Month: November 2022

Artemenko, M. V. published the artcileComplexing in the nickel nitrate-1-methyl-2-hydroxymethylbenzimidazole-methanol system, Synthetic Route of 7467-35-8, the publication is Ukrainskii Khimicheskii Zhurnal (Russian Edition) (1971), 37(9), 859-62, database is CAplus.

The spectra of MeOH solutions of Ni(NO3)2 and 1-methyl-2-hydroxy-methylbenzimidazole (I) of varying concentrations were analyzed for their gaussian components. The frequencies 26,500, 16,250, 14,250, and 9500 cm-1 were assigned to 3 I.Ni(NO3)2 and 25,500, 15,250, and 13,250 cm-1 to I.Ni(NO3)2. The instability constant of 3 I.Ni(NO3)2 is 4.2 × 10-3. The magnetic moment is 2.76 ± 0.07 μB, and the paramagnetic Curie point is 53°K. The spectra of the complex as a solid and in solution are analogous and indicate an octahedral structure.

Ukrainskii Khimicheskii Zhurnal (Russian Edition) published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Synthetic Route of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lee, Bong Soo published the artcileFunctionalization of Poly(oligo(ethylene glycol) methacrylate) Films on Gold and Si/SiO₂ for Immobilization of Proteins and Cells: SPR and QCM Studies, Synthetic Route of 359860-27-8, the publication is Biomacromolecules (2007), 8(12), 3922-3929, database is CAplus and MEDLINE.

Thin films of a biocompatible and nonbiofouling poly(oligo(ethylene glycol) methacrylate) (pOEGMA) with various thicknesses were formed on gold and Si/SiO₂ substrates by a combination of the formation of self-assembled monolayers (SAMs) terminating in bromoester – an initiator of atom transfer radical polymerization (ATRP) – and surface-initiated ATRP. After the formation of the pOEGMA films, terminal hydroxyl groups of side chains divergent from the methacrylate backbones were activated with N,N’-disuccinimidyl carbonate (DSC), and the DSC-activated pOEGMA films were reacted with (+)-biotinyl-3,6,9-trioxaundecanediamine (Biotin-NH₂) to form biotinylated pOEGMA films. By surface plasmon resonance experiments with the target protein (streptavidin) and model proteins (fibrinogen and lysozyme), the authors verified that the resulting films showed the enhanced signal-to-noise ratio (âˆ?0-fold enhancement) for the biospecific binding of streptavidin compared with the biotinylated substrate prepared from carboxylic acid-terminated SAMs. Quartz crystal microbalance measurements were also carried out to obtain the surface coverage of streptavidin and fibrinogen adsorbed onto the biotinylated pOEGMA films with various thicknesses and to investigate the effect of film thicknesses on the biospecific binding of streptavidin. Both the binding capacity of streptavidin and the signal-to-noise ratio of streptavidin/fibrinogen were saturated at the 20 nm thick pOEGMA film. In addition, to demonstrate a wide applicability of the pOEGMA films, the authors constructed micropatterns of streptavidin and cells by microcontact-printing biotin-NH₂ and poly-L-lysine onto the DSC-activated pOEGMA films, resp.

Biomacromolecules published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Synthetic Route of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Ying published the artcileDetection of Membrane-Binding Proteins by Surface Plasmon Resonance with an All-Aqueous Amplification Scheme, Formula: C18H34N4O5S, the publication is Analytical Chemistry (Washington, DC, United States) (2012), 84(7), 3179-3186, database is CAplus and MEDLINE.

The authors report here a surface plasmon resonance (SPR) method for detection of cell membrane binding proteins with high degree signal amplification carried out in an all-aqueous condition. Ultrahigh detection sensitivity was achieved for a membrane-based biosensing interface through the use of functional gold nanoparticles (AuNP) in combination with in situ atom transfer radical polymerization (ATRP) reaction. Fusion of phosphatidylcholine vesicles on a calcinated SPR gold chip established a supported bilayer membrane in which cell receptor monosialoganglioside GM1 was embedded for capture of bacterial cholera toxin (CT). The surface-bound CT was recognized with biotinylated anti-CT, which was linked to the biotin-AuNP through an avidin bridge. The biotin-AuNP surface was functionalized with ATRP initiator that triggers localized growth of poly(hydroxyl-Et methacrylate) (PHEMA) brush, contributing to marked SPR signal enhancement and quant. measurement of CT at very low concentrations The resulting polymer film has been characterized by optical and at. force microscopy. A calibration curve for CT detection has been obtained displaying a response range from 6.3 × 10^-16 to 6.3 × 10^-8 M with a detection limit of 160 aM (equivalent to âˆ?500 mols. in 100 μL sample solution). Sensitive detection of biomols. in complex medium has been conducted with CT-spiked serum, and the detection limit can be effectively improved by 6 orders of magnitude compared to direct measurement in serum. The combined AuNP/ATRP method reported here opens new avenues for ultrasensitive detection of proteins on delicate sensor interfaces constructed by lipid membranes or cell membrane mimics.

Analytical Chemistry (Washington, DC, United States) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wang, Xing published the artcileSynthesis and biological evaluation of benzimidazole phenylhydrazone derivatives as antifungal agents against phytopathogenic fungi, Related Products of imidazoles-derivatives, the publication is Molecules (2016), 21(11), 1574/1-1574/14, database is CAplus and MEDLINE.

A series of benzimidazole phenylhydrazone derivatives I (R¹ = H, CH₃, Cl; R² = H, CH₃; R³ = 2,4-F₂, 3,5-Cl₂, 2,6-Cl₂, etc.) was synthesized. The structure of I (R¹ = H; R² = H; R² = 2-F) was further confirmed by single crystal X-ray diffraction as (E)-configuration. All the compounds were screened for antifungal activity against Rhizoctonia solani and Magnaporthe oryzae employing a mycelium growth rate method. Compound I (R¹ = H; R² = H; R² = 2,4-F₂) exhibited significant inhibitory activity against R. solani and M. oryzae with the EC₅₀ values of 1.20 and 1.85 μg/mL, resp. In vivo testing demonstrated that I (R¹ = H; R² = H; R² = 2,4-F₂) could effectively control the development of rice sheath blight (RSB) and rice blast (RB) caused by the above two phytopathogens. This work indicated that the compound I (R¹ = H; R² = H; R² = 2,4-F₂) with a benzimidazole phenylhydrazone scaffold could be considered as a leading structure for the development of novel fungicides.

Molecules published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C13H10O3, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Li, Qi published the artcileHighly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection, Application In Synthesis of 332026-86-5, the publication is Journal of Medicinal Chemistry (2021), 64(10), 6856-6876, database is CAplus and MEDLINE.

Butyrylcholinesterase (BChE) has been considered as a potential therapeutic target for Alzheimer’s disease (AD) because of its compensation capacity to hydrolyze acetylcholine (ACh) and its close association with Aβ deposit. Here, we identified S06-1011 (hBChE IC₅₀ = 16 nM) and S06-1031 (hBChE IC₅₀ = 25 nM) as highly effective and selective BChE inhibitors, which were proved to be safe and long-acting. Candidate compounds exhibited neuroprotective effects and the ability to improve cognition in scopolamine- and Aβ_1-42 peptide-induced cognitive deficit models. The best candidate S06-1011 increased the level of ghrelin, a substrate of BChE, which can function as improving the mental mood appetite. The weight gain of the S06-1011-treated group remarkably increased. Hence, BChE inhibition not only plays a protective role against dementia but also exerts a great effect on treating and nursing care.

Journal of Medicinal Chemistry published new progress about 332026-86-5. 332026-86-5 belongs to imidazoles-derivatives, auxiliary class Oxadiazole,Amine,Benzimidazole, name is 4-(1H-Benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine, and the molecular formula is C9H7N5O, Application In Synthesis of 332026-86-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Lo, Pui Kin Tony published the artcileNickel(II)-Catalyzed Synthesis of Sulfinates from Aryl and Heteroaryl Boronic Acids and the Sulfur Dioxide Surrogate DABSO, Recommanded Product: Imidazo[1,2-a]pyridine-6-boronic acid, the publication is ACS Catalysis (2019), 9(12), 10668-10673, database is CAplus.

A redox-neutral Ni(II)-catalyzed sulfination of readily available aryl and heteroaryl boronic acids is reported. Using the combination of com. available, air-stable NiBr₂·(glyme), a com. available phenanthroline ligand and DABSO, boronic acids are efficiently converted to the corresponding sulfinate salts, which can be further elaborated to valuable sulfonyl-containing groups, including sulfones, sulfonamides, sulfonyl fluorides, and sulfonate esters. The catalyst loading can be reduced to 2.5 mol % on a gram scale. This practically simple protocol tolerates an unprecedented range of pharmaceutically relevant and electron-poor (hetero)aryl boronic acids, allowing the direct synthesis of active pharmaceutical ingredients.

ACS Catalysis published new progress about 913835-63-9. 913835-63-9 belongs to imidazoles-derivatives, auxiliary class Other Aromatic Heterocyclic,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is Imidazo[1,2-a]pyridine-6-boronic acid, and the molecular formula is C7H7BN2O2, Recommanded Product: Imidazo[1,2-a]pyridine-6-boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhang, Tong published the artcileDeep Oxidative Desulfurization of Model Fuels Catalyzed by Subnanosized Ti Oxoclusters, Application In Synthesis of 79917-90-1, the publication is Energy & Fuels (2022), 36(3), 1402-1416, database is CAplus.

Oxidative desulfurization is a highly effective approach to decrease the sulfur content in transportation fuel and has become an attractive research topic in recent years. Herewith, we have developed a new kind of carboxylic acid-functionalized imidazolium-based ionic liquid-stabilized Ti oxoclusters via a solvothermal method. The as-synthesized Ti oxoclusters were investigated by elemental anal., Fourier transform IR spectroscopy, diffuse reflectance UV-vis, X-ray diffraction, thermogravimetric anal., high-resolution transmission electron microscopy (HRTEM), and high-angle annular dark field-scanning TEM. Characterization indicated that Ti oxoclusters existed in the form of subnanosized structure and uniformly dispersed with an average particle size of ca. 1 nm due to the protection role of the ionic liquids (ILs). Especially, Ti oxo-HSO₄ afforded a superior catalytic activity in the extraction and catalytic oxidative desulfurization process with MeOH as an extractant and H₂O₂ as an oxidant. The full removal of dibenzothiophene in model fuels was achieved within 30 min at 60 °C. Besides, the Ti oxoclusters were robust and exhibited high stability in consecutive catalytic recycles. The parent Ti oxoclusters treated with H₂O₂ can afford Ti-OOH species, which was catalytically active species. The anion HSO₄^– in IL played a crucial role in the activation of Ti-hydroperoxo species by forming hydrogen bonds. This may provide a new insight into the construction of metal oxoclusters for oxidative desulfurization.

Energy & Fuels published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C10H10N2, Application In Synthesis of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Shu-kai published the artcileSynthesis of Carbophosphinocarbene and Their Donating Ability: Expansion of the Carbone Class, Computed Properties of 4760-35-4, the publication is Organometallics (2020), 39(23), 4395-4401, database is CAplus.

In recent years, carbones (CL₂) established themselves to be reliable ligands in organometallic and catalytic reactions. With its superb donating ability as well as a 2nd lone pair for extra coordination, it distinguishes itself from the widely used carbenes and phosphines. However, a lack of modular structural diversity in carbones has limited its use. A carbophosphinocarbene (CPC), a subclass of carbones containing a carbene and phosphine as flanking groups, offers an easy structural modification. The authors report a new modular synthetic procedure for CPCs by using readily available starting materials. The phosphine moiety can be easily exchanged and directly used out of the bottle. The resulting CPCs offer a strong donating ability. Their electronic properties were determined using Ga and Au complexes.

Organometallics published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Computed Properties of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Mei, Xiao-Meng published the artcileEnantioseparation characteristics of the chiral stationary phases based on natural and regenerated chitins, HPLC of Formula: 161796-78-7, the publication is Journal of Separation Science (2017), 40(8), 1710-1717, database is CAplus and MEDLINE.

Natural and regenerated chitins were derivatized with 3,5-dimethyphenyl isocyanate. The corresponding chiral stationary phases were prepared by coating the resulting chitin derivatives on 3-aminopropyl silica gel. The swelling capacity of the chitin derivatives, enantioseparation capability, as well as eluents tolerance of the chiral stationary phases were evaluated. The results demonstrated no remarkable difference in enantioseparation capability between natural and regenerated chitins based chiral stationary phases. The similar enantioseparation characteristics of two chiral stationary phases could be understood by comparing the IR spectra of related chitin derivatives One of the two chiral stationary phases prepared by coating the chitin derivative with a lower mol. weight generally provided better enantioseparations All chiral stationary phases can work in 100% chloroform, 100% Et acetate, 100% acetone, and the mobile phases containing a certain amount of THF. The chiral stationary phase prepared from the chitin derivative with the highest swelling capacity exhibited better enantioseparations than others. This chiral stationary phase was damaged by flushing with 100% THF; however, the enantioseparation capability was recovered again after the column was allowed to stand for 1 mo. Furthermore, the recovered chiral stationary phase provided better enantioseparations for some chiral analytes than before.

Journal of Separation Science published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, HPLC of Formula: 161796-78-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhang, Jian-gong published the artcileOptimization of synthesis process for cyazofamid by response surface methodology, COA of Formula: C11H8ClN3, the publication is Nongyao (2014), 53(5), 325-327, database is CAplus.

Fungicide cyazofamid was synthesized with 4-chloro-2-cyano-5-(4′-Me phenyl) imidazole and N,N-dimethylsulfamoyl chloride as the raw materials to optimize the process. The effects of raw material ration time, reaction temperature on the reaction yield were researched. The reaction conditions were optimized by using the response surface method (RSM). The optimal technol. condition was obtained. The results showed that the highest yield could reach 65.2% when the raw material ratio was 1.13:1, reaction time was 4.6 h, and reaction temperature was 75 degree C. This study provided the optimization condition of synthesis process for cyazofamid in industry.

Nongyao published new progress about 120118-14-1. 120118-14-1 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Nitrile,Benzene, name is 4-Chloro-5-(p-tolyl)-1H-imidazole-2-carbonitrile, and the molecular formula is C12H25Br, COA of Formula: C11H8ClN3.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem