Month: November 2022

One-pot oxidative conjugate hydrothiocyanation-hydrosulfenylation of Baylis-Hillman alcohols promoted by a protic ionic liquid was written by Yadav, Lal Dhar Singh;Patel, Rajesh;Srivastava, Vishnu Prabhakar. And the article was included in Synlett in 2008.Synthetic Route of C10H20N2O4S The following contents are mentioned in the article:

The first example of one-pot oxidative conjugate hydrothiocyanation-hydrosulfenylation of acrylic ester derived Baylis-Hillman alcs., i.e., Me 3-aryl-3-hydroxy-2-methylenepropanoate, was reported. The reaction involved protic ionic liquid [Hmim]HSO₄-mediated oxidation of Baylis-Hillman alcs. with NaNO₃ to give Me (E)-α-formylcinnamates followed by conjugate addition of sulfur-centered nucleophiles (NH₄SCN/PhSH) to afford the corresponding Me β-thiocyanato (or β-phenylsulfenyl)-α-formylhydrocinnamates diastereoselectively in 74-87% yields in a one-pot procedure. After isolation of the product, the ionic liquid [Hmim]HSO₄ could be easily recycled for further use without any loss of efficiency. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Synthetic Route of C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Synthetic Route of C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Thermal and kinetic studies of trialkylimidazolium salts was written by Fox, Douglas M.;Awad, Walid H.;Gilman, Jeffrey W.;Maupin, Paul H.;Trulove, Paul C.;De Long, Hugh C.. And the article was included in ACS Symposium Series in 2005.COA of Formula: C8H15F6N2P The following contents are mentioned in the article:

The thermal properties of trialkylimidazolium room temperature ionic liquids (RTILs) have been determined using a flash point apparatus and the technique of thermal gravimetric anal. (TGA). Using a Setaflash flash point analyzer, all the salts studied were found to have flash points above 200 °C. TGA was utilized to study the decomposition of imidazolium based RTILs. The effects of C-2 hydrogen substitution, structural isomerism, alkyl chain length, anion type, and purge gas type is discussed. The decomposition kinetics of 1,2-dimethyl-3-butylimidazolium hexafluorophosphate was investigated using TGA. The global kinetic model and TGA Arrhenius parameters have been determined by employing both constant heating rate and isothermal programs. This study involved multiple reactions and reactants, such as 1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1COA of Formula: C8H15F6N2P).

1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.COA of Formula: C8H15F6N2P

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Study of 5(6)-hydroxybenzimidazole aminomethylation was written by Smirnov, L. D.;Kuznetsov, Yu. V.;Stolyarova, L. G.;Lezina, V. P.. And the article was included in Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya in 1985.Reference of 101018-70-6 The following contents are mentioned in the article:

Treating benzimidazole I (R = Me, R¹ = R² = H) with N-(methoxymethyl)piperidine, -morpholine, and N,N,N‘,N‘-tetramethylmethylenediamine in alc. gave 92.7, 88.7, and 65.4% aminomethylated derivatives I (R = Me, R¹ = piperidinomethyl, morpholinomethyl, Me₂NCH₂; R² = H). Treating I (R-R² = H) with piperidine and paraformaldehyde under Mannich reaction conditions gave I (R = H, R¹ = piperidinomethyl, R² = H, piperidinomethyl). Analogously obtained was I (R = H, R¹ = R² = Me₂NCH₂). This study involved multiple reactions and reactants, such as 4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6Reference of 101018-70-6).

4-((Dimethylamino)methyl)-2-methyl-1H-benzo[d]imidazol-5-ol (cas: 101018-70-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Reference of 101018-70-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

2-Aldehydes of imidazo[4,5-b]- and imidazo[4,5-c]pyridines was written by Yutilov, Yu. M.;Kovaleva, L. I.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1975.Application In Synthesis of 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine The following contents are mentioned in the article:

Imidazopyridinecarboxaldehydes (I, R = Me, PhCH2, Ph, R1 = CHO), II (R1 = CHO), III (R1 = CHO), and IV (R = PhCH2, Ph, R1 = CHO) were obtained in 50-84% yields by oxidation of the corresponding 2-methyl derivative with SeO2 in dioxane at 70-80°. Condensation of the aldehydes with CH2(CO2H)2 gave 43-60% acrylic acid derivatives I (R = Me, R1 = CH:CHCO2H). II (R1 = CH:CHCO2H), and IV (R = Ph, R1 = CH:CHCO2H). The cyano derivatives I (R = Me, PhCH2R1 = CN), II (R1 = CN), and IV (R = PhCH2, Ph, R1 = CN) were obtained in 65-93% by boiling the corresponding aldoximes with Ac2O 7 hr. Amides I (R = Me, PhCH2, R1 = CONM2), II (R1 = CONH2), and IV (R = Ph, R1 = CONH2) were obtained in 60-82% yields by oxidation of the corresponding nitriles with concentrated H2SO4. This study involved multiple reactions and reactants, such as 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7Application In Synthesis of 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine).

2,3-Dimethyl-3H-imidazo[4,5-c]pyridine (cas: 52538-09-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application In Synthesis of 2,3-Dimethyl-3H-imidazo[4,5-c]pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tuning Proton Exchange and Transport in Protic Ionic Liquid Solution through Anion Chemistry was written by Huang, Gongyue;Porcarelli, Luca;Forsyth, Maria;Zhu, Haijin. And the article was included in Journal of Physical Chemistry Letters in 2021.SDS of cas: 478935-29-4 The following contents are mentioned in the article:

Herein, we demonstrate that the p.d. of proton reduction and hydrogen gas oxidation of protic ionic liquids is closely related to the proton exchange rate in the electrolyte. Through a careful design of anion chem., the proton exchange rate can be boosted by several orders of magnitude, reaching 200 kHz at 100°C. It is found that the enhanced proton exchange rate can effectively decrease the potential loss at the electrode, most likely through alleviating the H⁺ concentration gradient incurred by electrochem. reactions at the electrode surfaces. This research therefore highlights the strategy of using anions of medium-strength acids, such as H₂PO₄^–, for protic ionic liquids with enhanced proton exchange capability. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4SDS of cas: 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.SDS of cas: 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Dual intercalating molten electrolyte batteries was written by Carlin, Richard T.;De Long, Hugh C.;Fuller, Joan;Trulove, Paul C.. And the article was included in Journal of the Electrochemical Society in 1994.Recommanded Product: 157310-73-1 The following contents are mentioned in the article:

The reductive and oxidative intercalation of ions into graphite from room- and low-temperature molten salts was demonstrated. The molten salts used 1-ethyl-3-methylimidaziolium (EMI⁺) or 1,2-dimethyl-3-propylimidazolium (DMPI⁺) as the cation and AlCl₄^–, BF₄^–, PF₆^–, CF₃SO₃^–, or PhCO₂^– as the anion. In a 2-electrode battery configuration, the molten salt electrolyte provides both the cation and anion, which are intercalated into the graphite anode and cathode, resp. A battery using a (DMPI)(AlCl₄) electrolyte and 2 graphite rod electrodes achieved an open-circuit voltage of 3.5 V and a cycling efficiency of 85%. This study involved multiple reactions and reactants, such as 1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1Recommanded Product: 157310-73-1).

1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Recommanded Product: 157310-73-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Cyclometalated 2-Phenylimidazole Palladium Carbene Complexes in the Catalytic Suzuki-Miyaura Cross-Coupling Reaction was written by Micksch, Maik;Tenne, Mario;Strassner, Thomas. And the article was included in Organometallics in 2014.Electric Literature of C21H24N2 The following contents are mentioned in the article:

We present the syntheses of cyclometalated palladium C-N 2-phenylimidazole carbene complexes with different N-1 groups as well as different substituents at the C-2 Ph group of the cyclometalating imidazole. We investigated the influence of these substituents by comparing the catalytic performance of the complexes in the Suzuki-Miyaura cross-coupling reaction of aryl chlorides. We can show a strong dependence between the steric demand of the N-1 substituent of the cyclometalating imidazole and the catalytic activity in the cross-coupling reaction. The most active complex shows a wide substrate scope, where several aryl as well as benzyl chlorides could be coupled with different boronic acids in excellent yields using very low catalyst concentrations of 0.05 mol %. This study involved multiple reactions and reactants, such as 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6Electric Literature of C21H24N2).

1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Electric Literature of C21H24N2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of propylparaben catalyzed by acidic ionic liquid was written by Huang, Yanxian;Shen, Jinlan. And the article was included in Guangdong Huagong in 2013.Application In Synthesis of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:

With p-hydroxybenzoic acid and n-propanol as raw materials, synthesis of propylparaben catalyzed by acidic ionic liquid [Hmim]HSO₄ was researched. The structure of propylparaben was characterized by IR and LC-MS. The effects of the molar ratio of p-hydroxybenzoic acid to n-propanol, reaction time, reaction temperature and catalyst amount on the yield of propylparaben were investigated. The optimal conditions were obtained as follows: the molar ratio of p-hydroxybenzoic acid to n-propanol 1:3, the catalyst amount of reactant total mass 4%, reaction time 3 h, and reaction temperature 90°C. Under above conditions, the yield of the propylparaben reached 91.8%. The catalytic activity of [Hmim]HSO₄, was remained mostly after it was reused for 5 times. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Application In Synthesis of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Development, In Vitro and In Vivo Evaluation of Hydrogel Based System of Carboxymethyl Arabinoxylan for Controlled Delivery of Rabeprazole Sodium was written by Tulain, Ume Ruqia;Ahmad, Mahmood;Rashid, Ayesha. And the article was included in Polymer-Plastics Technology and Engineering in 2018.Synthetic Route of C18H20N3NaO3S The following contents are mentioned in the article:

Present study deals with development of polymeric systems for rabeprazole sodium to accomplish a lingering therapeutic outcome. Carboxymethyl arabinoxylan exhibited variety of ideal characteristics for polymeric drug carrier. Free radical polymerization was successfully employed to prepare pH responsive polymeric network of carboxymethyl arabinoxylan with acrylic acid. FTIR, SEM, thermogravimetric anal. and X-ray diffraction verified the graft copolymerization Graft copolymers revealed highly pH responsive swelling, consequently drug release at intestinal pH. In vivo evaluation indicated improvement in relative bioavailability by exhibiting increase in Cmax of polymeric system and same oral dose of rabeprazole sodium were 103.71 ± 16.081 and 61.263 ± 5.37 ng/mL, resp. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Synthetic Route of C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Synthetic Route of C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Oxidative desulfurization of model oil extracted and catalyzed by acidic ionic liquid was written by Yan, Biying. And the article was included in Huagong Xinxing Cailiao in 2015.Category: imidazoles-derivatives The following contents are mentioned in the article:

Three kinds of acidic functional ionic liquid [HMIM]HSO₄, [HPy]HSO₄ and [Hnhp]HSO₄ were synthesized, and used in the desulfurization process of DBT in the model oil. The ionic liquids all performed excellent performance of desulfurization, in which [Hnhp]HSO₄ explained the highest desulfurization rate. The effects of conditions of the desulfurization process on the sulfur removal rate were studied catalyzed by ionic liquid [Hnhp]HSO₄. The results showed that the sulfur removal of DBT in model oil could reach 99.4% when n (H₂O₂)/n (S) = 8, t = 60 min, T = 60°C, V ([Hnhp]HSO₄):V (model oil) = 1:5. [Hnhp]HSO₄ could be recycled 6 times with merely a slight decrease in activity. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Category: imidazoles-derivatives).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem