Inorganic Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Formula: C9H9ClN2.
Monzani, Enrico published the artcileMechanistic, Structural, and Spectroscopic Studies on the Catecholase Activity of a Dinuclear Copper Complex by Dioxygen, Formula: C9H9ClN2, the publication is Inorganic Chemistry (1999), 38(23), 5359-5369, database is CAplus.
Dinuclear Cu(II) complexes with the new ligand 1,6-bis[[bis(1-methyl-2-benzimidazolyl)methyl]amino]-n-hexane (EBA) were synthesized, and their reactivity as models for tyrosinase was studied in comparison with that of previously reported dinuclear complexes containing similar aminobis(benzimidazole) donor groups. [Cu2(EBA)(H2O)4]4+, five-coordinated square pyramidal, with three N donors from the ligand and two H2O mols. per Cu, can be reversibly converted into the bis(hydroxo) complex [Cu2(EBA)(OH)2]2+ by addition of base (pKa1 = 7.77, pKa2 = 9.01). The latter complex can also be obtained by air oxidation of [Cu2(EBA)]2+ in MeOH. The x-ray structural characterization of [Cu2(EBA)(OH)2]2+ shows that a double μ-hydroxo bridge is established between the two Cu(II) centers in this complex. The coordination geometry of the coppers is distorted square planar, with two benzimidazole donors and two hydroxo groups in the equatorial plane, and an addnl., lengthened and severely distorted axial interaction (â?.5 Ã
) with the tertiary amine donor. The small size and the quality of the single crystal as well as the fair loss of crystallinity during data collection required the use of synchrotron radiation at 100 K. [Cu2(EBA)(OH)2][PF6]2: orthorhombic Pca21 space group, a 22.458(2), b 10.728(1), c 19.843(2) Ã
, R = 0.089. Besides OH–, the [Cu2(EBA)(H2O)4]4+ complex binds azide as a bridging ligand, with the μ-1,3 mode. Azide can also displace μ-OH in [Cu2(EBA)(OH)2]2+ as a bridging ligand. In general, the binding constants indicate that the long alkyl chain of EBA is less easily folded in the structures containing bridging ligands than the m-xylyl residue present in the previously reported dicopper(II) complexes. Electrochem. experiments show that [Cu2(EBA)(H2O)4]4+ undergoes a single, partially chem. reversible, two-electron reduction to the corresponding dicopper(I) congener at pos. potential values (E0‘ = 0.22 V, vs. SCE). Interestingly, however, coordination to azide ion makes the reduction process proceed through two separated 1-electron steps. The catalytic activity of [Cu2(EBA)(H2O)4]4+ in the oxidation of 3,5-di-tert-butylcatechol was examined in MeOH/aqueous buffer, pH 5.1. The mechanism of the catalytic cycle parallels that of tyrosinase, where no H2O2 is released and dioxygen is reduced to H2O. Low-temperature (-80°) spectroscopic experiments show that oxygenation of the reduced complex [Cu2(EBA)]2+ does not produce a stable dioxygen adduct and leads to a μ-oxodicopper(II) species in a fast reaction.
Inorganic Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Formula: C9H9ClN2.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem