Month: November 2022

Beillard, Audrey published the artcileMechanochemistry for facilitated access to N,N-diaryl NHC metal complexes, Related Products of imidazoles-derivatives, the publication is New Journal of Chemistry (2017), 41(3), 1057-1063, database is CAplus.

A user-friendly and solvent-free mechanosynthetic strategy allowed light-sensitive Ag(I) complexes featuring N,N-diaryl N-heterocyclic carbenes (NHC), including challenging and sterically hindered ligands, to be yielded efficiently. The 1st transmetalations using ball-milling to obtain Pd and Cu NHC complexes were performed. A convenient 1-pot two-step metalation/transmetalation procedure was also realized.

New Journal of Chemistry published new progress about 258278-25-0. 258278-25-0 belongs to imidazoles-derivatives, auxiliary class Achiral NHCs Ligands, name is 1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chloride, and the molecular formula is C27H39ClN2, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Xu, Yida published the artcileIon Channel Mimetic Chronopotentiometric Polymeric Membrane Ion Sensor for Surface-Confined Protein Detection, Related Products of imidazoles-derivatives, the publication is Langmuir (2009), 25(1), 568-573, database is CAplus and MEDLINE.

The operation of ion channel sensors is mimicked with functionalized polymeric membrane electrodes, using a surface confined affinity reaction to impede the electrochem. imposed ion transfer kinetics of a marker ion. A membrane surface biotinylated by covalent attachment to the polymeric backbone is used here to bind to the protein avidin as a model system. The results indicate that the protein accumulates on the ion-selective membrane surface, partially blocking the current-induced ion transfer across the membrane/aqueous sample interface, and subsequently decreases the potential jump in the so-called super-Nernstian step that is characteristic of a surface depletion of the marker ion. The findings suggest that such a potential drop could be utilized to measure the concentration of protein in the sample. Because the sensitivity of protein sensing is dependent on the effective blocking of the active surface area, it can be improved with a hydrophilic nanopore membrane applied on top of the biotinylated ion-selective membrane surface. On the basis of cyclic voltammetry characterization, the nanoporous membrane electrodes can indeed be understood as a recessed nanoelectrode array. The results show that the measuring range for protein sensing on nanopore electrodes is shifted to lower concentrations by more than 1 order of magnitude, which is explained with the reduction of surface area by the nanopore membrane and the related more effective hemispherical diffusion pattern.

Langmuir published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C14H12N2S, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Rasoolzadeh, Ali published the artcileA thermodynamic framework for determination of gas hydrate stability conditions and water activity in ionic liquid aqueous solution, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, the publication is Journal of Molecular Liquids (2022), 118358, database is CAplus.

The formation of gas hydrates in pipelines and plugging of the gas flow path are a major cause of operating expenses, safety issues, pressure drop, and fatal accidents. Therefore, the inhibition of gas hydrate formation is of paramount importance. The utilization of a new class of inhibitors such as ionic liquids (ILs) is currently of great interest. In this regard, adjusting water activity in the inhibitor blend (water + IL) is a vital factor. Several models have been developed to calculate the activity of water in the presence of IL(s). The major disadvantage of these models is their correlative basis. This study aimed to propose a rigorous predictive model for the calculation of water activity in the presence of IL(s), which would then be applied in the prediction of the gas hydrate stability conditions. The model is made up of a mol. term (the short-range interactions from Free-Volume-Flory-Huggins (FVFH) activity model) as well as a contribution from ionic interactions as a result of IL(s) dissociation in water (the long-range electrostatic interactions from the extended Debye-Huckel (EDH) model). The overall absolute temperature deviation and the average absolute relative deviation percent in the calculated gas (methane and carbon dioxide) hydrate dissociation temperatures for the whole databank (500 data points including 37 ILs) were found to be 0.61 K and 0.22%, resp. This proves the superiority of the model over the previous correlative-basis ones. Finally, it is concluded that the higher temperature, the higher the IL(s) concentration, and the lower IL(s) mol. weight(s) result in larger model deviations.

Journal of Molecular Liquids published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Recommanded Product: 3-Butyl-1-methyl-1H-imidazol-3-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Yun, Tae Gwang published the artcileIon-permselective conducting polymer-based electrokinetic generators with maximized utility of green water, HPLC of Formula: 79917-90-1, the publication is Nano Energy (2022), 106946, database is CAplus.

Hydro-elec. technol. has gathered much attention by the virtue of water as the energy source. However, the low energy d. of this technol. severely limits its practical use. Here, we demonstrate a PEDOT:PSS-based transpiration-driven electrokinetic power generator (p-TEPG) that enables the utilization of a wider variety of real-world water resources for maximizing energy generation efficiencies. In addition to the conventional elec. double layer on the material surface, the p-TEPG builds an addnl. p.d. in the polymer matrix by the selective penetration of cations into the matrix that contains sulfonate functional groups. p-TEPG exhibits 80-250% higher energy d. than carbon-based TEPG at the same resistance. Moreover, seawater produced enhanced volumetric energy/power densities (34.36 mJ cm^-3 and 44.70μW cm^-3) and areal energy/power densities (410μJ cm^-2 and 0.45μW cm^-2), resp., compared to DI water on a single p-TEPG device, which is sufficient to charge elec. energy storage systems and directly operate low-powered electronic.

Nano Energy published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C7H13BrSi, HPLC of Formula: 79917-90-1.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Marszall, Michal Piotr published the artcileEvaluation of the silanol-suppressing potency of ionic liquids, Name: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, the publication is Journal of Separation Science (2006), 29(8), 1138-1145, database is CAplus and MEDLINE.

Recently, increasing attention was paid to the use of ionic liquids for HPLC and capillary electrophoresis. The silanol-suppressing potency of ionic liquids was evaluated by HPLC using the two-retention site model proposed previously by Nahum and Horvath. The binding constant, K_A, in that approach was demonstrated to reliably reflect the ability of the ionic liquids to block the silanols of the silica support material of the stationary phase. The determinations were carried out for ionic liquids of the 1-alkyl-3-methylimidazolium group using basic drugs as the test analytes. Comparison of ionic liquids with standard mobile phase additives such as triethylamine showed the former to possess advantages as silanol suppressors in HPLC. The main advantage of the method is that it provides a simple and fast determination of the silanol complex stability, which allowed comparison of the suppressing efficiency of several ionic liquids

Journal of Separation Science published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Name: N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Marszall, Michal Piotr published the artcileReduction of silanophilic interactions in liquid chromatography with the use of ionic liquids, Synthetic Route of 2508-72-7, the publication is Analytica Chimica Acta (2005), 547(2), 172-178, database is CAplus.

A suppression of silanophilic interactions by the selected ionic liquids added to the mobile phase in thin-layer chromatog. (TLC) and HPLC is reported. Acetonitrile was used as the eluent, alone or with various concentrations of water and phosphoric buffer pH 3. Selectivity of the normal (NP) and the reversed (RP) stationary phase material was examined using proton-acceptor basic drugs analytes. The ionic liquids studied appeared to significantly affect analyte retention in NP-TLC, RP-TLC and RP-HPLC systems tested. Consequently, the increased separation selectivity was attained. Due to ionic liquid additives to eluent even analytes could be chromatographed, which were not eluted from the silica-based stationary phase materials with 100% of acetonitrile in the mobile phase. Addition of ionic liquid already in very small concentration (0.5%, volume/volume) could reduce the amount of acetonitrile used during the optimization of basic analytes separations in TLC and HPLC systems. Also, the influence of temperature on the separation of basic analytes was demonstrated and considered in practical HPLC method development.

Analytica Chimica Acta published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Synthetic Route of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ooki, Atsuhi published the artcileEstimation of a eutectic composition of imidazolium chloride ionic liquids using video imaging and impedance methods, Formula: C8H15ClN2, the publication is Fluid Phase Equilibria (2022), 113442, database is CAplus.

The eutectic temperature Te and composition Xe of binary systems composed of three ionic liquids, 1-ethyl-3-methylimidazolium chloride ([C₂mim]Cl), 1-methyl-3-propylimidazolium chloride ([C₃mim]Cl), and 1-butyl-3-methylimidazolium chloride ([C₄mim]Cl), were estimated using a video imaging method, in which the formation of a liquid phase on solidified ionic liquids at a given composition stored in a vial was detected from time-lapse images taken during temperature scanning. The advantage of this method is that multiple samples (five samples in this study) could be measured simultaneously, whereas its disadvantage is a less accurate determination of the m.p. compared with the conventional differential scanning calorimetry (DSC) method. The Te and Xe of [C₂mim]Cl-[C₃mim]Cl, [C₂mim]Cl-[C₄mim]Cl, and [C₃mim]Cl-[C4mim]Cl binary systems were roughly estimated Furthermore, the Te of the ternary system of the [C2mim]Cl-[C3mim]Cl-[C4mim]Cl with limited compositions was estimated, which was lower than that of the binary systems. The transition of the electrochem. impedance of [C2mim]Cl ionic liquids was also measured using two Pt wire electrodes as a function of temperature The differential inversed resistance curve (dR-1/dT)-T shows an obvious peak corresponding to the phase transition from a low conductive solid phase to a highly conductive liquid phase. This peak was comparable with the peak obtained in the DSC measurement.

Fluid Phase Equilibria published new progress about 79917-90-1. 79917-90-1 belongs to imidazoles-derivatives, auxiliary class Ionic Liquid,Ionic Liquid, name is 3-Butyl-1-methyl-1H-imidazol-3-ium chloride, and the molecular formula is C8H15ClN2, Formula: C8H15ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Kidd, James M. published the artcilePhysical Compatibility of Meropenem and Vaborbactam With Select Intravenous Drugs During Simulated Y-site Administration, Name: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is Clinical Therapeutics (2018), 40(2), 261-269, database is CAplus and MEDLINE.

Meropenem/vaborbactam is a novel i.v. antibiotic combining the carbapenem, meropenem, with a novel β-lactamase inhibitor, vaborbactam. Meropenem/vaborbactam is administered as a 3-h infusion given every 8 h, thereby potentially restricting an i.v. line for 9 h/d. I.v. medications may be given concurrently via Y-site when compatibility data are available. Herein, phys. compatibility was determined for the identification which medications can be coadministered with meropenem/vaborbactam via Y-site.Y-site administration was simulated in vitro by admixing 5 mL of meropenem 8 mg/mL and vaborbactam 8 mg/mL with an equal volume of 88 other diluted i.v. medications, including 34 antimicrobials. All other medications were diluted with 0.9% sodium chloride to the upper range of concentrations considered standard for i.v. infusion. Visual inspection, turbidity measurement, and pH measurement were performed prior to admixture, directly after admixture, and at time points up to 3 h after admixtureOf the 88 medications tested, meropenem/vaborbactam was compatible with 73 (83%), including many antibiotics such as aminoglycosides (amikacin, gentamicin, and tobramycin), colistin, fosfomycin, linezolid, tedizolid, tigecycline, and vancomycin. Phys. incompatibility was observed with albumin, amiodarone, anidulafungin, calcium chloride, caspofungin, ceftaroline, ciprofloxacin, daptomycin, diphenhydramine, dobutamine, isavuconazole, midazolam, nicardipine, ondansetron, and phenytoin.The majority of i.v. medications tested were found to be phys. compatible with meropenem/vaborbactam. These data will help pharmacists and nurses to improve line access in patients receiving meropenem/vaborbactam.

Clinical Therapeutics published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Name: Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Asempa, Tomefa E. published the artcilePhysical compatibility of plazomicin with select i.v. drugs during simulated Y-site administration, Safety of Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, the publication is American Journal of Health-System Pharmacy (2018), 75(14), 1048-1056, database is CAplus and MEDLINE.

The results of a study to determine the phys. compatibility of plazomicin sulfate solution during simulated Y-site administration with 92 i.v. drugs are reported. Plazomicin injection solution (500 mg/10 mL) was diluted in 0.9% sodium chloride or 5% dextrose for injection to a final volume of 50 mL (final plazomicin concentration, 24 mg/mL), consistent with a 15-mg/kg dose administered to an 80-kg patient (i.e., 1,200 mg). All other i.v. drugs were reconstituted according to manufacturers’ recommenda- tions and diluted with 0.9% sodium chloride or 5% dextrose for injection to the upper range of concentrations used clin. Y-site conditions were simulated by mixing 5 mL of plazomicin solution with 5 mL of tested drug solutions in a 1:1 ratio. Solutions were assessed for visual (via color and Tyndall beam testing), turbidity (using a laboratory-grade turbidimeter), and pH changes over a 60-min observation period. Incompatibility was defined a priori as precipitation, color change, a pos. Tyndall test, or a turbidity change of â‰?.5 nephelometric turbidity units at any time during the 60-min observation period. Plazomicin was phys. compatible with 79 of the 92 drugs tested. Determinations of phys. incompatibility with plazomicin were made for 13 drugs: albumin, amiodarone, amphotericin B deoxycholate, anidulafungin, calcium chloride, daptomycin, esomeprazole, heparin, le- vofloxacin, methylprednisolone, micafungin, phenytoin, and propofol, Conclusion. Plazomicin at a concentration of 24 mg/mL was phys. compatible with 85% of the drugs tested, including 31 of 36 antimicrobial agents.

American Journal of Health-System Pharmacy published new progress about 161796-78-7. 161796-78-7 belongs to imidazoles-derivatives, auxiliary class Membrane Transporter/Ion Channel,Proton Pump, name is Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide, and the molecular formula is C17H18N3NaO3S, Safety of Sodium (S)-6-methoxy-2-(((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Liu, Feng published the artcileThe Engineering of Bacteria Bearing Azido-Pseudaminic Acid-Modified Flagella, HPLC of Formula: 359860-27-8, the publication is ChemBioChem (2009), 10(8), 1317-1320, database is CAplus and MEDLINE.

Catch a tiger by the tail: We have demonstrated that by feeding nonmotile mutant C. jejuni bacteria with a neutral azide-labeled pseudaminic acid precursor we can restore their ability to generate functional flagella. The presence of azido-pseudaminic acid on the surface of the flagella provides a bio-orthogonal chem. handle that can be used to modify the flagellar proteins.

ChemBioChem published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, HPLC of Formula: 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem