Month: November 2022

Waleed, Hadeer Q.; Csecsi, Marcell; Hadjadj, Rachid; Thangaraj, Ravikumar; Pecsmany, Daniel; Owen, Michael; Szori, Milan; Fejes, Zsolt; Viskolcz, Bela; Fiser, Bela published an article in 2022, the title of the article was Computational Study of Catalytic Urethane Formation.Synthetic Route of 5036-48-6 And the article contains the following content:

Polyurethanes (PUs) are widely used in different applications, and thus various synthetic procedures including one or more catalysts are applied to prepare them. For PU foams, the most important catalysts are nitrogen-containing compounds Therefore, in this work, the catalytic effect of eight different nitrogen-containing catalysts on urethane formation will be examined The reactions of Ph isocyanate (PhNCO) and methanol without and in the presence of catalysts have been studied and discussed using the G3MP2BH and HLYP composite method. The solvent effects have also been considered by applying the SMD implicit solvent model. A general urethane formation mechanism has been proposed without and in the presence of the studied catalysts. The proton affinities (PA) were also examined The barrier height of the reaction significantly decreased (螖E0 > 100 kJ/mol) in the presence of the studied catalysts, which proves the important effect they have on urethane formation. The achieved results can be applied in catalyst design and development in the near future. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Synthetic Route of 5036-48-6

The Article related to urethane phenyl isocyanate proton affinity computational study, dft, catalyst-free, catalysts, composite method, proton affinities, urethane formation, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Catalytic Reactions and other aspects.Synthetic Route of 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 5, 2018, Su, Feng; Sun, Ziqing; Su, Weike; Liang, Xianrui published an article.Related Products of 73590-85-9 The title of the article was NMR investigation and theoretical calculations on the tautomerism of benzimidazole compounds. And the article contained the following:

The tautomerism of three benzimidazole compounds: Omeprazole sulfide, 1, (R)-Lansoprazole, 2, and Omeprazole sulfone, 3 were investigated by NMR with the effect of variant solvents and temperature The dielec. constant of the medium and the ability of solvents to form hydrogen bond with the tautomer had a profound effect on the tautomeric equilibration. The chem. shifts and resonance lines of compounds 1-3 differed greatly in different solvent system mainly due to intra- and intermol. hydrogen bonds. Variable temperature-NMR (VT-NMR) experiments showed that at 203 K the two tautomers of compound 1 were separated and determined to be 6:4 and those of compound 3 be 7:3. In contrast, compound 2 presented only one tautomer at the same temperature while the tautomerism was observed again with temperature increasing. The free energy of activation of the tautomeric interchange of compounds 1-3 were 13.77 kcal/mol, 13.47 kcal/mol and 13.06 kcal/mol, resp. D. function theory (DFT) calculations results showed the tautomers of compound 2 had higher energy differences among the three compounds demonstrating only one preferred conformation existed at 203 K. The preferred conformations of compounds 1 and 3 were also given. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Related Products of 73590-85-9

The Article related to omeprazole sulfide sulfone lansoprazole tautomerism hydrogen bond nmr, Physical Organic Chemistry: Rearrangements, Including Isomerization and Tautomerization and other aspects.Related Products of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 31, 2013, Li, Yihua; Yang, Wenge; Zhang, Tuan; Wang, Chaoyuan; Wang, Kai; Hu, Yonghong published an article.Category: imidazoles-derivatives The title of the article was Solubility of Omeprazole Sulfide in Different Solvents at the Range of 280.35-319.65 K. And the article contained the following:

Solubility data were measured for omeprazole sulfide in ethanol, 95 mass-% ethanol, Et acetate, isopropanol, methanol, acetone, n-butanol and n-propanol in the temperature range from 280.35 to 319.65 K by employing the gravimetric method. The solubilities increase with temperature and they are in good agreement with the calculated solubility of the modified Apelblat equation and the 位h equation. The exptl. solubility and correlation equation in this work can be used as essential data and model in the purification process of omeprazole sulfide. The thermodn. properties of the solution process, including the Gibbs energy, enthalpy, and entropy were calculated using the van’t Hoff equation. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Category: imidazoles-derivatives

The Article related to solubility omeprazole sulfide solvent temperature range, gravimetric method, omeprazole sulfide, purification, solubility, solution thermodynamics, Phase Equilibriums, Chemical Equilibriums, and Solutions: Phase Equilibriums, Solubility and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 3, 2021, Cao, Jianhua; Su, Xuehui; Li, Chenghui; Cheng, Youwen; Liu, Saisai; Zhao, Yani; Song, Xiaodong published a patent.Category: imidazoles-derivatives The title of the patent was Metal complex with high luminous efficiency and application in organic electroluminescent device. And the patent contained the following:

An easy metal complex having deep red electroluminescence, high luminous efficiency, good thermal stability of the material, and very wide market prospect is provided. The metal complex with mol. formula is M(LA)X(LB)Y(LC)Z, which was characterized by the following chem. structural formula LAI, LAII and LAIII. The metal complex was used in an organic electroluminescent device, the organic electroluminescent device includes a substrate, an anode layer disposed on the substrate, a hole transport layer disposed on the anode layer, an organic light emitting layer disposed on the hole transport layer, an electron transport layer disposed on the organic light emitting layer, and a cathode layer disposed on the electron transport layer, wherein the material of the organic light emitting layer includes the metal complex. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Category: imidazoles-derivatives

The Article related to iridium platinum heterocyclic diketonate complex preparation oled, Organometallic and Organometalloidal Compounds: Group Viii – Co, Ni, Ru, Rh, Pd, Os, Ir, Pt and other aspects.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 27, 2014, Radaram, Bhasker; Levine, Mindy published an article.Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole The title of the article was A green bromination method for the synthesis of benzylic dibromides. And the article contained the following:

Reported herein is the identification of a new methodol. for the dibromination of benzylic diols. This method proceeds in moderate to good yields for a wide variety of electron-deficient, electron-neutral, and electron-rich aromatic substrates. Moreover, the reagent, 1,3-dibromo-5,5-dimethylhydantoin, and the solvent, THF, are substantially more environmentally benign than traditional solvents and reagents used for bromination. The utility of this methodol. was demonstrated in the high-yielding synthesis of a key intermediate in the synthesis of omeprazole. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

The Article related to benzylic dibromide green preparation, dibromination benzylic diol dibromo dimethylhydantoin, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Safety of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 7, 2015, Talsi, Evgenii P.; Rybalova, Tatyana V.; Bryliakov, Konstantin P. published an article.Product Details of 73590-85-9 The title of the article was Isoinversion Behavior in the Enantioselective Oxidations of Pyridylmethylthiobenzimidazoles to Chiral Proton Pump Inhibitors on Titanium Salalen Complexes. And the article contained the following:

The oxidation of two pyridylmethylthiobenzimidazoles to proton pump inhibitors (S)-omeprazole and (R)-lansoprazole, and to their enantiomers, with H2O2 is achieved by using chiral titanium salalen complexes as catalysts. The latter ensure high enantioselectivities (up to 96% ee) and efficiencies (TN 200-300), with high sulfoxide yields (up to >96%). The oxidation enantioselectivities vary with temperature in a nonmonotonic manner, demonstrating isoinversion behavior. Maximum enantioselectivity is attained at 273路路路283 K, which temperature region may be recommended for preparative oxidations Kinetic peculiarities and the oxidation mechanism are discussed. The experimental process involved the reaction of 5-Methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]benzimidazole(cas: 73590-85-9).Product Details of 73590-85-9

The Article related to isoinversion behavior enantioselective oxidation pyridylmethylthiobenzimidazole chiral proton pump inhibitor, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Product Details of 73590-85-9

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 31, 2009, Marzok, Mohamed; El-Khodery, Sabry published an article.Related Products of 65896-14-2 The title of the article was Sedative and analgesic effects of romifidine in camels (Camelus dromedarius). And the article contained the following:

To evaluate the clin. effectiveness and the sedative and analgesic effects of i.v. romifidine in camels. Randomized prospective study. Eighteen healthy adult Dromedary camels. Romifidine was administered i.v. to camels (n = 6) at three different doses (40, 80 or 120 渭g/kg-1). Time of onset, degree and duration of sedation and analgesia were recorded immediately after drug administration. Heart rate, respiratory rate, ruminal contractions, muscle relaxation, response to auditory and tactile stimulation, distance between ears, distance from lower lip to the ground, and degree of ataxia were also recorded pre-administration and at 5, 15, 30, 45, 60, 90, 120, and 180 min post-administration. Plasma glucose, blood urea nitrogen and creatinine were measured. Romifidine produced dose dependent sedation and analgesia. Significant decreases in heart rate (p < 0.001), ruminal contractions (p < 0.05), distance from lower lip to the ground (p < 0.001), response to auditory and tactile stimuli (p < 0.01), and significant increases in the degree of ataxia (p < 0.01), distance between the ear tips (p < 0.001) and blood glucose (p < 0.01) concentration were recorded after administration of romifidine until recovery. However, no significant changes in rectal temperature and respiratory rate were recorded. I.v. administration of romifidine at three different doses appeared to be an effective sedative and analgesic agent for camels. Bradycardia, ruminal atony, and hyperglycemia were the most important adverse effects after i.v. administration of romifidine. The i.v. administration of romifidine at a dose rate of 120 渭g/kg-1 caused profound sedation and analgesia. Romifidine could be used for chem. restraint for a variety of diagnostic and minor surgical procedures in camels. The experimental process involved the reaction of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride(cas: 65896-14-2).Related Products of 65896-14-2

The Article related to camelus sedative analgesic sedivet, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Related Products of 65896-14-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On December 31, 2001, Saxena, Apra; Sharma, A. K.; Kumar, Naveen published an article.Electric Literature of 65896-14-2 The title of the article was Sedivet as a premedicant in barbiturate and nonbarbiturate anaesthesia in goats. And the article contained the following:

Sedivet (12.5 渭g/kg) was administered i.v. Behavioral changes were observed on after sedivet administration in atropine (0.5 mg/kg,s.c.) pre-medicated goats. Increased salivation was noticed during experimentation. Corneal palpebral, pharyngeal and laryngeal reflexes were mildly depressed (++) in group B while they were absent in group A during anesthesia. Analgesia in flank in group B persisted for 80.39卤31.85 min and in group A for 50.83卤20.30 min. Polyurea occurred in both the groups. Marked reduction in rectal temperature, heart rate and respiration rate was noticed in sedivet ketamine group. ABP and CVP increased significantly at 2 min of sedivet injection. TEC, TLC, PCV, HB altered nonsignificantly. Serum glucose, bilirubin, urea, SUN and OCT exhibited significant rise (P<0.05) at different intervals while total proteins, albumin, globulin and A:G ratio were slightly lower at 1 h. Hematobiochem. parameters were recorded close to base value at 72 h. Recovery was smooth and uncomplicated. The experimental process involved the reaction of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride(cas: 65896-14-2).Electric Literature of 65896-14-2

The Article related to sedivet premedicant anesthesia goat, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Electric Literature of 65896-14-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 15, 2013, Woodhouse, Kerry J.; Brosnan, Robert J.; Nguyen, Kyvan Q.; Moniz, Gale W.; Galuppo, Larry D. published an article.Safety of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride The title of the article was Effects of postanesthetic sedation with romifidine or xylazine on quality of recovery from isoflurane anesthesia in horses. And the article contained the following:

Objective-To test the hypothesis that postanesthetic sedation with romifidine would dose-dependently improve recovery quality of recovery from isoflurane anesthesia in horses more than postanesthetic sedation with xylazine. Design-Prospective, randomized, blinded clin. trial. Animals-101 healthy adult horses examined at the University of California-Davis Veterinary Medical Teaching Hospital from 2007 to 2009. Procedures-Horses were sedated with xylazine, and anesthesia was induced with guaifenesin, diazepam, and ketamine via a standardized drug protocol. Anesthesia for surgical or diagnostic procedures was maintained with isoflurane in oxygen for 1 to 4 h. At the end of anesthesia, horses were moved to a padded stall for recovery. Once the breathing circuit was disconnected and the patient was spontaneously breathing, either xylazine (100 or 200 渭g/kg [45 or 91 渭g/lb]) or romifidine (10 or 20 渭g/kg [4.5 or 9.1 渭g/lb]) was administered IV. Objective patient, surgical, and anesthesia data were recorded. Subjective visual analog scale (VAS) scores of recovery quality were assigned by a single individual who was unaware of the treatment received. A stepwise linear regression model was used to correlate patient and procedure factors with the VAS score. Results-Painful procedures, longer anesthesia times, and the Arabian horse breed were associated with poorer VAS scores. Adjustment for these factors revealed an improved VAS recovery score associated with the use of a romifidine dose of 20 渭g/kg. Conclusions and Clin. Relevance-In healthy adult horses anesthetized with isoflurane for > 1 h, the results of this study supported the use of 20 渭g of romifidine/kg, IV, rather than lower romifidine doses or xylazine, for postanesthetic sedation to improve recovery quality. The experimental process involved the reaction of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride(cas: 65896-14-2).Safety of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride

The Article related to horse sedivet sedation isoflurane anesthetic, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Safety of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 30, 2010, Devisscher, Lindsey; Schauvliege, Stijn; Dewulf, Jeroen; Gasthuys, Frank published an article.Electric Literature of 65896-14-2 The title of the article was Romifidine as a constant rate infusion in isoflurance anaesthetized horses: a clinical study. And the article contained the following:

Objective: To evaluate the effects of a constant rate infusion (CRI) of romifidine on the requirement of isoflurane, cardiovascular performance and recovery in anesthetized horses undergoing arthroscopic surgery. Study design: Randomized blinded prospective clin. trial. Animals Thirty horses scheduled for routine arthroscopy. Methods: After premedication (acepromazine 0.02 mg kg-1, romifidine 80 渭g kg-1, methadone 0.1 mg kg-1) and induction (midazolam 0.06 mg kg-1 ketamine 2.2 mg kg-1), anesthesia was maintained with isoflurane in oxygen. Horses were assigned randomly to receive a CRI of saline (group S) or 40 渭g kg-1 hour-1 romifidine (group R). The influences of time and treatment on anesthetic and cardiovascular parameters were evaluated using an anal. of variance. Body weight (t-test), duration of anesthesia (t-test) and recovery score (Wilcoxon Rank Sum Test) were compared between groups. Significance was set at p < 0.05. Results All but one horse were positioned in the dorsal recumbent position and ventilated from the start of anesthesia. End tidal isoflurane concentrations were similar in both groups at similar time points and over the whole anesthetic period. Cardiac output was significantly lower in horses of the R group, but there were no significant differences between groups in cardiac index, body weight or age. All other cardiovascular parameters were similar in both groups. Quality of recovery did not differ significantly between groups, but more horses in group R stood without ataxia at the first attempt. One horse from group S had a problematic recovery. Conclusions and clin. relevance: No inhalation anesthetic sparing effect or side effects were observed by using a 40 渭g kg-1 hour-1 romifidine CRI in isoflurane anesthetized horses under clin. conditions. Cardiovascular performance remained acceptable. Further studies are needed to identify the ED of romifidine that will induce an inhalation anesthetic sparing effect in anesthetized horses. The experimental process involved the reaction of N-(2-Bromo-6-fluorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride(cas: 65896-14-2).Electric Literature of 65896-14-2

The Article related to sedivet infusion isoflurane anesthesia horse, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Electric Literature of 65896-14-2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem