml-1, the conversion of the omeprazole sulfide, the (S)-omeprazole yield and ee were 93.75%, 91.56% and 96.08%, resp., under the optimal conditions: Wo of 15.85, the concentration of H2O2 of 22.44 mM and reaction temperature of 49.68°C, resp. The proposed mechanism of asym. sulfoxidations catalyzed by SPP involves three concomitant mechanisms as follows: (1) a two-electron reduction of SPP-I, (2) a single-electron transfer to SPP-I and (3) nonenzymic reactions. Based on the proposed mechanism which is reasonable and can express the oxidations, the reaction system includes five enzymic and two nonenzymic reactions. With 5.44% of the average relative error, a kinetic model based on the mechanisms fitting observed data very well was established, and the SPP-catalyzed reactions including both the two-electron reduction and the single-electron transfer mechanisms obey ping-pong mechanism with substrate and product inhibition, while nonenzymic reactions follow a power law. This study has also demonstrated the feasibility of SPP as a substitute with low cost, excellent enantioselectivity and better thermal stability. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Recommanded Product: 73590-85-9

The Article related to soybean peroxidase water in oil microemulsion omeprazole optimization rsm, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.Recommanded Product: 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On April 1, 2019, Zhang, Yan; Wu, Yin-Qi; Xu, Na; Zhao, Qian; Yu, Hui-Lei; Xu, Jian-He published an article.Category: imidazoles-derivatives The title of the article was Engineering of cyclohexanone monooxygenase for the enantioselective synthesis of (S)-omeprazole. And the article contained the following:

Enzymic asym. sulfoxidation using mol. oxygen as the oxidant is a promising green chem. approach to chiral sulfoxide production Despite the broad substrate spectrum of cyclohexanone monooxygenases (CHMOs), some unnatural substrates with bulky functional groups, such as the pharmaceutically relevant omeprazole sulfide, cannot be effectively accepted by CHMOs. Herein, we describe a set of variants derived from an Acinetobacter calcoaceticus CHMO (AcCHMO), whose active sites adjacent to the substrate tunnel were altered to shift the substrate specificity from cyclohexanone monooxygenation toward omeprazole sulfide sulfoxidation We performed homologous modeling and mol. docking to identify key residues that might affect the substrate specificity. Two libraries of residues lining the active center of AcCHMO were then constructed and screened by an effective halo-based selection method using the solubility difference between the substrate (omeprazole sulfide) and product (esomeprazole). Functional evaluation of the resultant variants showed that the substrate specificity of AcCHMO was markedly altered from the small natural substrate (cyclohexanone) toward the desired bulky substrate (omeprazole sulfide) despite the extremely poor activity detected even for the best variant, M2 (0.61 U/gprot). The crystal structure of M2 complexed with a FAD prosthetic group was determined, which provided insight into the altered substrate specificity. To improve the activity of enzyme M2 toward pharmaceutical precursor omeprazole sulfide, we performed both local and global protein engineering among the two CASTing libraries surrounding FAD+ and NADP+ prosthetic groups and an error-prone PCR library of the full-length AcCHMO. As a result, variant M6 was obtained, giving a 50-fold higher activity compared to M2. This structure-guided protein engineering of AcCHMO provided a promising candidate for converting omeprazole sulfide into (S)-omeprazole using a green biocatalytic method. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Category: imidazoles-derivatives

The Article related to cyclohexanone monooxygenase engineering enantioselective synthesis s omeprazole, Fermentation and Bioindustrial Chemistry: Pharmaceuticals (Including Nutrients) and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 27, 2022, Le, My Linh; Grzetic, Douglas J.; Delaney, Kris T.; Yang, Kai-Chieh; Xie, Shuyi; Fredrickson, Glenn H.; Chabinyc, Michael L.; Segalman, Rachel A. published an article.Safety of N-(3-Aminopropyl)-imidazole The title of the article was Electrostatic Interactions Control the Nanostructure of Conjugated Polyelectrolyte-Polymeric Ionic Liquid Blends. And the article contained the following:

Polyelectrolyte complexation offers unique opportunities to compatibilize polymers with different backbone chemistries and to control the morphol. of the resulting blend via electrostatic manipulation. In this study, we demonstrate the ability to formulate homogeneous complexes of a conjugated polyelectrolyte with a polymeric ionic liquid, utilizing the electrostatic attraction among their oppositely charged side chains. Variation of electrostatic parameters, such as counterion concentration or polymer charge fraction, tunes the morphol. of these polymer complexes from homogeneously disordered blend to weakly structured microemulsion where the local ordering arises from backbone-immiscibility-induced microphase segregation. Our exptl. observations are in qual. agreement with both field-theoretic simulation and RPA calculations Simulated morphol. snapshots suggest and exptl. evidence also indicates that the microphase-segregated complex likely takes on a cocontinuous microemulsion structure. Our findings show that ionic interactions are an effective pathway to compatibilize polymers at macroscopic length scales while achieving controlled nanostructures in these ionic blends. Such systems have great potential for engineering the nanostructure of polymers to tailor applications such as nanofiltration, catalysis, and energy storage, where local ordering can enhance the phys. properties of an otherwise macroscopically homogeneous structure. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Safety of N-(3-Aminopropyl)-imidazole

The Article related to electrostatic nanostructure conjugated polyelectrolyte polymeric ionic liquid blend, Physical Properties of Synthetic High Polymers: Physical Properties Of Polymers and other aspects.Safety of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cao, Siyu; Yoshio, Masafumi; Seki, Atsushi published an article in 2020, the title of the article was Ion-conductive nanostructured polymer films formed by photopolymerization of lyotropic columnar liquid-crystalline monomers, composed of a zwitterionic compound and a protic ionic liquid.Related Products of 5036-48-6 And the article contains the following content:

Here, we report on a new family of columnar nanostructured polymer films forming protic nanochannels that exhibit good ionic conductivities in the order of 10-4-10-3 S cm-1 at ambient temperature These polymer films were obtained by the in situ photopolymerization of lyotropic columnar liquid crystals, consisting of a polymerizable taper-shaped zwitterionic compound and a protic ionic liquid (imidazolium bis(trifluoromethylsulfonyl)imide), in the presence of 15 wt% water. The composition of the protic ionic liquid in the mixture was changed from 40 to 60 mol%. The ionic conductivities were measured by an a.c. impedance method. The ionic conductivity increased with the increase of the protic ionic liquid The conductivities of columnar nanostructured polymer films were about 2-3 orders of magnitude higher than those of amorphous polymer films prepared by photopolymerization of the corresponding monomers in an isotropic liquid state. The formation of nanochannels in the polymer matrixes significantly enhanced the ion conduction. The present two-component lyotropic liquid-crystalline self-assembly followed by photopolymerization is a promising approach to the development of high ion-conductive polymer membranes. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Related Products of 5036-48-6

The Article related to lyotropic columnar liquid crystalline monomer photopolymerization ionic conductivity, Physical Properties of Synthetic High Polymers: Physical Properties Of Polymers and other aspects.Related Products of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

O’Harra, Kathryn E.; Noll, Danielle M.; Kammakakam, Irshad; DeVriese, Emily M.; Solis, Gala; Jackson, Enrique M.; Bara, Jason E. published an article in 2020, the title of the article was Designing imidazolium poly(amide-amide) and poly(amide-imide) ionenes and their interactions with mono- and tris(imidazolium) ionic liquids.Computed Properties of 5036-48-6 And the article contains the following content:

Here we introduce the synthesis and thermal properties of a series of sophisticated imidazolium ionenes with alternating amide-amide or amide-imide backbone functionality, and investigate the structural effects of mono(imidazolium) and unprecedented tris(imidazolium) ionic liquids (ILs) in these ionenes. The new set of poly(amide-amide) (PAA) and poly(amide-imide) (PAI) ionenes represent the intersection of conventional high-performance polymers with the ionene archetype-presenting polymers with alternating functional and ionic elements precisely sequenced along the backbone. The effects of polymer composition on the thermal properties and morphol. were analyzed. Five distinct polymer backbones were synthesized and combined with a stoichiometric equivalent of the IL 1-benzyl-3-methylimidazolium bistriflimide ([Bnmim][Tf2N]), which were studied to probe the self-assembly, structuring, and contributions of intermol. forces when IL is added. Furthermore, three polyamide (PA) or polyimide (PI) ionenes with simpler xylyl linkages were interfaced with [Bnmim][Tf2N] as well as a novel amide-linked tris(imidazolium) IL, to demonstrate the structural changes imparted by the inclusion of functional, ionic additives dispersed within the ionene matrix. This work highlights the possibilities for utilizing concepts from small mols. which exhibit supramol. self-assembly to guide creative design and manipulate the structuring of ionenes. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Computed Properties of 5036-48-6

The Article related to imidazolium polyamide amide imide ionene ionic liquid, composites, copolymers, ionenes, polyamides, polyelectrolytes, polyimides, Physical Properties of Synthetic High Polymers: Physical Properties Of Polymers and other aspects.Computed Properties of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On March 15, 2012, Lin, Hong; Erhard, Karl; Hardwicke, Mary Ann; Luengo, Juan I.; Mack, James F.; McSurdy-Freed, Jeanelle; Plant, Ramona; Raha, Kaushik; Rominger, Cynthia M.; Sanchez, Robert M.; Schaber, Michael D.; Schulz, Mark J.; Spengler, Michael D.; Tedesco, Rosanna; Xie, Ren; Zeng, Jin J.; Rivero, Ralph A. published an article.Quality Control of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one The title of the article was Synthesis and structure-activity relationships of imidazo[1,2-a]pyrimidin-5(1H)-ones as a novel series of beta isoform selective phosphatidylinositol 3-kinase inhibitors. And the article contained the following:

A series of PI3K-beta selective inhibitors, imidazo[1,2-a]-pyrimidin-5(1H)-ones, has been rationally designed based on the docking model of the more potent R enantiomer of TGX-221, identified by a chiral separation, in a PI3K-beta homol. model. Synthesis and SAR of this novel chemotype are described. Several compounds in the series demonstrated potent growth inhibition in a PTEN-deficient breast cancer cell line MDA-MB-468 under anchorage independent conditions. The experimental process involved the reaction of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one(cas: 57473-33-3).Quality Control of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one

The Article related to phosphatidylinositol kinase isoform inhibitor imidazopyrimidinone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of 7-Chloroimidazo[1,2-a]pyrimidin-5(1H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 20, 2022, Venkatraman, Shankar; Katz, Jason; Roush, William R.; Seidel, Hans Martin published a patent.Category: imidazoles-derivatives The title of the patent was Preparation of indoles, imidazopyridines, pyrazolopyrimidines and related heterocycles useful alone or in compositions in treatment of diseases associated with STING activity. And the patent contained the following:

The invention relates to preparation of indoles, imidazopyridines, pyrazolopyrimidines and related heterocycles(I) or a pharmaceutically acceptable salt, hydrate, cocrystal, or drug combination that inhibit (e.g., antagonize) Stimulator of Interferon Genes (STING). Compounds I wherein X1 and X2 each independently is O, S, N, etc.; Z and Y1-Y3 each independently is heteroaryl; ring B is bicyclic or polycyclic C5-15 cycloalkyl or C5-15 cycloalkenyl, etc.; etc., are claimed. The example compound II was prepared via 4-steps synthesis using 5-bromo-1H-indole as starting material (procedure given). Compounds I were evaluated for their biol. activity (data given). Compounds I are useful, e.g., for treating a diseases in which increased (e.g., excessive) STING activation (e.g., STING signaling) contributes to the pathol. and/or symptoms and/or progression of the disease (e.g., cancer) in a subject (e.g., a human). The experimental process involved the reaction of 6-(Trifluoromethyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid(cas: 1774893-22-9).Category: imidazoles-derivatives

The Article related to pyrazolopyrimidine preparation sting activation inhibitor cancer disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem