Month: November 2022

Comparative in vitro drug release examination of dissimilar brands of Rabeprazole sodium gastro-resistant tablets was written by Yarra, Shravani;Abdul ahad, Hindustan;Haranath, Chinthaginjala;Musa, Gamaa birir mohamed;Adam, Adam ali omer;Reddy, Kethari rushiketh. And the article was included in International Journal of Life Science and Pharma Research in 2020.Synthetic Route of C18H20N3NaO3S The following contents are mentioned in the article:

The present work was aimed to test the relative physicochem. and in vitro drug release properties of some popular enteric coated brands of Rabeprazole sodium tablets marketed in India. The generic drugs should accept challenges on par with patent innovative drug mols. in the in vitro evaluation parameters. Six different Indian brands of Rabeprazole sodium tablets (marketed in India) with a strength of 20 mg were purchased from the market and they were judged for uniformity of weight, thickness, diameter, hardness, disintegration time, drug content, and in vitro release. The disintegration time and in-vitro drug release studies were examined in 0.1M HCl (for 2h) and buffer solution of pH 6.8 (till drug dissolves). The evaluated brands of the Rabeprazole sodium tablets passed all the tests conducted as per the pharmacopoeial standards and comply in all the parameters. All the brands represented their resistance to disintegrate/dissolve the stomach environment (2h) and disintegrate/dissolve in the intestinal environment (within 1h). The dissolution summary revealed that the Rabeprazole sodium tablet brand (RST-1) was faster while Rabeprazole sodium tablet brand (RST-2) was slower, and the remaining brands of Rabeprazole sodium showed identical results. The authors conclude from the study that all the brands evaluated for all physicochem. constraints including in vitro dissolution are satisfactory and identical with each other, and patients can take any of these brands as prescribed by the physician. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Synthetic Route of C18H20N3NaO3S).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division.Synthetic Route of C18H20N3NaO3S

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Experimental and theoretical study of bifunctional electro-catalysts constructed from different Polyoxometalates and Ag-bimpy segments was written by Zheng, Yanping;Zhou, Wanli;Liu, Xuekun;Yuan, Gang;Peng, Jun. And the article was included in Electrochimica Acta in 2021.Application of 1374155-84-6 The following contents are mentioned in the article:

In this work, upon subtle POMs variation, we reported on the assembly and performances of three new bimetallic component organic-inorganic hybrids, [Ag₂(bimpy)(V^V₂O₆)](1), [Ag₃(bimpy)₂(β-Mo^VI₈O₂₆)](2), [Ag₄(bimpy)₂(H₂O)₂(α-SiW^VI₁₂O₄₀)]â€?H₂O (3) (bimpy = 3,5-bis(1-imidazoly) pyridine). Compound 1 with 3D framework structure is featured by {-V-O-V-}n helical chains, {Ag₃} clusters and {bimpy-Ag-bimpy} units. Compound 2 has a 3,3,6,6-connected 3D architecture with the (4³)(4³)(4²â€?⁹â€?â€?³)(4⁶â€?²â€?⁴â€?â€?²) topol. Compound 3 has a 3,3,4-connected 2D layer with (6²â€?)(6²â€?)(6⁶) topol. The electrochem. and bifunctional electro-catalytic activities of three compounds have been conducted. The exptl. results show that β-[Mo₈O₂₆]^4- hybrid displays better electrocatalytic performance than [V₂O₆]^2- and Keggin-type hybrids for reduction of nitrite, while [V₂O₆]^2- hybrid exhibits better electrocatalytic activity than β-[Mo₈O₂₆]^4- and Keggin hybrids towards oxidations of ascorbic acid. Furthermore, the mol. electrostatic potential and frontier MO were performed. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Application of 1374155-84-6).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Application of 1374155-84-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Therapy of gastroesophageal reflux disease and functional dyspepsia overlaps with symptoms after usual-dose proton pump inhibitor: Acotiamide plus usual-dose proton pump inhibitor versus double-dose proton pump inhibitor was written by Takeuchi, Toshihisa;Takahashi, Yoshiaki;Kawaguchi, Shinpei;Ota, Kazuhiro;Harada, Satoshi;Kojima, Yuichi;Sakamoto, Hiroki;Kuramoto, Takanori;Kojima, Keishi;Sanomura, Makoto;Hoshimoto, Masahiro;Higashino, Takeshi;Itabashi, Tsukasa;Takada, Ko;Sakaguchi, Masahiro;Tominaga, Kazunari;Kusano, Motoyasu;Higuchi, Kazuhide. And the article was included in Journal of Gastroenterology and Hepatology in 2018.Safety of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide The following contents are mentioned in the article:

Background and Aim : Gastroesophageal reflux disease (GERD) and functional dyspepsia (FD) often coexist or overlap. In this study, the efficacy of acotiamide in combination with a standard dose of rabeprazole for GERD and FD was compared with that of a double dose of rabeprazole. Methods : Patients with overlap between GERD and FD experiencing heartburn and epigastric fullness symptoms after standard-dose proton pump inhibitor (PPI) for �8 wk were randomized into two groups and received either acotiamide 300 mg/day + rabeprazole 10 mg/day or rabeprazole 20 mg/day for 4 wk. Efficacy was assessed by reductions in symptom scores using the Izumo scale questionnaire and modified F-scale questionnaire. Results : As the primary endpoint, three upper gastrointestinal symptoms (heartburn, epigastralgia, and epigastric fullness) were reduced by �50% in 40.8% and 46.9% of patients in the combination and PPI double-dose groups, resp., with no significant difference between the two groups. Essentially similar results were obtained for the modified F-scale questionnaire. No serious adverse events were noted. Conclusions : Acotiamide 300 mg/day in combination with rabeprazole 10 mg/day or rabeprazole 20 mg/day relieved symptoms in patients with overlap between GERD and FD experiencing heartburn and epigastric fullness symptoms after standard-dose PPI for �8 wk, and the efficacies did not differ between the two treatments. The combination therapy may be an alternative option for persistent symptoms in these patients. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Safety of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. The solubility of imidazoles in ethers is lower than that in alcohols and decreases with increasing chain length of the ethers . In contrast, the solubility of benzimidazoles in alcohols (C3–C6) is higher than in water and generally decreases with a Imidazole also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes.Safety of Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Influence of rabeprazole and famotidine on pharmacodynamic profile of dual antiplatelet therapy in clopidogrel-sensitive patients: The randomized, prospective, PROTECT trial was written by Ahn, Jong-Hwa;Park, Yongwhi;Bae, Jae Seok;Jang, Jeong Yoon;Kim, Kye-Hwan;Kang, Min Gyu;Koh, Jin-Sin;Park, Jeong Rang;Hwang, Seok-Jae;Kwak, Choong Hwan;Hwang, Jin-Yong;Jeong, Young-Hoon. And the article was included in Platelets in 2020.SDS of cas: 117976-90-6 The following contents are mentioned in the article:

Although acid suppressants are needed to attenuate gastrointestinal bleeding (GIB) after percutaneous coronary intervention (PCI), pharmacodynamic interaction between clopidogrel and proton pump inhibitor (PPI) can increase the risk of high platelet reactivity (HPR). We sought to evaluate serial changes of platelet measures and influence of rabeprazole on platelet measures. After 600-mg clopidogrel loading for elective PCI, clopidogrel-sensitive patients were recruited and randomly assigned to add rabeprazole of daily 20 mg (n = 40) or famotidine of daily 40 mg (n = 40). Platelet measures were performed with light transmittance aggregometry and VASP-P assay. Primary endpoint was 5 μM ADP-induced platelet aggregation (PA) at 30-day follow-up. HPR was defined as 5 μM ADP-induced PA > 46%. Baseline platelet measures did not differ significantly between the groups. The 30-day level of 5 μM ADP-induced PA was similar between the famotidine vs. rabeprazole group (30.0 ± 16.4% vs. 30.2 ± 13.9%, P= .956). In addition, other platelet measures were comparable between the groups. At 30-day follow-up, the incidence of HPR was similar between the famotidine and rabeprazole groups (20.5% vs. 15.4%; P= .555). In conclusion, adjunctive use of rabeprazole showed the similar antiplatelet effect even in clopidogrel-sensitive patients compared with adjunctive famotidine, which may support the similar effect of rabeprazole and famotidine on the antiplatelet effect of dual antiplatelet therapy with clopidogrel plus aspirin. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6SDS of cas: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).SDS of cas: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The efficient hydroxyalkylation of phenol with formaldehyde to bisphenol F over a thermoregulated phase-separable reaction system containing a water-soluble Bronsted acidic ionic liquid was written by Wang, Qing;Wu, Zhi Min;Li, Yongfei;Tan, Ying;Liu, Ning;Liu, Yuejin. And the article was included in RSC Advances in 2014.Product Details of 478935-29-4 The following contents are mentioned in the article:

The efficient hydroxyalkylation of phenol with formaldehyde to bisphenol F over a thermoregulated phase-separable reaction system containing a water-soluble Bronsted acidic ionic liquid(IL) was studied. The reaction system containing the water-soluble IL showed thermoregulated biphasic behavior with change of the alkyl chain length of IL, temperature and water amount. Four types of imidazolium-, ammonium-, phosphonium- and pyridinium-based water-soluble ionic liquids with different anions of dihydrogen phosphate [H₂PO₄]^–, acetate [CH₃COO]^– and hydrogen sulfate [HSO₄]^– were used as both Bronsted acidic catalysts and thermoregulated solvents. Among them, [C₆MIM][HSO₄] gave a high yield of 80.5% and a selectivity of 96.9% for bisphenol F, and the optimal reaction conditions were stirring speed 450 rpm, phenol-formaldehyde ratio 6 : 1, IL catalyst molar concentration 12.5%, reaction temperature 90 ° and reaction time 1 h. [C₆MIM][HSO₄] could be recovered by simple decantation and could retain its original activity even after six recycling-uses [C_nMIM][HSO₄] with the alkyl chain length n = 6 found to be the most suitable for the synthesis of bisphenol F because of both the formation of a thermoregulated monophasic reaction system at 90 °C to enhance the reaction efficiency and as a thermoregulated phase-transition solvent to facilitate its recovery from the reaction system. This study involved multiple reactions and reactants, such as 1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4Product Details of 478935-29-4).

1-Hexyl-3-methyl-1H-imidazol-3-ium hydrogensulfate (cas: 478935-29-4) belongs to imidazole derivatives. Many natural products, especially alkaloids, contain the imidazole ring. These imidazoles share the 1,3-C3N2 ring but feature varied substituents. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Product Details of 478935-29-4

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Rational design of three bifunctional MOFs for photocatalysis degradation and selective adsorption of wastewater organic dyes removal was written by Zhang, Xiaoyin;Zong, Ziao;Zhang, Xia;Zhang, Dongmei;Luo, Qingdan;Bi, Caifeng;Fan, Yuhua. And the article was included in Polyhedron in 2020.Application of 1374155-84-6 The following contents are mentioned in the article:

Three metal-organic frameworks (MOFs) based on transition metals, namely {[Cd(HL)(tib)(H₂O)]·1.5H₂O}_n (1), {[Co₃(L)₂(tib)₂]·4H₂O}_n (2), [Cu(L)(3,5-bibp)]_n (3) (H₃L = 4-(3,5-dicarboxylatobenzyloxy)benzoic, tib = 1,3,5-tris(1-imidazolyl)benzene and 4,4′-bibp = 4,4′-bis(imidazol-1-yl)biphenyl) were designed and successfully synthesized under solvothermal conditions. These three compounds were characterized by single crystal X-ray diffraction, elemental anal., IR spectra, powder X-ray diffraction (PXRD), TGA(TGA) and electrochem. studies. Single crystal X-ray diffraction anal. reveals that compound 1 possesses a 2-nodal (3,5)-connected hms topol. framework with the point symbol (6³·6^9.8), compound 2 unprecedented 3-nodal (8,8,11)-connected 3D framework with a (3⁷·4¹²·5⁹) (3⁸·4¹³·5⁷) (3⁹·4¹⁹·5²³·6⁴) topol., while compound 3 displays a 3D 4-connected sql topol. The electrochem. studies for compound 2 and 3 are discussed. Photocatalytic degradation and adsorption for organic dyes removal from wastewater using three compounds were studied. Significantly, all of the three compounds show good photocatalytic activities for MB and selective adsorption capacity for CR. This study involved multiple reactions and reactants, such as 3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6Application of 1374155-84-6).

3,5-Di(1H-imidazol-1-yl)pyridine (cas: 1374155-84-6) belongs to imidazole derivatives. 1H-imidazole is an imidazole tautomer which has the migrating hydrogen at position 1. It is a conjugate base of an imidazolium cation. It is a conjugate acid of an imidazolide. It is a tautomer of a 4H-imidazole. This ring system is present in important biological building blocks, such as histidine and the related hormone histamine.Application of 1374155-84-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

The protective effect of rabeprazole on cisplatin-induced apoptosis and necroptosis of renal proximal tubular cells was written by Chen, Shi-qing;Hu, Bing-feng;Yang, Ya-ru;He, Yuan;Yue, Lin;Guo, Dong;Wu, Ting-ni;Feng, Xiao-wen;Li, Qing;Zhang, Wei;Wen, Jia-gen. And the article was included in Biochemical and Biophysical Research Communications in 2022.Recommanded Product: 117976-90-6 The following contents are mentioned in the article:

Nephrotoxicity is a major adverse reaction of cisplatin-based chemotherapy. Organic cation transporter 2 (OCT2) which is located on the basement membrane of human proximal renal tubules is responsible for the renal accumulation of cisplatin and its nephrotoxicity. This study aimed to investigate the protective effect of PPIs to CP-induced nephrotoxicity. Three kinds of PPIs including lansoprazole, omeprazole and rabeprazole (Rab) were co-administrated with CP to mice. In addition, OCT2-overexpressed HEK293, HK-2 and A549 cells were co-incubated with CP and PPIs. The results showed that PPIs can attenuate CP-induced increase of CRE, BUN and histol. damage of kidney. Among the three PPIs, Rab was found with a superior protective effect. It significantly reduced the accumulation of CP in OCT2-overexpressed HEK293 cells and in the renal cortex tissues of mice, but not in HK-2 cells. Moreover, Rab reduced the expression levels of cleaved-caspase-3, RIPK1, RIPK3, MLKL and p-MLKL and the apoptosis rate of renal tubular cells induced by CP in vivo, but not in HK-2 cells. However, Rab increased the viability of CP-treated cells in a concentration-dependent manner and attenuated CP-induced apoptosis and necroptosis in OCT2 over-expressed HEK293 cells. Finally, we demonstrated that Rab have no influence on the antitumor effect of CP. In conclusion, Rab attenuate CP-induced nephrotoxicity mainly through inhibiting OCT2-mediated CP uptake, without interfering with its anti-tumor property of inducing apoptosis and necroptosis. This study involved multiple reactions and reactants, such as Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6Recommanded Product: 117976-90-6).

Sodium 2-(((4-(3-methoxypropoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide (cas: 117976-90-6) belongs to imidazole derivatives. Imidazole derivatives generally have good solubility in protic solvents. Simple imidazole derivatives, such as 1H-imidazole, 2-methyl-1H-imidazole, and 1,2-dimethylimidazole, have very high solubility in water. Imidazole has been usedin the lysis, wash and elution buffer for the purification of histidine tagged Sonic Hedgehog(shh-N) protein, in elution buffer in stepwise gradient for the purification of histidine tagged aldo keto reductases using nickel affinity chromatography, as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells.Recommanded Product: 117976-90-6

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Carfilzomib, bendamustine, and dexamethasone in patients with advanced multiple myeloma: The EMN09 phase 1/2 study of the European Myeloma Network was written by Gay, Francesca;Guenther, Andreas;Offidani, Massimo;Engelhardt, Monika;Salvini, Marco;Montefusco, Vittorio;Patriarca, Francesca;Aquino, Sara;Ponisch, Wolfram;Spada, Stefano;Schub, Natalie;Gentili, Silvia;Wasch, Ralph;Corradini, Paolo;Straka, Christian;Palumbo, Antonio;Einsele, Hermann;Boccadoro, Mario;Sonneveld, Pieter;Gramatzki, Martin. And the article was included in Cancer (Hoboken, NJ, United States) in 2021.Computed Properties of C16H21Cl2N3O2 The following contents are mentioned in the article:

Combined therapy with carfilzomib, bendamustine, and dexamethasone was evaluated in this multicenter phase 1/2 trial conducted within the European Myeloma Network (EMN09 trial). Sixty-three patients with relapsed/refractory multiple myeloma who had received ≥2 lines of prior therapy were included. The phase 1 portion of the study determined the maximum tolerated dose of carfilzomib with bendamustine set at 70 mg/m² on days 1 and 8. After 8 cycles, responding patients received maintenance therapy with carfilzomib and dexamethasone until progression. On the basis of the phase 1 results, the recommended phase 2 dose for carfilzomib was 27 mg/m² twice weekly in weeks 1, 2, and 3. Fifty-two percent of patients achieved a partial response or better, and 32% reached a very good partial response or better. The clin. benefit rate was 93%. After a median follow-up of 21.9 mo, the median progression-free survival was 11.6 mo, and the median overall survival was 30.4 mo. The reported grade ≥3 hematol. adverse events (AEs) were lymphopenia (29%), neutropenia (25%), and thrombocytopenia (22%). The main nonhematol. grade ≥3 AEs were pneumonia, thromboembolic events (10%), cardiac AEs (8%), and hypertension (2%). In heavily pretreated patients who have relapsed/refractory multiple myeloma, combined carfilzomib, bendamustine, and dexamethasone is an effective treatment option administered in the outpatient setting. Infection prophylaxis and attention to patients with cardiovascular predisposition are required. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Computed Properties of C16H21Cl2N3O2).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).Computed Properties of C16H21Cl2N3O2

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Long-term outcomes of elderly hairy cell leukemia patients treated with cladribine was written by Hermel, David J.;Cheng, Brian;Bhangoo, Munveer S.;Burian, Carol;Waalen, Jill;Saven, Alan. And the article was included in Annals of Hematology in 2022.Application of 16506-27-7 The following contents are mentioned in the article:

Hairy cell leukemia (HCL) is a rare hematol. disorder characterized by pancytopenia and splenomegaly for which a single course of cladribine is highly effective in inducing complete remissions. However, there is limited real-world data on outcomes and complications among geriatric patients with HCL treated with cladribine. We conducted a retrospective review of all patients 70 years or older within the Scripps Clinic HCL Database at the time of first treatment with cladribine. Of the 45 patients meeting inclusion criteria, 32 (71%) achieved CR and 4 (9%) achieved PR. Of the 9 remaining patients, 7 achieved normalization of peripheral blood counts after a single course of cladribine (complete hematol. response, CHR) and 2 had no response. The median duration of response for all responders was 119 mo. Nine (20%) patients relapsed with a median time to first relapse of 28 mo. Ten patients subsequently developed 12 primary malignancies with an excess frequency (observed-to-expected ratio) of 0.85 (95% confidence interval, 0.48-1.49). Median overall survival for the entire cohort was 166 mo from time of HCL diagnosis and 119 mo from time of first cladribine administration. Forty patient deaths were observed; the standardized mortality ratio (observed-to-expected ratio) was 1.42 (95% confidence interval, 1.03-1.96), representing a statistically significant increase in the risk of death (P = .03). This study supports the high rate of complete and durable responses following a single course of cladribine in geriatric patients. This study involved multiple reactions and reactants, such as 4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7Application of 16506-27-7).

4-(5-(Bis(2-chloroethyl)amino)-1-methyl-1H-benzo[d]imidazol-2-yl)butanoic acid (cas: 16506-27-7) belongs to imidazole derivatives. Imidazole is the basic core of some natural products such as histidine, purine, histamine and DNA based structures, etc. Among the different heterocyclic compounds, imidazole is better known due to its broad range of chemical and biological properties. Many drugs contain an imidazole ring, such as certain antifungal drugs, the nitroimidazole series of antibiotics, and the sedative midazolam.Application of 16506-27-7

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem