Month: November 2022

Yanai, Mitsuji; Takeda, Shigeko; Baba, Tsuyomi; Kitagawa, Koichi published an article in 1974, the title of the article was Heterocyclic compounds. XVIII. Synthesis of imidazo[1,2-c]- and pyrimido[1,2-c]pyrimidine derivatives.Name: Imidazo[1,2-c]pyrimidin-5(6H)-one And the article contains the following content:

Reaction of the amino alcs. H2N(CH2)nOH (n = 2,3) and HN(CH2CH2OH)2 with the chloropyrimidines I (R = H, Me) and 4,6-dichloropyrimidine nII) gave the 4-substituted derivatives which, when treated with SOCl2 in THF, cyclized to give III, IV (R1 = H, Cl), V (R2 = H, Me, Cl; R3 = H, CH2CH2Cl), and VI. Treatment of V (R2 = Cl, R3 = CH2CH2Cl) with mild alk. solution gave the imidazolidines VII (R4 = H, CHO). Treatment of I and II with the amino acetal H2NCH2CH(OEt)2 gave the 4-(2,2-diethoxyethylamino) derivatives, which when treated with 6N HCl followed by concentrated H2SO4 gave III (R1 = H) and VIII resp. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Name: Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to imidazopyrimidine, pyrimidopyrimidine, amino alc chloropyrimidine cyclization, alc acetal chloropyrimidine cyclization, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Name: Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 7, 2015, Jansa, Josef; Lycka, Antonin; Ruzicka, Ales; Grepl, Martin; Vanecek, Jan published an article.Quality Control of Imidazo[1,2-c]pyrimidin-5(6H)-one The title of the article was Synthesis, structure and rearrangement of iodinated imidazo[1,2-c]pyrimidine-5(6H)-ones derived from cytosine. And the article contained the following:

We describe mild and selective iodination of various 8-substituted imidazo[1,2-c]pyrimidine-5(6H)-ones (ethenocytosines). Starting ethenocytosines were obtained by cyclization of 5-halogenocytosines with chloroacetaldehyde or by subsequent Suzuki-Miyaura cross-coupling between 8-iodoimidazo[1,2-c]pyrimidine-5(6H)-one 1d and corresponding arylboronic acids. When imidazo[1,2-c]pyrimidine-5(6H)-one or 8-iodoimidazo[1,2-c]pyrimidine-5(6H)-one 1d was iodinated by N-iodosuccinimide (NIS) in DMF, pure 3,8-diiododerivative 2d was obtained. Under basic or acidic conditions, this mol. is subject to rearrangement into 2,8-diododerivative 3d, which can be subsequently iodinated to 2,3,8-triododerivative 4d. Since the positions of iodine atoms on the imidazole ring could not be determined convincingly from NMR spectra only, x-ray anal. of 2d was carried out with the aim of confirming the structure undoubtedly. The same sequence of reactions was applied to another eight ethenocytosines, providing excellent regioselectivity, easy rearrangement and high yields of iodinated products. All ethenocytosines were properly characterized by 1H, 13C and 15N NMR spectroscopy. The experimental process involved the reaction of Imidazo[1,2-c]pyrimidin-5(6H)-one(cas: 55662-66-3).Quality Control of Imidazo[1,2-c]pyrimidin-5(6H)-one

The Article related to cytosine cyclization suzuki miyaura coupling iodination dimroth rearrangement, iodinated imidazopyrimidine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of Imidazo[1,2-c]pyrimidin-5(6H)-one

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On January 31, 2021, AlNeyadi, Shaikha S.; Adem, Abdu; Amer, Naheed; Ghattas, Mohammad A.; Atatreh, Noor; Salem, Alaa A.; Abdou, Ibrahim M. published an article.COA of Formula: C6H11N3 The title of the article was Activation of the GLP-1 receptor by chloropyrimidine derivatives. And the article contained the following:

The anti-diabetic activities of a series of chloropyrimidine derviativeswere investigated after they were designed, synthesized, and docked against the GLP-1 receptor target. In comparison to exenatide, which was utilized as a reference drug, the three chloropyrimidine synthesized compounds I, II and III exhibited potent in vitro and in vivo antidiabetic activities. Interestingly, compounds I, II and III showed to be the most effective in lowering blood glucose levels and led to even higher glucose uptake than the reference drug, exenatide. Consistent with the in vitro and in vivo data, compounds II and III had the lowest docking energy scores (Glide-XP score = 5.1 kcal/mol) and the greatest ligand efficiency score (> – 0.40 kcal/mol) among all docked compounds These findings give up new possibilities for the development of high-efficacy compounds to treat hyperglycemia. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).COA of Formula: C6H11N3

The Article related to alkylated chloropyrimidine prpen antidiabetic sar mol docking glp receptor, aliphatic and aromatic amine nucleophilic substitution, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.COA of Formula: C6H11N3

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 11, 2009, Berger, Dan Maarten; Levin, Jeremy Ian; Dutia, Minu Dhanjisha; Norton, Emily Boucher; Diamantidis, George published a patent.Application of 40644-16-4 The title of the patent was Preparation of aminosulfonylphenyl pyrazolo[1,5-a]pyrimidines as Raf kinase inhibitors.. And the patent contained the following:

Title compounds [I; R = H, halo, NO2, N3, cyano, CHO, CF3, OCF3, R5, OR5, N(R5)2, etc.; R1 = (substituted) heteroaryl, heterocyclyl; R2 = (substituted) aryl, heteroaryl, heterocyclyl; R3, R4 = H, (substituted) alkyl, cycloalkyl, heteroaryl; R5 = H, alkyl, alkenyl, alkynyl, cycloalkyl; N(R5)2 = atoms to form a substituted ring containing 2-7 C atoms], were prepared Thus, N-[2-(diethylamino)ethyl]-N-ethyl-3-[3-(3-hydroxyphenyl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-7-yl]benzenesulfonamide (multistep preparation given) inhibited B-Raf kinase with IC50 <0.0003 μM. The experimental process involved the reaction of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one(cas: 40644-16-4).Application of 40644-16-4

The Article related to phenylsulfonamide pyrazolopyrimidine preparation raf kinase inhibitor, cancer inflammation treatment aminosulfonylphenylpyrazolopyrimidine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Application of 40644-16-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 3, 2009, Levin, Jeremy Ian; Hopper, Darrin William; Torres, Nancy; Dutia, Minu Dhanjish; Berger, Dan Maarten; Wang, Xiaolun; Di Grandi, Martin Joseph; Zhang, Chunchun; Dunnick, Alejandro Lee published a patent.Synthetic Route of 40644-16-4 The title of the patent was Preparation of bridged, bicyclic heterocyclic or spiro bicyclic heterocyclic derivatives of pyrazolo[1,5-a]pyrimidines as Raf kinase inhibitors.. And the patent contained the following:

Title compounds [I; R1 = (substituted) 5-7 membered heterocyclyl, heteroaryl; R2 = (substituted) (bicyclic) aryl, heteroaryl; R3-R5 = H, cyano, (substituted) alkyl, cycloalkyl aryl, heterocyclyl, heteroaryl, etc.], were prepared Thus, title compound 3-[7-[6-[(1-azabicyclo[2.2.2]oct-4-ylmethyl)amino]pyridin-3-yl]-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidin-3-yl]phenol [multistep preparation from 5-acetyl-2-bromopyridine, DMF di-Me acetal, 3-methoxyphenylacetonitrile, Me isonicotinate, and 1-(1-azabicyclo[2.2.2]oct-4-yl)methylamine given] inhibited B-Raf kinase with IC50 = 0.002 μM. The experimental process involved the reaction of 4-Bromo-1H-benzo[d]imidazol-2(3H)-one(cas: 40644-16-4).Synthetic Route of 40644-16-4

The Article related to pyrazolopyrimidine preparation raf kinase inhibitor, cancer inflammation treatment azabicyclooctylmethylaminopyridinylpyridin4ylpyrazolopyrimidinylphenol preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 40644-16-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 30, 1983, Kashik, T. V.; Ponomareva, S. M.; Abramova, N. D.; Skvortsova, G. G. published an article.Computed Properties of 5709-67-1 The title of the article was Effect of meso-substituents on NH-acidity of benzimidazoles. And the article contained the following:

The pK2 values of I (R = Me, Et, H, Ph, OEt, COMe, SMe, SCH:CH2, Cl, NO2) decreased in the order stated, ranging from 26.43 to 18.75 in MeCN at 20°. A linear correlation with σm constants of R was obtained, and the following 2-parameter equation was obtained: pKa = 25.58-9.83σI – 3.86σC, where σI and σC are inductive and conjugation substituent constants The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Computed Properties of 5709-67-1

The Article related to benzimidazole acidity lfer, Physical Organic Chemistry: Acid-Base, Tautomerism, and Other Equilibrium Studies and other aspects.Computed Properties of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Demirayak, Seref; Ogretir, Cemil published an article in 1990, the title of the article was Proton-loss behaviors of some benzimidazole derivatives and their Hammett relationships.Synthetic Route of 5709-67-1 And the article contains the following content:

The proton-loss acidity constants, pKa, of 39 (un)substituted benzimidazole derivatives were determined by UV-visible spectroscopy. The calculated ΔpKa values were plotted vs. δm values to get Hammett graphs, and the results were discussed. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Synthetic Route of 5709-67-1

The Article related to lfer acidity benzimidazole, Physical Organic Chemistry: Acid-Base, Tautomerism, and Other Equilibrium Studies and other aspects.Synthetic Route of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On November 26, 2020, Aspnes, Gary E.; Bagley, Scott W.; Curto, John M.; Dowling, Matthew; Edmonds, David James; Fernando, Dilinie; Flanagan, Mark E.; Futatsugi, Kentaro; Griffith, David Andrew; Huard, Kim; Ingle, Gajendra; Jiao, Wenhua; Lacasse, Shawn M.; Lian, Yajing; Limberakis, Chris; Londregan, Allyn T.; Mathiowetz, Alan M.; Piotrowski, David Walter; Ruggeri, Roger B.; Wiglesworth, Kristin published a patent.Application In Synthesis of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride The title of the patent was Combinations comprising benzodioxol as GLP-1R agonists for use in the treatment of NASH/NAFLD and related diseases and their preparation. And the patent contained the following:

The invention provides a new combination comprising (1) a GLP-1R agonist and (2) an ACC inhibitor or a DGAT2 inhibitor, or a KHK inhibitor or FXR agonist. The invention further provides new methods for treating diseases and disorders, for example, fatty liver, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, nonalcoholic steatohepatitis with liver fibrosis, nonalcoholic steatohepatitis with cirrhosis, and nonalcoholic steatohepatitis with cirrhosis and with hepatocellular carcinoma or with a metabolic-related disease, obesity, and type 2 diabetes, for example, using the new combination described herein. Example compound I•TFA was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their GLP-1R agonistic activity (some data given). The experimental process involved the reaction of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride(cas: 1255717-13-5).Application In Synthesis of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride

The Article related to benzodioxole preparation glp 1r agonist treatment nash nafld, Heterocyclic Compounds (More Than One Hetero Atom): Dioxoles, Oxathioles, Dithioles and other aspects.Application In Synthesis of (1-Ethyl-1H-imidazol-5-yl)methanamine dihydrochloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 3, 2021, Du, Liang; Nosratabad, Neda Arabzadeh; Jin, Zhicheng; Zhang, Chengqi; Wang, Sisi; Chen, Banghao; Mattoussi, Hedi published an article.HPLC of Formula: 5036-48-6 The title of the article was Luminescent Quantum Dots Stabilized by N-Heterocyclic Carbene Polymer Ligands. And the article contained the following:

We have tested the ability of N-heterocyclic carbene (NHC)-modified ligands to coordinate and stabilize luminescent CdSe-ZnS core-shell quantum dot (QD) dispersions in hydrophilic media. In particular, we probed the effects of ligand structure and coordination number on the coating affinity to the nanocrystals. We find that such NHC-based ligands rapidly coordinate onto the QDs (requiring ~5-10 min of reaction time), which reflects the soft Lewis base nature of the NHC groups, with its two electrons sharing capacity. Removal of the hydrophobic cap and promotion of carbene-driven coordination on the nanocrystals have been verified by 1H NMR spectroscopy, while 13C NMR was used to identify the formation of carbene-Zn complexes. The newly coated QD dispersions exhibit great long-term colloidal stability over a wide range of conditions. Addnl., we find that coordination onto the QD surfaces affects the optical and spectroscopic properties of the nanocrystals. These include a size-dependent red-shift of the absorption and fluorescence spectra and a pronounced increase in the measured fluorescence intensity when the samples are stored under white light exposure compared to those stored in the dark. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).HPLC of Formula: 5036-48-6

The Article related to luminescent quantum dot stabilized heterocyclic carbene polymer ligand, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Luminescence and other aspects.HPLC of Formula: 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On November 25, 2015, Guo, Qirun; Hu, Yonghong; Yang, Wenge; Zhang, Tuan; Wu, Keyi; Yang, Shouhai; Shi, Ying published an article.Category: imidazoles-derivatives The title of the article was Thermodynamic models for determination of the solubility of omeprazole sulfide in (ethanol + ethyl acetate) binary solvent mixtures. And the article contained the following:

The solubility of omeprazole sulfide in (ethanol + Et acetate) binary solvent mixtures was measured within the temperature range from 277.65 to 333.15 K. The exptl. data were fitted using CNIBS/R-K equation and the Jouyban-Acree equation, resp. All the two equations were proven to give good representations of the exptl. values. Computational results showed that the CNIBS/R-K equation was superior to the other equation. The thermodn. properties of the solution process, including the Gibbs free energy, enthalpy and entropy, were calculated by the van’t Hoff anal. The values of both the enthalpy change and the standard molar Gibbs free energy change of solution were pos., which indicated that the process was endothermic. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Category: imidazoles-derivatives

The Article related to omeprazole sulfide ethanol ethyl acetate solvent mixture thermodn solubility, Phase Equilibriums, Chemical Equilibriums, and Solutions: Nonelectrolytic Solutions and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem