Month: November 2022

Kracmar, J.’s team published research in Cesko-Slovenska Farmacie in 25 | CAS: 2508-72-7

Cesko-Slovenska Farmacie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Related Products of imidazoles-derivatives.

Kracmar, J. published the artcileUltraviolet spectrophotometry in drug control. XX. Study on the effect of substitution and solvents in more recent medicinal substances with the chromophores of benzene rings in the molecules, Related Products of imidazoles-derivatives, the publication is Cesko-Slovenska Farmacie (1976), 25(7), 243-57, database is CAplus.

Thirty RPh, RC6H4-alkyl, RC6H4-halo, RC6H4O-alkyl, RC6H4OH, RC6H4N alkyl2, RC6H4NO2, RC6H4NH2NHaryl, and RC6H4Ch:N(N:N) drugs were characterized by the absorption bands E, K, B, and R, and vibration structures of the bands K and B. Absorption maximum at 235 nm were used for quant. determination of active substances in drugs. More specific long-wave absorption maximum were used for determination of substances having several absorption maximum Agreement with Beer’s law at the recommended absorption maximum was verified.

Cesko-Slovenska Farmacie published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Related Products of imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Sloboda-Rozner, Dorit’s team published research in Journal of the American Chemical Society in 125 | CAS: 79047-41-9

Journal of the American Chemical Society published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C12H25Br, COA of Formula: C8H13ClN2O.

Sloboda-Rozner, Dorit published the artcileA Water-Soluble and “Self-Assembled” Polyoxometalate as a Recyclable Catalyst for Oxidation of Alcohols in Water with Hydrogen Peroxide, COA of Formula: C8H13ClN2O, the publication is Journal of the American Chemical Society (2003), 125(18), 5280-5281, database is CAplus and MEDLINE.

A water-soluble polyoxometalate, Na12[WZnZn2(H2O)2(ZnW9O34)2], synthesized from readily available zinc nitrate and sodium tungstate in the presence of nitric acid, is an effective catalyst for the preparation of ketones and carboxylic acids by selective alc. oxidation with hydrogen peroxide in biphasic (water-alc.) reaction media. Carboxylic acids are obtained by oxidation of primary alcs. with hydrogen peroxide in the presence of Na12[WZnZn2(H2O)2(ZnW9O34)2]; addition of catalytic amounts of TEMPO to oxidation mixtures yields increased proportions of the aldehyde in addition to the carboxylic acid. Secondary alcs. are oxidized in preference to primary alcs. to give ketones; carbon-carbon bond cleavage byproducts are seen in one case. The catalyst generated in situ is as active as the isolated catalyst; in addition, the catalyst can be separated and recycled without losses in either selectivity or in activity.

Journal of the American Chemical Society published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C12H25Br, COA of Formula: C8H13ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Nystroem, Lina’s team published research in Biomacromolecules in 19 | CAS: 359860-27-8

Biomacromolecules published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Nystroem, Lina published the artcileAvidin-Biotin Cross-Linked Microgel Multilayers as Carriers for Antimicrobial Peptides, Formula: C18H34N4O5S, the publication is Biomacromolecules (2018), 19(12), 4691-4702, database is CAplus and MEDLINE.

Herein, we report on the formation of cross-linked antimicrobial peptide-loaded microgel multilayers. Poly(Et acrylate-co-methacrylic acid) microgels were synthesized and functionalized with biotin to enable the formation of microgel multilayers cross-linked with avidin. Microgel functionalization and avidin crosslinking were verified with IR spectroscopy, dynamic light scattering, and z-potential measurements, while multilayer formation (up to four layers) was studied with null ellipsometry and quartz crystal microbalance with dissipation (QCM-D). Incorporation of the antimicrobial peptide KYE28 (KYEITTIHNLFRKLTHRLFRRNFGYTLR) into the microgel multilayers was achieved either in one shot after multilayer formation or through addition after each microgel layer deposition. The latter was found to strongly promote peptide incorporation. Further, antimicrobial properties of the peptide-loaded microgel multilayers against Escherichia coli were investigated and compared to those of a peptide-loaded microgel monolayer. Results showed a more pronounced suppression in bacterial viability in suspension for the microgel multilayers. Correspondingly, LIVE/DEAD staining showed promoted disruption of adhered bacteria for the KYE28-loaded multilayers. Taken together, cross-linked microgel multilayers thus show promise as high load surface coatings for antimicrobial peptides.

Biomacromolecules published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Thomas, Andrew P.’s team published research in Journal of Medicinal Chemistry in 35 | CAS: 79047-41-9

Journal of Medicinal Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C3H9ClOS, Synthetic Route of 79047-41-9.

Thomas, Andrew P. published the artcileNew nonpeptide angiotensin II receptor antagonists. 1. Synthesis, biological properties and structure-activity relationships of 2-alkylbenzimidazole derivatives, Synthetic Route of 79047-41-9, the publication is Journal of Medicinal Chemistry (1992), 35(5), 877-85, database is CAplus and MEDLINE.

Based on 2-[4-{2-butyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-ylmethyl}phenyl]benzoic acid, a known angiotensin II receptor antagonist, a series of 1H-benzimidazol-1-yl analogs and 4-[(2-alkyl-1H-benzimidazol-1-yl)methyl]benzoic acids (I, R1 = alkyl; R2 = H, Cl, F, OMe, NO2; R3 = H, Br, Cl, F, Me, OMe) were prepared The antihypertensive structure-activity relationship of these benzimidazolyl derivatives and some rigid analogs, such as 2-(3-butyl-1-chloro-5H,11H-imidazo[5,1-c][1,4]benzoxazepin-8-yl)benzoic acid (II), was determined

Journal of Medicinal Chemistry published new progress about 79047-41-9. 79047-41-9 belongs to imidazoles-derivatives, auxiliary class Imidazole,Chloride,Alcohol, name is (2-Butyl-4-chloro-1H-imidazol-5-yl)methanol, and the molecular formula is C3H9ClOS, Synthetic Route of 79047-41-9.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Davood, Asghar’s team published research in Turkish Journal of Chemistry in 32 | CAS: 45533-87-7

Turkish Journal of Chemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Application In Synthesis of 45533-87-7.

Davood, Asghar published the artcileEfficient synthesis of imidazole derivatives: an important synthon for the preparation of biologically active compounds, Application In Synthesis of 45533-87-7, the publication is Turkish Journal of Chemistry (2008), 32(3), 389-395, database is CAplus.

4(5)-Chloroimidazole-5(4)-carboxaldehydes are important precursors for the preparation of biol. active compounds A simple, novel, and efficient method for the synthesis of these compounds was developed starting from aldehydes, (HOCH2)2CO, and NH4OH. The chem. described is amenable to large-scale use and is flexible enough to allow the preparation of analogs.

Turkish Journal of Chemistry published new progress about 45533-87-7. 45533-87-7 belongs to imidazoles-derivatives, auxiliary class Imidazole,Alcohol,Imidazole, name is (2-Methyl-1H-imidazol-4-yl)methanol, and the molecular formula is C5H8N2O, Application In Synthesis of 45533-87-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Saha, Prasenjit’s team published research in Organic & Biomolecular Chemistry in 8 | CAS: 2622-67-5

Organic & Biomolecular Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Name: 1,2-Diphenyl-1H-benzo[d]imidazole.

Saha, Prasenjit published the artcileCobalt-catalyzed intramolecular C-N and C-O cross-coupling reactions: synthesis of benzimidazoles and benzoxazoles, Name: 1,2-Diphenyl-1H-benzo[d]imidazole, the publication is Organic & Biomolecular Chemistry (2010), 8(24), 5692-5699, database is CAplus and MEDLINE.

Cobalt(II)-complex catalyzes efficiently the intramol. C-N and C-O cross-couplings of Z-N’-(2-halophenyl)-N-phenylamidines, e.g. I, and N-(2-bromophenyl)benzamides, e.g. II, to afford the corresponding substituted benzimidazoles and benzoxazoles, e.g. III [X = NPh, O], in the presence of K2CO3 at moderate temperature The protocol is general, air stable and affords the products selectively in moderate to high yield.

Organic & Biomolecular Chemistry published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Name: 1,2-Diphenyl-1H-benzo[d]imidazole.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Petryayeva, Eleonora’s team published research in Analytical and Bioanalytical Chemistry in 408 | CAS: 359860-27-8

Analytical and Bioanalytical Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Synthetic Route of 359860-27-8.

Petryayeva, Eleonora published the artcileA job for quantum dots: use of a smartphone and 3D-printed accessory for all-in-one excitation and imaging of photoluminescence, Synthetic Route of 359860-27-8, the publication is Analytical and Bioanalytical Chemistry (2016), 408(11), 2913-2925, database is CAplus and MEDLINE.

Point-of-care (POC) diagnostic technologies are needed to improve global health and smartphones are a prospective platform for these technologies. While many fluorescence or photoluminescence-based smartphone assays have been reported in the literature, common shortcomings are the requirement of an excitation light source external to the smartphone and complicated integration of that excitation source with the smartphone. Here, the photog. flash associated with the smartphone camera can be used to enable all-in-one excitation and imaging of photoluminescence (PL), thus eliminating the need for an excitation light source external to the smartphone. A simple and low-cost 3D-printed accessory was designed to create a dark environment and direct excitation light from the smartphone flash onto a sample. Multiple colors and compositions of semiconductor quantum dot (QD) were evaluated as photoluminescent materials for all-in-one smartphone excitation and imaging of PL, and these were compared with fluorescein and R-phycoerythrin (R-PE), which are widely used mol. and protein materials for fluorescence-based bioanal. The QDs exhibit much better brightness and have the best potential for two-color detection. A model protein binding assay with a sub-microgram per mL detection limit and a Forster resonance energy transfer (FRET) assay for proteolytic activity were demonstrated, including imaging with serum as a sample matrix. In addition, FRET within tandem conjugates of a QD donor and fluorescent dye acceptor enabled smartphone detection of dye fluorescence that was otherwise unobservable without the QD to enhance its brightness. The ideal properties of photoluminescent materials for all-in-one smartphone excitation and imaging are discussed in the context of several different materials, where QDs appear to be the best overall material for this application.

Analytical and Bioanalytical Chemistry published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Synthetic Route of 359860-27-8.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Gaber, Abd El-Aal M.’s team published research in Journal of Analytical and Applied Pyrolysis in 82 | CAS: 2622-67-5

Journal of Analytical and Applied Pyrolysis published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Category: imidazoles-derivatives.

Gaber, Abd El-Aal M. published the artcileThermal fragmentation and rearrangement of N-arylbenzamidoxime and O-phenylsulfonyloxime derivatives, Category: imidazoles-derivatives, the publication is Journal of Analytical and Applied Pyrolysis (2008), 82(1), 110-116, database is CAplus.

Thermal fragmentation of N-arylbenzamide oximes I, II (Ar = Ph, p-tolyl) under nitrogen gives rise to benzanilide and 2-phenylbenzoxazole as the major products, in addition to benzonitrile, arylamines, phenols, benzoic acid, o- and p-aminophenols and benzimidazole derivatives In the presence of naphthalene as radical scavenger, I gave α- and β-naphthols beside the previous products. Also, heating N-arylbenzamide O-phenylsulfonyloximes III under reflux in boiling tetralin lead to the formation of benzonitrile, arylamines, diphenylamine, benzenesulfonic acid, di-Ph sulfone, 1-hydroxytetralin, α-tetralone, and 1,1′-bitetralyl as the major products. Analogous results are obtained on heating III in the presence of isoquinoline as a radical trap which formed 1-phenylisoquinoline. The isolated products have been interpreted in terms of a free radical mechanism involving the homolysis of N-O and/or C-N bonds.

Journal of Analytical and Applied Pyrolysis published new progress about 2622-67-5. 2622-67-5 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Benzene,Benzimidazole, name is 1,2-Diphenyl-1H-benzo[d]imidazole, and the molecular formula is C19H14N2, Category: imidazoles-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Gilchrist, M. Lane’s team published research in Analytical Chemistry (Washington, DC, United States) in 88 | CAS: 359860-27-8

Analytical Chemistry (Washington, DC, United States) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Gilchrist, M. Lane published the artcileImaging and Functional Analysis of γ-Secretase and Substrate in a Proteolipobead System with an Activity-Based Probe, Formula: C18H34N4O5S, the publication is Analytical Chemistry (Washington, DC, United States) (2016), 88(2), 1303-1311, database is CAplus and MEDLINE.

Investigation of intramembranal protease catalysis demands the generation of intact biomembrane assemblies with structural integrity and lateral mobility. Here, we report the development of a microsphere supported-biomembrane platform enabling characterization of γ-secretase and substrate within proteolipobead assemblies via microscopy and flow cytometry. The active enzyme loading levels were tracked using an activity-based probe, with the biomembranes delineated by carbocyanine lipid reporters. Proteolipobeads formed from HeLa proteoliposomes gave rise to homogeneous distributions of active γ-secretase within supported biomembranes with native-like fluidity. The substrate loading into supported biomembranes was detergent-dependent, as evidenced by even colocalization of substrate and lipid tracers in confocal 3D imaging of individual proteolipobeads. Moreover, the loading level was tunable with bulk substrate concentration γ-Secretase substrate cleavage and its inhibition within γ-secretase proteolipobeads were observed This platform offers a means to visualize enzyme and substrate loading, activity, and inhibition in a controllable biomembrane microenvironment.

Analytical Chemistry (Washington, DC, United States) published new progress about 359860-27-8. 359860-27-8 belongs to imidazoles-derivatives, auxiliary class Other Aliphatic Heterocyclic,Chiral,Amine,Amide,Ether,Inhibitor, name is N-(2-(2-(2-(2-Aminoethoxy)ethoxy)ethoxy)ethyl)-5-((3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamide, and the molecular formula is C18H34N4O5S, Formula: C18H34N4O5S.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem

Ali, Amir’s team published research in Acta Chimica Slovenica in 64 | CAS: 2508-72-7

Acta Chimica Slovenica published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Quality Control of 2508-72-7.

Ali, Amir published the artcileStability indicating UHPLC-PDA assay for simultaneous determination of antazoline hydrochloride and naphazoline hydrochloride in ophthalmic formulations, Quality Control of 2508-72-7, the publication is Acta Chimica Slovenica (2017), 64(2), 332-341, database is CAplus and MEDLINE.

In the present study, a newly developed method based on ultrahigh performance liquid chromatog. (UHPLC) was optimized for the simultaneous determination of antazoline hydrochloride (ANZ) and naphazoline hydrochloride (NFZ) in ophthalmic formulations. Isocratic separation of ANZ and NFZ was performed at 40 °C with an ACE Excel 2 C18-PFP column (2 μm, 2.1 × 100 mm) at a flow rate of 0.6 mL min-1 whereas the mobile phase consisted of acetonitrile/phosphate buffer (60.40, volume/volume, pH 3.0) containing 0.5% triethylamine. Both analytes were detected at a wavelength of 285 nm and the injection volume was 1.0 μL. The overall run time per sample was 4.5 min with retention time of 0.92 and 1.86 min for NFZ and ANZ, resp. The calibration curve was linear from 0.500-100 μg mL-1 for ANZ and NFZ with a correlation coefficient ≥ 0.9981 while repeatability and reproducibility (expressed as relative standard deviation) were lower than 1.28 and 2.14%, resp. In comparison with high-performance liquid chromatog. (HPLC), the developed UHPLC method had remarkable advantages over HPLC as the run time was significantly reduced by 3.4-fold with a 5-fold decreased solvent consumption. Forced degradation studies indicated a complete separation of the analytes in the presence of their degradation products providing high degree of method specificity. The proposed UHPLC method was demonstrated to be simple and rapid for the determination of ANZ and NFZ in com. available ophthalmic formulations providing recoveries between 99.6 and 100.4%.

Acta Chimica Slovenica published new progress about 2508-72-7. 2508-72-7 belongs to imidazoles-derivatives, auxiliary class Inhibitor,Immunology/Inflammation,Histamine Receptor, name is N-Benzyl-N-((4,5-dihydro-1H-imidazol-2-yl)methyl)aniline hydrochloride, and the molecular formula is C17H20ClN3, Quality Control of 2508-72-7.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem