Month: November 2022

Garcia-Alvarez, Ana C.’s team published research in Chemical Communications (Cambridge, United Kingdom) in 57 | CAS: 7467-35-8

Chemical Communications (Cambridge, United Kingdom) published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Application of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Garcia-Alvarez, Ana C. published the artcileSelf-assembled nickel cubanes as oxygen evolution catalysts, Application of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(69), 8608-8611, database is CAplus and MEDLINE.

Ni4O4 cubanes [(μ3-L1O)NiCl(MeOH)]4 and [(μ3-L2O)NiCl(H2O)]4 (L1OH = 1-H-2-benzimidazolylmethanol, L2OH = 1-methyl-2-benzimidazolylmethanol) self-assemble from com. available 1-H- and 1-methyl-2-benzimidazolylmethanol and NiCl2·6H2O in high yields under mild conditions. Both complexes were characterised spectroscopically and by X-ray crystallog. The cubanes oxidise water electrocatalytically to dioxygen at neutral pH in aqueous potassium phosphate buffer solutions

Chemical Communications (Cambridge, United Kingdom) published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Application of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Tanaka, Fujie’s team published research in Bioconjugate Chemistry in 18 | CAS: 359860-27-8

Bioconjugate Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C3H7NO2, Category: imidazoles-derivatives.

Tanaka, Fujie published the artcileDevelopment of a Small Peptide Tag for Covalent Labeling of Proteins, Category: imidazoles-derivatives, the publication is Bioconjugate Chemistry (2007), 18(4), 1318-1324, database is CAplus and MEDLINE.

A 21-mer peptide that can be used to covalently introduce synthetic mols. into proteins has been developed. Phage-displayed peptide libraries were subjected to reaction-based selection with 1,3-diketones. The peptide was further evolved by addition of a randomized region and reselection for improved binding. The resulting 21-mer peptide had a reactive amino group that formed an enaminone with 1,3-diketone and was used as a tag for labeling of maltose binding protein. Using this peptide tag and 1,3-diketone derivatives, a variety of mols. such as reporter probes and functionalities may be covalently introduced into proteins of interest.

Bioconjugate Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C3H7NO2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Shi, Yoa Jun’s team published research in Synthetic Communications in 23 | CAS: 79047-41-9

Synthetic Communications published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C5H10O2S, COA of Formula: C8H13ClN2O.

Shi, Yoa Jun published the artcileA practical synthesis of 2-butyl-4(5)-chloro-5(4)-hydroxymethyl-1H-imidazole, COA of Formula: C8H13ClN2O, the publication is Synthetic Communications (1993), 23(18), 2623-30, database is CAplus.

A practical process for the synthesis of 2-butyl-4-hydroxymethylimidazole (I, R = H) followed by silylation-chlorination-desilylation to provide chloroimidazole I (R = Cl) in an overall 71% yield has been developed.

Synthetic Communications published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C5H10O2S, COA of Formula: C8H13ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Veenboer, Richard M. P.’s team published research in Organometallics in 36 | CAS: 258278-25-0

Organometallics published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C13H26N2, Safety of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Veenboer, Richard M. P. published the artcileExpedient Syntheses of Neutral and Cationic Au(I)-NHC Complexes, Safety of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is Organometallics (2017), 36(18), 3645-3653, database is CAplus.

The synthesis and isolation of Au(I) precatalysts often requires the generation of several isolable intermediates as well as numerous purification steps. New protocols for the expedient synthesis of neutral [Au(OH)(NHC)] and [Au(CH2COCH3)(NHC)] species from [AuCl(NHC)] or [AuCl(DMS)] precursors bearing a variety of N-heterocyclic carbene (NHC) ligands are presented. These methods can be employed in a telescoping manner for the synthesis of catalytically relevant [Au(NTf2)(NHC)] and [Au(NHC)(NCCH3)][BF4] complexes. These attractive methods are straightforward and practical leading to various complexes in high isolated yields and purity.

Organometallics published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C13H26N2, Safety of 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hosadurga, K. Keerthy’s team published research in PLoS One in 9 | CAS: 79047-41-9

PLoS One published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, SDS of cas: 79047-41-9.

Hosadurga, K. Keerthy published the artcileSynthesis and characterization of novel 2-amino-chromene-nitriles that target Bcl-2 in acute myeloid leukemia cell lines, SDS of cas: 79047-41-9, the publication is PLoS One (2014), 9(9), e107118/1-e107118/11, 11 pp., database is CAplus and MEDLINE.

The anti-apoptotic protein Bcl-2 is a well-known and attractive therapeutic target for cancer. In the present study the solution-phase T3P-DMSO mediated efficient synthesis of 2-amino-chromene-3-carbonitriles I (R1 = 3-O2NC6H4, 4-BrC6H4, 1H-indol-3-yl, etc.) from alcs., malanonitrile and 2-naphthalenol is reported. Addnl. chromenecarbonitriles from resorcinol and 4-hydroxy-2-chromenones were also reported. These novel 2-amino-chromene-3-carbonitriles showed cytotoxicity in human acute myeloid leukemia (AML) cell lines. Compound I (R1 = 2,6-Cl2C6H3) was found to be the most bioactive, decreasing growth and increasing apoptosis of AML cells and moreover, it (at a concentration of 5 μM) increased the G2/M and sub-G1 (apoptosis) phases of AML cells and when the AML cells were treated with this compound it exhibited decreased levels of Bcl-2 and increased levels of caspase-9. In silico mol. interaction anal. showed that this compound shared a similar global binding motif with navitoclax (another small mol. that binds Bcl-2), however it occupies a smaller volume within the P2 hot spot of Bcl-2. The intermol. π-stacking interaction, direct electrostatic interactions, and docking energy predicted for I (R1 = 2,6-Cl2C6H3) in complex with Bcl-2 suggest a strong affinity of the complex, rendering it as a promising Bcl-2 inhibitor for evaluation as a new anticancer agent.

PLoS One published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C8H13ClN2O, SDS of cas: 79047-41-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Dai, Yu-ting’s team published research in Fenxi Ceshi Jishu Yu Yiqi in 19 | CAS: 161796-78-7

Fenxi Ceshi Jishu Yu Yiqi published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Name: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Dai, Yu-ting published the artcileMicroanalysis for flame atomic absorption spectroscopy in determination of high content sodium, Name: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is Fenxi Ceshi Jishu Yu Yiqi (2013), 19(1), 24-27, database is CAplus.

A new method using Flame Atomic Absorption Spectroscopy (FAAS) and Microanal. to determine high content sodium is developed. The developed method involves the choosing of suitable absorption line of sodium, the optimization of testing parameters and the evaluation of the linearity of the method. The linearity is 0-5 mg/L, the detection limit is 0.02 mg/L and the repeatability is 0.5% RSD. By comparing the measured sodium content with its truth value in some known organic and inorganic compounds, the absolute error is less than 0.3%, the relative error is less than 1%, and the recovery is 99.2%-100.6%.

Fenxi Ceshi Jishu Yu Yiqi published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Name: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kim, Dong-Ki’s team published research in Polymers for Advanced Technologies in 22 | CAS: 359860-27-8

Polymers for Advanced Technologies published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, SDS of cas: 359860-27-8.

Kim, Dong-Ki published the artcileMicropatterning of proteins on ion beam-induced poly(acrylic acid)-grafted polyethylene film, SDS of cas: 359860-27-8, the publication is Polymers for Advanced Technologies (2011), 22(12), 1989-1992, database is CAplus.

Micropatterns of proteins were created by using patterned ion beam irradiation onto a polyethylene film and graft polymerization of acrylic acid. Acrylic acid was selectively graft polymerized on the irradiated regions. The results of the grafting study revealed that the optimum fluence to achieve the maximum grafting degree was 1 × 1015 ions/cm2. Biotin was covalently immobilized on the grafted regions of the polyethylene film. Protein patterning was achieved through specific binding of biotin and streptavidin. The resolved protein patterns with the maximum fluorescence intensity were achieved on the poly(acrylic acid) (PAA)-grafted polyethylene films prepared at the fluence of 1 × 1015 ions/cm2. This method can be used for patterning of various biomols. and for further biol. applications.

Polymers for Advanced Technologies published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, SDS of cas: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Choi, Jae-Hak’s team published research in Journal of Polymer Science, Part A: Polymer Chemistry in 47 | CAS: 359860-27-8

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Choi, Jae-Hak published the artcilePatterned immobilization of biomolecules by using ion irradiation-induced graft polymerization, Formula: C18H34N4O5S, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2009), 47(22), 6124-6134, database is CAplus.

A new method for biomol. patterning based on ion irradiation-induced graft polymerization was demonstrated in this study. Ion irradiation on a polymer surface resulted in the formation of active species, which was further used for surface-initiated graft polymerization of acrylic acid. The results of the grafting study revealed that the surface graft polymerization using 20 vol % of acrylic acid on the poly(tetrafluoroethylene) (PTFE) film irradiated at the fluence of 1 × 1015 ions/cm2 for 12 h was the optimum graft polymerization condition to achieve the maximum grafting degree. The results of the fluorescence microscopy also revealed that the optimum fluence to achieve the maximum fluorescence intensity was 1 × 1015 ions/cm2. The grafting of acrylic acid on the PTFE surfaces was confirmed by a fluorescence labeling method. The grafted PTFE films were used for the immobilization of amine-functionalized p-DNA, followed by hybridization with fluorescently tagged c-DNA. Biotin-amine was also immobilized on the acrylic acid grafted PTFE surfaces. Successful biotin-specific binding of streptavidin further confirmed the potential of this strategy for patterning of various biomols. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 6124-6134, 2009.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Luo, Ching-Zong’s team published research in Chemistry – A European Journal in 19 | CAS: 2622-67-5

Chemistry – A European Journal published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Quality Control of 2622-67-5.

Luo, Ching-Zong published the artcileRhIII-catalyzed C-H activation: a versatile route towards various polycyclic pyridinium salts, Quality Control of 2622-67-5, the publication is Chemistry – A European Journal (2013), 19(42), 14181-14186, database is CAplus and MEDLINE.

An efficient and convenient method for the synthesis of highly substituted polycyclic pyridinium salts from the reaction of various 2-aryl-pyridines and 2-aryl-sp2-nitrogen-atom-containing heterocycles with alkynes through rhodium(III)-catalyzed C-H activation and annulation under an O2 atmosphere is described. A possible mechanism that involves the chelation-assisted C-H activation of the 2-aryl-pyridine substrate, insertion of the alkyne, and reductive elimination is proposed. This mechanism was supported by the isolation of a five-membered rhodacycle (I’). In addition, kinetic isotope studies were performed to understand the intimate reaction mechanism.

Chemistry – A European Journal published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Quality Control of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Garcia-Alvarez, Ana C.’s team published research in Chemical Communications (Cambridge, United Kingdom) in 57 | CAS: 7467-35-8

Chemical Communications (Cambridge, United Kingdom) published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Application of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Garcia-Alvarez, Ana C. published the artcileSelf-assembled nickel cubanes as oxygen evolution catalysts, Application of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(69), 8608-8611, database is CAplus and MEDLINE.

Ni4O4 cubanes [(μ3-L1O)NiCl(MeOH)]4 and [(μ3-L2O)NiCl(H2O)]4 (L1OH = 1-H-2-benzimidazolylmethanol, L2OH = 1-methyl-2-benzimidazolylmethanol) self-assemble from com. available 1-H- and 1-methyl-2-benzimidazolylmethanol and NiCl2·6H2O in high yields under mild conditions. Both complexes were characterised spectroscopically and by X-ray crystallog. The cubanes oxidise water electrocatalytically to dioxygen at neutral pH in aqueous potassium phosphate buffer solutions

Chemical Communications (Cambridge, United Kingdom) published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Application of (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem