Month: November 2022

Syntheses, characterizations and luminescence properties of four novel coordination polymers based on 4,4′-(phenylazanediyl)dibenzoic acid with two rigid N-donor imidazol ligand was written by Zhao, Changjiang;Zhao, Lun;Zhang, Min. And the article was included in Inorganica Chimica Acta in 2018.HPLC of Formula: 1374155-84-6 The following contents are mentioned in the article:

Four novel coordination polymers (CPs), namely, [ZnL(bimb)]路DMF (1), [ZnL(bimb)]路6(H₂O)_0.5 (2), [ZnL(bimp)_0.5]路3H₂O (3) and [ZnL(bimp)]路7H₂O (4), (H₂L = 4,4′-(phenylazanediyl)dibenzoic acid, bimb = 1,4-bis(imidazol-1-yl)benzene, bimp = 3,5-bis(1-imidazoly)pyridine), were synthesized under hydrothermal conditions with different solvents and decreased temperature rates. Their structures were determined by single-crystal x-ray diffraction analyses and further characterized by IR spectra (IR), elemental analyses, and thermogravimetric analyses (TGA). 1 Exhibits an infinite 4-fold interpenetrated three-dimensional (3D) framework with (6⁶) topol. 2 Displays the 2-dimensional undulated sheets leading to form a 3-dimensional framework with 蟺-蟺 interactions among layers in ABAB fashion. 3 Exhibits an infinite 2-fold interpenetrated 3-dimensional framework with (4¹²路6³) topol. 4 Exhibited 2-dimensional layer with {4²路6³路8} topol. structure. Photoluminescence properties of 1–4 in solid state at ambient temperature were studied, too. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6HPLC of Formula: 1374155-84-6).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.HPLC of Formula: 1374155-84-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

DNA unchained: two assays to discover and study inhibitors of the DNA clustering function of barrier-to-autointegration factor was written by Burger, Michael;Schmitt-Koopmann, Caroline;Leroux, Jean-Christophe. And the article was included in Scientific Reports in 2020.Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:

The protein barrier-to-autointegration factor (BAF) and its interaction partners, the LEM (LAP2B, emerin, MAN1)-domain proteins, constitute a powerful cytoplasmic DNA defense mechanism. Invading DNA mols. are quickly bound by the BAF system and trapped in membrane compartments. This decreases the nuclear uptake of DNA from the cytoplasm. Inhibition of the BAF system is therefore expected to enhance the efficacy of non-viral DNA transfection agents. In this study, we introduced a protocol for the recombinant expression of soluble BAF and developed two ELISA-type assays to discover small mol. inhibitors of BAF-dependent DNA retention by high throughput screening (HTS). The proton pump inhibitor rabeprazole as well as three compounds of the Maybridge library were identified as inhibitors of the LEM-BAF-DNA interaction chain. The inhibition was based on adduct formation with BAF cysteine residues. An enhancing effect of the compounds on cell culture transfection, however, was not observed, which may be attributed to the reducing environment of the cytoplasm that prevents the adduct formation with BAF cysteine residues. The novel assays developed here can provide new tools to further study the biol. functions of the BAF system, and may lead to the identification of suitable BAF inhibitors in future HTS campaigns. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Chiral separation in the class of proton pump inhibitors by chromatographic and electromigration techniques: An overview was written by Papp, Lajos Attila;Hancu, Gabriel;Kelemen, Hajnal;Toth, Gergo. And the article was included in Electrophoresis in 2021.Category: imidazoles-derivatives The following contents are mentioned in the article:

A review. Proton pump inhibitors (PPIs) are benzimidazole-derivative chiral sulfoxides, frequently used in the treatment of gastric hyperacidity-related disorders. Due to their stereoselective metabolism, the eutomeric forms of PPIs can present a more advantageous pharmacokinetic profile by comparison with the distomers or racemates. Moreover, two representatives of the class are used in therapy both as racemates and as pure enantiomers (esomeprazole, dexlansoprazole). A relatively large number of enantioseparation methods employed for the stereoselective determination of PPIs from pharmaceutical, biol., and environmental matrixes were published in the past three decades. The purpose of the current overview is to provide a systematic survey of the available chiral separation methods published since the introduction of PPIs in the therapy up to the present. Anal. and bioanal. methods using different chromatog. and electromigration techniques reported for the enantioseparation of omeprazole, lansoprazole, pantoprazole, rabeprazole, ilaprazole, and tenatoprazole are included. The anal. conditions of the presented methods are summarized in three comprehensive tables, while a critical discussion of the applied techniques, possible mechanism of enantiorecognition, and future perspectives on the topic are also presented. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Category: imidazoles-derivatives).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Category: imidazoles-derivatives

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Zanubrutinib for treatment-naive and relapsed/refractory chronic lymphocytic leukaemia: long-term follow-up of the phase I/II AU-003 study was written by Cull, Gavin;Burger, Jan A.;Opat, Stephen;Gottlieb, David;Verner, Emma;Trotman, Judith;Marlton, Paula;Munoz, Javier;Johnston, Patrick;Simpson, David;Stern, Jennifer C.;Prathikanti, Radha;Wu, Kenneth;Novotny, William;Huang, Jane;Tam, Constantine S.. And the article was included in British Journal of Haematology in 2022.Product Details of 16506-27-7 The following contents are mentioned in the article:

Summary : The phase I/II AU-003 study in patients with treatment-naive (TN) or relapsed/refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma demonstrated that zanubrutinib therapy results in clin. meaningful and durable responses with acceptable safety and tolerability. We report updated safety and efficacy data for 123 patients with a median follow-up of 47路2 mo. Patients received zanubrutinib 160 mg twice daily (81 patients), 320 mg once daily (40), or 160 mg once daily (two). Discontinuations due to adverse events or disease progression were uncommon. The overall response rate (ORR) was 95路9% (TN, 100%; R/R, 95%) with 18路7% achieving complete response (CR). Ongoing response at 3 years was reported in 85路7%. The ORR in patients with del(17p)/tumor protein p53 mutation was 87路5% (CR 16路7%). The 2- and 3-yr progression-free survival estimates were 90% (TN, 90%; R/R, 91%) and 83% (TN, 81%; R/R, 83%) resp. The most reported Grade 鈮? adverse events were neutropenia (15路4%), pneumonia (9路8%), hypertension (8路9%) and anemia (6路5%). The annual incidence of atrial fibrillation, major hemorrhage, Grade 鈮? neutropenia and Grade 鈮? infection decreased over time. With a median follow-up of 鈭? years, responses remain clin. meaningful and durable and long-term tolerability to zanubrutinib therapy continues. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Product Details of 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Product Details of 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Esterification of oleic acid in [Bmim]BF₄/[Hmim]HSO₄ + TX-100/cyclohexane ionic liquid microemulsion was written by Jiang, Dongyu;Chen, Li;Wang, Aili;Yan, Zongcheng. And the article was included in RSC Advances in 2014.COA of Formula: C10H20N2O4S The following contents are mentioned in the article:

Esterification of oleic acid was carried out in a 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF₄)/Triton X-100 + 1-hexyl-3-methylimidazolium hydrogen sulfate ([Hmim]HSO₄)/cyclohexane microemulsion. A pseudo ternary phase diagram of the designed systems was drawn to investigate the phase behavior of the microemulsion, with the surfactant [Hmim]HSO₄ acting as a catalyst. The effects of various reaction parameters were explored. The results showed that the maximum yield of lauryl oleate reaches 91.17% and its selectivity reaches 98.55% under optimum reaction conditions. The reaction was carried out with 8 wt% catalyst at 373 K for 6 h. The molar ratios of [Bmim]BF₄ to the surfactant and of oleic acid to lauryl alc. were 0.24 and 0.2, resp. Comparison reactions between different alcs. and oleic acid were also performed, and the results showed that long alkyl chain alcs. promote the reaction rate. UV-vis absorption spectra demonstrated that the generated water enters the [Bmim]BF₄ microdomain of the ionic liquid microemulsions. A possible mechanism of the reaction was also presented. All the results indicate that the [Bmim]BF₄/TX-100 + [Hmim]HSO₄/cyclohexane microemulsion is a very efficient catalyst system for esterification reactions. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4COA of Formula: C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.COA of Formula: C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Isomeric Effect on the anticancer Behavior of two Zinc(II) complexes based on 3,5-bis(1-imidazolyl)pyridine: Experimental and Theoretical Approach was written by Zhu, Mingchang;Song, Da;Liu, Ning;Wang, Kehua;Su, Junqi;Xiong, Meng;Zhang, Xi;Xu, Yuang;Gao, Enjun. And the article was included in Applied Organometallic Chemistry in 2019.Name: 3,5-Di(1H-imidazol-1-yl)pyridine The following contents are mentioned in the article:

Two isomeric Zinc(II) complexes constructed by 3,5-bis(1-imidazolyl)pyridine has been synthesized and characterized by single crystal x-ray diffraction, elemental analyses and IR spectroscopy. The binding mode and ability of complex 1–2 with CT-DNA were studied by UV and fluorescence spectra. The intrinsic binding constant K_b (K_b1 = 2.305 脳 10⁴ M^-1, K_b2 = 3.095 脳 10⁴ M^-1) and the observed association constant K_obs (K_obs1 = 1.523*10⁶ M^-1, K_obs2 = 2.057*10⁶ M^-1) indicated that the insertion ability of complex 2 with CT-DNA is stronger than complex 1. Gel electrophoresis showed that complexes have a good ability to hydrolyze cleavage pBR322 plasmid DNA. The cytotoxicity and apoptosis studies showed that complexes exhibited excellent cytotoxic activity against HeLa cells, especially complex 2 had better growth inhibition than Cisplatin. Mol. docking study simulated the binding model of complexes with DNA (PDB:4av1), showing an imidazole plane of complex 2 can be inserted into a DNA base pair in relative parallel. Both complexes can be used as potential anticancer agents. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Name: 3,5-Di(1H-imidazol-1-yl)pyridine).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Name: 3,5-Di(1H-imidazol-1-yl)pyridine

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Green synthesis of monolithic column incorporated with graphene oxide using room temperature ionic liquid and eutectic solvents for capillary electrochromatography was written by Li, Xin-Xin;Zhang, Li-Shun;Wang, Chao;Huang, Yan-Ping;Liu, Zhao-Sheng. And the article was included in Talanta in 2018.Recommanded Product: 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate The following contents are mentioned in the article:

A hybrid monolith incorporated with graphene oxide (GO) was prepared in the first time with binary green porogens of deep eutectic solvents (DESs) and room temperature ionic liquids (RTILs). GO was modified with 3-(trimethoxysilyl) propylmethacrylate (纬-MPS), and the resultant GO-MPS can be incorporated into poly(methacrylic acid-co-butylmethacrylate-coethylene glycol dimethacrylate) monoliths covalently. A hybrid monolithic column with high permeability and homogeneity can be achieved due to good dispersion of GO-MPS in the green solvents. The GO-MPS incorporated monolith was characterized by TEM, SEM, TGA and nitrogen adsorption tests. The separation of small organic mols. of alkylphenones and alkylbenzenes was used to evaluate the performance of GO-MPS grafted monolith. The GO-MPS grafted monolith displayed the maximum column efficiency of 147,000 plates/m, about twice higher than the GO-free monolith. In addition, all of the retention and selectivity of small mols. of alkylphenones and alkylbenzenes increased due to the addition of GO-MPS. The use of DESs and RTILs is a powerful approach for the preparation of GO incorporated polymer monoliths. The monolith was further applied to the separation of tryptic digests from bovine serum albumin, and the result indicated its potential in the anal. of some complex samples. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Recommanded Product: 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole is incorporated into many important biological compounds. The most pervasive is the amino acid histidine, which has an imidazole side-chain. Histidine is present in many proteins and enzymes, e.g. by binding metal cofactors, as seen in hemoglobin.Recommanded Product: 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Three d¹⁰ coordination polymers assembled from 3,5-bis(imidazole-1-yl)pyridine and different polycarboxylates: Syntheses, structures and luminescence properties was written by Pan, Jie;Zhang, Di;Xue, Zhen-Zhen;Wei, Li;Han, Song-De;Wang, Guo-Ming. And the article was included in Solid State Sciences in 2017.Electric Literature of C11H9N5 The following contents are mentioned in the article:

Three novel Zn(II)/Cd(II) coordination polymers, [Cd₂(bip)₂(m-bdc)₂(H₂O)₂路3H₂O]_n (1), [Zn₂(bip)₂(p-bdc)₂路2.5H₂O]_n (2) and [Zn(bip) (p-bdc)路3H₂O]_n (3), where bip = 3,5-bis(imidazole-1-yl)pyridine, m-H₂bdc = 1,3-benzenedicarboxylic acid, p-H₂bdc = 1,4-benzenedicarboxylic acid, have been successfully synthesized under solvothermal conditions. The linkage of different ligands with Cd(II) ions in compound 1 affords a (3,5)-connected layer. Furthermore, 2D鈫?D parallel polycatenation occurs wherein the layers are polycatenated with the adjacent two parallel layers to form a 3D framework. In 2 and 3, the polycarboxylates act as pillars to combine the metal-bip chains, yielding the layered structures. These 2D networks are extended to the final 3D supramol. architectures by 蟺-蟺 stacking interactions. The results show that bip can act as a versatile building block for the construction of various coordination polymers. Moreover, the fluorescent properties of 1–3 in the solid state at room temperature have been investigated. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Electric Literature of C11H9N5).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Electric Literature of C11H9N5

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ligand based 3D-QSAR model, pharmacophore, molecular docking and ADME to identify potential fibroblast growth factor receptor 1 inhibitors was written by Huang, Lu;Wu, Xulong;Fu, Xiaoli;Wang, Haoxiang;Tang, Biao;Xiao, Yirong;Zhou, Caixia;Zhao, Zhiqiao;Wan, Yujun;Chen, Hui;Tang, Zizhong;Yao, Huipeng;Shan, Zhi;Bu, Tongliang. And the article was included in Journal of Biomolecular Structure and Dynamics in 2022.Application of 117976-90-6 The following contents are mentioned in the article:

The FGF/FGFR system may affect tumor cells and stromal microenvironment through autocrine and paracrine stimulation, thereby significantly promoting oncogene transformation and tumor growth. Abnormal expression of FGFR1 in cells is considered to be the main cause of tumorigenesis and a potential target for the treatment of cancer. In this study, a combination of structure-based drug carriers and mol. docking-based virtual screening was used to screen new potential FGFR1 inhibitors. Forty eight known inhibitors were collected to establish 3 D-QSAR models and pharmacophore models, investigate the relationship between the activity and conformation of compounds, and verify the efficiency of pharmacophore. In Accelrys Discovery Studio 2016, the ZINC database was filtered by Lipinski鈥瞫 Rule of Five and SMART鈥瞫 filtration. Then, Hypo01 was used for virtual screening of ZINC database. Compounds with predicted activity values less than 1 渭M were molecularly docked with FGFR1 protein crystals, the docking results were observed, and the interaction between compounds and targets was studied. The absorption, distribution, metabolism and excretion (ADME) and toxicity of potential inhibitors were studied, and a compound with new structural scaffolds were obtained. It could be further studied to explore their better therapeutic effects. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Application of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Prognostic impact of rapid reduction of involved free light chains in multiple myeloma patients under first-line treatment with Bendamustine, Prednisone, and Bortezomib (BPV) was written by Holzhey, Tanja;Poenisch, Wolfram;Wang, Song-Yau;Holzvogt, Madlen;Holzvogt, Bruno;Andrea, Marc;Zehrfeld, Thomas;Hammerschmidt, Doreen;Hoffmann, Franz Albert;Becker, Cornelia;Schwarzer, Andreas;Schwarz, Maik;Schoenfelder-Fricke, Uta;Edelmann, Thomas;Braunert, Leanthe;Franke, Georg-Nikolaus;Jentzsch, Madlen;Schwind, Sebastian;Bill, Markus;Grimm, Juliane;Remane, Yvonne;Platzbecker, Uwe;Scholz, Markus. And the article was included in Journal of Cancer Research and Clinical Oncology in 2021.Electric Literature of C16H21Cl2N3O2 The following contents are mentioned in the article:

Light chain involvement is observed in almost every patient (pt) with newly diagnosed multiple myeloma (MM). Owing to a relatively short half-life, rapid reduction in the involved free light chain (iFLC) is of potential prognostic value. This retrospective anal. included 92 pts with newly diagnosed MM treated with bendamustine, prednisone, and bortezomib (BPV). After a median number of two (range 1-5) BPV cycles, the majority of pts (n = 86; 93%) responded with either sCR (n = 21), CR (n = 1), nCR (n = 25), VGPR (n = 20), or PR (n = 19). PFS and OS at 48 mo were 39% and 67%, resp. At baseline, 79 out of 92 pts (86%) had iFLC levels above the upper standard level and an abnormal ratio of involved to uninvolved free light chain 鈮?8. In a subgroup anal. of these pts, we evaluated the prognostic importance of an early reduction of the iFLC during the first two BPV cycles. A reduction 鈮?50% of the iFLC on day 8 of the first cycle was observed in 31 of 69 pts. These pts had a significantly better median PFS of 49 mo as compared to 20 mo in 38 pts with a lower iFLC reduction (p = 0.002). In contrast, OS did not differ significantly with a 48 mo survival of 77% vs 69% (p > 0.05). These results indicate that a rapid decrease in the iFLC on day 8 is an early prognostic marker for newly diagnosed MM pts undergoing BPV treatment. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Electric Literature of C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Electric Literature of C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem