Month: November 2022

Zhang, Gaopeng published the artcilePalladium-catalyzed allylic alkylation reaction of α-substituted benzyl nitriles with branched allyl carbonates, Application In Synthesis of 258278-25-0, the publication is Youji Huaxue (2020), 40(10), 3399-3409, database is CAplus.

Pd-catalyzed allylic alkylation reaction of α-substituted benzyl nitriles with branched allyl carbonates in the presence of bulkier N-heterocyclic carbene ligand was reported, which provided the corresponding allylated products in good yield with high regio- and diastereo-selectivity.

Youji Huaxue published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C15H24O2, Application In Synthesis of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhang, Zeyu published the artcileSynthesis of renewable soybean protein and acrylate copolymers via ATRP in ionic liquid, COA of Formula: C8H15ClN2, the publication is Industrial Crops and Products (2022), 114720, database is CAplus.

In this paper, acrylate and glycidyl methacrylate (GMA) were grafted onto the main chain of soy protein isolate (SPI) in 1-butyl-2,3-dimethylimidazole chloride ionic liquid ([BDMIM][Cl]), to prepare a renewable soy protein graft copolymer via atom transfer radical polymerization (ATRP). The effect of unfolding degree of soy protein structure on pretreated SPI was studied via Fourier-transform IR spectroscopy (FT-IR), hydrogen NMR spectroscopy (¹ H NMR), surface tension (ST) and contact angle (CA) measurements. The results of FT-IR, ¹ H NMR and energy dispersive spectrometry (EDS) indicated the successful synthesis of 2-bromoisobutyryl-functionalized SPI. The anal. of FT-IR and ¹H NMR spectra showed that the soybean protein graft copolymer was successfully synthesized. In addition, the grafting of acrylate onto soybean protein enhanced the hydrophobicity of the copolymer, and the static contact angle was above 90°. Differential scanning calorimetry (DSC) anal. revealed that the thermal stability of pretreated SPI was reduced. The new glass transition temperature in the copolymers also proved the successful synthesis of the copolymers. The tensile strength of the carbon fiber multifilament infiltrated with the copolymers was improved, indicating their potential application in the reinforcement of carbon fiber material.

Industrial Crops and Products published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C11H7ClFNO3, COA of Formula: C8H15ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Jiangjun published the artcileNickel-Catalyzed Intramolecular Desulfitative C-N Coupling: A Synthesis of Aromatic Amines, Synthetic Route of 258278-25-0, the publication is Journal of Organic Chemistry (2020), 85(8), 5702-5711, database is CAplus and MEDLINE.

A nickel-catalyzed intramol. C-N coupling reaction via SO₂ extrusion was presented. The use of a catalytic amount of BPh₃ allowed the transformation to take place under much milder conditions (60°C) than previously reported C-N coupling reactions by CO or CO₂ extrusion (160-180°C). In addition, this method displayed good functional group tolerance and versatility, as it can be applied to the synthesis of dialkyl aryl amines, alkyl diaryl amines and triaryl amines. The robustness of the desulfitative C-N coupling was demonstrated by three high-yielding gram-scale reactions.

Journal of Organic Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Synthetic Route of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhao, Chao-Yang published the artcilePd-Catalyzed Redox Divergent Coupling of Ketones with Terpenols, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is ACS Catalysis (2021), 11(12), 6825-6834, database is CAplus.

A Pd-catalyzed redox divergent coupling of ketones e.g., 6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one with terpenols like trans-geraniol, (E,E)-farnesyl alc. and (E)-phytol has been developed to access α-substituted ketones, e.g., 6-isopentyl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-5-one with varying degrees of unsaturation The control of oxidation states of the product is facilitated by employing different additives. With the aid of BnOH as an external hydrogen source, a reductive coupling pathway is thermodynamically favored. The use of LiBr as the additive will reduce the reactivity of Pd-H to divert the selectivity toward α,β-unsaturated ketones. By switching the solvent from toluene to chlorobenzene, the active species Pd-H will be fully quenched to enable oxidative coupling. Gram-scale reaction with lower catalyst loading (0.5 mol%) was also accomplished to highlight the practicability of this protocol. Furthermore, detailed exptl. studies were carried out to elucidate the reaction mechanism and the factors enabling manipulation of the redox selectivity. This redox divergent coupling protocol provides an important complement for known precedents on Tsuji-Trost allylation of ketones.

ACS Catalysis published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C10H11FN2O2S, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kam, Nadine Wong Shi published the artcileNanotube molecular transporters: internalization of carbon nanotube-protein conjugates into mammalian cells, Formula: C18H34N4O5S, the publication is Journal of the American Chemical Society (2004), 126(22), 6850-6851, database is CAplus and MEDLINE.

The interactions between various functionalized carbon nanotubes and several types of human cancer cells are explored. We have prepared modified nanotubes and have shown that these can be derivatized in a way that enables attachment of small mols. and of proteins, the latter through a novel noncovalent association The functionalized carbon nanotubes enter nonadherent human cancer cells as well as adherent cell lines (CHO and 3T3) and by themselves are not toxic. While the fluoresceinated protein streptavidin (MW ≈ 60 kD) by itself does not enter cells, it readily enters cells when complexed to a nanotube-biotin transporter and exhibits dose-dependent cytotoxicity. The uptake pathway is consistent with adsorption-mediated endocytosis. The use of carbon nanotubes as mol. transporters could be exploited for various cargos. The biocompatibility and unique phys., elec., optical, and mech. properties of nanotubes provide the basis for new classes of materials for drug, protein, and gene delivery applications.

Journal of the American Chemical Society published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Madsen, Christian published the artcile5-Substituted Imidazole-4-acetic Acid Analogues: Synthesis, Modeling, and Pharmacological Characterization of a Series of Novel γ-Aminobutyric Acid_C Receptor Agonists, Synthetic Route of 45533-87-7, the publication is Journal of Medicinal Chemistry (2007), 50(17), 4147-4161, database is CAplus and MEDLINE.

A series of ring-substituted analogs of imidazole-4-acetic acid (IAA), a partial agonist at both GABA_A and GABA_C receptors (GABA = γ-aminobutyric acid), have been synthesized. The synthesized compounds, e.g. I·HCl, have been evaluated as ligands for the α₁β₂γ_2S GABA_A receptors and the ρ₁ GABA_C receptors using the FLIPR membrane potential (FMP) assay and by electrophysiol. techniques. None of the tested compounds displayed activity at the GABA_A receptors at concentrations up to 1000 μM. However, the 5-Me, 5-Ph, 5-p-Me-Ph, and 5-p-F-Ph IAA analogs, displayed full agonist activities at the ρ₁ receptors in the FMP assay (EC₅₀ in the range 22-420 μM). Ligand-protein docking identified the Thr129 in the α₁ subunit and the corresponding Ser168 residue in ρ₁ as determinants of the selectivity displayed by the 5-substituted IAA analogs. The fact that GABA, IAA, and I·HCl displayed decreased agonist potencies at a ρ₁Ser168Thr mutant compared to the WT ρ₁ receptor strongly supported this hypothesis. However, in contrast to GABA and IAA, which exhibited increased agonist potencies at a α₁(Thr129Ser)β₂γ₂ mutant compared to WT GABA_A receptor, the data obtained for I·HCl at the WT and mutant receptors were nonconclusive.

Journal of Medicinal Chemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Synthetic Route of 45533-87-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Dolgosheina, Elena V. published the artcileRNA Mango Aptamer-Fluorophore: A Bright, High-Affinity Complex for RNA Labeling and Tracking, Formula: C18H34N4O5S, the publication is ACS Chemical Biology (2014), 9(10), 2412-2420, database is CAplus and MEDLINE.

Because RNA lacks strong intrinsic fluorescence, it has proven challenging to track RNA mols. in real time. To address this problem and to allow the purification of fluorescently tagged RNA complexes, the authors have selected a high affinity RNA aptamer called RNA Mango. This aptamer binds a series of thiazole orange (fluorophore) derivatives with nanomolar affinity, while increasing fluorophore fluorescence by up to 1100-fold. Visualization of RNA Mango by single-mol. fluorescence microscopy, together with injection and imaging of RNA Mango/fluorophore complex in C. elegans gonads demonstrates the potential for live-cell RNA imaging with this system. By inserting RNA Mango into a stem loop of the bacterial 6S RNA and biotinylating the fluorophore, the aptamer can be used to simultaneously fluorescently label and purify biol. important RNAs. The high affinity and fluorescent properties of RNA Mango are therefore expected to simplify the study of RNA complexes.

ACS Chemical Biology published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kurtoglu-Oztulum, Samira F. published the artcileThermal stability limits of imidazolium, piperidinium, pyridinium, and pyrrolidinium ionic liquids immobilized on metal oxides, Safety of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Journal of Molecular Liquids (2022), 119804, database is CAplus.

Twenty-nine different ionic liquids (ILs) consisting of imidazolium, pyridinium, piperidinium, and pyrrolidinium cations and I^–, Cl^–, Br^–, PF^–₆, BF^–₄, [DCA]^–, and [NTf₂]^– anions were immobilized on MgO and SiO₂. Their short-term thermal stability limits were investigated by thermogravimetric anal. and compared with those of the corresponding bulk ILs. Data showed that the thermal stability limits of ILs change significantly when the ILs are immobilized on metal oxides. These changes were evaluated based on the structural interactions determined by IR spectroscopy. Systematic structural differences were considered to investigate the factors affecting the thermal stability of bulk ILs, and their counterparts immobilized on MgO and SiO₂. These structural changes were the change in the alkyl chain length, the methylation on C2 site in imidazolium ILs, the change in substituent position in the pyridinium ring, the change in the anion, and the change in the IL family. The strongest factor controlling the thermal stability limits of both bulk ILs and their supported counterparts was determined as the anion type. Accordingly, the basicity of the anion and the surface acidity of the metal oxide and their resulting interactions were found to have a significant effect on the thermal stability limits. Data presented here offer the opportunity to pick a suitable anion and cation pair according to the metal oxide, so that the supported IL can withstand the desired operation conditions in various applications, such as catalysis or gas separation

Journal of Molecular Liquids published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Safety of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Priyadarshini, Antara published the artcileNanofiltration of Aqueous Dye Solution through the Diffused Rough Pores of a Carbonaceous-Kaolinite Amalgamation Membrane, SDS of cas: 79917-90-1, the publication is ACS ES&T Water (2022), 2(3), 414-424, database is CAplus.

This study demonstrates a supported carbonaceous-kaolinite composite membrane that has a highly porous medium with prevalent submicron pores. These pores exhibit a diffused configuration assembled by carbonaceous (Cn) nodules and kaolin particles wrapped by a thin Cn sheath. The membrane was prepared by three steps: (i) applying an acrylic-kaolin coating to a porous stainless-steel tube; (ii) compressing the dried coated layer in an isopress chamber to ratchet the amalgamated coating layer; and (iii) conducting partial pyrolysis to achieve the Cn-kaolin membrane (CKM), exhibiting a rough and diffused CK amalgam frame inherited from the intense compression. The membrane displays attractive nanofiltration performance, i.e., >95% rejection over 30 h and mean permeances of 4-10 L/h·m²·bar for the four probe dyes in water (50 ppm) with different mol. masses and charge types. The intricate and rough pore channels of the membrane agitate tiny turbulences amid the thin permeate streams, which drives an effective solute interaction with the pore walls. Solute retention occurred through entrapment along the pore walls, leading to a boundary layer, which assists further retention via dragging, circulating solute mols., and transferring them to the retentate. The filtrate permeates through nanopores of the CK amalgam frame.

ACS ES&T Water published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, SDS of cas: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zerressen, Andreas published the artcileToward the Selection of Ribozymes for 1,3-Dipolar Cycloaddition Reactions, Application In Synthesis of 359860-27-8, the publication is Journal of Molecular Evolution (2005), 61(2), 236-244, database is CAplus and MEDLINE.

In vitro selection from combinatorial RNA libraries has repeatedly been used to study the catalytic and binding potential of nucleic acids. These selections not only led to RNA sequences catalyzing transformations known from metabolic pathways but also generated novel ribozymes for typical organic reactions. We were interested in 1,3-dipolar cycloaddition reactions, which are important tools for the formation of heterocyclic systems in organic chem. and might also be found in the hypothetic RNA world. Here we describe our strategy and experiments to isolate RNA mols. catalyzing a 1,3-dipolar cycloaddition between nitrile oxides and an acrylate conjugated to RNA. We used direct selection with linker-coupled reactants, which has previously allowed the generation of true trans-acting catalysts for bimol. reactions. A photocleavable linker was introduced to provide for a more stringent selection criterion. The 1,3-dipolar cycloaddition reaction was established in aqueous solution using a modified dinucleotide that was tethered to the dipolarophilic substrate. Two selection protocols were established, namely, a low-stringency affinity-based selection protocol, and a high-stringency procedure using the photocleavable moiety. In neither case was an increased activity toward the desired reaction obtained after 15 and 11 selection rounds, resp. The resulting pools of RNA from several rounds were investigated both in cis and in trans. The limitations of this selection methodol. are discussed in comparison with other catalysts for dipolar cycloadditions and, also, with respect to the unconventional substrates used.

Journal of Molecular Evolution published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C13H10N2S, Application In Synthesis of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem