Month: November 2022

On September 30, 2015, Dong, Qian; Peng, Xia; Wang, Wen; Dai, Yang; Zhao, Weili; Ai, Jing; Dong, Xiaochun published an article.Computed Properties of 5709-67-1 The title of the article was Design and synthesis of 5-aminopyrazole and 5-aminotriazole derivatives as fibroblast growth factor receptor inhibitors. And the article contained the following:

Fibroblast growth factor receptor (FGFR) is a promising therapeutic target for cancer treatment. A series of 5-aminopyrazole and 5-amino-1,2,3-triazole derivatives were designed as FGFR inhibitors based on the docking mode of Debio1347 within the FGFR kinase domain. The inhibitory effects on FGFR2 kinase and the antitumor activities against human gastric cancer SNU16 cell lines were evaluated. Furthermore, the preliminary structure-activity relationships (SAR) were discussed. The results demonstrated that several compounds presented good potency against FGFR2 kinase. 1-(5-Amino-1-(2-methyl-1H-benzo[d]imidazol-6-yl)-1H-pyrazol-4-yl)-1-(1H-thieno[3,2-b]pyrrol-2-yl) methanone (I) and 1-(5-amino-1-(2-methyl-1H-benzo[d]imidazol-6-yl)-1H-1,2,3-triazol-4-yl)-1-(1H-indol-2-yl)methanone (II) were the most potent with IC50 values of 3.3 and 2.3 nmol路L-1, resp., which were similar to that of Debio1347. Compounds I and II exhibited slightly weaker antitumor activity against SNU16 cell lines than Debio1347 with IC50 value of 77.3 and 155.2 nmol路L-1, resp. The experimental process involved the reaction of 2-Nitro-1H-benzo[d]imidazole(cas: 5709-67-1).Computed Properties of 5709-67-1

The Article related to aminopyrazole preparation sar fibroblast growth factor receptor inhibitory antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Computed Properties of 5709-67-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On May 28, 2020, Panarese, Joseph; Davis, Dexter; Bartlett, Samuel; Chong, Katherine; Kenton, Nathaniel; Or, Yat Sun published a patent.Name: 5-Bromo-1H-imidazole-4-carbaldehyde The title of the patent was Functionalized heterocycles as antiviral agents and their preparation. And the patent contained the following:

The invention discloses compounds of formula I, or pharmaceutically acceptable salts, thereof which inhibit the protein(s) encoded by hepatitis B virus (HBV) or interfere with the function of the HBV life cycle of the hepatitis B virus and are also useful as antiviral agents. The invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HBV infection. Compounds of formula I wherein Q1, Q2, Q3 and Q4 are independently H, halo, (un)substituted C1-6 alkyl, (un)substituted C1-6 alkoxy, etc.; Y1 is H, halo and (un)substituted C1-6 alkyl; Y2 is O, NH and derivatives, NOH and derivatives and NNH and derivatives; Y3 is CO2H and derivatives, CONHSO2H and derivatives, (un)substituted aryl; Y4 is H and (un)substituted methyl; Y2Y3 may be taken together to form 5- to 12-membered heterocyclic ring; Z1 is N and CR1; Z2 is N and CR2; Z3 is N and CR3; provided that at least one of Z1 – Z3 is N, and when Z3 is N, Z1 is CR1, Z2 is CR2, and R2 is not H; R1, R2 and R3 are independently H, halo, NO2, CN, (un)substituted C1-6 alkyl, etc.; and pharmaceutically acceptable salts, N-oxides, esters and prodrugs thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their antiviral activity. From the assay, it was determined that compound II exhibited an EC50 value of < 0.1渭M and a CC50 value of > 25渭M. The experimental process involved the reaction of 5-Bromo-1H-imidazole-4-carbaldehyde(cas: 50743-01-6).Name: 5-Bromo-1H-imidazole-4-carbaldehyde

The Article related to heterocycle preparation antiviral, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Name: 5-Bromo-1H-imidazole-4-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On July 12, 2007, Hupe, Eike; Zagar, Cyrill; Witschel, Matthias; Kuehn, Toralf; Moberg, William Karl; Parra Rapado, Liliana; Stelzer, Frank; Vescovi, Andrea; Reinhard, Robert; Sievernich, Bernd; Grossmann, Klaus; Ehrhardt, Thomas published a patent.SDS of cas: 50743-01-6 The title of the patent was Preparation of piperazine-2,5-diones as herbicides. And the patent contained the following:

Title compounds [I; R1, R2 = cyano, alkyl, cycloalkyl, (cyclo)alkenyl, (cyclo)alkynyl, Ph, phenylalkyl, heterocyclyl, etc.; R3 = H, halo, cyano, alkyl, cycloalkyl, alkenyl, alkynyl, cycloalkynyl, Ph, phenylalkyl, etc.; R4-R6 = H, OH, (substituted) alkyl, alkoxy; A1, A2 = (hetero)aryl; R9 = halo, cyano, NO2, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkadienyl, alkynyl, etc.; R10-R14 = H, halo, cyano, NO2, alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkadienyl, alkynyl, etc.], were prepared Thus, methanesulfonic acid [(5-benzyl-1,4-dimethyl-3,6-dioxopiperazin-2-yl)-(2-nitrophenyl)methyl] ester (preparation given) was dropwise treated with DBU in THF at 0掳 followed by 4 h stirring at 0掳 to give 76% 3-benzyl-1,4-dimethyl-6-(2-nitrobenzylidene)piperazine-2,5-dione. I at 0.5-3 kg/ha were said to show very strong pre- and postemergent herbicidal activity. The experimental process involved the reaction of 5-Bromo-1H-imidazole-4-carbaldehyde(cas: 50743-01-6).SDS of cas: 50743-01-6

The Article related to piperazinedione preparation herbicide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.SDS of cas: 50743-01-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On August 21, 2008, McCormick, Kevin D.; Boyce, Christopher W.; Shih, Neng-Yang; Aslanian, Robert G.; Fevrier, Salem; Mangiaracina, Pietro; De Lera Ruiz, Manuel; Yu, Younong; Zheng, Junying; Huang, Chia-Yu; Liang, Bo; Liu, Rong-Qiang; Liu, Ruiyan; Guise Zawacki, Lisa published a patent.Safety of 5-Bromo-1H-imidazole-4-carbaldehyde The title of the patent was 3,4-Dihydro-1,4-benzoxazine, 3,4-dihydro-1,4-benzothiazine and 1,2,3,4-tetrahydroquinoxaline derivatives as alpha2C adrenoreceptor agonists and their preparation. And the patent contained the following:

The invention relates to a class of benzomorpholine and benzothiomorpholine compounds of formula I useful as alpha2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the alpha2C adrenergic receptor agonists, such as allergic rhinitis, congestion, pain, diarrhea, glaucoma, congestive heart failure, cardiac ischemia, manic disorders, depression, anxiety and schizophrenia. Compounds of formula I wherein A is (un)substituted 5-membered heterocyclic ring; X is O, S, SO, SO2 and NH and derivatives; J1, J2, J3 and J4 are independently, N, NO and CR2, with the proviso that 0-3 of J1-J4 are N; R2 is H, OH, halo, CN, NO2, etc.; Y is (CH2)1-3; each R3 is H, halo, =O, alkyl, alkoxy, alkenyl, etc.; R4 is H, CN, halo, alkyl, alkoxy, alkenyl, etc.; n is 1-5; m is 0-4; and their pharmaceutically acceptable salts, esters, solvates and prodrugs thereof are claimed. Example compound II was prepared by reductive alkylation of 3,4-dihydro-2H-1,4-benzoxazine with imidazole-4-carboxaldehyde. All the invention compounds were evaluated for their 伪2C adrenoreceptor agonistic activity (some data given). The experimental process involved the reaction of 5-Bromo-1H-imidazole-4-carbaldehyde(cas: 50743-01-6).Safety of 5-Bromo-1H-imidazole-4-carbaldehyde

The Article related to benzoxazine benzothiazine quinoxaline preparation adrenoceptor agonist treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of 5-Bromo-1H-imidazole-4-carbaldehyde

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Harris, Anthony R.; Nason, Deane M.; Collantes, Elizabeth M.; Xu, Wenjian; Chi, Yushi; Wang, Zhihan; Zhang, Bingzhi; Zhang, Qingjian; Gray, David L.; Davoren, Jennifer E. published an article in 2011, the title of the article was Synthesis of 5-bromo-6-methyl imidazopyrazine, 5-bromo and 5-chloro-6-methyl imidazopyridine using electron density surface maps to guide synthetic strategy.Safety of 5-Bromo-6-methylimidazo[1,2-a]pyridine And the article contains the following content:

Small heteroaromatic rings are valuable monomers in drug discovery that can enable rapid access to novel and desirable chem. space. Installation of a synthetic handle on a heteroaromatic core may be difficult if steric and electronic factors are not in alignment with the desired transformation. Described are practical routes for the construction of 5-bromo-6-Me imidazopyrazine I as well as Me imidazopyridines, e.g., II, developed using electron d. surface maps encoded with ionization potential to guide synthetic strategy. The experimental process involved the reaction of 5-Bromo-6-methylimidazo[1,2-a]pyridine(cas: 1346157-13-8).Safety of 5-Bromo-6-methylimidazo[1,2-a]pyridine

The Article related to bromomethyl imidazopyrazine preparation, methyl imidazopyridine preparation reaction mechanism, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of 5-Bromo-6-methylimidazo[1,2-a]pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On September 10, 2021, Liu, Ming; Jiang, Yufeng; Liu, Duanzijing; Wang, Junjie; Ren, Zhongjie; Russell, Thomas P.; Liu, Yao published an article.HPLC of Formula: 5036-48-6 The title of the article was Imidazole-Functionalized Imide Interlayers for High Performance Organic Solar Cells. And the article contained the following:

Imidazole-functionalized naphthalene diimide and perylene diimide were efficiently synthesized at low cost and used as versatile cathode interlayers in organic solar cells. These imidazole-functionalized small mols. show high electron affinity and conductivity and efficiently reduce the work function of air-stable metal electrodes, removing the energy barriers of electron transport in organic electronic devices. Compared to widely used amine-functionalized small-mol. cathode interlayers, the crystallinities of imidazole-functionalized mols. were moderately suppressed, affording good film-forming properties. The substitution of amine with the imidazole group is a simple and powerful strategy to improve both film morphol. and charge transport of imide-based small-mol. interlayer materials. The imidazole-functionalized interlayers are compatible with numerous active layers in solar cells, affording high efficiencies over a wide thickness range from ~5 nm to ~33 nm, with a maximum efficiency of 17.98%, showing promising applications in organic electronics. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).HPLC of Formula: 5036-48-6

The Article related to imidazole functionalized imide interlayer solar cell, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.HPLC of Formula: 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On October 15, 2021, Liu, Ruihong; Wang, Jin; Che, Xuefu; Wang, Ting; Aili, David; Li, Qingfeng; Yang, Jingshuai published an article.Name: N-(3-Aminopropyl)-imidazole The title of the article was Facile synthesis and properties of poly(ether ketone cardo)s bearing heterocycle groups for high temperature polymer electrolyte membrane fuel cells. And the article contained the following:

Novel high temperature polymer electrolyte membranes (HT-PEMs) are fabricated from com. and low-cost poly (ether ketone cardo) (PEK-Cardo). Rather than normal chloromethylation and quaternization procedure to introduce basic groups into poly (arylene ether)s, three different long side-chain basic groups are grafted into PEK-Cardo through a facile one-step lactamization between the cardo phenolphthalein type moiety in PEK-Cardo and amino compounds (i.e. 1-(3-aminopropyl) imidazole (APIm), 1-(3-aminopropyl) pyrrolidin-2-one (APy) and 3-(dimethylamino)-1-propylamine). The obtained lactamized PEK-Cardo membranes exhibit excellent phosphoric acid doping capability and the physicochem. properties are optimized by adjusting the chem. structure and grafting degree of side-chain basic groups. Fuel cell results demonstrate a big potential for HT-PEM fuel cell applications. Thus, this proposal provides a new, straightforward and low-cost method to prepare high-performance HT-PEMs. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Name: N-(3-Aminopropyl)-imidazole

The Article related to polyether ketone polymer electrolyte membrane fuel cell, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.Name: N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On June 25, 2022, Ahn, Yeonho; Kim, Dukjoon published an article.Quality Control of N-(3-Aminopropyl)-imidazole The title of the article was High energy efficiency and stability of vanadium redox flow battery using pore-filled anion exchange membranes with ultra-low V4+ permeation. And the article contained the following:

Anion exchange membranes for vanadium redox flow battery are prepared by filling pore of polytetrafluoroethylene (PTFE) substrates with poly(arylene ether ketone) with imidazole (PAPI). For facile impregnation of PAPI mols. into pore of hydrophobic PTFE, catechol and polyethyleneimine (PEI) are co-deposited to hydrophilize the surface of PTFE. Compared with the pristine PAPI membranes, dimensional and mech. properties of the pore-filled membranes improved due to the reinforcing effect of PTFE substrate. While this process reduces water uptake and swelling ratio by 10% and 8%, resp., it enhances the tensile strength by 5 folds. Strikingly, the ion conductivity even slightly increases along with the huge reduction of vanadium ion permeability. Pore filed membranes reveal vanadium ion permeability of 1.4 x 10-7 cm2 min-1-2.08 x 10-7 cm2 min-1 at room temperature, which is 10 times and 3 times lower than those of the com. Nafion117 and FAP450 membranes, resp. For the cycling test of VRFB cell with 200 cycles, it shows the coulombic and energy efficiency over 96.5% and 85%, resp., because of the low vanadium permeability. In association with this, the capacity retention behavior is more stable than the com. membranes. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Quality Control of N-(3-Aminopropyl)-imidazole

The Article related to anion exchange membrane vanadium permeation energy redox flow battery, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.Quality Control of N-(3-Aminopropyl)-imidazole

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On February 23, 2022, Jones, Seamus D.; Nguyen, Howie; Richardson, Peter M.; Chen, Yan-Qiao; Wyckoff, Kira E.; Hawker, Craig J.; Clement, Raphaele J.; Fredrickson, Glenn H.; Segalman, Rachel A. published an article.SDS of cas: 5036-48-6 The title of the article was Design of Polymeric Zwitterionic Solid Electrolytes with Superionic Lithium Transport. And the article contained the following:

Progress toward durable and energy-dense lithium-ion batteries has been hindered by instabilities at electrolyte-electrode interfaces, leading to poor cycling stability, and by safety concerns associated with energy-dense lithium metal anodes. Solid polymeric electrolytes (SPEs) can help mitigate these issues; however, the SPE conductivity is limited by sluggish polymer segmental dynamics. We overcome this limitation via zwitterionic SPEs that self-assemble into superionically conductive domains, permitting decoupling of ion motion and polymer segmental rearrangement. Although crystalline domains are conventionally detrimental to ion conduction in SPEs, we demonstrate that semicrystalline polymer electrolytes with labile ion-ion interactions and tailored ion sizes exhibit excellent lithium conductivity (1.6 mS/cm) and selectivity (t+ 鈮?0.6-0.8). This new design paradigm for SPEs allows for simultaneous optimization of previously orthogonal properties, including conductivity, Li selectivity, mechanics, and processability. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).SDS of cas: 5036-48-6

The Article related to design polymeric zwitterionic solid electrolytes superionic lithium transport, Electrochemical, Radiational, and Thermal Energy Technology: Energy-Conversion Devices and Their Components and other aspects.SDS of cas: 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

On November 30, 2021, Sarikaya, Ikbal; Bilgen, Selcuk; Unver, Yasemin; Inan Bektas, Kadriye; Akbas, Halide published an article.Recommanded Product: 5036-48-6 The title of the article was Preparation, characterization, antibacterial activity, and interfacial and micellar features of cationic gemini surfactants with different spacers. And the article contained the following:

In the present study, four novel imidazolium-based cationic gemini surfactants (IBCGS) have been synthesized, having same hydrocarbon chain lengths and different spacers. The impacts of type and nature of spacer on Krafft temperatures (TK) have been examined Micellization behaviors of IBCGS have been investigated at different temperatures above TK by both surface tension and specific conductivity measurements. Surface activity properties of aqueous systems have been calculated using the results of the measurement data. Critical micelle concentration (CMC), surface pressure at CMC (螤CMC), min. area of head group (Amin), degree of counterion binding (尾), degree of counterion dissociation (伪), and maximum surface excess (螕max) of IBCGS have been calculated with data of surface tension and specific conductivity IBCGS have low CMC values than other imidazole categories of gemini and monomeric cationic surfactants. Micelle aggregation number (Nagg) values have been determined with the steady-state fluorescence quenching method. The values of Nagg have been found in the range of 19-28. Addnl., the antibacterial activities of IBCGS on gram-pos. and gram-neg. bacteria have been investigated. IBCGS studied in this article have showed perfect antibacterial activity particularly against gram-pos. bacteria. The data obtained in this study may be benefical for the surfactant applications in different areas. The experimental process involved the reaction of N-(3-Aminopropyl)-imidazole(cas: 5036-48-6).Recommanded Product: 5036-48-6

The Article related to cationic gemini surfactant critical micelle concentration antibacterial activity, Surface Active Agents and Detergents: Preparation, Analysis, and Properties Of Surfactants Other Than Soaps and other aspects.Recommanded Product: 5036-48-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem