Month: November 2022

Blood concentrations of tacrolimus upon conversion from rabeprazole to vonoprazan in renal transplant recipients: Correlation with cytochrome P450 gene polymorphisms was written by Watari, Shogo;Araki, Motoo;Matsumoto, Jun;Yoshinaga, Kasumi;Sekito, Takanori;Maruyama, Yuki;Mitsui, Yosuke;Sadahira, Takuya;Kubota, Risa;Nishimura, Shingo;Wada, Koichiro;Kobayashi, Yasuyuki;Takeuchi, Hidemi;Tanabe, Katsuyuki;Kitagawa, Masashi;Morinaga, Hiroshi;Kitamura, Shinji;Sugiyama, Hitoshi;Ariyoshi, Noritaka;Wada, Jun;Watanabe, Masami;Watanabe, Toyohiko;Nasu, Yasutomo. And the article was included in Drug Metabolism and Pharmacokinetics in 2021.Product Details of 117976-90-6 The following contents are mentioned in the article:

We evaluated the impact of vonoprazan on blood concentrations of tacrolimus via a retrospective anal. of 52 renal transplant recipients who took tacrolimus and converted from rabeprazole to vonoprazan between August 2018 and Sept. 2019. We compared tacrolimus trough levels upon conversion among groups that were classified based on cytochrome P 450 (CYP) gene polymorphisms. CYP3A5 groups were heterozygous or homozygous for CYP3A5*1 and CYP3A5*3 alleles. CYP2C19 genotypes were classified as extensive (*1/*1), intermediate (*1/*2 and *1/*3) or poor metabolizers (*2/*2, *2/*3 and *3/*3). Tacrolimus trough levels increased only 0.3 ng/mL upon conversion in the CYP3A5*3/*3 group: 5.8 [3.4-7.2] vs 6.1 [3.8-7.9]; p = 0.06. No statistically significance changes in tacrolimus levels also occurred in the CYP3A5*1/*1 or CYP3A5*1/*3 groups. Subgroup analyses of CYP3A5*3/*3 demonstrated low changes for all three CYP2C19 subgroups: 5.2 [4.3-6.5] vs 6.2 [4.3-7.9]; p = 0.07, 6.1 [3.4-7.2] vs 6.7 [4.6-7.9]; p = 0.12 and 5.4 [3.6-6.5] vs 4.7 [3.8-6.3]; p = 1.00, resp. Conversion to vonoprazan thus resulted in little increase of tacrolimus trough levels, even in the group predicted to be most susceptible (CYP3A5*3/*3 and 2C19*1/*1), thus supporting the safety of concomitant use of vonoprazan with tacrolimus. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Product Details of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Product Details of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rabeprazole inhibits several functions of Entamoeba histolytica related with its virulence. was written by Mart铆nez-P茅rez, Yoalli;Nequiz-Avenda帽o, Mario;Garc铆a-Torres, Itzhel;Gudi帽o-Zayas, Marco E;L贸pez-Vel谩zquez, Gabriel;Enr铆quez-Flores, Sergio;Mendoza, Edith;Saavedra, Emma;P茅rez-Tamayo, Ruy;Le贸n-Avila, Gloria;Olivos-Garc铆a, Alfonso. And the article was included in Parasitology research in 2020.Computed Properties of C18H20N3NaO3S The following contents are mentioned in the article:

Amoebiasis is a human parasitic disease caused by Entamoeba histolytica. The parasite can invade the large intestine and other organs such as liver; resistance to the host tissue oxygen is a condition for parasite invasion and survival. Thioredoxin reductase of E. histolytica (EhTrxR) is a critical enzyme mainly involved in maintaining reduced the redox system and detoxifying the intracellular oxygen; therefore, it is necessary for E. histolytica survival under both aerobic in vitro and in vivo conditions. In the present work, it is reported that rabeprazole (Rb), a drug widely used to treat heartburn, was able to inhibit the EhTrxR recombinant enzyme. Moreover, Rb affected amoebic proliferation and several functions required for parasite virulence such as cytotoxicity, oxygen reduction to hydrogen peroxide, erythrophagocytosis, proteolysis, and oxygen and complement resistances. In addition, amoebic pre-incubation with sublethal Rb concentration (600聽渭M) promoted amoebic death during early liver infection in hamsters. Despite the high Rb concentration used to inhibit amoebic virulence, the wide E. histolytica pathogenic-related functions affected by Rb strongly suggest that its molecular structure can be used as scaffold to design new antiamoebic compounds with lower IC₅₀ values. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Computed Properties of C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Computed Properties of C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Brentuximab vedotin and bendamustine: an effective salvage therapy for relapsed or refractory Hodgkin lymphoma patients was written by Uncu Ulu, Bahar;Dal, Mehmet Sinan;Yonal Hindilerden, Ipek;Akay, Olga Meltem;Mehtap, Ozgur;Buyukkurt, Nurhilal;Hindilerden, Fehmi;Gunes, Ahmet Kursad;Yigenoglu, Tugce Nur;Basci, Semih;Kizil Cakar, Merih;Yanardag Acik, Didar;Korkmaz, Serdal;Ulas, Turgay;Ozet, Gulsum;Ferhanoglu, Burhan;Nalcaci, Meliha;Altuntas, Fevzi. And the article was included in Journal of Chemotherapy (Abingdon, United Kingdom) in 2022.Application of 16506-27-7 The following contents are mentioned in the article:

The prognosis is poor for relapsed or refractory (R/R) classical Hodgkin Lymphoma (cHL) patients. The brentuximab vedotin (Bv) and bendamustine (B) combination has been used as a preferable salvage regimen in R/R cHL patient trials. We retrospectively evaluated response rates, toxicities, and the survival in R/R cHL patients treated with the BvB combination. In a multi-center real-life study, 61 R/R HL patients received i.v. doses of 1.8 mg/kg Bv on the first day plus 90 mg/m² B on the first and second days of a 21-day cycle as a second-line or beyond-salvage regimen. Patients’ median age at BvB initiation was 33 (range: 18-76 years). BvB was given as median third-line treatment for a median of four cycles (range: 2-11). The overall and complete response rates were 82% and 68.9%, resp. After BvB initiation, the median follow-up was 14 mo, and one- and two-year overall survival rates were 85% and 72%, resp. Grade 3/4 toxicities included neutropenia (24.6%), lymphopenia (40%), thrombocytopenia (13%), anemia (13%), infusion reactions (8.2%), neuropathy (6.5%), and others. The BvB combination could be given as salvage regimen aiming a bridge to autologous stem cell transplant (ASCT), in patients relapse after ASCT or to transplant-ineligible patients with manageable toxicity profiles. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Application of 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application of 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Adverse event burden in older patients with CLL receiving bendamustine plus rituximab or ibrutinib regimens: Alliance A041202 was written by Ruppert, Amy S.;Booth, Allison M.;Ding, Wei;Bartlett, Nancy L.;Brander, Danielle M.;Coutre, Steven;Brown, Jennifer R.;Nattam, Sreenivasa;Larson, Richard A.;Erba, Harry;Litzow, Mark;Owen, Carolyn;Kuzma, Charles S.;Abramson, Jeremy S.;Little, Richard F.;Smith, Scott E.;Stone, Richard M.;Byrd, John C.;Mandrekar, Sumithra J.;Woyach, Jennifer A.. And the article was included in Leukemia in 2021.Recommanded Product: 16506-27-7 The following contents are mentioned in the article:

Ibrutinib has superior progression-free survival compared with bendamustine plus rituximab (BR) in older CLL patients, however, differences in treatment duration, six monthly BR cycles vs. continuous ibrutinib, complicate adverse event (AE) comparisons. We introduce the AE burden score (AE_sc) to compare AEs, calculated for each patient by summing over products of reporting period length and grade for each all-cause grade 1-4 AE and dividing by the length of time over which AEs are assessed. A total of 176 patients received BR and 361 ibrutinib alone or with six cycles of rituximab. At 38 mo median follow-up, 64% remained on ibrutinib. Median AE_sc was higher with BR vs. ibrutinib in the first six cycles (7.2 vs. 4.9, p < 0.0001). Within ibrutinib arms, median AEsc decreased significantly to 3.7 after six cycles (p < 0.0001). 10% and 14% of BR and ibrutinib patients discontinued treatment for AEs. In ibrutinib arms, cumulative incidence of grade 3 or higher atrial fibrillation, hypertension, and infection (AEs of clin. interest) at 12 mo was 4.5%, 17.5%, and 12.8%, resp., and increased more slowly thereafter to 7.7%, 25.4%, and 20.5% at 36 mo. Anal. tools including the AE_sc and cumulative incidence of AEs can help to better characterize AE burden over time. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Recommanded Product: 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Proton pump inhibitors selectively suppress MLL rearranged leukemia cells via disrupting MLL1-WDR5 protein-protein interaction was written by Chen, Wei-Lin;Li, Dong-Dong;Chen, Xin;Wang, Ying-Zhe;Xu, Jun-Jie;Jiang, Zheng-Yu;You, Qi-Dong;Guo, Xiao-Ke. And the article was included in European Journal of Medicinal Chemistry in 2020.Application of 117976-90-6 The following contents are mentioned in the article:

Genetic rearrangements of the mixed lineage leukemia (MLL) leading to oncogenic MLL-fusion proteins (MLL-FPs). MLL-FPs occur in about 10% of acute leukemias and are associated with dismal prognosis and treatment outcomes which emphasized the need for new therapeutic strategies. In present study, by a cell-based screening inhouse compound collection, we disclosed that Rabeprazole specially inhibited the proliferation of leukemia cells harboring MLL-FPs with little toxicity to non-MLL cells. Mechanism study showed Rabeprazole down-regulated the transcription of MLL-FPs related Hox and Meis1 genes and effectively inhibited MLL1 H3K4 methyltransferase (HMT) activity in MV4-11 cells bearing MLL-AF4 fusion protein. Displacement of MLL1 probe from WDR5 protein suggested that Rabeprazole may inhibit MLL1 HMT activity through disturbing MLL1-WDR5 protein-protein interaction. Moreover, other proton pump inhibitors (PPIs) also indicated the inhibition activity of MLL1-WDR5. Preliminary SARs showed the structural characteristics of PPIs were also essential for the activities of MLL1-WDR5 inhibition. Our results indicated the drug reposition of PPIs for MLL-rearranged leukemias and provided new insight for further optimization of targeting MLL1 methyltransferase activity, the MLL1-WDR5 interaction or WDR5. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Application of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rabeprazole-amoxicillin dual therapy as first-line treatment for H pylori eradication in special patients: A retrospective, real-life study was written by Gao, Wen;Ye, Hui;Deng, Xin;Wang, Chi;Xu, Ying;Li, Yixuan;Zhang, Xuezhi;Cheng, Hong. And the article was included in Helicobacter in 2020.Synthetic Route of C18H20N3NaO3S The following contents are mentioned in the article:

The currently recommended quadruple regimens for Helicobacter pylori infection might not be appropriate for every patient, especially in elderly patients or those with multiple comorbidities. To evaluate the efficacy and safety of rabeprazole amoxicillin dual therapy in H pylori-pos. elderly patients or those with multiple comorbidities. From Nov. 2013 to May 2017, the clin. data of H pylori pos. patients 鈮?0 years old or with multiple comorbidities were collected and reviewed. All patients were given rabeprazole 10 mg three times a day and amoxicillin 1000 mg thrice a day (RA dual therapy) for 14 days as first line treatment. H pylori eradication was evaluated by ¹³C urea breath test 6 wk after treatment. Adverse effects were recorded. A total of 198 patients were enrolled, including 116 elderly patients and 82 patients with multiple comorbidities. Successful eradication was achieved in 90.9% (180/198, 95% CI: 86.1%-94.2%) patients. Adverse effects, which were mainly mild (referring to skin rash, abdominal pain, and diarrhea), occurred in 22 patients (22/198, 11.1%) and resolved spontaneously. Dual therapy composed of rabeprazole and amoxicillin as a first line treatment appears to be effective and safe for H pylori infection in elderly patients or those with multiple comorbidities. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Synthetic Route of C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Synthetic Route of C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Structure of the Room-Temperature Ionic Liquid 1-Hexyl-3-methylimidazolium Hydrogen Sulfate: Conformational Isomerism was written by Kiefer, Johannes;Pye, Cory C.. And the article was included in Journal of Physical Chemistry A in 2010.COA of Formula: C10H20N2O4S The following contents are mentioned in the article:

The acidic room-temperature ionic liquid 1-hexyl-3-methylimidazolium hydrogen sulfate has recently been identified to have beneficial properties for practical applications in catalysis and electrochem. In the present work, the conformational isomerism of this ionic liquid is studied by means of d. functional theory calculations and experiments in terms of IR absorption and Raman scattering spectroscopy. For the hydrogen sulfate anion, the trans conformer is found to be the favored isomer in the ionic liquid For the 1-hexyl-3-methylimidazolium cation, three different low-energy conformations were obtained, differing only in the orientation of the hexyl chain. The comparison of vibrational frequencies with IR and Raman data showed good agreement for all three conformations, indicating their presence in the ionic liquid Beyond revealing the conformational information, the exptl. spectra indicate strong interionic interactions. Vibrations of sulfuric acid could be observed, indicating possible proton transfer from the cation to the anion. This is further supported by the appearance of modes around 2000 cm^-1 in the IR spectrum, which could tentatively be assigned to C2-H stretching vibrations red-shifted as a result of strong interionic hydrogen bonds as a prerequisite of proton transfer. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4COA of Formula: C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. COA of Formula: C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Formulation and in-vitro evaluation of enteric coated tablet incorporating rabeprazole was written by Mehetre, Gautam D.;Cheke, Rameshwar S.;Shrikhande, Vinayak N.. And the article was included in Journal of Drug Delivery and Therapeutics in 2020.Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:

The objective of the work is to try and assess the applicability and manufacturing possibilities to optimize an enteric coated tablet formulation containing Rabeprazole sodium as the drug aiming at the anti-acidity activity with desired drug release properties. Enteric coated tablet was chosen as dosage form being a cost-effective technol. for pharmaceutical industry requiring fewer procedures. Before the implementation of the pharmaceutical technol. aims, anal. of critical factors influencing the manufacture was carried out. Reproducible manufacturing processes are required to achieve suitability and tablets uniformity to achieve the uniform properties of tablets, which could influence exptl. parameters. Rabeprazole in core content of tablet is blended with HPMC (different grades), xanthan gum, PVPK30, mannitol, crosspovidone, Sodium starch glycolate, Colloidal silicon dioxide to formulate the product. Prepared formulation was tested for weight and content uniformity, phys. characteristics, in vitro dissolution behavior, acid resistance and accelerated stability studies. All studies performed resulted and revealed for assurance of such enteric coated tablet formulation for drug Rabeprazole with optimum characteristics, concluding it as a promising approach to enhance drug release characteristics. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Radiofrequency ablation is safe and effective in the treatment of Chinese patients with gastroesophageal reflux disease: A single-center prospective study was written by Liu, Pei Pei;Meng, Qian Qian;Lin, Han;Han, Yan;Qian, Wei;Li, Zhao Shen;Wang, Luo Wei. And the article was included in Journal of Digestive Diseases in 2019.Reference of 117976-90-6 The following contents are mentioned in the article:

Objective : This study aimed to evaluate the safety and efficiency of radiofrequency ablation (RFA) in Chinese patients with gastroesophageal reflux disease (GERD). Methods : This was a single-center, prospective study including 27 Chinese patients with GERD. The outcomes in all patients were evaluated before and at 3, 6, and 12 mo after RFA, including their GERD health-related quality of life (GERD-HRQL) score, esophageal acid exposure, DeMeester score, lower esophageal sphincter (LES) resting pressure, and patient’s satisfaction with symptom control. Furthermore, rabeprazole sodium (RS) administration, reflux esophagitis (RE), and intraoperative and postoperative complications were also evaluated. Results : RFA treatment significantly reduced the GERD-HRQL score, the percentage of time that esophageal pH < 4, and the DeMeester score, and significantly increased the LES resting pressure in GERD patients. A need for RS administration was reduced and RE symptoms were relieved. Satisfaction rate of 92.6% and 96.3% was reported by these patients at 6 and 12 mo post-treatment, resp. Mild bleeding (<20 mL) occurred in one patient during RFA, and no serious intraoperative and postoperative complications were observed Conclusion : RFA is safe and effective in the treatment of GERD in Chinese patients. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Reference of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Reference of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Three Coordination Polymers based on 3,5-Bis(imidazol-1-yl)pyridine and Benzoic Acid: Synthesis, Crystal Structures and Photoluminescent Properties was written by Xu, Jiakun;Yan, Xingchen;Sun, Xiaochun;Sun, Guolong;Bi, Caifeng;Sun, Mi. And the article was included in Zeitschrift fuer Anorganische und Allgemeine Chemie in 2014.Quality Control of 3,5-Di(1H-imidazol-1-yl)pyridine The following contents are mentioned in the article:

Three metal coordination polymers {[Co(L)₂(H₂O)₂]²⁺路2NO₃^–}_n (1), {[Mn(L)₂(H₂O)₂]²⁺路2Cl^–路3H₂O}_n (2), and [ZnL(ba)₂]_n (3) [L = 3,5-bis(imidazol-1-yl)pyridine and Hba = benzoic acid] were synthesized and structurally characterized by IR spectroscopy, elemental anal., x-ray powder diffraction, and X-ray single crystal diffraction. Complex 1 shows a one-dimensional (1D) chain structure. Adjacent chains are connected by hydrogen bonding and nitrate groups to form a 3D network. Complex 2 features a 2D layer structure. A three-dimensional network is constructed through the cluster consisting of two chloride ions and three water mols. Complex 3 shows a 1D zigzag chain structure that further twists together to form a 3D network. The x-ray powder diffraction patterns were compared with the simulated ones. Also, the luminescent properties of 1–3 were investigated in the solid state at room temperature, and the thermogravimetric analyses were carried out to study the thermal stability of the three complexes. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Quality Control of 3,5-Di(1H-imidazol-1-yl)pyridine).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Quality Control of 3,5-Di(1H-imidazol-1-yl)pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem