Eom, Young Woo published the artcileCytotoxicity of substituted benzimidazolyl curcumin mimics against multi-drug resistance cancer cell, Quality Control of 7467-35-8, the publication is Bulletin of the Korean Chemical Society (2013), 34(4), 1272-1274, database is CAplus.
Recently, we discovered that introduction of benzimidazole groups to the feruloyl scaffold through aldol condensation greatly improved the cytotoxicity of synthetic curcumin mimics against various cancer cells. Because the benzimidazole mols. exhibit a variety of biol. properties such as anticancer, antiviral, and anti-hypertensive activity, we can expect their novel cytotoxic properties come from benzimidazolyl groups attached to the feruloyl structure. Our goal was to evaluate the cytotoxicity of novel curcumin mimics with structurally diverse benzimidazol moieties against multidrug resistance (MDR) cancer cells. A novel curcumin mimics library has been synthesized with the purpose of discovering novel anticancer drug candidates that inhibit a proliferation both MDR cancer cells and non-MDR cancer cells at the same time. We confirmed that our novel curcumin mimics inhibit the growth of MDR cancer cells more strongly than our previous inhouse curcumin mimic libraries and curcumin; among the tested derivatives, 13b, 14b, and 14h are the strongest candidates inhibiting multidrug resistance cancer cells.
Bulletin of the Korean Chemical Society published new progress about 7467-35-8. 7467-35-8 belongs to imidazoles-derivatives, auxiliary class Benzimidazole,Alcohol, name is (1-Methyl-1H-benzo[d]imidazol-2-yl)methanol, and the molecular formula is C9H10N2O, Quality Control of 7467-35-8.
Referemce:
https://en.wikipedia.org/wiki/Imidazole,
Imidazole | C3H4N2 – PubChem