Month: November 2022

Atmospheric-pressure cold plasma for fabrication of anatase-rutile mixed TiO₂ with the assistance of ionic liquid was written by Zhang, Xiuling;Zhang, Lijuan;Li, Yanchun;Di, Lanbo. And the article was included in Catalysis Today in 2015.Electric Literature of C10H20N2O4S The following contents are mentioned in the article:

An atm.-pressure dielec. barrier discharge (DBD) gas-liquid cold plasma was employed to synthesize TiO₂ nanoparticles in an aqueous solution, with the assistance of nine imidazolium-based ionic liquids and using air as working gas. X-ray diffraction, N₂ adsorption-desorption measurements, and transmission electron microscopy were used to characterize the samples. The results showed that the samples prepared by the DBD gas-liquid cold plasma were anatase-rutile mixed TiO₂ with mesoporous structures. The effects of the cations, anions, and the amount of the ionic liquids on the structure of the TiO₂ samples were investigated, and the corresponding mechanism of actions were analyzed. The photocatalytic activity of the TiO₂ photocatalysts was evaluated by photodegradation of Methylene blue. The TiO₂ prepared with the assistance of 0.2 mL 1-ethyl-3-methylimidazolium tetrafluoroborate in Ti precursor solution exhibited the highest photocatalytic activity. Atm.-pressure DBD cold plasma was found to be a fast, simple, and environmentally friendly method for fabricating mixed-phase TiO₂. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Electric Literature of C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Electric Literature of C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Coordination Frameworks based on 3,5-Bis(imidazole-1-yl)pyridine and Aromatic Dicarboxylate Ligands: Synthesis, Crystal Structures, and Photoluminescent Properties was written by Xu, Jiakun;Sun, Xiaochun;Yang, Lirong;Yan, Xincheng;Bi, Caifeng;Sun, Mi. And the article was included in Zeitschrift fuer Anorganische und Allgemeine Chemie in 2014.Name: 3,5-Di(1H-imidazol-1-yl)pyridine The following contents are mentioned in the article:

Three metal coordination polymers [Zn(bdc)(L)(H₂O)]n (1), [Co(pta)(L)(H₂O)₂]n (2), and [Cd(tda)(L)(H₂O)]n (3) [H₂bdc = 1,2-benzene dicarboxylate acid, H₂pta = terephthalic acid, H₂tda = 2, 5-thiophenedicarboxylic acid, L = 3,5-bis(imidazole-1-yl)pyridine] were synthesized and structurally characterized by IR spectroscopy, elemental anal., x-ray powder diffraction, and X-ray single crystal diffraction. Complex 1 shows a three-dimensional (3D) structure with cco topol. with the symbol 6⁵路8, whereas complex 2 features a 3-dimensional structure with cds topol. with the symbol 6⁵路8. Complex 3 has a 2-dimensional network constructed by the cadmium atoms bridged through the ligands tda and L. Their x-ray powder diffraction patterns were compared with the simulated ones. Also, their luminescent properties were studied in the solid state at room temperature, and the thermogravimetric analyses were carried out to study the thermal stability of the 3-dimensional networks. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Name: 3,5-Di(1H-imidazol-1-yl)pyridine).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Name: 3,5-Di(1H-imidazol-1-yl)pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

How I treat and prevent venous thrombotic complications in patients with lymphoma was written by Schmidt, Robert A.;Lee, Agnes Y. Y.. And the article was included in Blood in 2022.Quality Control of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

Venous thromboembolism (VTE) is a common complication occurring in 5% to 10% of patients with lymphoma. As the complexity of lymphoma management has increased with novel therapies, so too has the treatment of VTE. Therapeutic options for the treatment of cancer-associated VTE have expanded from only warfarin and low-mol.-weight heparins (LMWHs) to include the direct oral anticoagulants (DOACs) apixaban, edoxaban and rivaroxaban. There have been no head-to-head trials comparing different DOACs in this setting, and randomized trials comparing a DOAC with LMWH dalteparin differ in trial design and results. Drug-drug interactions, drug-specific side effects, and patient selection are important considerations when prescribing anticoagulant therapy. In all patients, the relative risks of thrombosis and bleeding, the availability of the anticoagulant, and the life expectancy of the patient are vital elements in selecting the most appropriate anticoagulant (which can vary over time) for the individual patient. We describe the intricacies and challenges of treating thrombotic complications in patients with lymphoma with an emphasis on evidence and guideline-based care. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Quality Control of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formulation and evaluation of rabeprazole sodium delayed release tablets was written by Gupta, Aditya;Singh, Gurdeep. And the article was included in American Journal of PharmTech Research in 2020.Related Products of 117976-90-6 The following contents are mentioned in the article:

Rabeprazole sodium is a proton pump inhibitor used to treat peptic ulcer, duodenal ulcer, gastro oesophageal reflux disease by inhibiting the enzyme H+ /K+ATPase, the acidic pump. It is also used to treat Zollinger-Ellison syndrome, erosive esophagitis. This study is aimed to develop pharmaceutically equivalent and stable enteric-coated tablets of Rabeprazole sodium comparable to innovator product. The present work aims to avoid degradation of drug in acidic environment of stomach. Ten Formulations of Rabeprazole core tablets were developed using mannitol as diluents, magnesium stearate and talc as lubricant and glidant, Et cellulose as seal coating, Eudragit L-30, Plasacrylic HTP, Instacoat EN HPMC Pthalate as enteric coated. Among the ten uncoated tablet batches F9 obtained good drug release profile compared to innovator. So a batch F9 was selected for further steps of formulation i.e., sub coating and enteric coating. After enteric coated batches F9 was evaluated for acid resistance test and in-vitro dissolution test compared with innovator found to be suitable for Rabeprazole sodium delayed release tablet. The stability studies were conducted at 40掳C/75% RH for 3 mo. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Related Products of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Related Products of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Implementing pharmacogenetic testing in rural primary care practices: a pilot feasibility study was written by Dressler, Lynn G.;Bell, Gillian C.;Abernathy, Pearl M.;Ruch, Karl;Denslow, Sheri. And the article was included in Pharmacogenomics in 2019.Application of 117976-90-6 The following contents are mentioned in the article:

Aim: Assess feasibility and perspectives of pharmacogenetic testing/PGx in rural, primary care physician (PCP) practices when PCPs are trained to interpret/apply results and testing costs are covered. Methods: Participants included PCPs who agreed to training, surveys and interviews and eligible patients who agreed to surveys and testing. 51 patients from three practices participated. Results: Prestudy, no PCP had ever ordered a PGx test. Test results demonstrated gene variations in 30% of patients, related to current medications, with PCPs reporting changes to drug management. Poststudy, test cost was still a concern, but now PCPs reported practical barriers, including the utilization of PGx results over time. PCPs and patients had favorable responses to testing. Summary: PGx testing is feasible in rural PCP practices. Lay abstract : Although genetic tests exist to predict response to drug therapy for commonly used drugs, test use among primary care physicians is low. Surveys demonstrated satisfaction with the testing experience. Results indicate 30% of patients had a genetic variation potentially affecting a currently used drug. Genetic testing is feasible in primary care. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Application of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Application of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Drug perturbation gene set enrichment analysis (dpGSEA): a new transcriptomic drug screening approach was written by Fang, Mike;Richardson, Brian;Cameron, Cheryl M.;Dazard, Jean-Eudes;Cameron, Mark J.. And the article was included in BMC Bioinformatics in 2021.Safety of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

In this study, we demonstrate that our modified Gene Set Enrichment Anal. (GSEA) method, drug perturbation GSEA (dpGSEA), can detect phenotypically relevant drug targets through a unique transcriptomic enrichment that emphasizes biol. directionality of drug-derived gene sets. We detail our dpGSEA method and show its effectiveness in detecting specific perturbation of drugs in independent public datasets by confirming fluvastatin, paclitaxel, and rosiglitazone perturbation in gastroenteropancreatic neuroendocrine tumor cells. In drug discovery experiments, we found that dpGSEA was able to detect phenotypically relevant drug targets in previously published differentially expressed genes of CD4+T regulatory cells from immune responders and non-responders to antiviral therapy in HIV-infected individuals, such as those involved with virion replication, cell cycle dysfunction, and mitochondrial dysfunction. dpGSEA is publicly available at https://github.com/sxf296/drug_targeting. DpGSEA is an approach that uniquely enriches on drug-defined gene sets while considering directionality of gene modulation. We recommend dpGSEA as an exploratory tool to screen for possible drug targeting mols. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Safety of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Safety of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Physical properties of 1-alkyl-3-methylimidazolium hydrogen sulfate was written by Sun, Hua;Li, Shengqing;Chen, Hao;Liu, Junchao;Liu, Hanlan. And the article was included in Huaxue Yanjiu in 2008.Product Details of 478935-29-4 The following contents are mentioned in the article:

Five ionic liquids, namely, 1-alkyl-3-methylimidazolium hydrogen sulfate ([C_nMIm]HSO₄; alkyl = Et, Bu, hexyl, octyl) were synthesized and characterized by NMR and FT-IR spectra. The phys. properties including solubility, d., viscosity, thermostability, conductivity, pK_a were measured. The results showed that the alkyl chain length had the most dramatic effect on phys. properties. The d. of [CnMIm] HSO₄ decreased with increasing length of alkyl in imidazole. Viscosities were correlated with the length of the alkyl chain in imidazole and the viscosity of [C₄MIm]HSO₄ was the lowest( 16.359*10^-3Pa路s). Because of the effect of hydrogen bonds and Van Der Waals forces, the pK_a of [C₆MIm]HSO₄ was the lowest (0.695). The limiting molar conductivity of [CnMIm]HSPO₄ was greater than that of KCl and the limiting molar conductivity of [C₄MIm]HSO₄ had the highest value. Solubility depended on the polarity of solvents and the compounds were easily dissolved in higher polarity solvents. These imidazolium compounds were stable at temperatures lower than 240掳 and behaved as Newtonian fluids. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Product Details of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Product Details of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Determination of hexafluorophosphate by ion chromatography with direct conductivity detection was written by Yang, Ling;Yu, Hong;Li, Siwen. And the article was included in Fenxi Ceshi Xuebao in 2009.COA of Formula: C8H15F6N2P The following contents are mentioned in the article:

A method was developed for the determination of hexafluorophosphate by ion chromatog. coupled with direct conductivity detection. The separation of analytes was performed on a Shim-pack IC-A3 anion-exchange column using benzoic acid as an eluent. The influences of the type, concentration and pH value of eluent, and column temperature on retention time of hexafluorophosphate were investigated. The optimized chromatog. conditions for determination of hexafluorophosphate were using 1.0 M benzoic acid with pH 7.5 as eluent with column temperature of 40掳 and flow rate of 1.0 mL/min. Under the optimal conditions, hexafluorophosphate could be separated in 12 min. A good linear relationship was obtained between chromatog. peak area and concentration of hexafluorophosphate in the range of 20.0-200.0 mg/L. The detection limit(S/N=2) of hexafluorophosphate was 9.2 mg/L. The RSDs (n=5) for retention time and peak area were 0.2% and 0.6%, resp. The method has been applied in the determination of hexafluorophosphate in ionic liquids The spiked recoveries of hexafluorophosphate were in 98-100%. The good linearity and the repeatability of the method could meet the requirements of quant. anal. of hexafluorophosphate in ionic liquids This study involved multiple reactions and reactants, such as 1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1COA of Formula: C8H15F6N2P).

1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.COA of Formula: C8H15F6N2P

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Vonoprazan is Superior to Rabeprazole for Healing Endoscopic Submucosal Dissection: Induced Ulcers was written by Yamasaki, Akira;Yoshio, Toshiyuki;Muramatsu, Yusuke;Horiuchi, Yusuke;Ishiyama, Akiyoshi;Hirasawa, Toshiaki;Tsuchida, Tomohiro;Sasaki, Yutaka;Fujisaki, Junko. And the article was included in Digestion in 2018.SDS of cas: 117976-90-6 The following contents are mentioned in the article:

Background and Aims: Endoscopic submucosal dissection (ESD) is a well-established minimally invasive treatment for early gastric cancer. To heal ESD-induced ulcers, we commonly prescribe proton pump inhibitors (PPIs). Vonoprazan is our new choice, which is reported to have a stronger and longer acid inhibitory effect than existing PPIs. Here, we aimed to evaluate the efficacy of vonoprazan for healing ESD-induced ulcers compared with rabeprazole. Methods: We reviewed 190 patients who underwent ESD before and after we switched the acid secretion inhibitor from rabeprazole to vonoprazan. We evaluated scarring and reduction rates at 4 wk after ESD. Results: Scarring rates were not different between vonoprazan and rabeprazole (31.7 vs. 18.9%; p = 0.07). However, for ulcers 鈮?5 mm, vonoprazan was superior to rabeprazole (42.2 vs. 19.2%; p < 0.05). Reduction rates were superior for vonoprazan compared with rabeprazole (93.0 vs. 90.4%; p < 0.05). In multivariate anal., vonoprazan was superior to rabeprazole for ulcer scarring (OR 2.21; p < 0.05), and ulcer location in the lower-third of the stomach had higher risk of incomplete scarring (OR 0.37; p < 0.05). Conclusion: Vonoprazan was superior to rabeprazole for healing ESD-induced ulcers. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6SDS of cas: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.SDS of cas: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Four structural diversity MOF-photocatalysts readily prepared for the degradation of the methyl violet dye under UV-visible light was written by Lu, Lu;Wang, Jun;Shi, Chuncheng;Sun, Yanchun;Wu, Weiping;Pan, Ying;Muddassir, Mohd.. And the article was included in New Journal of Chemistry in 2021.Application of 1374155-84-6 The following contents are mentioned in the article:

Four new metal-organic frameworks based on transition metals, namely [Mn₂(渭₂-H₂O)₂(H₂L)₂(CH₃CN)₂] (1), [Mn(L)_0.5 phen)路_0.5H₂O] (2), [Co(H₂O)₂(L)_0.5(bip)路H₂O] (3) and [Co₂(L)(bb)₂路HbbBr] (4), where (H₄L = 5,5鈥?(1,4-phenylenebis(methyleneoxy))diisophthalic acid, bip = 3,5-bis(1-imidazoly)pyridine, phen = 1,10-phenanthroline, bb = 4,4鈥?bis(imidazolyl)biphenyl), have been successfully synthesized under solvothermal conditions. 1 showed a 2D layer featuring a polythreaded network with alternate left-and right-handed 21 helical chains. 2 possessed a 1D [Mn(H₂L)]n chain that was further expanded into a 2D layer through O-H路路路O hydrogen bonds. 3 exhibited a 3D threefold interpenetrating network with a point symbol of (64路82)(66)2. 4 had a 3D 3-fold interpenetrated motif with 2-nodal 4,4-c connectivity. The photocatalytic results demonstrated that all of them could exhibit efficient photocatalytic abilities towards the degradation of methyl violet (MV) under UV irradiation The mechanism of the photocatalytic performance was explored and discussed. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Application of 1374155-84-6).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Application of 1374155-84-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem