Butera, John A. published the artcileSynthesis and selective class III antiarrhythmic activity of novel N-heteroaralkyl-substituted 1-(aryloxy)-2-propanolamine and related propylamine derivatives, Category: imidazoles-derivatives, the publication is Journal of Medicinal Chemistry (1991), 34(11), 3212-28, database is CAplus and MEDLINE.
The synthesis and biol. evaluation of a series of novel 1-(aryloxy)-2-propranolamines and several related deshydroxy analogs are described. The compounds were prepared and investigated for their class III electrophysiol. activity in isolated canine Purkinje fibers and in anesthetized open-chest dogs. None of these compounds showed any class I activity. On the basis of the in vitro data, structure-activity relations for the series are discussed. Two compounds, WAY-123,223 (I) and WAY-125,971 (II) were identified and characterized as potent and specific class III antiarrhythmic agents in vitro and in vivo. I was orally bioavailable, to produce large increases of ventricular fibrillation threshold (VFT), and, in some instances, to restore sinus rhythm from ventricular fibrillation in anesthetized open-chest dogs at a dose of 5 mg/kg (i.v.). The enantiomers of I were synthesized and found to exhibit similar electrophysiol. effects in the Purkinje fiber screen. II, a propylamine analog with potency and efficacy comparable to those of UK-68798 and E-4031, was studied in voltage-clamp experiments (isolated cat myocytes) and found to be a potent and specific blocker of the delayed rectifier potassium current (IK).
Journal of Medicinal Chemistry published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Category: imidazoles-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem