Month: November 2022

Synthesis of phenethyl acetate with acidic ionic liquid as catalyst was written by Liu, Xiaoyu. And the article was included in Henan Huagong in 2015.Electric Literature of C10H20N2O4S The following contents are mentioned in the article:

Phenethyl acetate (PEAC) is synthesized by using an acidic ionic liquid n-hexyl-methylimidazolium bisulfate abbreviated as [n-C₆Im][HSO₄] as catalyst. By studying on the effect of various factors on the conversion rate, the optimal conditions include 1:1.2 2-Ph ethanol/vinyl acetate, the ionic liquid 5wt%, 140°C reaction temperature and 6 h of reaction time, the conversion of PEAC is 91.8%. After the reaction completed, the [n-C₆Im][HSO₄] could be used for a new synthesis of PEAC. Although the conversion slightly reduced after the [n-C₆Im][HSO₄] was reused for four times, its catalytic activity could reach to original level by adding suitable sulfuric acid. Compared with classical strong acid catalysts, the reaction system using ionic liquid [n-C₆Im][HSO₄] as catalyst offers many advantages of good color of PPAE, easy recovery, and reuse of the catalyst. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Electric Literature of C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Electric Literature of C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Highly efficient preparation of 5-hydroxymethylfurfural from sucrose using ionic liquids and heteropolyacid catalysts in dimethyl sulfoxide-water mixed solvent was written by Yu, Song-Bai;Zang, Hong-Jun;Yang, Xiao-Li;Zhang, Ming-Chuan;Xie, Rui-Rui;Yu, Pei-Fei. And the article was included in Chinese Chemical Letters in 2017.Related Products of 478935-29-4 The following contents are mentioned in the article:

Several types of ILs and solid acids were used as catalysts in one-pot conversion of sucrose to 5-hydroxymethylfurfural (abbreviated as 5-HMF) in a DMSO/water mixed solvent under hydrothermal conditions. A remarkable 5-HMF yield of 91.8% was achieved catalyzed by the cesium salt of dodecatungstophosphoric acid (Cs_2.3H_0.7PW₁₂O₄₀) within 3 h at 180 °C. The ionic liquid N-methylimidazolium hydrogen sulfate ([Hmim][HSO₄]) gave the 5-HMF in 82.0% yield from sucrose. To the best of our knowledge, it was almost the highest yield of HMF from sucrose by now. Various reaction parameters including reaction temperature and time and catalyst dosage were optimized. A possible mechanism for this catalytic process was proposed. Furthermore, fructose and glucose were also investigated, good yields of 5-HMF was obtained resp. This increases the possibility of large-scale production of 5-HMF from carbohydrates. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Related Products of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Related Products of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Two novel Co (II) bifunctional MOFs: Syntheses and applications in photocatalytic degradation of dyes and electrocatalytic water oxidation was written by Cui, Guanning;Liu, Wenbo;Wang, Lulu;Wu, Ruixue;Bi, Caifeng;Zhang, Dongmei;Fan, Yuhua. And the article was included in Journal of Solid State Chemistry in 2021.Safety of 3,5-Di(1H-imidazol-1-yl)pyridine The following contents are mentioned in the article:

Two novel Co (II) MOFs based on 5-(4-(imidazolyl-1-yl)phenyl) isophthalic acid (H₂L), [Co(L)(tib)(H₂O)₂]_n (CP 1) and [Co(L)(bip)_0.5]_n (CP 2) (tib = 1,3,5-tris (1-imidazolyl) benzene, bip = 3,5-bis(1-imidazolyl) pyridine ether) were synthesized under solvothermal conditions and characterized by powder x-ray diffraction, single crystal x-ray diffraction. The photodegradation studies demonstrate that CPs 1–2 show high-efficiency degradation of MV (Methyl violet), and the mechanism studies demonstrate that the main active species are ·OH radicals. Meanwhile, electrochem. studies demonstrate that CPs 1–2 can catalyze water oxidation under alk. conditions, and CPs 1–2 only need the overpotential of 348 mV-760 mV to deliver the c.d. of 1 mA cm^-2. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Safety of 3,5-Di(1H-imidazol-1-yl)pyridine).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Safety of 3,5-Di(1H-imidazol-1-yl)pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Conversion of platform chemical glycerol to cyclic acetals promoted by acidic ionic liquids was written by Wang, Bo;Shen, Yue;Sun, Jiankui;Xu, Feng;Sun, Runcang. And the article was included in RSC Advances in 2014.Quality Control of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:

The condensation of glycerol, a platform chem. from renewable materials, with benzaldehyde to generate cyclic acetals was investigated using acidic ionic liquid as catalyst. Evidence was presented that the product mixture of 4-hydroxymethyl-2-phenyl-1,3-dioxolane and 5-hydroxyl-2-phenyl-1,3-dioxane, with cis and trans two stereo-isomers for each one identified by ¹H NMR were obtained. Further modification of reaction conditions promoted by N-butyl-pyridinium bisulfate ([BPy]HSO₄) led to the totally cyclic acetals with 99.8% yield at room temperature A micro water-removal reactor constituted by ionic liquids was proposed, which favorably shifted the condensation equilibrium to the product side by transferring the produced water out of the organic phase in time, so that the water-carrying agent or reactive distillation was avoided. Moreover, the product separation made this methodol. more accessible to sustainable green biomass chem. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Quality Control of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Quality Control of 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Extractive and oxidative desulfurization of fuel oils using hydrosulfate based ionic liquids was written by Xiao, Jing;Wang, Qiang;Zhou, Mingdong;Yan, Wenchao;Zang, Shuliang. And the article was included in Shiyou Huagong Gaodeng Xuexiao Xuebao in 2013.HPLC of Formula: 478935-29-4 The following contents are mentioned in the article:

A series of N-methylimidazolium hydrosulfate type of ionic liquids (ILs) bearing different length of alkyl chains were synthesized. The ionic liquids were applied both as extracting reagent and catalyst for the model or true oil desulfurization using hydrogen peroxide (35%) as the oxidant. The desulfurization conditions were optimized by varying extraction time, the ratio of ILs/oil, temperature and so on. Under the optimal conditions, the ILs were also used for the desulfurization of FCC gasoline and diesel. The results show that, [C₃mim]HSO₄ has the highest desulfurization rate. The best desulfurization rate was obtained after 1.5 h under the condition of V ([C₃mim]HSO₄)/V (H₂O₂)/V (oil) = 1 : 1 : 30 at 60°C for the model oil (88.38%) and diesel (80%). The sulfur content of FCC gasoline has decreased to 10 μg/g below, which shows a very promising perspective for industrial applications. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4HPLC of Formula: 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bronsted acid ionic liquid activated electrodes catalyze water electrolysis for production of hydrogen was written by Chen, Jia-zhi;Meng, Ling-yi;Wang, Ya-jing;Meng, Jin-lei;Jiang, Feng;Chu, Zhe;Liu, Hong-tao. And the article was included in Fenxi Huaxue in 2016.Related Products of 478935-29-4 The following contents are mentioned in the article:

The water electrolysis for production of hydrogen in the Bronsted acid ionic liquid [HMIm]HSO₄ aqueous solutions was investigated using glassy carbon (GC), platinum (Pt), and gold (Au) electrodes, resp. It was found that the catalytic activity of the electrodes in the acid ionic liquid electrolytes ranked in sequence as Pt > Au >> GC. The optimal concentration of [HMIm]HSO₄ in aqueous solutions was 30% (V/V), and the catalytic c.d. on Pt electrode for hydrogen evolution reaction (HER) at -0.5 V (Ag QRE) reached 110.52 mA/cm². This was 15 and 650-fold larger than the current on the Au and GC electrode, resp. The Arrhenius activation energy of the Pt electrode in the electrolyte solution was 5.68 kJ/mol. The high catalytic activity of the electrode was attributed to the [HMIm]HSO₄ that would release protons enabling H₂O mols. ionization, and facilitating the capture of electrons from the electrode. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Related Products of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Related Products of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Bendamustine plus rituximab in Japanese patients with relapsed or refractory diffuse large B-cell lymphoma was written by Murayama, Kayoko;Kiguchi, Toru;Izutsu, Koji;Kameoka, Yoshihiro;Hidaka, Michihiro;Kato, Harumi;Rai, Shinya;Kuroda, Junya;Ishizawa, Kenichi;Ichikawa, Satoshi;Ando, Kiyoshi;Ogura, Michinori;Fukushima, Koji;Terui, Yasuhito. And the article was included in Annals of Hematology in 2022.Recommanded Product: 16506-27-7 The following contents are mentioned in the article:

This single-arm phase 3 study was conducted to confirm the results of our phase 2 study of bendamustine (B)-rituximab (R) in patients with relapsed/refractory diffuse large B cell lymphoma (rrDLBCL). The primary endpoint was overall response rate (ORR). Autologous stem cell transplantation-ineligible rrDLBCL patients with �2 prior chemotherapy regimens received R 375 mg/m2 IV on day 1 and B 120 mg/m2/day IV on days 2 and 3 every 21 days up to 6 cycles. Thirty-eight patients with a median age of 74 years (range, 43-86) received BR. The ORR and complete response rates were 76.3% and 47.4%, resp. With a median follow-up of 19.5 mo including long-term follow-up, median progression-free survival was 11.9 mo. Median OS was 29.2 mo. Discontinuation of treatment due to Gr3-5 TEAE was observed among 13 of 38 patients (34.2%). One patient with cytomegalovirus enterocolitis died during follow-up. This BR regimen was confirmed to be effective and tolerable in studied patients. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Recommanded Product: 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

BR (bendamustine plus rituximab) versus R-CHOP for patients with indolent B-cell lymphomas: a systematic review and Meta-analysis was written by Ou, Wenxin;Jiang, Tiantian;Tang, Xiaoqiong. And the article was included in Journal of Chemotherapy (Abingdon, United Kingdom).HPLC of Formula: 16506-27-7 The following contents are mentioned in the article:

A review. Bendamustine plus rituximab (BR) and rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) have been shown to be effective in the treatment of indolent B-cell lymphomas (iBCL). The survival outcomes and adverse events of BR and R-CHOP are still controversial, thus we did a systematic review and meta-anal. to assess them. We searched articles in Pubmed, Cochrane, Embase and Web of Science comparing BR to R-CHOP in patients with iBCL. A total of 3141 patients were included. The results of our meta-anal. revealed that BR has the potential of improving PFS (HR = 0.67, p = 0.03). No apparent benefit of BR was noted in patients with iBCL for OS (HR = 1.18, p = 0.04). Compared with R-CHOP, we found that BR regimen had the potential of prolonging PFS, minor toxicity, a better quality of life, and better cost-effectiveness. These results supported BR as a preferred first-line treatment option for patients (especially for elders) with iBCL. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7HPLC of Formula: 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).HPLC of Formula: 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

A single-center analysis of patients with extranodal marginal zone lymphoma of the breast was written by Iyer, Sunil Girish;Kuker, Russ;Florindez, Jorge A.;Saul, Eduardo;Trabolsi, Asaad;Rodriguez, Gregor;Chapman, Jennifer R.;Lossos, Izidore S.;Alderuccio, Juan Pablo. And the article was included in Leukemia & Lymphoma in 2022.Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

Breast extranodal marginal zone lymphoma (EMZL) is a rare malignancy. We performed the largest published to date single-center retrospective anal. of 13 patients with breast EMZL focusing on clin. characteristics and treatment-related outcomes. The rarity of this disease at our center was concordant with the prevalence reported in the literature, with breast EMZL comprising 2% of 654 MZL cases. Most patients presented with stage I-II disease however four (30.8%) patients had stage IV disease mostly due to occult bone marrow (BM) involvement. Interestingly, EMZL was frequently non-FDG avid (66.7%) on staging PET/CT. With a median follow-up of 3.1 years (range 5 mo to 10.2 years), the 3-yr progression free survival was 68.7% (95%CI 30.2%-88.9%) and overall survival 80.2% (95%CI 40.3%-94.8%). No patient experienced higher-grade transformation. Herein we show that localized breast EMZL can be effectively treated with radiation therapy providing long term disease control. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Name: 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Long-term follow up of relapsed/refractory non-Hodgkin lymphoma patients treated with single-agent selinexor – a retrospective, single center study was written by Ben Barouch, Sharon;Bhella, Sita;Kridel, Robert;Kukreti, Vishel;Prica, Anca;Crump, Michel;Kuruvilla, John. And the article was included in Leukemia & Lymphoma in 2022.Application of 16506-27-7 The following contents are mentioned in the article:

Selinexor is a first-in-class, oral therapy that selectively inhibits nuclear export. The drug is active with an overall response rate (ORR) of approx. 30% in relapsed/refractory (r/r) non-Hodgkin lymphoma (NHL). Long-term patient follow-up has not been reported. Thirty-one NHL patients were treated between July 2012 and July 2018; 22 were evaluated for response. ORR was 32% (7/22). Two patients achieved complete remission (CR) and were alive and lymphoma-free at the end of follow-up. Fifteen patients (68%) progressed during treatment, most of them died within 3-10 mo. The most common grade 3/4 adverse events were gastrointestinal and hematol. Median follow up was 50 mo. Overall survival for the entire cohort was 16%. Selinexor monotherapy for r/r NHL is an active therapy with the potential for long-term disease control. It may serve as a ‘bridge’ to subsequent therapy. Addnl. studies are needed to identify predictive biomarkers and to evaluate combination approaches. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Application of 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem