Month: November 2022

Yang, Daoshan published the artcileCatalyst-Free Regioselective C-3 Nitrosation of Imidazopyridines with tert-Butyl Nitrite under Neutral Conditions, SDS of cas: 1023-01-4, the main research area is regioselective nitrosation imidazopyridine.

We have successfully developed a novel and efficient catalyst-free method for the synthesis of 3-nitroso-substituted imidazopyridines from readily available imidazo[1,2-a]pyridines and tert-Bu nitrite in good to excellent yields. Importantly, the use of transition-metal catalysts, stoichiometric amounts of acids, and toxic or potentially dangerous oxidants is avoided. This easy and practical method complements nitrosation reactions by expanding the scope and practicality, and should attract much attention in synthetic and pharmaceutical chem.

Synthesis published new progress about Crystal structure. 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, SDS of cas: 1023-01-4.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Song, Yang published the artcileEffect of solvent and temperature on the photoluminescent properties of Ag(I) complexes base on two different flexibility imidazole functionalized benzoic acid linkers, HPLC of Formula: 94084-75-0, the main research area is preparation silver imidazolebenzoate complex; crystal structure silver imidazolebenzoate complex; photoluminescence silver imidazolebenzoate complex.

Two novel Ag(I) complexes zero-dimensional (0D) [Ag(ibz)(Hibz)]2 (Ag1) (Hibz = 4-(1H-imidazolyl)benzoic acid) and two-dimensional (2D) [Ag(imbz)(Himbz)]n (Ag2) (Himbz = 4-(1H-imidazolyl-1-methyl)benzoic acid) were synthesized through the hydrothermal method. By changing the ligands from rigid Hibz to flexible Himbz, the distance between two aromatic rings in the ligand is controlled to get different dimensional complexes. Both complexes were characterized by single-crystal x-ray diffraction, IR, elemental anal. and thermal gravimetric analyses (TGA). Ag1 is coordinated with two N atoms, forming a two-coordination linear configuration. While Ag2 possesses interesting 2-dimensional frameworks, exhibiting 2-fold interpenetrating sql topol. structure. The luminescent properties of Ag1 and Ag2 were studied both in the solid state and in different solvents (DMSO, MeCN and MeOH) at 298 K and 77 K. Ag1 displays stable blue luminescent in the solid state and in solvents at 298 K and 77 K. Whereas, Ag2 shows tunable luminescence by changing the temperature from 298 K to 77 K, indicating thermochromic luminescence for Ag2. The emission efficiency of Ag1 and Ag2 is found with quantum yields ranging from 0.073 to 0.208, which is much higher than that of free ligand.

Inorganic Chemistry Communications published new progress about Crystal structure. 94084-75-0 belongs to class imidazoles-derivatives, name is 4-((1H-Imidazol-1-yl)methyl)benzoic acid, and the molecular formula is C11H10N2O2, HPLC of Formula: 94084-75-0.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tykarska, Ewa published the artcile2-(5-Bromo-2-methyl-4-nitroimidazol-1-yl)-1-(2-chlorophenyl)ethanone, HPLC of Formula: 18874-52-7, the main research area is mol structure bromomethylnitroimidazolyl chlorophenyl ethanone; crystal structure bromomethylnitroimidazolyl chlorophenyl ethanone.

In the title compound, C12H9BrClN3O3, the nitro group lies in the plane of the imidazole ring, whereas the benzene and acetyl groups are markedly twisted relative to the heterocyclic ring. A weak C-H…O interaction helps to establish the crystal packing. Crystal data: monoclinic, space group Cc, a 8.4929(8), b 23.8609(13), c 7.5005(5) Å, β 120.190(7)°, Z = 4, 2476 observed reflections with I > 2σ(I), 182 refined parameters, R[F2 > 2σ(F2)] = 0.022, wR(F2) = 0.054 at T = 220(2) K.

Acta Crystallographica, Section E: Structure Reports Online published new progress about Crystal structure. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, HPLC of Formula: 18874-52-7.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Feng, Zihao published the artcileConstruction and investigation of chiral and photoluminescent Metal-Organic framework based on Zn(II) ions and achiral methoxy-functionalized benzimidazolate linkers, SDS of cas: 72721-02-9, the main research area is dimethoxy benzimidazolate zinc metal organic framework preparation crystal structure; chiral photoluminescent dimethoxy benzimidazolate zinc MOF preparation crystal structure.

A Zn(II)-based metal-organic framework, namely MeOBim-Zn (1), has been prepared by the reaction between 5,6-dimethoxy-1H-benzo[d]imidazole (MeOBimH) and Zn(NO3)2 in the presence of aqueous ammonia through solvothermal method and characterized by single-crystal x-ray diffraction, TGA and FT-IR. 1 Exhibits a (10,3)-a chiral network constructing from achiral MeOBim- linker and Zn(II) ions via spontaneous resolution In addition, 1 shows photoluminescent emission at 433 nm upon photoexcitation at 365 nm and this emission may originate from dissipation of metal-perturbed π(MeOBim-) to π*(MeOBim-) intraligand (IL) excited state.

Inorganic Chemistry Communications published new progress about Crystal structure. 72721-02-9 belongs to class imidazoles-derivatives, name is 5,6-Dimethoxy-1H-benzo[d]imidazole, and the molecular formula is C9H10N2O2, SDS of cas: 72721-02-9.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Lingscheid, Yves published the artcileDetermination of inter-ionic and intra-ionic interactions in a monofluorinated imidazolium ionic liquid by a combination of X-ray crystallography and NOE NMR spectroscopy, Category: imidazoles-derivatives, the main research area is inter ionic intra interaction monofluorinated imidazolium liquid; X ray crystallog NOE NMR spectroscopy.

We report the very first application of a Transient 1D 1H{19F} NOE NMR experiment in neat ionic liquids In comparison with classical 2D HOESY NMR spectroscopy, a substantial reduction in measurement time is gained with comparable quality and information content of the spectra. In combination with classical X-ray crystallog., we have applied this technique for the determination of inter-ionic distances (i.e. probabilities of presence) utilizing an ionic liquid containing a monofluorinated imidazolium cation. Copyright © 2017 John Wiley & Sons, Ltd.

Magnetic Resonance in Chemistry published new progress about Crystal structure. 30086-17-0 belongs to class imidazoles-derivatives, name is 5-Fluoro-1H-imidazole, and the molecular formula is C3H3FN2, Category: imidazoles-derivatives.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Wagner, Pawel published the artcileCrystal packing of two 5-substituted 2-methyl-4-nitro-1H-imidazoles, Safety of 5-Bromo-2-methyl-4-nitroimidazole, the main research area is crystal packing methyl nitro imidazole derivative; mol structure bromomethylnitroimidazole methylnitroimidazolecarbonitrile; structure crystal bromomethylnitroimidazole methylnitroimidazolecarbonitrile; hydrogen bond bromomethylnitroimidazole methylnitroimidazolecarbonitrile.

Infinite chains connected by N-H···N H bonding form the primary packing motif in two closely related 4-nitroimidazole derivatives, viz. 5-bromo-2-methyl-4-nitro-1H-imidazole, C4H4BrN3O2, (I), and 2-methyl-4-nitro-1H-imidazole-5-carbonitrile, C5H4N4O2, (II). These chains are almost identical, even though in (II) there are two symmetry-independent mols. in the asym. unit. The differences appear in the interactions between the chains; in (I), there are strong C-Br···O halogen bonds, which connect the chains into a two-dimensional grid, while in (II), the cyano group does not participate in specific interactions and the chains are only loosely connected into a three-dimensional structure. Crystallog. data are given.

Acta Crystallographica, Section C: Crystal Structure Communications published new progress about Crystal structure. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Safety of 5-Bromo-2-methyl-4-nitroimidazole.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Salgado-Zamora, Hector published the artcileA convenient approach to the synthesis of the imidazo[5,1-b]oxazole ring system, Product Details of C4H4BrN3O2, the main research area is imidazole bromomethylnitrophenacyl intramol cyclization potassium butoxide; imidazooxazole preparation; oxazole imidazo preparation.

Reaction of 4(5)-bromo-2-methyl-5(4)-nitroimidazole with phenacyl bromide derivatives ArCOCH2Br (Ar = Ph, 4-ClC6H4, 3-F3CC6H4, etc.) led to 4-bromo-2-methyl-1-phenacyl-5-nitro- and 5-bromo-2-methyl-1-phenacyl-4-nitroimidazoles I (X1 = NO2, X2 = Br; X1 = Br, X2 = NO2). Treatment of the latter isomers with potassium tert-butoxide in dry THF yielded imidazo[5,1-b]oxazoles II.

Heterocycles published new progress about Crystal structure. 18874-52-7 belongs to class imidazoles-derivatives, name is 5-Bromo-2-methyl-4-nitroimidazole, and the molecular formula is C4H4BrN3O2, Product Details of C4H4BrN3O2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Yang, Daoshan published the artcileCatalyst-Free Regioselective C-3 Thiocyanation of Imidazopyridines, Recommanded Product: 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, the main research area is regioselective thiocyanation imidazopyridine.

A direct and straightforward approach for highly regioselective thiocyanation of imidazoheterocycles through sp2 C-H functionalization has been realized at room temperature Various C-3 thiocyanated imidazopyridines are formed in moderate to good yield. The present method exhibits a mild and selective access to a variety of imidazopyridine derivatives of pharmacol. interest.

Journal of Organic Chemistry published new progress about Crystal structure. 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, Recommanded Product: 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Tufail, Fatima published the artcileCatalyst-Free, Glycerol-Assisted Facile Approach to Imidazole-Fused Nitrogen-Bridgehead Heterocycles, COA of Formula: C14H11BrN2, the main research area is imidazopyridine imidazopyrimidine imidazopyrazine preparation regioselective green chem; phenacyl bromide aminopyridine aminopyrimidine aminopyrazine coupling glycerol solvent.

A completely regioselective, environmentally benign strategy for the facile synthesis of biol. important imidazole-fused nitrogen-bridgehead heterocycles has been developed using glycerol/water 4:1 as a green promoting media. The methodol. involves the simple coupling of 2-halocarbonyl compounds with 2-aminopyridines, 2-aminopyrimidine, 2-aminopyrazine to obtain a variety of 2-aryl substituted imidazo-pyridines, imidazo-pyrimidines and imidazo-pyrazines containing bridgehead nitrogen. This protocol eliminates the use of toxic catalysts and volatile organic solvents – two key principles in the development of a green chem. process. Other significant highlights include mild reaction conditions, operational simplicity, short reaction times, easy workup and purification process, high yields and potential for scale-up.

ChemistrySelect published new progress about Coupling reaction. 1023-01-4 belongs to class imidazoles-derivatives, name is 2-(4-Bromophenyl)-6-methylimidazo[1,2-a]pyridine, and the molecular formula is C14H11BrN2, COA of Formula: C14H11BrN2.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem

Demissie, Taye B. published the artcileMechanism and Site Selectivity in Visible-Light Photocatalyzed C-H Functionalization: Insights from DFT Calculations, Recommanded Product: Imidazo[1,2-c]pyrimidine, the main research area is selectivity visible photocatalyzed carbon hydrogen functionalization DFT.

Visible-light photocatalyzed (VLPC) late-stage C-H functionalization is a powerful addition to the chem. synthesis toolkit. VLPC has a demonstrated potential for discovery of elusive and valuable transformations, particularly in functionalization of bioactive heterocycles. To fully harvest the potential of VLPC in the context of complex mol. synthesis, a thorough understanding of the elementary processes involved is crucial. This would enable more rational design of suitable reagents and catalysts, as well as prediction of activated C-H sites for functionalization. Such knowledge is essential when VLPC is to be employed in retrosynthetic anal. of complex mols. Herein, the authors present a d. functional theory (DFT) study of mechanistic details in the C-H functionalization of bioactive heterocycles exemplified by the methylation of the antifungal agent voriconazole. Also, readily computed at. charges can predict major site-selectivity in good agreement with exptl. studies and thus be informative tools for the identification of active C-H functionalization sites in synthetic planning.

Journal of Organic Chemistry published new progress about C-C bond cleavage. 274-78-2 belongs to class imidazoles-derivatives, name is Imidazo[1,2-c]pyrimidine, and the molecular formula is C6H5N3, Recommanded Product: Imidazo[1,2-c]pyrimidine.

Referemce:
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem