Ganguli, Kasturi’s team published research in Dalton Transactions in 48 | CAS: 4760-35-4

Ganguli, Kasturi published the artcileCooperative Mn(I)-complex catalyzed transfer hydrogenation of ketones and imines, Product Details of C9H9ClN2, the publication is Dalton Transactions (2019), 48(21), 7358-7366, database is CAplus and MEDLINE.

The synthesis and reactivity of Mn(I) complexes bearing bifunctional ligands comprising both the amine N-H and benzimidazole fragments I and II (R = H, Me; R¹ = H, Me, phenyl; R² = H, Me) are reported. Among the various ligands, the N-((1H-benzimidazol-2-yl)methyl)aniline ligand containing Mn(I) complex II (R = R² = H; R¹ = Ph) presented higher reactivity in the transfer hydrogenation (TH) of ketones R³C(O)R⁴ (R³ = Ph, thiophen-2-yl, cyclopropyl, etc.; R⁴ = Me, propan-2-yl, tert-Bu, etc.; R³R⁴ = 9H-fluoren-9-yl, 1,2,3,4-tetrahydronaphthalen-1-yl, cyclohexyl) in 2-propanol. Exptl., it was established that both the benzimidazole and amine N-H proton played a vital role in the enhancement of the catalytic activity. Utilizing this system, a wide range of ketones R³C(O)R⁴ and aldehydes R⁵CHO (R⁵ = 4-CH₃C₆H₄, thiophen-2-yl, pentyl, etc.) was reduced efficiently. Notably, the TH of several imines R⁶R⁷C=NR⁸ (R⁶ = 4-OCH₃C₆H₄, thiophen-2-yl, naphthalen-2-yl, etc.; R⁷ = H, Me, Et; R⁸ = C₆H₅, 4-OCH₃C₆H₄, CH₃(CH₂)₃, etc.), as well as chemoselective reduction of unsaturated ketones, was achieved in the presence of this catalyst. DFT calculations were carried out to understand the plausible reaction mechanism which disclosed that the transfer hydrogenation reaction followed a concerted outer-sphere mechanism.

Dalton Transactions published new progress about 4760-35-4. 4760-35-4 belongs to imidazoles-derivatives, auxiliary class Chloride,Benzimidazole, name is 2-(Chloromethyl)-1-methyl-1H-benzo[d]imidazole, and the molecular formula is C9H9ClN2, Product Details of C9H9ClN2.

Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem