Month: November 2022

Yin, Zhiqiang published the artcileMulti-residue determination of 210 drugs in pork by ultra-high-performance liquid chromatography-tandem mass spectrometry, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Journal of Chromatography A (2016), 49-59, database is CAplus and MEDLINE.

This paper presents a multi-residue anal. method for 210 drugs in pork using ultra-high-performance liquid chromatog.-Q-Trap tandem mass spectrometry (UPLC-MS/MS) within 20 min via pos. ESI in scheduled multi-reaction monitoring (MRM) mode. The 210 drugs, belonging to 21 different chem. classes, included macrolides, sulfonamides, tetracyclines, β-lactams, β-agonists, aminoglycosides, antiviral drugs, glycosides, phenothiazine, protein anabolic hormones, non-steroidal anti-inflammatory drugs (NSAIDs), quinolones, antifungal drugs, corticosteroids, imidazoles, piperidines, piperazidines, insecticides, amides, alkaloids and others. A rapid and simple preparation method was applied to process the animal tissues, including solvent extraction with an acetonitrile/water mixture (80/20, volume/volume), defatting and clean-up processes. The recoveries ranged from 52% to 130% with relative standard deviations (RSDs) < 20% for spiked concentrations of 10, 50 and 250 μg/kg. More than 90% of the analytes achieved low limits of quantification (LOQs) < 10 μg/kg. The decision limit (CCα), detection capability (CCβ) values were in the range of 2-502 μg/kg and 4-505 μg/kg, resp. This method is significant for food safety monitoring and controlling veterinary drug use.

Journal of Chromatography A published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C14H12N2S, Recommanded Product: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Izquierdo, Rodolfo published the artcileDo certain imidazolium-based ionic liquid ion pairs/mordenite capture H₂S by conformational traps? An ONIOM-DFT study, Synthetic Route of 79917-90-1, the publication is Microporous and Mesoporous Materials (2022), 112053, database is CAplus.

We present detailed ONIOM(ωB97X-D:PM6) calculations for the formation mechanism of novel composites combining protonic mordenites (H-MOR) with various ionic liquids: 1,3-dimethyl-imidazolium chloride [MMIm]Cl, 1-ethyl-3-methyl-imidazolium chloride [EMIm]Cl; 1-methyl-3-propyl-imidazolium chloride [PMIm]Cl; 1-butyl-3-methyl-imidazolium chloride [BMIm]Cl, 1-(2-hydroxyethyl)-3-methyl-imidazolium chloride [HEMIm]Cl, 1,3-dimethyl-1,3,2-diazasilolium chloride [MMSiN]Cl, and 1,3-dimethyl-1,3-diphospholium chloride [MMPP]Cl. The most feasible [M]-MOR formation mechanism ([M]⁺ = [MMIm]⁺, [EMIm]⁺, [PMIm]⁺, [BMIm]⁺, [HEMIm]⁺, [MMSiN]⁺ [MMPP]⁺) involves an ion exchange at the T4O10 position favoring the isolation of a minimal number of [M]⁺ isomers (i.e., conformational traps). The interaction of these [M]-MOR composites with pollutant gases has afterward been evaluated. Among the studied systems, [EMIm]-MOR and [HEMIm]-MOR present electronic and steric conditions for potential applications in gas separation, capture, and storage (H₂ and H₂S). The H-MOR framework exhibits two structural conformers with the [HEMIm]+ cation in the confined space. Both, the MOR-T4O10-[HEMIm] and MOR-T4O10-[HEMIm]HB conformers, interconvert by a dynamic equilibrium with a transition state MOR-T4O10-TS1 acting as a conformational switch (Image 1-Image 2) that selectively recognizes and captures H₂S through a plier-like conformation.

Microporous and Mesoporous Materials published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Synthetic Route of 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Alberti, Guido published the artcileCationic dyes for acrylic fibers. V. Cationic dyes derived from several heterocyclic amines with two or more heteroatoms, SDS of cas: 13682-33-2, the publication is Annali di Chimica (Rome, Italy) (1975), 65(5-6), 305-14, database is CAplus.

Fourteen cationic azo dyes (I, R = dimethylimidazolium, dimethylbenzimidazolium, methylindazolium, dimethyltriazolium, dimethyltetrazolium, dimethylthiadiazolium residues; R1 = OH, CN; X = MeSO4, ZnCl3; n = 0, 1) were prepared by coupling the diazotized heterocyclic base derivative with PhN(CH2CH2CN)2 [1555-66-4] or PhN(CH2CH2OH)2 [120-07-0] and quaternizing the resulting azo dye base. The dyeing properties of I on acrylic fibers, their shades,, their exhaust properties, and absorption spectra were determined

Annali di Chimica (Rome, Italy) published new progress about 13682-33-2. 13682-33-2 belongs to imidazoles-derivatives, auxiliary class Imidazole,Amine,Benzene, name is 4-(1H-Imidazol-2-yl)aniline, and the molecular formula is C9H9N3, SDS of cas: 13682-33-2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Pisano, Gianmarco published the artcileMechanochemical synthesis of Cu(I)-N-heterocyclic carbene complexes, Quality Control of 258278-25-0, the publication is Green Chemistry (2020), 22(16), 5253-5256, database is CAplus.

It is reported a general, operationally simple and scalable mechanochem. method for the synthesis of [Cu(Cl)(NHC)] complexes. This solid-state and solvent-less methodol. was shown to be applicable to a wide range of NHC ligand precursors, allowing access to complexes of the type [Cu(Cl)(NHC)] under aerobic conditions and with minimised environmental impact.

Green Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Quality Control of 258278-25-0.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Pisano, Gianmarco published the artcileGeneral Mechanochemical Synthetic Protocol to Late Transition Metal-NHC (N-Heterocyclic Carbene) Complexes, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, the publication is ACS Sustainable Chemistry & Engineering (2021), 9(29), 9625-9631, database is CAplus.

A user-friendly and highly efficient mechanochem. strategy for the synthesis of a number of well-defined, catalytically relevant N-heterocyclic carbene-metal complexes under aerobic conditions is reported. This protocol proceeds in good to excellent yields and limits solvent usage to the purification step, which can be carried out, after judicious selection, using minimal amounts of environmentally benign solvents.

ACS Sustainable Chemistry & Engineering published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Recommanded Product: 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Machado, Poliana A. L. published the artcileLiquid-Liquid Phase Equilibrium and Ion-Exchange Exploration for Aqueous Two-Phase Systems of ([C₄mim]Cl + K₂CO₃ or K₃C₆H₅O₇ + water) at Different Temperatures, Related Products of imidazoles-derivatives, the publication is Journal of Solution Chemistry (2022), 51(3), 320-344, database is CAplus.

Liquid-liquid equilibrium (LLE) data and phase diagrams for new aqueous two-phase systems (ATPSs) containing 1-butyl-3-methylimidazolium chloride ([C₄mim]Cl) + tripotassium citrate or potassium carbonate + water were determined exptl. at T = (283.15, 293.15, 298.15, 308.15, and 313.15) K and p = 94 kbar. The effect of the temperature, anion, composition, and ion exchange were evaluated in the formation of these ATPSs. It was observed that decreasing the temperature promoted the phase separation in both ATPSs indicating the exothermic character of the process. The ability of different anions to induce phase separation was compared and the order for the strength of the salting out effect observed was PO^3-₄ > HPO^2-₄ > CO^2-₃ > C₆H₅O^3-₇>HO^–. The extent of ion exchange between the equilibrium phases in the two different ATPSs was exptl. evaluated and found to be negligible. The binodal curves were fitted to an empirical non-linear expression and the salting out effect was explored using the type-Setschenow equation and the consistence of equilibrium data was evaluated theor. using the Othmer-Tobias, Hand and Bancroft equations. Finally, the liquid-liquid equilibrium in the ATPSs evaluated in the present work were modeled by NRTL model.

Journal of Solution Chemistry published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Andrade, U. M. S. published the artcileImidazolium-based ionic liquids binding to DNA: Mechanical effects and thermodynamics of the interactions, Application of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is International Journal of Biological Macromolecules (2022), 500-511, database is CAplus and MEDLINE.

We performed a robust characterization of the mol. interactions between the DNA mol. and two imidazolium-based ionic liquids (ILs): 1-Butyl-3-methylimidazolium chloride ([bmim]Cl) and 1-Octyl-3-methylimidazolium chloride ([omim]Cl), using single mol. approaches (optical and magnetic tweezers) and bulk techniques (isothermal titration calorimetry and conductivity measurements). Optical and magnetic tweezers allowed us to obtain the changes on the mech. properties of the DNA complexes formed with both ILs, as well as the relevant physicochem. (binding) parameters of the interaction. Despite the weak binding measured between DNA and the two ILs, we identify a transition on the regime of polymer elasticity of the complexes formed, which results in a relevant DNA compaction for high IL concentrations In addition, isothermal titration calorimetry and conductivity complemented the single mol. investigation, giving a complete thermodn. characterization of the interactions and allowing the identification of the most relevant driving forces at various different concentration ranges of the ILs. Based on the results obtained with all the employed techniques, we propose a model for the binding schemes involving DNA and both [bmim]Cl and [omim]Cl.

International Journal of Biological Macromolecules published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Application of 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Suwalsky, Mario published the artcileIn vitro effects of benzimidazole/thioether-copper complexes with antitumor activity on human erythrocytes, SDS of cas: 4760-35-4, the publication is Journal of Inorganic Biochemistry (2018), 87-93, database is CAplus and MEDLINE.

Two cytotoxic copper(II) complexes with N-H and N-methylated benzimidazole-derived ligands (Cu-L¹ and Cu-L^1Me; L¹ = bis(2-methylbenzimidazolyl)(2-methylthioethyl)amine, L^1Me = bis(1-methyl-2-methylbenzimidazolyl)(2-methylthioethyl)amine) were synthesized and exposed to human erythrocytes and mol. models of its membrane. The latter were bilayers built-up of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE), classes of lipids present in the external and internal moieties of the human red cell membrane, resp. SEM of erythrocytes incubated with solutions of both Cu(II) complexes showed that they induced morphol. changes to the normal cells to echinocytes, and hemolysis at higher concentrations Real-time observation of the dose-dependent effects of the complexes on live erythrocytes by defocusing microscopy (DM) confirmed SEM results. The formation of echinocytes implied that complex mols. inserted into the outer moiety of the red cell membrane. X-ray diffraction studies on DMPC and DMPE showed that none of these complexes interacted with DMPE and only Cu-L¹ interacted with DMPC. This difference was explained by the fact that Cu-L^1Me complex is more voluminous than Cu-L¹ because it has two addnl. Me groups; on the other hand, DMPC mol. has three Me groups in its bulky terminal amino end. Thus, by steric hindrance Cu-L^1Me mols. cannot intercalate into DMPC bilayer, which besides is present in the gel phase. These results, together with the increased antiproliferative capacity of the N-methylated complex Cu-L^1Me over that of Cu-L¹ are rationalized mainly based on its higher lipophilicity.

Journal of Inorganic Biochemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C7H13ClNNaO5S, SDS of cas: 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Casella, Luigi published the artcileHemocyanin and tyrosinase models. Synthesis, azide binding, and electrochemistry of dinuclear copper(II) complexes with poly(benzimidazole) ligands modeling the met forms of the proteins, Quality Control of 4760-35-4, the publication is Inorganic Chemistry (1993), 32(10), 2056-67, database is CAplus.

The new poly(benzimidazole) ligands α,α’-bis[[bis(1-methyl-2-benzimidazolyl)methyl]amino]-m-xylene (L-5,5) and α,α’-bis[bis[2-(1-methyl-2-benzimidazolyl)ethyl]amino]-m-xylene (L-6,6) and their dicopper(I) and bis(aqua)-dicopper(II) complexes are reported. The ligands provide 1 tertiary amino and 2 benzimidazole N donors to each metal center; each of the 2 arms of L-5,5 binds the metal with 2 adjacent 5-membered chelate rings, while with L-6,6 these chelate rings are 6-membered. The dicopper(I) complexes react with dioxygen to produce the bis(hydroxo)dicopper(II) complexes. The bis(aqua)- and bis(hydroxo)dicopper(II) complexes can be interconverted in a single step by addition of base and acid, resp. The electrochem. behavior of the bis(aqua)dicopper(II) complex of L-6,6 shows reversible reduction to the corresponding dicopper(I) complex whereas the analogous complex of L-5,5 is irreversibly reduced. The bis(hydroxo)dicopper(II) complexes of both ligands also undergo irreversible reduction Azide adducts of the dicopper(II) complexes were isolated; the anion bridges the 2 coppers in μ-1,1 fashion in the L-5,5 derivative and in μ-1,3 fashion in the L-6,6 derivative The spectral properties of the 2 complexes are significantly different. Binding studies performed in solution for the bis(aqua)- and bis(hydroxo)dicopper(II) complexes show that up to 4 azide mol. can bind to the complexes and the affinity of azide decreases with the charge of the complex. Electrochem. shows that, upon increasing the number of bound azide groups, the successive reductions of the 2 Cu(II) centers tend to coalesce, thus indicating progressive lowering of the electronic communication between the metal centers. The relevance of the spectroscopic and binding data of these azide complexes to hemocyanin and tyrosinase is discussed.

Inorganic Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Quality Control of 4760-35-4.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Seo, Young Ho published the artcileFacile synthesis and biological evaluation of a cell-permeable probe to detect redox-regulated proteins, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(2), 356-359, database is CAplus and MEDLINE.

We have developed an improved synthesis for the cell-permeable, sulfenic acid probe DAz-1. Using DAz-1, we detect sulfenic acid modifications in the cell-cycle regulatory phosphatase Cdc25A. In addition, we show that DAz-1 has superior potency in cells compared to a biotinylated derivative Collectively, these findings set the stage for the development of activity-based inhibitors of Cdc25 cell-cycle phosphatases, which are sensitive to the redox state of the active-site cysteine and demonstrate the advantage of bioorthogonal conjugation methods to detect protein sulfenic acids in cells.

Bioorganic & Medicinal Chemistry Letters published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C11H15NOS, Recommanded Product: N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem