Month: November 2022

Two- and three-dimensional hybrid zinc phosphites: syntheses, structures and photoluminescence properties was written by Han, Song-De;Zhang, Xiu-Rong;Pan, Jie;Mu, Ying;Li, Jin-Hua;Wang, Guo-Ming. And the article was included in Dalton Transactions in 2018.Synthetic Route of C11H9N5 The following contents are mentioned in the article:

Two zinc-phosphites modified by a rigid amine 3,5-bis(imidazole-1-yl)pyridine (BIP), [Zn₂(HPO₃)₂(BIP)]·H₂O (1) and [Zn₃(HPO₃)₃(BIP)(H₂O)]·H₂O (2), were solvothermally prepared Compound 1 possesses a zincophosphite layer decorated by BIP moieties via coordinating to intralayer Zn(II) ions. Compound 2 features a 3-dimensional frame with a pillar-layer structure, in which the organic BIP pillars the inorganic zincophosphite layer via coordinating to interlayer Zn(II) ions. The structural diversity from a 2-dimensional layer to a 3-dimensional frame was mainly attributable to the different bridging modes of BIP in the process of assembly. Their temperature-dependent photoluminescence properties also were studied. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Synthetic Route of C11H9N5).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Synthetic Route of C11H9N5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Unexpected tandem reaction of new type Morita-Baylis-Hillman adducts promoted by [Hmim]HSO₄/NaNO₃ system was written by Zhong, Weihui;Wang, Guan;Chen, Kai. And the article was included in Heterocycles in 2012.Related Products of 478935-29-4 The following contents are mentioned in the article:

A tandem reaction of a new type of Baylis-Hillman adduct, such as R-C₆H₄CCl=CH(OH)C(CH₂)CO₂R¹ (R = 4-MeO, 4-NO₂, 4-Me, H, 4-F, 3-Cl; R¹ = Me, Et) was promoted by the ionic liquid 1-hexyl-3-methylimidazolium·HSO₄/NaNO₃ system and the unexpected products 6-aryl-2H-pyran-3-carboxylates and the corresponding imidazolium salts I (R = 4-NO₂, H, 3-Cl, 4-F, R¹ = Me; R = 4-NO₂, 4-F, R¹ = Et) were efficiently formed via rearrangement and substitution reactions. While mediated by 1-ethyl-3-methylimidazolium·HSO₄/NaNO₃ system, the key intermediates, nitrates II (R = 4-OMe, 4-F, R¹ = Me; R = 3-Cl, R¹ = Et) were isolated. A plausible mechanism for the transformation was given. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Related Products of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Related Products of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of N-cyanoethyl-N-hydroxyethylaniline catalyzed by acidic ionic liquid was written by Guo, Hui;Yin, Yuanyuan;Zhang, Xueying;Zhuang, Yuwei;Cao, Jian;Zhang, Guobao. And the article was included in Yingyong Huaxue in 2020.Application of 478935-29-4 The following contents are mentioned in the article:

N-Cyanoethyl-N-hydroxyethylaniline is an important dye intermediate with a wide range of applications. A green and efficient protocol for the synthesis of N-cyanoethyl-N-hydroxyethylaniline by reaction of acrylonitrile and N-hydroxyethyl aniline with 1-butyl-3-methylimidazolium hydrogen sulfate ionic liquid ([Bmim]HSO₄) as a catalyst has been developed, eliminating inert-gas welding and complex operation of traditional methods. The effect of ionic liquid, the amount of ionic liquid, the ratio of substrates, temperature and time were investigated. The optimum reaction conditions were obtained as follow: [BMIM]HSO₄ 0.8 mmol, n (N-hydroxyethyl aniline):n (acrylonitrile) = 1:1.2, reaction time of 12 h, reaction temperature of 90°C. The acidic ionic liquid could be easily separated and reused for at least 5 times without significantly decrease in catalytic activity. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Application of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Application of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Enhancement of the selective enzymatic biotransformation of rutin to isoquercitrin using an ionic liquid as a co-solvent was written by Wang, Jun;Sun, Guo-Xia;Yu, Liang;Wu, Fu-An;Guo, Xi-Jie. And the article was included in Bioresource Technology in 2013.COA of Formula: C10H20N2O4S The following contents are mentioned in the article:

An ionic liquid (IL)-containing buffer system was first applied in the conversion of rutin to isoquercitrin. High substrate solubility was achieved to enhance the selectivity and efficiency of hesperidinase-catalyzed reaction. Ten ILs were selected as co-solvents to assist catalytic reactions in this biotransformation process. The transformed products of rutin were identified by LC-MS. The [Bmim][BF₄]-glycine-sodium hydroxide buffer (pH 9) (10:90, volume/volume) was found to be the best medium for the biotransformation of isoquercitrin from rutin with higher selectivity and efficiency. The reaction time was reduced by 0.33-fold while the conversion of rutin and the yield of isoquercitrin were increased by 1.67-fold and 2.33-fold. The results suggest that IL co-solvents have great potential to enhance the selectively enzymic hydrolysis of rutin for isoquercitrin production This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4COA of Formula: C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Study on synthesis of methyl oleate catalyzed by 1-alkyl-3-methylimidazolium hydrosulfate was written by Sun, Hua;Li, Shengqing;Chen, Hao;Liu, Junchao;Xue, Aifang;Liu, Hanlan. And the article was included in Wuhan Gongcheng Daxue Xuebao in 2009.Safety of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:

Five acidic ionic liquids with an hydrogen sulfate group were synthesized ([C_nMIm]HSO₄, n = 0, 2, 4, 6 and 8). Their acidity was studied. Their application in esterification utilizing oleic acid and methanol was explored. The exptl. results showed 1-hexyl-3-methyl-imidazolium hydrogen sulfate ([C₆MIm]HSO₄) was the best catalyst of acidic ionic liquid in esterification. Under optimal esterification conditions: n_(methanol):n_{(oleic acid)} = 2.5:1, m_{(oleic acid)}:m_{([C6MIm]HSO4)} = 1:0.08, temperature 90°C and time 14 h, mass fraction of fatty acid Me ester could reach more than 91%. The ionic liquids were stable and could be reused. Me oleate was separated from raw material easily, and even if ionic liquid was reused beyond 6 times, the conversion of esterification did not decrease. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Safety of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Safety of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Commentary: post-transplantation cyclophosphamide uniquely restrains alloreactive CD4+ T-cell proliferation and differentiation after murine MHC-haploidentical hematopoietic cell transplantation was written by Stokes, Jessica;Simpson, Richard J.;Katsanis, Emmanuel. And the article was included in Frontiers in Immunology in 2022.Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

Herein authors investigated whether post-transplant cyclophosphamide (PT-CY) is unique in protecting against graft-vs.-host disease (GvHD) by comparing it to multiple other ′′optimally dosed′â€?chemotherapeutics. They concluded that PT-CY was superior to all other agents in ameliorating both clin. and histopathol. GvHD. It discuss about post-transplantation cyclophosphamide which uniquely restrains alloreactive CD4+ T-cell proliferation and differentiation after murine MHC-haploidentical hematopoietic cell transplantation. Authors discuss on the use of post-transplant bendamustine (PT-BEN) as an alternative agent that could replace PT-CY. They demonstrated that PT-BEN was equally effective in preventing early GvHD and protecting against late GvHD, while enabling superior graft-vs.-leukemia (GvL), when compared to PT- CY in murine haploidentical bone marrow transplantation (haplo-BMT). This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Preparation of 5-hydroxymethylfurfural from cellulose degradation catalyzed by acidic ionic liquids was written by Fu, Nihong;Yuan, Yuguo;Wang, Jingyun;Zang, Shuliang. And the article was included in Huaxue Tongbao in 2016.COA of Formula: C10H20N2O4S The following contents are mentioned in the article:

In this study, imidazolium based acidic ionic liquids and CrCl₃·6H₂O were used to catalyze the hydrolysis of cellulose in ionic liquid 1-allyl-3-methylimidazolium chloride ([Amim]Cl) via microwave-assisted irradiation to prepare 5-hydroxymethylfurfural (5-HMF). The effects of the type and amount of catalysts, reaction temperature and time, amount of water on the degradation of cellulose were studied in details. The results indicated that [C₂mim]HSO₄ and CrCl₃·6H₂O were efficient catalysts for preparing 5-HMF. The cellulose could be completely converted with the highest total reducing sugars (TRS) yield of 87.22% and 5-HMF yield of 50% under the condition of n_MCC:n_Cr = 10:1, the mass of [C₂mim]HSO₄ = 0.02 g, and reaction temperature 160°C under microwave-assisted heating for 30 min. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4COA of Formula: C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).COA of Formula: C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bortezomib in combination with fludarabine plus cyclophosphamide for patients with relapsed or refractory mantle-cell lymphoma: results of the LYM-4003 study was written by Wang, Xiao-Xiao;Gao, Yan;Jin, Jie;Cao, Jun-Ning;Feng, Ji-Feng;Wang, Hua-Qing;Zhang, Hui-Lai;Cai, Qing-Qing;Li, Zhi-Ming;Jiang, Wen-Qi;Huang, Hui-Qiang;on behalf of the Lymphoma Committee, Chinese Anti-Cancer Association. And the article was included in Annals of Hematology in 2021.SDS of cas: 16506-27-7 The following contents are mentioned in the article:

This study aimed to identify the maximum-tolerated dose (MTD) of cyclophosphamide when combined with bortezomib and fludarabine (B-FC) in a phase 1b trial, and to assess the efficacy and safety of this combination in a phase 2 trial in patients with relapsed or refractory MCL (rrMCL). Forty patients were enrolled between Apr. 8, 2011, and Oct. 10, 2015. The MTD of cyclophosphamide was identified to be 250 mg/m² days 1-2. At a median follow-up of 31.6 mo (13.5-47.4), among 32 patients in phase 2, 10 (31%) had a complete response and 13 (41%) had a partial response. The median progression-free survival was 21 mo (95% CI 7.3-34.7), and the median overall survival was 32.4 mo (95% CI 17.8-47.0). Grade 3-4 hematol. AEs included neutropenia (27%) and thrombocytopenia (39%). The B-FC regimen has satisfactory responses and manageable toxicities in rrMCL patients (ClinicalTrials.gov NCT01322776). This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7SDS of cas: 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.SDS of cas: 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Supramolecular Self-Sorting Networks using Hydrogen-Bonding Motifs was written by Coubrough, Heather M.;van der Lubbe, Stephanie C. C.;Hetherington, Kristina;Minard, Aisling;Pask, Christopher;Howard, Mark J.;Fonseca Guerra, Celia;Wilson, Andrew J.. And the article was included in Chemistry – A European Journal in 2019.Product Details of 1384100-95-1 The following contents are mentioned in the article:

A current objective in supramol. chem. is to mimic the transitions between complex self-sorted systems that represent a hallmark of regulatory function in nature. In this work, a self-sorting network, comprising linear hydrogen motifs, was created. Selecting six hydrogen-bonding motifs capable of both high-fidelity and promiscuous mol. recognition gave rise to a complex self-sorting system, which included motifs capable of both narcissistic and social self-sorting. Examination of the interactions between individual components, exptl. and computationally, provided a rationale for the product distribution during each phase of a cascade. This reasoning holds through up to five sequential additions of six building blocks, resulting in the construction of a biomimetic network in which the presence or absence of different components provides multiple unique pathways to distinct self-sorted configurations. This study involved multiple reactions and reactants, such as 4-(tert-Butyl)-1H-imidazol-2-amine hydrochloride (cas: 1384100-95-1Product Details of 1384100-95-1).

4-(tert-Butyl)-1H-imidazol-2-amine hydrochloride (cas: 1384100-95-1) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Product Details of 1384100-95-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Homoleptic tris-cyclometalated iridium(III) complexes with phenylimidazole ligands for highly efficient sky-blue OLEDs was written by Zhuang, Jinyong;Li, Wanfei;Wu, Weichen;Song, Minshun;Su, Wenming;Zhou, Ming;Cui, Zheng. And the article was included in New Journal of Chemistry in 2015.Application of 914306-50-6 The following contents are mentioned in the article:

As an extension of the authors’ previous study, three sky-blue homoleptic Ir(III) complexes 1-3 with F-free phenylimidazole ligands were synthesized and their photophys., electrochem. and thermal properties were studied. All the complexes showed high photoluminescence quantum yields ranging from 0.50 to 0.53. The introduction of a bulky iso-Pr group at the 2,6-position of N-Ph of the phenylimidazole ligands increases the quantum yield and the decomposition temperature of the IR(III) complexes. As the conjugated system of the ligand becomes larger, a very small bathochromic-shift of 1 nm was observed in complex 3 (475 nm) compared with complexes 1 (474 nm) and 2 (474 nm). All the OLED devices showed high current efficiencies of over 20 cd A^-1 at the luminance of 1000 cd m^-2. Devices incorporated with complexes 1-3 all showed longer lifetime in comparison with that of a FIrpic-based device. This study involved multiple reactions and reactants, such as 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6Application of 914306-50-6).

1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole (cas: 914306-50-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application of 914306-50-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem