Month: November 2022

Enantioseparation and modelling study of six proton pump inhibitors on a novel 3, 5-dichloro-phenylcarbamated 尾-cyclodextrin chemically bonded chiral stationary phase by high performance liquid chromatography was written by Li, Meng;Jiang, Zhen;Guo, Xingjie;Di, Xin;Yu, Jia. And the article was included in Microchemical Journal in 2021.Application In Synthesis of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:

A fully substituted 尾-cyclodextrin derivative chem. bonded chiral stationary phase for high performance liquid chromatog., named MDCPC was prepared by linking 3, 5-dichloro-phenylcarbamated mono-6-ethylenediamine-尾-cyclodextrin to the surface of silica support. The as-prepared MDCPC was successfully characterized by SEM, fourier transform IR spectra, solid state NMR spectra, elemental anal. and thermogravimetric anal. The enantioselectivity of MDCPC was systematically evaluated by using proton pump inhibitors including omeprazole, lansoprazole, pantoprazole sodium, ilaprazole, rabeprazole sodium and tenatoprazole under the normal phase, polar organic phase, and reversed phase conditions. Effects of the mobile phase compositions and buffers on enantioseparation were investigated in different modes. As a result, MDCPC showed a better chromatog. performance in enantioselectivity, and all tested compounds were successfully enantiosepd. Findings of the mol. docking showed that hydrogen bonding, hydrophobic interaction and inclusion complexation played an important role in improving enantioselectivity. Addnl., good repeatability, column-to-column reproducibility and stability of MDCPC were observed by the study of chiral or achiral separation As a novel chiral stationary phase, MDCPC was supposed to be a promising prospect in the further anal. of chiral drugs. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Application In Synthesis of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has become an important synthon in the development of new drugs. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application In Synthesis of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Inverse Gas Chromatography: Effects of the Experimental Temperature and Molecular Structure on the Solubility Parameters of 1-Alkyl-3-methylimidazolium Hydrogen Sulfate ([C_nMIM][HSO₄], n = 4, 6, and 8) was written by Wang, Wenna;Wang, Qiang;Yu, Kaile. And the article was included in Journal of Chemical & Engineering Data in 2020.Product Details of 478935-29-4 The following contents are mentioned in the article:

Thermodn. parameters at infinite dilution for thirty-one organic solutes in a series of imidazolyl hydrogen sulfate ionic liquids (ILs) were determined by inverse gas chromatog. (IGC). The IGC characterization was carried out at temperatures ranging between 303.15 and 343.15 K for determining the Hildebrand solubility parameter (未₂) as well as the Flory-Huggins interaction parameter (蠂₁₂^{鈭?/sup>), the activity coefficient at infinite dilution (纬₁₂鈭?/sup>), and the thermodn. functions. In addition, based on the 纬₁₂鈭?/sup> results, the selectivity and capacity were directly calculated for two separation problems (hexane/benzene and hexane/thiophene). Under the different effects of the three ILs, it was found that the values of 蠂₁₂鈭?/sup> and 纬₁₂鈭?/sup> were significantly different for the solutes tested, but all the values follow a certain pattern: they increase with temperature or decrease with temperature As the temperature increased, the solubility parameters of the three ILs showed a linear decrease trend. The solubility parameters of the three ionic liquids at room temperature were obtained by extrapolation as 未_{2([BMIM][HSO4])} = 24.15 MPa1/2, 未_{2([HMIM][HSO4])} = 24.10 MPa1/2, and 未_{2([OMIM][HSO4])} = 23.66 MPa1/2. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Product Details of 478935-29-4).}

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Product Details of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Fabrication of pH-Responsive Hydrogel and Its In Vitro and In Vivo Evaluation was written by Tulain, Ume Ruqia;Ahmad, Mahmood;Rashid, Ayesha;Malik, Muhammad Zubair;Iqbal, Furqan Muhammad. And the article was included in Advances in Polymer Technology in 2018.Related Products of 117976-90-6 The following contents are mentioned in the article:

The present research work deals with the development of pH-responsive hydrogel by free radical polymerization in aqueous media to protect the rabeprazole sodium from acidic environment of stomach. Swelling behavior of hydrogels that was observed in buffer of various pH indicated highly pH-dependent swelling of hydrogels. Characterization of pH-responsive hydrogels by FTIR, SEM, and thermal anal. revealed that hydrogel has porous structure, favors swelling, drug loading, and drug release at a specific site in gastrointestinal tract and thermally more stable than parent polymer. In comparison with simple drug solution and hydrogel formulations, pharmacokinetic parameters of hydrogels formulations showed a significant difference in C_max values of (CMC-g-AA) CA and the same oral dose of rabeprazole sodium was 87.28 卤 12.671 and 61.263 卤 5.37 ng/mL, resp., T_max of graft copolymer matrixes CA (4.43 h) was significantly (P < 0.05) higher than drug solution (1 h) and area under curves (AUCs) for CA (952.25 卤 191 ng路/mL) was significantly (P < 0.05) higher than the drug solution (83.67 卤 8.28 ng路/mL) indicated the effect of dosage form would last for longer duration. Thus, in vitro and in vivo drug release studies of hydrogels proved their controlled release behavior with preferential delivery into alk. pH environment and for a prolonged period of time. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Related Products of 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Related Products of 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Durable remissions following combined targeted therapy in patients with CLL harboring TP53 deletions and/or mutations was written by Cramer, Paula;Tausch, Eugen;von Tresckow, Julia;Giza, Adam;Robrecht, Sandra;Schneider, Christof;Fuerstenau, Moritz;Langerbeins, Petra;Al-Sawaf, Othman;Pelzer, Benedikt W.;Fink, Anna Maria;Fischer, Kirsten;Wendtner, Clemens-Martin;Eichhorst, Barbara;Kneba, Michael;Stilgenbauer, Stephan;Hallek, Michael. And the article was included in Blood in 2021.Safety of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid The following contents are mentioned in the article:

Fifty-one of 189 evaluable patients from 3 prospective phase 2 trials evaluating a sequential targeted treatment had high-risk chronic lymphocytic leukemia (CLL) with a 17p deletion, TP53 mutation, or both. Twenty-seven patients started treatment with bendamustine debulking before induction and maintenance treatment, which was ibrutinib/ofatumumab (IO) in 21 patients, ibrutinib/obinutuzumab (IG) in 13, and venetoclax/obinutuzumab (AG) in 17. The primary end point was overall response rate after 8 mo of induction treatment, which was 81%, 100%, and 94% for IO, IG, and AG, resp. Minimal residual disease (MRD) was undetectable (uMRD) in peripheral blood (<10^-4 by flow cytometry) in 0%, 23%, and 82% of patients, resp. Median progression-free survival (PFS) was 45 mo. Seventeen patients discontinued maintenance treatment due to uMRD: 9 progressed, 2 died without progression (median PFS, 28 mo after discontinuation of treatment), and 6 remained in remission after a median observation time of 46 mo (range, 6-47 mo) after treatment discontinuation. Thus, MRD-guided fixed-duration therapies combining obinutuzumab with venetoclax or ibrutinib can induce deep and durable remissions in CLL patients with high-risk genetic lesions, which can persist after treatment discontinuation (due to a predefined fixed-duration or MRD-guided early termination). The median PFS was 45 mo. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Safety of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Safety of 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Viral Evolution and Immunology of SARS-CoV-2 in a Persistent Infection after Treatment with Rituximab was written by Van der Moeren, Nathalie;Selhorst, Philippe;Ha, My;Heireman, Laura;Van Gaal, Pieter-Jan;Breems, Dimitri;Meysman, Pieter;Laukens, Kris;Verstrepen, Walter;Van Gasse, Natasja;Ogunjimi, Benson;Arien, Kevin K.;Naesens, Reinout. And the article was included in Viruses in 2022.Formula: C16H21Cl2N3O2 The following contents are mentioned in the article:

Prolonged shedding of SARS-CoV-2 in immunocompromised patients has been described. Furthermore, an accumulation of mutations of the SARS-CoV-2 genome in these patients has been observed We describe the viral evolution, immunol. response and clin. course of a patient with a lymphoma in complete remission who had received therapy with rituximab and remained SARS-CoV-2 RT-qPCR pos. for 161 days. The patient remained hospitalised for 10 days, after which he fully recovered and remained asymptomatic. A progressive increase in Ct-value, coinciding with a progressive rise in lymphocyte count, was seen from day 137 onward. Culture of a nasopharyngeal swab on day 67 showed growth of SARS-CoV-2. Whole genome sequencing (WGS) demonstrated that the virus belonged to the wildtype SARS-CoV-2 clade 20B/GR, but rapidly accumulated a high number of mutations as well as deletions in the N-terminal domain of its spike protein. SARS-CoV-2 persistence in immunocompromised individuals has important clin. implications, but halting immunosuppressive therapy might result in a favorable clin. course. The long-term shedding of viable virus necessitates customized infection prevention measures in these individuals. The observed accelerated accumulation of mutations of the SARS-CoV-2 genome in these patients might facilitate the origin of new VOCs that might subsequently spread in the general community. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Formula: C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Formula: C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

X-ray diffraction studies of electrochemical graphite intercalation compounds of ionic liquids was written by Sutto, Thomas E.;Duncan, Teresa T.;Wong, Tiffany C.. And the article was included in Electrochimica Acta in 2009.Reference of 157310-73-1 The following contents are mentioned in the article:

Electrochem. intercalation studies are used to characterize ionic liquids composed of a variety of cationic and anionic species. Electrochem., the ionic liquids are characterized by cyclic voltammograms and charge-discharge experiments for the intercalation and de-intercalation of the various cationic and anionic species into graphite. X-ray structure anal. is also performed to determine the relation between the electrochem. behavior of the ionic liquids, and the formation of intercalated graphitic compounds Two different types of imidazolium cations are studied, specifically the di- and trisubstituted imidazolium. These cations are paired with the following anions: tetrafluoroborate, hexafluorophosphate, bis(trifluoromethanesulfonyl)imide, bis(perfluoroethanesulfonyl)imide, nitrate and H sulfate. Results indicate stronger intercalation chem. for the trisubstituted imidazoliums, correlating with the greater charge-discharge efficiencies found for these types of ionic liquids Many of the anions exhibit very poor charge-discharge efficiencies, correlating to very poorly formed graphite intercalates. The exception to this is the H sulfate intercalate, which had low charge-discharge efficiencies but formed a well defined graphite intercalate. Only the imide based anions exhibited both high charge-discharge efficiencies and the formation of a clearly defined graphite intercalate. This study involved multiple reactions and reactants, such as 1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1Reference of 157310-73-1).

1,2-Dimethyl-3-propyl-1H-imidazol-3-ium hexafluorophosphate(V) (cas: 157310-73-1) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Reference of 157310-73-1

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Stereoselective pharmacokinetics of (R)-(+)- and (S)-(-)-rabeprazole in human using chiral LC-MS/MS after administration of rabeprazole sodium enteric-coated tablet was written by Sun, Lu-Ning;Shen, Yi-Wen;Ying, Yu-Wen;Li, Duo;Li, Teng-Fei;Zhang, Xue-Hui;Zhao, Ping;Ding, Li;Wang, Yong-Qing. And the article was included in Chirality in 2018.Recommanded Product: 117976-90-6 The following contents are mentioned in the article:

Rabeprazole is an effective proton pump inhibitor to treat acid-related diseases. To achieve the simultaneous determination of rabeprazole enantiomers in human plasma, a chiral LC-MS/MS method was developed and validated. Acetonitrile including 0.1% ammonium were used as protein precipitating agent. Analytes were separated within 8 min on a Chiralpak IC column (4.6 mm 脳 150 mm, 5 渭m). The mobile phase was 10 mM ammonium acetate including 0.2% acetic acid-acetonitrile (35:65, volume/volume). An API 4000 mass spectrometer was used as detector for the anal., and the multiple reactions monitoring transitions of m/z 360.1 鈫?242.2 and 346.1 鈫?198.1 were opted for quantifying rabeprazole enantiomers and internal standard Matrix effects were not apparent for each enantiomer and internal standard (esomeprazole), the calibration curves were linear over the concentration of 0.500 to 400 ng路mL^-1, the intra-run precisions were below 5.4%, the inter-run precisions were below 9.9%, and the accuracy was between -9.2% and 9.3%. There was no chiral inversion observed during sample storage, preparation procedure, and anal., demonstrating that analytes were stable in this study. This method was applied to the stereoselective pharmacokinetic study of (R)-(+)- and (S)-(-)-rabeprazole after oral administration of 10-mg rabeprazole sodium enteric-coated tablet in healthy Chinese subjects. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Recommanded Product: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Recommanded Product: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Proton Pump Inhibitors and Bone Health: An Update Narrative Review was written by Lespessailles, Eric;Toumi, Hechmi. And the article was included in International Journal of Molecular Sciences in 2022.Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:

Proton pump inhibitors (PPIs) are an antacid drug often used in acid-related disorders. They decrease acid secretion in the stomach by blocking an enzyme called H+/K+ ATPase which controls acid production Introduced to the market in 1989, their use has increased rapidly worldwide and they are now among the top 10 most prescribed drugs in the United States. As of 2015, the FDA has already approved six drugs of this class (omeprazole, esomeprazole, lansoprazole, dexlansoprazole, pantoprazole and rabeprazole). Recently, the risks and benefits of long-term PPI use were questioned and many studies indicated that their use should be carefully considered, especially in young patients, whose treatment with these drugs could last many years. Even greater concerns have been raised about a potential pos. association between PPIs and osteoporotic fracture risk including the hip, spine and wrist. Although based on observational studies, there is substantial evidence associating the long-term use of PPIs and fracture. This relationship is only partially admitted due to the lack of consistent effects of PPIs on bone mineral d. loss. Therefore, this narrative review aimed to discuss the recent findings pertaining to the risk of osteoporotic fracture associated with PPIs, in particular prolonged use, and to call for further research to elucidate the mechanisms associated with this bone fragility. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3鈥揅6) is higher than in water and generally decreases with a Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Recommanded Product: Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Impact of rituximab on COVID-19 outcomes was written by Levavi, Hannah;Lancman, Guido;Gabrilove, Janice. And the article was included in Annals of Hematology in 2021.Reference of 16506-27-7 The following contents are mentioned in the article:

Rituximab is associated with prolonged B-cell depletion and secondary hypogammaglobulinemia and is associated with a dampened humoral response and increased infectious complications. To describe the potential impact of prior rituximab therapy on clin. outcomes from SARS-CoV-2 infection and development of COVID-19 antibodies, we conducted a retrospective study of adults across the Mount Sinai Health System diagnosed with COVID-19 who received rituximab for any indication from Feb. 2019 to Oct. 2020. Patients’ baseline characteristics, markers of disease severity, clin. outcomes, and antibody development were examined Of the 49 patients included in the anal., 63.2% required hospitalization for COVID-19, 24.5% required an ICU admission, and 32.7% died. Proximity of last rituximab infusion and COVID-19 diagnosis did not affect rates of hospitalization, admission to intensive care units or death. Over half (51.7%) of those whose antibodies were checked developed neutralizing anti-spike protein antibodies. The median time between rituximab administration and COVID-19 diagnosis was not significantly different between those who developed antibodies and those who did not (p = .323). Of the 14 patients with documented neg. COVID-19 antibody titers, 11 of them survived SARS-CoV-2 infection, indicating that development of neutralizing antibodies may not be necessary for recovery from COVID-19. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Reference of 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. The pharmacophore of imidazole exists in bioactive compounds including amino acids, plant growth regulators and therapeutic agents.n increase of the alkyl chain length of the alcohols. Reference of 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Synthesis of dimethyl succinate catalyzed by ionic liquids was written by Zhao, Dishun;Liu, Mengshuai;Xu, Zhice;Zhang, Juan;Zhang, Di;Fu, Jiangtao;Ren, Peibing. And the article was included in Huagong Xuebao (Chinese Edition) in 2012.Electric Literature of C10H20N2O4S The following contents are mentioned in the article:

Seven kinds of ionic liquids, 1-hexyl-3-methylimidazolium hydrogensulfate ([Hmim]HSO₄), 1-butyl-3-methylimidazolium dihydrogen phosphate ([Bmim]H₂PO₄), 1-butyl-3-methylimidazolium hydrogen sulfate ([Bmim]HSO₄), 1-butyl-3-methylimidazolium tetrafluoroborate ([Bmim]BF₄), 1-butylpyridinium hydrogen sulfate ([Bpy]HSO₄), 1-butylpyridinium dihydrogen phosphate ([Bpy]H₂PO₄), 1-ethylpyridinium hydrogen sulfate ([Epy]HSO₄), were designed and synthesized. The synthesis of di-Me succinate catalyzed by ionic liquids was studied for the first time. It was shown that [Epy]HSO₄ had the best catalytic performance, and optimal conditions for the synthesis of di-Me succinate were obtained, succinic acid and methanol molar ratio 1 : 3.0, amount of catalyst 5% (g/g) of succinic acid, reaction temperature 70掳C and reaction time 2 h. Under the optimal conditions, the yield of di-Me succinate was up to 91.83%, esterification rate was 96.32%. The catalyst was recycled 7 times without substantial decrease in activity. Moreover, compared to conventional industrial catalysts, ionic liquid catalyst had the superiority of smaller catalyst dosage, less byproduct, mild reaction conditions, high yield, and recycled catalyst usage. Finally, the mechanism of esterification catalyzed by ionic liquids was discussed. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Electric Literature of C10H20N2O4S).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Electric Literature of C10H20N2O4S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem