Month: November 2022

Oxidation of cyclooctene to suberic acid using perrhenate-containing composite ionic liquids as green catalysts was written by Wang, J. Y.;Zhou, M. D.;Yuan, Y. G.;Fu, N. H.;Zang, S. L.. And the article was included in Russian Journal of General Chemistry in 2015.Synthetic Route of C10H20N2O4S The following contents are mentioned in the article:

A series of quaternary ammonium perrhenate/3-hexyl-1-methyl-imidazolium hydrogen sulfate ([Hmim]HSO₄) composite ionic liquids has been prepared For the first time, the composite ionic liquids are used both as catalyst and solvent in oxidation of cyclooctene to suberic acid in the presence of hydrogen peroxide as a green oxidant. It was found that organic perrhenate salts play the important role in improving the selectivity of cyclooctene oxidation to suberic acid. The yield of suberic acid under the mild conditions is from good to high. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Synthetic Route of C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Synthetic Route of C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Crystal structure of poly[diaqua-bis(μ₂-thiophene-2,5-dicarboxylate-κ²O:O’)(3,5-di(1H-imidazol-1-yl)pyridine-κ²N:N’)cobalt(II)], Co(H₂O)₂(C₆H₂O₄S)(C₁₁N₄H₉), C₁₇H₁₅CoN₅O₆S was written by Liu, Shu-Hua;Xu, Qing-Zhong;Li, Sai-Yu;Zhang, Rui-Ling;Wang, Li-Hong;Liu, Jian-Hua. And the article was included in Zeitschrift fuer Kristallographie – New Crystal Structures in 2014.Recommanded Product: 3,5-Di(1H-imidazol-1-yl)pyridine The following contents are mentioned in the article:

This article discusses on crystal structure of poly[diaqua-bis(μ₂-thiophene-2,5-dicarboxylate-κ²O:O’)(3,5-di(1H-imidazol-1-yl)pyridine-κ²N:N’)cobalt(II)], Co(H₂O)₂(C₆H₂O₄S)(C₁₁N₄H₉),C₁₇H₁₅CoN₅O₆S. Thus on hydrothermal synthesis and crystal structure of a new cobalt coordination polymer based on the tdc^2- dianion and 3,5-di(1H-imidazol-1-yl)pyridine ligands is also discussed. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Recommanded Product: 3,5-Di(1H-imidazol-1-yl)pyridine).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 3,5-Di(1H-imidazol-1-yl)pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Efficient Combination of Recyclable Task Specific Ionic Liquid and Microwave Dielectric Heating for the Synthesis of Lipophilic Esters was written by Arfan, Atef;Bazureau, Jean Pierre. And the article was included in Organic Process Research & Development in 2005.SDS of cas: 478935-29-4 The following contents are mentioned in the article:

Mild and efficient esterification reactions of carboxylic acids with neo-pentanol were carried out using task-specific ionic liquids with hydrogen sulfate counter-anion under microwave irradiation The latent acidity of the ionic liquid was introduced by anion metathesis from hydrogen sulfate with the corresponding imidazolium or pyridinium halides. The catalyst [C₄mim][HSO₄] modified with 5% of concentrated sulfuric acid was reused three times without considerable loss of activity in esterification using classical heating in oil bath. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4SDS of cas: 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Diamide amino-imidazoles: A novel series of γ-secretase inhibitors for the treatment of Alzheimer’s disease was written by Brodney, Michael A.;Auperin, David D.;Becker, Stacey L.;Bronk, Brian S.;Brown, Tracy M.;Coffman, Karen J.;Finley, James E.;Hicks, Carol D.;Karmilowicz, Michael J.;Lanz, Thomas A.;Liston, Dane;Liu, Xingrong;Martin, Barbara-Anne;Nelson, Robert B.;Nolan, Charles E.;Oborski, Christine E.;Parker, Christine P.;Richter, Karl E. G.;Pozdnyakov, Nikolay;Sahagan, Barbara G.;Schachter, Joel B.;Sokolowski, Sharon A.;Tate, Barbara;Van Deusen, Jeffrey W.;Wood, Douglas E.;Wood, Kathleen M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Recommanded Product: Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate The following contents are mentioned in the article:

The synthesis and structure-activity relationship (SAR) of a novel series of di-substituted imidazoles, e.g. I (R = n-Pr, Me, i-Bu, s-Bu, Ph), derived from modification of DAPT, are described. Subsequent optimization led to identification of a highly potent series of inhibitors that contain a β-amine in the imidazole side-chain resulting in a robust in vivo reduction of plasma and brain Aβ in guinea pigs. The therapeutic index between Aβ reductions and changes in B-cell populations were studied for compound aminoimidazole II. This study involved multiple reactions and reactants, such as Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate (cas: 865774-07-8Recommanded Product: Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate).

Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate (cas: 865774-07-8) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: Methyl 2-methyl-2-(4-nitro-1H-imidazol-1-yl)propanoate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

An Efficient and Expeditious Synthesis of Di- and Monosubstituted 2-Aminoimidazoles was written by Soh, Chai Hoon;Chui, Wai Keung;Lam, Yulin. And the article was included in Journal of Combinatorial Chemistry in 2008.Product Details of 160072-56-0 The following contents are mentioned in the article:

A microwave-assisted protocol was developed for the construction of di- and monosubstituted 2-aminoimidazoles. The two-step reaction involves the synthesis of N-(1H-imidazol-2-yl)acetamides from readily available α-haloketones and N-acetylguanidine, followed by deacetylation. Significant rate enhancement was observed for both steps of the protocol, and the overall reaction time was shortened to 20 min compared to 48 h of the conventional procedures. A representative set of di- and monosubstituted 2-aminoimidazoles was prepared using com. available parallel reactors. This study involved multiple reactions and reactants, such as 4-Phenyl-1H-imidazol-2-amine hemisulfate (cas: 160072-56-0Product Details of 160072-56-0).

4-Phenyl-1H-imidazol-2-amine hemisulfate (cas: 160072-56-0) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Product Details of 160072-56-0

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Catalyzed esterifications in room temperature ionic liquids with acidic counteranion as recyclable reaction media was written by Fraga-Dubreuil, Joan;Bourahla, Khadidja;Rahmouni, Mustapha;Bazureau, Jean Pierre;Hamelin, Jack. And the article was included in Catalysis Communications in 2002.Product Details of 478935-29-4 The following contents are mentioned in the article:

Esterification reactions of acetic acid, methoxyacetic acid and methylmalonic acid with neo-pentanol, hexanol, heptanol and decanol have been investigated in three ionic liquids with hydrogen sulfate, dihydrogen phosphate as counteranions and also two ionic liquids modified with HPF₆ as catalyst. The nature of both the counteranion and cation influence the behavior of the catalyst. Good yields and high selectivities were obtained and all the produced esters could be easily recovered due to their immiscibility with the ionic liquid as green reaction medium. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Product Details of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Product Details of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

T-cell lymphomas, version 2.2022 was written by Horwitz, Steven M.;Ansell, Stephen;Ai, Weiyun Z.;Barnes, Jeffrey;Barta, Stefan K.;Brammer, Jonathan;Clemens, Mark W.;Dogan, Ahmet;Foss, Francine;Ghione, Paola;Goodman, Aaron M.;Guitart, Joan;Halwani, Ahmad;Haverkos, Bradley M.;Hoppe, Richard T.;Jacobsen, Eric;Jagadeesh, Deepa;Jones, Allison;Kallam, Avyakta;Kim, Youn H.;Kumar, Kiran;Mehta-Shah, Neha;Olsen, Elise A.;Rajguru, Saurabh A.;Rozati, Sima;Said, Jonathan;Shaver, Aaron;Shea, Lauren;Shinohara, Michi M.;Sokol, Lubomir;Torres-Cabala, Carlos;Wilcox, Ryan;Wu, Peggy;Zain, Jasmine;Dwyer, Mary;Sundar, Hema. And the article was included in Journal of the National Comprehensive Cancer Network in 2022.Formula: C16H21Cl2N3O2 The following contents are mentioned in the article:

Peripheral T-cell lymphomas (PTCLs) are a heterogeneous group of lymphoproliferative disorders arising from mature T cells, accounting for about 10% of non-Hodgkin lymphomas. PTCL-not otherwise specified is the most common subtype, followed by angioimmunoblastic T-cell lymphoma, anaplastic large cell lymphoma, anaplastic lymphoma kinase-pos., anaplastic large cell lymphoma, anaplastic lymphoma kinase-neg., and enteropathy-associated T-cell lymphoma. This discussion section focuses on the diagnosis and treatment of PTCLs as outlined in the NCCN Guidelines for T-Cell Lymphomas. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Formula: C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Formula: C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Regioselectivity for nitrochlorobenzene preparation over imidazolium ionic liquids media using nitric acid was written by Gong, D.;Peng, X.;Sun, Z.. And the article was included in Asian Journal of Chemistry in 2010.Related Products of 478935-29-4 The following contents are mentioned in the article:

Nitrochlorobenzene was regioselectively prepared over imidazolium ionic liquids media by using HNO₃ as nitrating agent. A variety of ionic liquids, [Hmim]HSO₄, [Hmim]NO₃ and [Hmim]CF₃CO₂ (Hmim = 1-methylimidazolium) were prepared for the improvement of regioselectivity in preparation of mononitrochlobenzene isomers. A high amount of para isomer was achieved when employing [Hmim]HSO₄. Ionic liquids were conveniently reused for five times by filtration with excellent yield of mono-nitration products and para-selectivity. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Related Products of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cation Radical Accelerated Nucleophilic Aromatic Substitution via Organic Photoredox Catalysis was written by Tay, Nicholas E. S.;Nicewicz, David A.. And the article was included in Journal of the American Chemical Society in 2017.Category: imidazoles-derivatives The following contents are mentioned in the article:

Nucleophilic aromatic substitution (S_NAr) is a direct method for arene functionalization; however, it can be hampered by low reactivity of arene substrates and their availability. Herein we describe a cation radical-accelerated nucleophilic aromatic substitution using methoxy- and benzyloxy-groups as nucleofuges. In particular, lignin-derived aromatics containing guaiacol and veratrole motifs were competent substrates for functionalization. We also demonstrate an example of site-selective substitutive oxygenation with trifluoroethanol to afford the desired trifluoromethylaryl ether. This study involved multiple reactions and reactants, such as 4-(1H-Imidazol-1-yl)-3-methoxybenzaldehyde (cas: 870837-70-0Category: imidazoles-derivatives).

4-(1H-Imidazol-1-yl)-3-methoxybenzaldehyde (cas: 870837-70-0) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of diethyl maleate catalyzed by acid functionalized ionic liquids was written by Yu, Dan;Guo, Hongyun. And the article was included in Gongye Cuihua in 2009.Reference of 478935-29-4 The following contents are mentioned in the article:

Di-Et maleate was obtained by a reaction of maleic anhydride and anhydrous ethanol in the presence of an ionic liquid [i.e., TEAPS sulfate, N,N,N-triethyl-3-sulfo-1-propanaminium sulfate (1:1)]. Factors influencing the product formation were confirmed and the above-mentioned Di-Et maleate [i.e., (2Z)-2-butenedioic acid 1,4-di-Et ester, 99% yield] was obtained under the following reaction conditions : n(maleic anhydride) : n(ethanol) = 1:4, dosage of ionic liquid = 20% (wt) of maleic anhydride, cyclohexane as water carrier, 115°, reflux and water segregation for 4 h. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Reference of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Reference of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem