Month: November 2022

Lee, Jeong-Hyeon published the artcileHierarchical nanostructured MnF₂ fabricated using rapid microwave synthesis as abnormal high-capacity of anode materials for Li-ion batteries, Safety of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Journal of Physics and Chemistry of Solids (2022), 110477, database is CAplus.

Tailoring various architectures of electrode material has been deemed a feasible route for improving the surface reactivity, the contact area between electrode and electrolyte, and enabling shortened electronic pathways to realize higher performance lithium-ion batteries. Here, we rapidly synthesized the manganese fluoride (MnF₂) with various morphologies by microwave irradiation using ionic liquid as the fluoride source, soft template, and microwave absorber solvent. The hierarchical nanostructured MnF₂ were optimized by controlling the purity of ionic liquid, microwave heating rate, and precursor concentration The dominant factors influencing the morphologies of MnF₂ were systematically investigated and relevant descriptions for the formation mechanism were suggested. Also, we demonstrated the abnormal high-capacity lithium-ion battery anode using the hierarchical nanostructured MnF₂ anode based on the conversion mechanism. The prepared MnF₂ anode yielded a maximum reversible specific capacity of 986 mAhg^-1 at 0.1C after 30 cycles. This study provides a comprehensive understanding of the morphol. control of the hierarchical structured MnF₂ using the microwave-ionic liquid combination method for high-capacity lithium-ion battery anode.

Journal of Physics and Chemistry of Solids published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Safety of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Shuvaev, Vladimir V. published the artcileEndothelial Targeting of Antibody-Decorated Polymeric Filomicelles, Formula: C18H34N4O5S, the publication is ACS Nano (2011), 5(9), 6991-6999, database is CAplus and MEDLINE.

The endothelial lining of the lumen of blood vessels is a key therapeutic target for many human diseases. Polymeric filomicelles that self-assemble from polyethylene oxide (PEO)-based diblock copolymers are long and flexible rather than small or rigid, can be loaded with drugs, and-most importantly-they circulate for a prolonged period of time in the bloodstream due in part to flow alignment. Filomicelles seem promising for targeted drug delivery to endothelial cells because they can in principle adhere strongly, length-wise to specific cell surface determinants. In order to achieve such a goal of vascular drug delivery, two fundamental questions needed to be addressed: (i) whether these supramol. filomicelles retain structural integrity and dynamic flexibility after attachment of targeting mols. such as antibodies, and (ii) whether the avidity of antibody-carrying filomicelles is sufficient to anchor the carrier to the endothelial surface despite the effects of flow that oppose adhesive interactions. Here we make targeted filomicelles that bear antibodies which recognize distinct endothelial surface mols. We characterize these antibody targeted filomicelles and prove that (i) they retain structural integrity and dynamic flexibility and (ii) they adhere to endothelium with high specificity both in vitro and in vivo. These results provide the basis for a new drug delivery approach employing antibody-targeted filomicelles that circulate for a prolonged time yet bind to endothelial cells in vascular beds expressing select markers.

ACS Nano published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C11H12O4, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

De Milito, Angelo published the artcileProton Pump Inhibitors Induce Apoptosis of Human B-Cell Tumors through a Caspase-Independent Mechanism Involving Reactive Oxygen Species, Computed Properties of 161796-78-7, the publication is Cancer Research (2007), 67(11), 5408-5417, database is CAplus and MEDLINE.

Proton pumps like the vacuolar-type H⁺ ATPase (V-ATPase) are involved in the control of cellular pH in normal and tumor cells. Treatment with proton pump inhibitors (PPI) induces sensitization of cancer cells to chemotherapeutics via modifications of cellular pH gradients. It is also known that low pH is the most suitable condition for a full PPI activation. Here, we tested whether PPI treatment in unbuffered culture conditions could affect survival and proliferation of human B-cell tumors. First, we showed that PPI treatment increased the sensitivity to vinblastine of a pre-B acute lymphoblastic leukemia (ALL) cell line. PPI, per se, induced a dose-dependent inhibition of proliferation of tumor B cells, which was associated with a dose- and time-dependent apoptotic-like cytotoxicity in B-cell lines and leukemic cells from patients with pre-B ALL. The effect of PPI was mediated by a very early production of reactive oxygen species (ROS), that preceded alkalinization of lysosomal pH, lysosomal membrane permeabilization, and cytosol acidification, suggesting an early destabilization of the acidic vesicular compartment. Lysosomal alterations were followed by mitochondrial membrane depolarization, release of cytochrome c, chromatin condensation, and caspase activation. However, inhibition of caspase activity did not affect PPI-induced cell death, whereas specific inhibition of ROS by an antioxidant (N-acetylcysteine) significantly delayed cell death and protected both lysosomal and mitochondrial membranes. The proapoptotic activity of PPI was consistent with a clear inhibition of tumor growth following PPI treatment of B-cell lymphoma in severe combined immunodeficient mice. This study further supports the importance of acidity and pH gradients in tumor cell homeostasis and suggests new therapeutic approaches for human B-cell tumors based on PPI.

Cancer Research published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Computed Properties of 161796-78-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Hikawa, Hidemasa published the artcilePalladium-Catalyzed Dehydrogenation of Benzyl Alcohols for Construction of 2-Arylbenzimidazoles ”On Water”, Formula: C19H14N2, the publication is Asian Journal of Organic Chemistry (2018), 7(2), 416-423, database is CAplus.

An ”on water” synthetic strategy for the selective construction of 2-arylbenzimidazoles involving the dehydrogenation of benzyl alcs. by a π-benzylpalladium(II) system was developed. This simple oxidant- and base-free protocol was achieved under mild conditions in an atom-economic process from o-phenylenediamines and benzyl alcs., affording the desired products in moderate to excellent yields. Notably, the ”on water” protocol was essential for achieving this synthetic method in this catalytic system.

Asian Journal of Organic Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Formula: C19H14N2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Youssef, M. K. published the artcileStudies on sorption affinity of polyvinyl chloride towards certain drugs, Related Products of imidazoles-derivatives, the publication is Bulletin of the Faculty of Pharmacy (Cairo University) (1974), 13(1), 15-21, database is CAplus.

Poly(vinyl chloride) [9002-86-2] had considerable sorption affinity towards tetracycline-HCl (I) [64-75-5] and chloramphenicol [56-75-7] but no sorption affinity towards antazoline-HCl [2508-72-7], with the highest affinity shown by I. The addition of KCl decreased the sorption affinity of the plastic granules for the antibiotics.

Bulletin of the Faculty of Pharmacy (Cairo University) published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C6H17NO3Si, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Bekele, Anbessa published the artcileDevelopment and validation of HPTLC densitometric method for simultaneous determination of antazoline hydrochloride and tetryzoline hydrochloride in eye drop and its application as stability indicator, Category: imidazoles-derivatives, the publication is Thai Journal of Pharmaceutical Sciences (2013), 37(3), 134-145, database is CAplus.

A sensitive, selective, precise, accurate, and stability indicating high-performance thin layer chromatog. (HPTLC)-densitometric method for anal. of antazoline hydrochloride and tetryzoline hydrochloride was developed. The method employed HPTLC aluminum plates precoated with silica gel 60 F₂₅₄ as the stationary phase. The solvent system consisted of Et acetate:MeOH:ammonia (10:10:1, volume/volume/v). Densitometric anal. of drugs was carried out in the absorbance mode at 216 nm. This system gave compact spots for both antazoline hydrochloride (R_f 0.60) and tetryzoline hydrochloride (R_f 0.31). Both drugs were subjected to stress test conditions like acid/alkali hydrolysis, oxidation by hydrogen peroxide, dry heat treatment, and photo degradation The spots for products of degradation were well resolved from the spots of resp. intact drugs. The linear regression data for the calibration plots showed good linear relationship with r² of 0.9979 and 0.9990 in the concentration range of 200-1800 ng/band for antazoline hydrochloride and 160-1440 ng/band for tetryzoline hydrochloride, resp. The results indicated that the drugs are susceptible to degradation, to different extent under the different conditions.

Thai Journal of Pharmaceutical Sciences published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Zhang, Chun published the artcilePatterning proteins on surfaces of cross-sectioned multilayer polymer films, Name: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Macromolecular Rapid Communications (2006), 27(14), 1173-1179, database is CAplus.

A new approach is introduced to create submicrometer patterned surfaces using multilayer polymer films that contain alternating layers of two polymers, linear low-d. polyethylene (LLDPE) and ethylene-co-(acrylic acid) copolymer (EAA). Patterned templates have been prepared by microtoming the multilayer molded sheets. Regionally confined chem. functionality is confirmed by grafting an amine-terminated biotin and adsorbing streptavidin specifically on the alternating layers of EAA.

Macromolecular Rapid Communications published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C7H16Cl2Si, Name: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Wilson, J. Gerald published the artcileIminodiacetic acid derivatives of benzimidazole. Synthesis of N-(benzimidazol-2-ylmethyl)iminodiacetic acids, SDS of cas: 4760-35-4, the publication is Australian Journal of Chemistry (1983), 36(11), 2317-25, database is CAplus.

Ten new N-(2-benzimidazolylmethyl)iminodiacetic acids I [R = 5(6)-Me, 5,6-Me₂, 5(6)-Bu, 5(6)-Cl, 5,6-Cl₂, 5(6)-Br, 5(6)-iodo, 5(6)-O₂N] were prepared from the corresponding o-phenylenediamines via intermediate 2-chloromethyl and 2-aminomethyl benzimidazoles as ligands for ^99mTc. Anomalies associated with the synthesis of the iodo-substituted compound are described.

Australian Journal of Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H13NO2, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Mondal, Ejabul published the artcile1,2-diphenylbenzimidazole-triarylamine hybrided bipolar host materials employing fluorene as bridge for RYB and white electrophosphorescent devices, Product Details of C19H14N2, the publication is Organic Electronics (2016), 115-125, database is CAplus.

Four novel bipolar hosts (DTAFNBI, m-DTAFNBI, DTAFCBI and m-DTAFCBI) comprising a hole-transport ditolylphenylamino donor and an electron-transport 1,2-diphenylbenzimidazole acceptor connected via a fluorene spacer were synthesized and characterized. Through the different linkage topologies of phenylbenzimidazole, the thermal, photophys., and electrochem. properties can be fine-tuned. The saturated fluorene spacer along with the ditolylphenylamino donor and the phenylbenzimidazole acceptor endowed high triplet energies (E_T = 2.47-2.62 eV, recorded in neat film at 20 K) and bipolar transporting abilities. Furthermore, the tetragonal geometry given by the sp³-hybridized C9 of fluorene encumbered intermol. packing and led to excellent thermal and morphol. stabilities (T_d = 379-392 °C, corresponding 5% weight loss; T_g = 148-162 °C). As a result, these bipolar materials were utilized as universal hosts for red, yellow, and blue (RYB) phosphorescent OLEDs, showing maximum external quantum efficiencies (η_ext) of 9.6%, 14.7%, and 18.9% for blue (FIrpic), yellow (m-(Tpm)₂Ir(acac) and red [Os(bpftz)₂(PPhMe₂)₂, OS1], resp. In addition, white organic light-emitting diodes combining a blue emitter (FIrpic) and yellow emitter m-(Tpm)₂Ir(acac) and a red emitter (OS1) within a single emitting layer were also fabricated which also exhibited good efficiencies (9.5-13.7%, 15.1-23.5 cd A^-1, 13.3-23.9 lm W^-1) with relatively low efficiency roll off.

Organic Electronics published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Product Details of C19H14N2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Gerlinger, Erich published the artcileMechanistic studies of the urocanase reaction using proton and phosphorus-31 NMR spectroscopy and the substrate analog 2-methylurocanate, Category: imidazoles-derivatives, the publication is Tetrahedron (1983), 39(21), 3523-8, database is CAplus.

The reaction of 2-methylurocanate with urocanase from Pseudomonas putida was monitored by ¹H NMR spectroscopy at 500 MHz. 2-Methylurocanate reacted 128-fold more slowly with urocanase than did urocanate. No signals for the enol form of the 2-methylimidazolone propionate produced were detected. 2-Methylimidazolone propionate was ∼25-fold more stable to hydrolysis than imidazolone propionate. The urocanase-catalyzed exchange of the 5-H of 2-methylurocanate with the solvent ²H was 1.3-fold faster than the overall reaction. The nonenzymic exchange of the Me protons of 2-methylimidazolone propionate with solvent ²H took place with a half-life of 5.8 h. ¹H NMR spectroscopy showed that the urocanase reaction is reversible. At 8° and pD 6.3, 1.6% of the total imidazolone propionate was converted into urocanate. Apart from the pyrophosphate ester group of NAD, no phosphorylated groups were detected in urocanase by ³¹P NMR spectroscopy.

Tetrahedron published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem