Month: November 2022

Marinakos, Stella M. published the artcilePlasmonic Detection of a Model Analyte in Serum by a Gold Nanorod Sensor, Application In Synthesis of 359860-27-8, the publication is Analytical Chemistry (Washington, DC, United States) (2007), 79(14), 5278-5283, database is CAplus and MEDLINE.

The authors describe the fabrication of a label-free, chip-based biosensor based on the localized surface plasmon resonance (LSPR) of gold nanorods. Gold nanorods were chemisorbed onto a mercaptosilane-modified glass substrate, followed by conjugation of biotin to the nanorods. Streptavidin binding to biotin was monitored by the wavelength shift of the LSPR peak in the UV-vis extinction spectrum of the immobilized gold nanorods due to the change in local refractive index at the gold nanorod surface induced by streptavidin binding. The limit of detection of the sensor is 0.005 μg/mL (94 pM) in PBS and 1 μg/mL (19 nM) in serum, and the dynamic range spans 94 pM to 0.19 μM. The advantages of the nanorod-based sensor over an LSPR sensor that the authors had previously fabricated from gold nanospheres (Nath, N., and Chilkoti, A., 2002 and 2004) are the significantly lower detection limit and the internal self-reference that the signal of the nanorod sensor provides based on the measurement of peak wavelength shift.

Analytical Chemistry (Washington, DC, United States) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Application In Synthesis of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhu, Shengbo published the artcileUnclogging electron-transporting channels via self-assembly for improving light harvesting and stability of dye-sensitized solar cells, Quality Control of 2622-67-5, the publication is Electrochimica Acta (2019), 518-530, database is CAplus.

Two nitrogen-rich heterocycle donor dyes, NP-2 and NP-3, have been strategically designed and synthesized to construct functionalized self-assembly layers. Through the formation of N···H hydrogen bonds between these nitrogen-rich heterocycle donors and 4-tert-butylbenzoic acid (PTBBA), the electron leak points (imine group (-N=)) may be plugged, thus blocking excited-state electron lateral transferring between the adsorbed dyes and electron leaking from electron-transporting channel into the electrolyte. Furthermore, the huge 3-dimensional sizes of such supramol. sensitizers can not only suppress dye aggregation, but enhance the photoresponse capacity in visible region. Therefore, the devices based on NP-2@PTBBA and NP-3@PTBBA, which obtained by the cocktail sensitization procedures, can be improved by increasing the open-circuit photovoltage (V_oc) without any loss of the short-circuit photocurrent d. (J_sc) owing to the synergy effect between self-assembly and co-sensitization. Although the device based on NP-3/PTBBA via the stepwise sensitization procedure delivers lower efficiency, it can remain at 103.14% of the initial efficiency as a result of parallel increase in J_sc and V_oc values. Overall, the design principles provide a clear road map of supramol. dye-sensitized solar cells (SDSSCs) and demonstrate the potential of 1,3,5-triazine-based dyes in solar cells research.

Electrochimica Acta published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C4H5F3O, Quality Control of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Shi, Xing-Xing published the artcileMonitoring fragmentation and oligomerization of a di-μ-methoxo bridged copper(II) complex: structure, mass spectrometry, magnetism and DFT studies, Application In Synthesis of 7467-35-8, the publication is Dalton Transactions (2019), 48(34), 13094-13100, database is CAplus and MEDLINE.

Analyses of the structural information of mol. fragments from the mass spectra of the solid-state products and their reaction solutions allow for the understanding of their formation and of their diverse properties. The reaction of CuCl₂ and (1-methyl-1H-benzo[d]imidazole-2-yl)methanol (HL) led only to crystals containing mol. dimers of [Cu₂(L)₂Cl₂] (Cu2). The Cu^II-Cu^II distance and Cu-OR-Cu angle in the structure are 3.044 Å and 104.8°, resp. The magnetic susceptibility (3-400 K) was characterized by a very strong intradimer antiferromagnetic interaction of J = -465 and interdimer zj = -0.83 cm^-1. But mass spectrometry of a dissolved single crystal in different source energies identifies both its fragmentation and oligomerization to [Cu^II₃] and [Cu^II₄]. DFT calculations give the relative stabilization energies of the fragments observed in ESI-MS to provide a formation process.

Dalton Transactions published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C8H6F3NO, Application In Synthesis of 7467-35-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Jiaming published the artcileEnantioselective anti- and syn-(Borylmethyl)allylation of Aldehydes via Bronsted Acid Catalysis, Category: imidazoles-derivatives, the publication is Organic Letters (2020), 22(22), 8967-8972, database is CAplus and MEDLINE.

The enantioselective anti- and syn-(borylmethyl)allylation of aldehydes via phosphoric acid catalysis is reported. Both (E)- and (Z)-γ-borylmethyl allylboronate reagents were prepared via the Cu-catalyzed highly stereoselective protoboration of 1,3-dienylboronate. Chiral phosphoric acid-catalyzed aldehyde allylation with either the (E)- or (Z)-allylboron reagent provided 1,2-anti- or 1,2-syn-adducts in good yields with high enantioselectivities. The application to the synthesis of morinol D was accomplished.

Organic Letters published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Deng, Qian-Jun published the artcileTwo tetranuclear butterfly-shaped Co(II) complexes: structure, mass spectrometric, and magnetism, Recommanded Product: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, the publication is Crystals (2019), 9(9), 477, database is CAplus.

The organic ligand (1-methyl-1H-benzo[d]imidazol-2-yl)methanol (HL) was used to react with CoX₂·6H₂O (X = Cl and Br) under solvothermal conditions to obtain the complex [Co₄(L)₆(X)₂] (1, X = Cl; 2, X = Br). The butterfly-shaped structure of complex 1 and 2 suggest that Co(II) ions have two different coordinated modes, which are five coordination with O₃NX environment and six coordination with O₄N₂ environment. In addition, the electrospray ionization mass spectrometry (ESI-MS) anal. indicated that the ion mol. fragment of highest intensity was [Co₄(L)₆]²⁺, and there existed a high nuclear fragment peak of [Co₇(L)₁₂] ²⁺. Interestingly, it was basically completely transformed into [Co₇(L)₁₂]²⁺ two days later, so those two complexes were relatively stable in CH₃OH. Magnetic characterization exhibited that complex 1 and 2 display field-induced single-mol. magnetic behavior, of which the energy hills Ueff/kB were 28 and 20 K under direct-current field of 0.1 T, resp.

Crystals published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Recommanded Product: (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Chang, Andrew T. published the artcile2-Amino-1,3-benzothiazole-6-carboxamide Preferentially Binds the Tandem Mismatch Motif r(UY:GA), Application of 4-(1H-Benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine, the publication is Biochemistry (2020), 59(35), 3225-3234, database is CAplus and MEDLINE.

RNA helixes are often punctuated with non-Watson-Crick features that may be targeted by chem. compounds, but progress toward identifying such compounds has been slow. We embedded a tandem UU:GA mismatch motif (5�UG-3�5�AU-3� within an RNA hairpin stem to identify compounds that bind the motif specifically. The three-dimensional structure of the RNA hairpin and its interaction with a small mol. identified through virtual screening are presented. The G-A mismatch forms a sheared pair upon which the U-U base pair stacks. The hydrogen bond configuration of the U-U pair involves O2 of the U adjacent to the G and O4 of the U adjacent to the A. The G-A and U-U pairs are flanked by A-U and G-C base pairs, resp., and the stability of the mismatch is greater than when the motif is within the context of other flanking base pairs or when the 5�3�orientation of the G-A and U-U pairs is swapped. Residual dipolar coupling constants were used to generate an ensemble of structures against which a virtual screen of 64480 small mols. was performed. The tandem mismatch was found to be specific for one compound, 2-amino-1,3-benzothiazole-6-carboxamide, which binds with moderate affinity but extends the motif to include the flanking A-U and G-C base pairs. The finding that the affinity for the UU:GA mismatch is dependent on flanking sequence emphasizes the importance of the motif context and potentially increases the number of small noncanonical features within RNA that can be specifically targeted by small mols.

Biochemistry published new progress about 332026-86-5. 332026-86-5 belongs to imidazoles-derivatives, auxiliary class Oxadiazole,Amine,Benzimidazole, name is 4-(1H-Benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine, and the molecular formula is C9H7N5O, Application of 4-(1H-Benzo[d]imidazol-2-yl)-1,2,5-oxadiazol-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Hao published the artcileAnti-oligomerization sheet molecules: Design, synthesis and evaluation of inhibitory activities against α-synuclein aggregation, Related Products of imidazoles-derivatives, the publication is Bioorganic & Medicinal Chemistry (2019), 27(14), 3089-3096, database is CAplus and MEDLINE.

Aggregation of α-synuclein (α-Syn) play a key role in the development of Parkinson Disease (PD). One of the effective approaches is to stabilize the native, monomeric protein with suitable mol. ligands. We have designed and synthesized a series of sheet-like conjugated compounds which possess different skeletons and various heteroatoms in the two blocks located at both ends of linker, which have good π-electron delocalization and high ability of hydrogen-bond formation. They have shown anti-aggregation activities in vitro towards α-Syn with IC50 down to 1.09 μM. The mol. is found binding in parallel to the NACore within NAC domain of α-Syn, interfering aggregation of NAC region within different α-Syn monomer, and further inhibiting or slowing down the formation of α-Syn oligomer nuclei at lag phase. The potential inhibitor obtained by our strategy is considered to be highly efficient to inhibit α-Syn aggregation.

Bioorganic & Medicinal Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Hui published the artcileLow-temperature Hg⁰ abatement by ionic liquid based on weak interaction, Name: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Journal of Hazardous Materials (2022), 127836, database is CAplus and MEDLINE.

Low-temperature gaseous elemental mercury (Hg0) abatement is an objective demand in industrial flue gas treatment. In this work, we proposed a new approach for Hg⁰ capture via weak interaction of ionic liquids Ionic liquids with varied anions (1-butyl-3-methylimidazolium thioacetate ([Bmim][ThAc]), 1-butyl-3-methylimidazolium diethyldithiocarbamate ([Bmim][DTCR]), and 1-butyl-3-methylimidazolium ethylxanthate ([Bmim][EX])) were designed and synthesized. The interaction energies between ionic liquids and elemental mercury were proved to be pos. related to mercury removal efficiency, revealing that the electrostatic interaction derived phys. adsorption from anions is the dominant factor affecting mercury removal performance. [Bmim][ThAc] with the largest anionic electrostatic interaction energy showed the best mercury abatement performance, achieving a Hg0 removal efficiency of over 98% and an adsorption capacity of 10.66 mg/g at 50 °C. The influence of temperature and the results of mercury temperature-programmed desorption (Hg-TPD), XPS further confirmed that the ionic liquid combines with elemental mercury through phys. adsorption. The work provides a new perspective on designing high-efficiency sorbents for mercury removal at low temperature

Journal of Hazardous Materials published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Name: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhao, Gongyuan published the artcilePalladium(II)-Catalyzed Sequential C-H Arylation/Aerobic Oxidative C-H Amination: One-Pot Synthesis of Benzimidazole-Fused Phenanthridines from 2-Arylbenzimidazoles and Aryl Halides, Recommanded Product: 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Journal of Organic Chemistry (2015), 80(5), 2827-2834, database is CAplus and MEDLINE.

Starting from 2-arylbenzimidazoles and aryl halides, an efficient palladium-based catalytic method for the synthesis of benzimidazole-fused phenanthridines, e.g., I, has been developed. This reaction sequence is comprised of an intermol. C-H arylation and intramol. aerobic oxidative C-H amination, which involved the rupture of two C-H bonds, one C-X bond, and one N-H bond in one pot. The Pd^II-Pd^IV-Pd^II and Pd^II-Pd⁰-Pd^II catalytic cycles worked together under the reported conditions to generate phenanthridines with diverse substituents.

Journal of Organic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C8H14O4, Recommanded Product: 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sun, Manman published the artcileOne-pot synthesis of 1,2-diphenyl-1H-benzo[d]imidazole derivatives by a Pd-catalyzed N-arylation and Cu-catalyzed C-H functionalization/C-N bond formation process, Application In Synthesis of 2622-67-5, the publication is RSC Advances (2014), 4(88), 47373-47376, database is CAplus.

A one-pot synthesis of 1,2-diaryl-1H-benzo[d]imidazole derivatives starting from N-arylbenzamidines and iodobenzenes or bromobenzenes was introduced. The process consisted of a Pd-catalyzed N-arylation and a Cu-catalyzed C-H functionalization/C-N bond formation.

RSC Advances published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C25H23NO4, Application In Synthesis of 2622-67-5.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem