Month: November 2022

Cooper, G. published the artcile1-styrylimidazoles, Related Products of imidazoles-derivatives, the main research area is styrylimidazole; imidazole styryl; benzimidazole styryl; dehydration hydroxyphenylethylimidazole.

Addnl. data considered in abstracting and indexing are available from a source cited in the original document. Styrene oxide reacted with imidazole, its 2-methyl, 2-phenyl, and 4,5-diphenyl derivatives and benzimidazole in DMF in the presence of catalytic quantities of K at room temperature to give 45-98% of the corresponding 1-(2-hydroxy-2-phenylethyl)imidazole, which on heating with SOCl2 and KOH were dehydrated to give 51-90% trans-1-styrylimidazoles.

Journal of the Chemical Society, Perkin Transactions 6: Organic and Bio-Organic Chemistry published new progress about styrylimidazole; imidazole styryl; benzimidazole styryl; dehydration hydroxyphenylethylimidazole. 5805-53-8 belongs to class imidazoles-derivatives, name is Methyl 1H-benzo[d]imidazole-2-carboxylate, and the molecular formula is C9H8N2O2, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kirk, Kenneth L. published the artcilePhotochemistry of diazonium salts. I. Synthesis of 4-fluoroimidazoles, 4-fluorohistamine, and 4-fluorohistidine, Related Products of imidazoles-derivatives, the main research area is photochem diazonium salt; fluorinated imidazole.

Imidazolediazonium ions, prepared by diazotization of aminoimidazoles in HBF4 and irradiated in situ, decompose with formation of fluoroimidazoles in 30-40% yield. 2-Fluoroimidazole, 4-fluoroimidazole, and Et 4-fluoroimidazole-5-carboxylate (I) were prepared I was the starting point for various transformations, including the synthesis of 4-fluorohistamine and 4-fluorohistidine. The fluorinated amino acid parallels histidine as a substrate for several enzymes and, in the case of histidine-ammonia lyase, serves as a competitive inhibitor.

Journal of the American Chemical Society published new progress about photochem diazonium salt; fluorinated imidazole. 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Albright, J. Donald published the artcileSynthesis of 4-aroyl-5-nitro-1H-imidazoles and 4-aroyl-5-aminoimidazoles, Related Products of imidazoles-derivatives, the main research area is nitroimidazole; aroylaminoimidazole; aminoimidazole aroyl; imidazole aroyl amino nitro.

The reaction of α-(aryl)-4-morpholineacetonitriles (masked aroyl anion equivalent) with N-protected 4(5)-bromo-5(4)-nitro-1H-imidazoles gave 4-aroyl-5-nitroimidazoles, which were reduced to afford 4-aroyl-5-aminoimidazoles. Thus, imidazole I (R = Bz) was prepared from I (R = Br) and nitrile II.

Journal of Heterocyclic Chemistry published new progress about nitroimidazole; aroylaminoimidazole; aminoimidazole aroyl; imidazole aroyl amino nitro. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Related Products of imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kochergin, P. M. published the artcileInvestigations in the imidazole series 97. Synthesis and some transformations of 5-nitro-5-hydroxyalkylamino- and 4-hydroxyalkylamino-5-nitroimidazoles, Application In Synthesis of 18874-52-7, the main research area is nitrohydroxyalkylaminoimidazole preparation reaction; imidazole nitro hydroxyalkylamino preparation reaction; hydroxyalkylaminoimidazole nitro preparation reaction.

A series of 1-alkyl(1,2-dialkyl)-substituted 4-nitro-5-hydroxyalkylamino- and 4-hydroxyalkylamino-5-nitroimidazoles were obtained by the reaction of 1-alkyl(1,2-dialkyl)-substituted 4-nitro-5-chloro(bromo)imidazoles with amino alcs. Their reactions with thionyl chloride and carboxylic acid halides and their catalytic hydrogenation were studied.

Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about nitrohydroxyalkylaminoimidazole preparation reaction; imidazole nitro hydroxyalkylamino preparation reaction; hydroxyalkylaminoimidazole nitro preparation reaction. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Application In Synthesis of 18874-52-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Kochergin, P. M. published the artcileSynthesis of 7-methyl-6-(nitroimidazolyl)thiopurines, Recommanded Product: 5-Bromo-2-methyl-4-nitroimidazole, the main research area is methylnitroimidazolylthiopurine preparation; purine methylnitroimidazolylthio preparation; imidazolylthiopurine methylnitro preparation.

We have studied the reactions of 7-methyl-6-thiopurine with 5(4)-halo-4(5)-nitroimidazoles and 6-chloro-7-methylpurine with sodium and ammonium salts of 5-mercapto-4-nitroimidazoles. We have obtained a series of 7-methyl-6-(nitroimidazolyl)thiopurines not previously described in the literature.

Chemistry of Heterocyclic Compounds (New York)(Translation of Khimiya Geterotsiklicheskikh Soedinenii) published new progress about methylnitroimidazolylthiopurine preparation; purine methylnitroimidazolylthio preparation; imidazolylthiopurine methylnitro preparation. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Recommanded Product: 5-Bromo-2-methyl-4-nitroimidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Ranganathan, Darshan published the artcileRepetitive imidazole synthesis using an immobilized imidazole template, HPLC of Formula: 21343-04-4, the main research area is imidazole repetitive synthesis template; ATP imidazole cycle model.

A model is presented for the chem. simulation of the ATP-imidazole cycle programmed to continuous production of the daughter imidazoles from the immobilized parent imidazole template. 6-Chloropurine was treated with chloromethylated polystyrene and hydrolysis of the product followed by alkylation with PhCOCH2Br afforded polymer-bound hypoxanthine I (R = CH2COPh, R1 = chloromethylated polystyrene). Treating I (R = CH2COPh, R1 = chloromethylated polystyrene) with PhCH2NH2 and p-MeC6H4SO3H produced the expected daughter mol., 1-benzyl-5-phenylimidazole (II) in 30% yield and the polymer-bound 5-aminoimidazole-4-carboxamide III, which, in turn, was transformed to the template hypoxanthine I (R = H) by treatment with MeSO3H followed by HCONH2. To prove the concept of the continuous generation of the daughter mol., the regenerated parent template was processed through a second cycle using the same protocol when the expected daughter product II was obtained in 14% yield. Polymer-bound adenine when subjected to a similar protocol failed to yield any daughter mol. Endeavors to prepare polymer-linked 4-oxoquinazoline and anthranilic acid are also reported.

Journal of Organic Chemistry published new progress about imidazole repetitive synthesis template; ATP imidazole cycle model. 21343-04-4 belongs to class imidazoles-derivatives, name is 5-Amino-1-methyl-1H-imidazole-4-carboxamide, and the molecular formula is C5H8N4O, HPLC of Formula: 21343-04-4.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Takeuchi, Y. published the artcileAcid-catalyzed isotope exchange of ring hydrogens in fluoroimidazoles, Application In Synthesis of 30086-17-0, the main research area is fluoroimidazole exchange ring hydrogen; mechanism hydrogen exchange fluoroimidazole; imidazole fluoro hydrogen exchange.

An alternative mechanism (E’) to electrophilic attack on the imidazolium ion (E pathway) involving electrophilic attack at C-(4) or C-(5) in the neutral mol., was demonstrated for imidazoles which have low pK values and which have one or two substituents capable of stabilizing a carbonium ion. Exchange by the E’ pathway occurs far more readily than E exchange. Thus, in 0.1-3 N DCl at 50°, t1/2 ≃ 9 h for 4-fluoro-2-methyl-, 12 h for 4-fluoro-1-Me, 16 h for 2-fluoro-4-methyl-, and 54h for 4-fluoroimidazole. Under these conditions, no exchange is observed at C-(2). The fluorine substituent provides the necessary combination of electronegativity and resonance overlap to permit facile exchange by the E’ pathway.

Journal of Organic Chemistry published new progress about fluoroimidazole exchange ring hydrogen; mechanism hydrogen exchange fluoroimidazole; imidazole fluoro hydrogen exchange. 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, Application In Synthesis of 30086-17-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Hagedorn, Alfred A. III published the artcileCardiotonic agents. 2. (Imidazolyl)aroylimidazolones, highly potent and selective positive inotropic agents, Application of 4-((1H-Imidazol-1-yl)methyl)benzoic acid, the main research area is imidazolylaroylimidazolone preparation inotropic activity; cardiac phosphodiesterase inhibition imidazolylbenzoylimidazolone; mol structure inotropic activity.

Twenty-two alkyldihydro[(imidazolyl)benzoyl]imidazolones (e.g., I; R = Me, R1 = H) was synthesized and evaluated in vitro for pos. inotropic and cAMP phosphodiesterase inhibitory activity. Thus, the imidazolone II was heated at 140° in molten imidazole to give 61% I (R = Me, R1 = H). A wide range of inotropic and enzyme-inhibitory potencies was observed, substitution on the imidazolyl moiety being the major determinant of activity. I (R = Et, R1 = H) exhibited the highest potency in vitro. Incorporation of a Me group at the imidazolyl 2-position gave I (R = Et, R1 = Me), which was less potent but remarkably selective in vivo for pos. inotropic effects over heart rate and hypotensive effects.

Journal of Medicinal Chemistry published new progress about Heart. 94084-75-0 belongs to class imidazoles-derivatives, name is 4-((1H-Imidazol-1-yl)methyl)benzoic acid, and the molecular formula is C11H10N2O2, Application of 4-((1H-Imidazol-1-yl)methyl)benzoic acid.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Freter, K. published the artcile4-(Indolyl-3)-1-(benzimidazolonylalkyl)piperidines, a novel group of potential antiallergy compounds, Quality Control of 52548-84-2, the main research area is benzimidazolone indolylpyridylalkyl antihistamine.

Antiallergic I (R1 = H, Me, Me2CH, R2 = H, Me, R3 = H, Me, isopropenyl, R5 = H, n = 2-6) were prepared in 34-92% yields by treating indole II with the corresponding N-(ω-chloroalkyl)benzimidazolinones III. I (R1 = R2 = R3 = R5 = H, n = 3) had an in vitro antihistaminic activity IC50 of 0.018 μg/mL compared to 0.030 μg/mL for oxatomide.

Arzneimittel-Forschung published new progress about Allergy. 52548-84-2 belongs to class imidazoles-derivatives, name is 1-(2-Chloroethyl)-1H-benzo[d]imidazol-2(3H)-one, and the molecular formula is C9H9ClN2O, Quality Control of 52548-84-2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Catalan, Javier published the artcileThe azoles: a theoretical study, Application In Synthesis of 30086-17-0, the main research area is MO azole; protonation azole; dipole moment azole; tautomerism azole.

Ab initio calculations were reported for 35 azoles (neutral mols. and protonated azolium salts) based on INDO optimized geometries. Calculated dipole moments agreed with measured values. Protonation sites (most basic N atoms) were determined from calculated protonation energies and N lone pair changes. Linear relations between exptl. aqueous basicity and calculated protonation energies for N-methylazoles and between exptl. aqueous acidity for N-unsubstituted azoles and the charge of the NH H atom, were observed Tautomerism of the triazoles and tetrazoles were discussed.

Chemica Scripta published new progress about Acidity. 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, Application In Synthesis of 30086-17-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem